WO1998015296A1 - Appareil et procede d'oxygenation de liquides biologiques - Google Patents

Appareil et procede d'oxygenation de liquides biologiques Download PDF

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Publication number
WO1998015296A1
WO1998015296A1 PCT/IB1997/001240 IB9701240W WO9815296A1 WO 1998015296 A1 WO1998015296 A1 WO 1998015296A1 IB 9701240 W IB9701240 W IB 9701240W WO 9815296 A1 WO9815296 A1 WO 9815296A1
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WO
WIPO (PCT)
Prior art keywords
accordance
flow
biological liquid
mesh
oxygenating
Prior art date
Application number
PCT/IB1997/001240
Other languages
English (en)
Inventor
Peter Lea
Original Assignee
Lifetech Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lifetech Corporation filed Critical Lifetech Corporation
Priority to AU43933/97A priority Critical patent/AU4393397A/en
Publication of WO1998015296A1 publication Critical patent/WO1998015296A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/32—Oxygenators without membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A61L2/0094—Gaseous substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/20—Gaseous substances, e.g. vapours
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/20—Gaseous substances, e.g. vapours
    • A61L2/202—Ozone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/02—Gases
    • A61M2202/0216—Ozone

Definitions

  • This invention relates generally to gas/liquid contact apparatus and methodology. More specifically the invention relates to apparatus and methods for introducing gaseous oxygen into a biological liquid; and more particularly for introducing such oxygen into blood or a blood fraction, or into a transfusible liquid such as a saline or glucose solution, or into a nutrient media or the like.
  • the invention is especially useful for sterilizing such liquids from contaminants such as viruses, bacteria and fungi which may be present.
  • Oxygen is an allotropic element, with the most common form of the gas being the di-atomic form (O 2 ).
  • Ozone (O 3 ) and singlet oxygen ( l 0 2 ) are other forms of the gas that occur naturally and that can be created artificially.
  • oxygen as used herein is meant to encompass all of these forms of the gas.
  • References to "oxygenation" of biological liquids similarly encompasses treatment by any of such forms of the gas, and refers to the transfer and absorption of the treating oxygen by the biological liquid, irrespective of whether the purpose of the transfer is for absorption of oxygen for any of a number of known purposes, or for sterilization of one or more components of the biological liquid.
  • active oxygen intermediates such as peroxides can also be formed as a direct result of ozone interaction with the biological liquid.
  • Ozone is the triatomic form of oxygen and is relatively unstable.
  • One method for generating ozone is to expose O 2 gas to electromagnetic radiation having a wave length of about 180 to 187 ran. Other methods of forming ozone are well-known.
  • Singlet oxygen is the monatomic form of oxygen and is highly unstable.
  • One method for generating singlet oxygen is to expose ozone to ultra-violet light at a wavelength of about 253.7 ran. It is also known to expose a mixture of oxygen gas containing ozone and singlet oxygen to visible light at a wavelength of between about 500 and 800 ran to further induce the formation of singlet oxygen. Other methods of forming singlet oxygen are well known.
  • Ozone and singlet oxygen are also well-known in the medical community as agents for treating blood and human tissue in order to fight disease or other pathogens.
  • Ozone has been found, e.g. , to be effective against various viruses and fungi, and to inactivate a wide variety of bacteria including pseudomonas aeruginosa, staphylococcus aureus and mycobacte ⁇ um tuberculosis.
  • the administration of ozone is also known to yield beneficial health effects by stimulating oxygen metabolism. Studies of the effects of singlet oxygen indicate similar or even more dramatic effects.
  • ozone and singlet oxygen are very important use in the sterilization of blood and blood products. Through the use of ozone and singlet oxygen, it is possible to deactivate a variety of bacterial, viral, and other contaminants of blood, including HIV-1 and Hepatitis. Oxygenation in this manner may be used to treat blood that has been withdrawn from one human, prior to its being transfused to a recipient. Blood products used for transfusion are each separately treated and subsequently used as desired.
  • oxygenating will be used in this disclosure and claims to include treatment of a biological liquid with oxygen whether or not the oxygen is relatively pure or comprises air which contains nitrogen and other gases.
  • the term also includes exposure of a biological substrate to oxygen which has been treated by means such as exposure to electrical discharge so that the treated gas is functioning as a carrier for ozone and singlet oxygen.
  • oxygen, ozone, and/or singlet oxygen gas molecules to a biological liquid such as human blood, can be a problematic process. It is desirable to have the gas molecules introduced as efficiently as possible to the biological liquid in order to minimize time, expense, and toxic effects. However, introduction of these gas molecules through the use of certain prior art technology can readily cause a formation of bubbles.
  • biological liquids encompasses a wide variety of substrates which may be oxygenated and/or sterilized by use of the invention. These include, for example, blood and blood products, such as whole blood, serum, plasma, and packed red blood cells; and as well, bone marrow and semen. Also included are fluids that may be administered to mammals, including humans, such as saline or glucose intravenous solutions and the like; parenteral admixtures; and fluid nutrient media such as are employed to grow bacteria, viruses, cells, parasites, and the like.
  • a "flowable biological liquid” is a biological liquid that behaves mechanically like a classic liquid, and can thus be made to flow in the manner of a liquid.
  • Such a system e.g. in the case of blood, need not be entirely liquid or homogeneous, but can e.g. consist of minute bodies such as cells, proteins or other organules or minerals contained in a liquid carrier.
  • minute bodies such as cells, proteins or other organules or minerals contained in a liquid carrier.
  • ozone include contacting the blood or blood product (i.e, serum or the like) with the ozone by passing the fluid medium as a film through a chamber containing the ozone, or by passing the blood through porous tubing which are present in a chamber containing the ozone.
  • the technique wherein the blood is contacted as a film is exemplified in this patent by the use of rotating vessels such as rotating bottles, which act to form the blood into a relatively thin film over most of the bottle interior surface, with the ozone being passed through the bottle interior.
  • the concentration of ozone in the treating atmosphere is said to be in the range of about 1 to 100 ppm, and usually in the range of from about 1 to 20 ppm.
  • the ozone level was at approximately 2 ppm, and apparently was even lower since the ozone was mixed with filtered air before being contacted with the blood in the rotating bottle.
  • the patentee emphasizes the need for what are referred to as "mild" contact conditions, apparently referring to the very low concentrations of ozone which are used.
  • a difficulty encountered in the method and apparatus contemplated in the 4,632,980 patent is that the treated film of blood is upon continued rotation of the bottle remixed with the untreated blood, thereby continually nullifying in whole or in part any salutary effects which are otherwise achieved.
  • the film of blood formed can at best be contacted only at one surface thereof since the film resides on the bottle surface and is not amenable to contact with the ozone from the support side.
  • This patent also illustrates oxygenation of a biological liquid for oxygenating a patient's blood during a medical procedure or the like, i.e. oxygenation here is ultimately directed at patient administration, and is not for purposes of sterilization.
  • a chamber is provided for receiving and collecting the liquid (such as blood) which is to be contacted with the oxygenating gas, such as oxygen containing ozone.
  • the oxygenating gas is introduced into a spray orifice in such a manner that the venturi effect generated by flow of the gas causes a flow of blood to be induced into and contacted with the gas stream, and to issue from the nozzle orifice as a dispersed spray of liquid droplets.
  • a spray collection surface is located within the chamber in the spray path of the liquid droplets, which collects substantially the entirety of the droplets of oxygenated liquid.
  • This collection surface is spaced from the spray orifice a distance selected so that the droplets impinge on the collection surface at relatively low velocity and form a film on the surface, where further contact with the gas can also be effected.
  • the method of contact achieved in the said apparatus is very effective in that high energy mechanical impact of the droplets with the collection surface is avoided, whereby hemolysis effects are eliminated or greatly reduced. Much higher concentrations of ozone can be safely utilized in this apparatus than have heretofore been taught.
  • Such apparatus should preferably be of relatively simple design and principles of operation, to enable high dependability, and ready maintenance in the event of failure or the like.
  • apparatus and methods are provided for effectively oxygenating a flowable biological liquid.
  • an open mesh surface is provided having opposed accessible faces.
  • Flow means are disposed to establish a flow of the biological liquid along the mesh surface, thereby forming the liquid into a membrane at the mesh openings of the surface.
  • Means are additionally provided for establishing an oxygenating gas atmosphere in contact with the opposed faces of the mesh surface, for oxygenating the biological liquid membrane from both sides of the mesh surface; and means are provided for collecting the flow of oxygenated biological liquid from the mesh.
  • the mesh surface may be formed as a cylinder, which is mounted with its axis vertically directed.
  • the means for flowing the biological liquid can in this instance comprise a distribution cap secured at the top of the cylinder with its periphery engaging the end of the cylinder.
  • a flow of biological liquid is provided onto the cap to enable a flow toward the circumferential edge of the cap and thereby onto the mesh surface where a thin membrane of the liquid is thus formed.
  • the cylinder and flow means are mounted within a reaction and liquid collection chamber.
  • the chamber is provided with a gas inlet for oxygenating gas and a spaced gas outlet for discharging the gas.
  • liquid inlet means for the biological liquid to be treated Also connected to the chamber are liquid inlet means for the biological liquid to be treated, and an outlet enabling the treated biological liquid to be collected.
  • the flow means may further comprise a liquid delivery conduit and a flow control means between the conduit and distribution cap for regulating the amount of flow to the mesh surface.
  • the mesh surface preferably comprises a material which is relatively inert to the biological liquid and is not rapidly damaged by the oxygenating gas used in the apparatus, and may be in the form of gauze, a screen, webbing or the like.
  • the mesh surface can take other forms than cylindrical.
  • the mesh surface can be flat and disposed in a substantially vertical or other plane; or the mesh surface can be distorted into a continuous but not planar form.
  • the flow control means comprises a flow distributing surface and means to deliver a controlled, relatively constant flow of biological liquid to the distributing surface to enable a controlled flow along the mesh surface.
  • a pump is used to control the flow of biological liquid onto the distributing surface.
  • a peristaltic pump is particularly preferred because such pump avoids direct contact with the biological liquid, thereby precluding contamination.
  • Flow along the mesh surface can be induced by other forces, for example by pressure differentials imposed upon the liquid.
  • the present invention also includes methods for effectively oxygenating a flowable biological liquid.
  • an open mesh surface is provided having opposed accessible faces.
  • a flow of the biological liquid is generated along the surface, which flow forms the biological liquid into a membrane at the mesh openings of the surface.
  • An oxygenating gas atmosphere is established in contact with the opposed faces of the mesh surface, for oxygenating the biological liquid membrane from both sides of said surface; and the flow of oxygenated biological liquid from the mesh is collected.
  • the oxygenating atmosphere is established by enclosing the mesh surface within a chamber, with the oxygenating gas preferably being flowed continuously through the chamber in contact with both sides of the biological liquid membrane at the mesh.
  • the oxygenating gas may comprise oxygen, ozone, singlet oxygen or a mixture of one or more of the foregoing with each other and/or air.
  • the oxygenating gas may include diluent gases not intended to react with the biological liquid, such as nitrogen or inert gases.
  • the ozone is typically at a concentration of 750 to 20,000 ppm ⁇ although in some instances concentrations as low as 75 ppm and as high as 40,000 ppm may be used.
  • Each volume of biological liquid to be oxygenated is typically exposed to the oxygenating gas for a period sufficient to either oxygenate the liquid or to sterilize the contaminants which are sought to be inactivated.
  • FIGURE 1 is a perspective, simplified schematic view of apparatus in accordance with the present invention.
  • FIGURE 2 is a schematic plan view of a further type of mesh surface which is utilizable in the invention.
  • Apparatus 10 comprises an outer substantially hollow cylindrical chamber 12, which is suitably supported for operational use by a conventional support base, or the like (not shown).
  • the bottom of chamber 12 is provided with a liquid exit port 13 for withdrawing flowable biological liquids following the oxygenating treatment thereof.
  • Mounted coaxially within chamber 12 is a an open mesh surface 14 which is formed as a hollow open-ended cylinder 15.
  • Cylinder 15 is of a smaller diameter than chamber 12 and thus the surface of the cylinder is spaced from the inner wall of the chamber.
  • the cylinder may be supported in the manner shown by being secured to and suspended from a flow distribution cap 21.
  • Mesh 14 is an open webbing or screen which can comprise any of numerous materials which are relatively resistant chemically and physically to the oxygenating gas being used and to the biological liquid which is treated in the apparatus.
  • the mesh should be provided with uniform circular, rectangular or other openings, which for most applications will have a mean opening dimension in the range of from about .02 to 10 mm.
  • Suitable materials for the mesh include gauze comprised of natural or synthetic materials, plastics such as polyethylenes, PVCs and the like; as well as highly inert metals and alloys.
  • the material should be generally flexible to enable accurate fabrication and assembly. Fabric gauze is a particularly useful material for the present invention, by virtue of its availability, low cost and ready disposability. Such factors encourages single use followed by environmentally safe and complete disposal.
  • the chamber 12 is generally enclosed at its upper end by a cover 16 through which passes (in sealed relation) a liquid inlet port 17 and a gas exit port 18.
  • Input port 17 in turn supports in sealed relation the coaxially mounted gas input conduit 19 for oxygenating gas which is to be introduced into the apparatus.
  • Conduit 19 is joined to a gas dispersing nozzle 20 which disperses the oxygenating gas to the upper interior of cylinder 15.
  • the oxygenating gas is provided to the conduit 19 from a conventional source as, for example, the apparatus described in commonly assigned Dunder, U.S. Patent No. 5,094,822.
  • the flowable biological liquid to be treated which may representatively be considered as whole blood, is provided to inlet port 17 under control of peristaltic pump 8, and flows to and over flow distribution cap 21, the periphery of which is smoothly adjoined by mechanical, adhesive or other means to the upper edge 24 of the mesh 14 comprising cylinder 15.
  • a liquid flow control or regulator 25 is positioned between inlet 17 and distribution cap 21.
  • the biological liquid to be treated after passing over distribution cap 21 flows in a generally axial and downward direction.
  • this membrane typically this membrane can be of the order of 50 to 750 microns thickness.
  • the membrane by virtue of the open mesh is fully accessible from both sides thereof to the oxygenating gas with which it is accordingly brought into highly intimate and effective contact. In consequence a very effective degree of gas mass transfer is achieved —one which far exceeds what has heretofore been achieved in this art.
  • the mode of liquid flow is extremely gentle. No sharp surface discontinuities are present in the flow which can mechanically degrade the structures present in the blood or the like which is being treated.
  • the oxygenating gas having contacted the liquid passes from the apparatus at exit port 18, and is preferably sent to a destruct unit to enable the vented ozone to be destroyed and thereby avoid any deleterious atmospheric effect.
  • the cylindrical mesh 14 is replaced by a flat or planar mesh sheet 32.
  • the sheet 32 is again mounted in a generally enclosed chamber 34.
  • the chamber can be of boxlike or other construction -or can again be cylindrical.
  • the biological liquid to be oxygenated is admitted through conduit 38 under control of a peristaltic pump (not shown) and after treatment in the manner already discussed, exits through port 40.
  • Oxygenating gas is admitted through port 36 and may be discharged through port 18 or through a port at the lower end of the apparatus.
  • Liquid to be treated is metered from the reservoir trough 42 which has a longitudinally extending slit opening at the bottom, the width of which can be varied to change the feed rate.
  • the liquid passes to the distributing surface 44, which in this instance takes the form of a cylinder which at the gravitationally lowest point of its cylindrical surface is smoothly joined to the upper edge of mesh sheet 32.
  • Sheet 32 can also be oriented horizontally or otherwise, provided that suitable forces are imposed on the liquid to create the desired flow along the sheet. Sheet 32 can also be distorted into non-planar forms, such as to present a corrugated surface, or a U-channel cross-section.
  • the apparatus of Figure 1 can be readily modified to other orientations of cylinder 15.
  • the cylinder 15 can be oriented horizontally, with gas and liquid flow proceeding about the cylinder in circumferential directions, rather than axially.
  • the liquid input port is displaced above the cylinder to flow the liquid onto the cylinder along its length, with the liquid output being taken from the underlying portion of chamber 12.
  • the flow about the cylinder in this instance is similar to the flow achieved in Figure 2 about surface 44, except that such surface is now an open cylindrical mesh like cylinder 15 in Figure 1.
  • the mesh sheet 32 is no longer necessary in this arrangement, although it or a non-porous sheet can still be used to facilitate a smooth flow toward outlet port 40.
  • the vertical dimension of chamber 34 is preferably foreshortened so that the treated liquid can flow to port 40 without a substantial drop.
  • a plurality of concentric spaced cylinders can be employed with suitable flow channeling means; and in analogy a plurality of parallel but spaced sheets 32 can be utilized with appropriate flow channeling enabling the biological liquid to flow along the surface of each said sheet.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)

Abstract

Appareil et procédé d'oxygénation efficace d'un liquide biologique fluide. Une surface de treillis ouverte présente des faces accessibles opposées. Un moyen d'écoulement établit un écoulement du liquide biologique le long de la surface du treillis, laquelle transforme le liquide biologique en une membrane au niveau des ouvertures de treillis en surface. Des moyens sont prévus pour établir une atmosphère de gaz d'oxygénation au contact des faces opposées de la surface du treillis, afin d'oxygéner la membrane du liquide biologique depuis les deux côtés de la surface, et on a prévu des moyens destinés à collecter le flux de liquide biologique oxygéné à partir du treillis.
PCT/IB1997/001240 1996-10-09 1997-10-07 Appareil et procede d'oxygenation de liquides biologiques WO1998015296A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU43933/97A AU4393397A (en) 1996-10-09 1997-10-07 Apparatus and method for oxygenating biological liquids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72801496A 1996-10-09 1996-10-09
US08/728,014 1996-10-09

Publications (1)

Publication Number Publication Date
WO1998015296A1 true WO1998015296A1 (fr) 1998-04-16

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ID=24925078

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1997/001240 WO1998015296A1 (fr) 1996-10-09 1997-10-07 Appareil et procede d'oxygenation de liquides biologiques

Country Status (2)

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AU (1) AU4393397A (fr)
WO (1) WO1998015296A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2833279A (en) * 1956-05-25 1958-05-06 Gollan Frank Blood oxygenating apparatus
FR1455775A (fr) * 1963-01-10 1966-05-20 Presna Mechanika Narodny Podni Oxygénateur cylindrique rotatif notamment pour appareils à circulation sanguine
FR2340101A1 (fr) * 1976-02-03 1977-09-02 Shiley Lab Inc Oxygenateur et procede d'oxygenation du sang
EP0261032A1 (fr) * 1986-09-16 1988-03-23 Association Regionale De Transfusion Sanguine Procédé d'inactivation par ozonolyse de micro-organismes contaminants présents dans des matériaux biologiques essentiellement protéiques, les produits obtenus et leurs applications biologiques et analytiques
WO1994015659A1 (fr) * 1993-01-07 1994-07-21 Lifetech Corporation Contacteur a film d'enrichissement au gaz basse pression

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2833279A (en) * 1956-05-25 1958-05-06 Gollan Frank Blood oxygenating apparatus
FR1455775A (fr) * 1963-01-10 1966-05-20 Presna Mechanika Narodny Podni Oxygénateur cylindrique rotatif notamment pour appareils à circulation sanguine
FR2340101A1 (fr) * 1976-02-03 1977-09-02 Shiley Lab Inc Oxygenateur et procede d'oxygenation du sang
EP0261032A1 (fr) * 1986-09-16 1988-03-23 Association Regionale De Transfusion Sanguine Procédé d'inactivation par ozonolyse de micro-organismes contaminants présents dans des matériaux biologiques essentiellement protéiques, les produits obtenus et leurs applications biologiques et analytiques
WO1994015659A1 (fr) * 1993-01-07 1994-07-21 Lifetech Corporation Contacteur a film d'enrichissement au gaz basse pression

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Publication number Publication date
AU4393397A (en) 1998-05-05

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