WO1998012327A3 - Compositions and methods comprising bard1 and other brca1 binding proteins - Google Patents

Compositions and methods comprising bard1 and other brca1 binding proteins Download PDF

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Publication number
WO1998012327A3
WO1998012327A3 PCT/US1997/016842 US9716842W WO9812327A3 WO 1998012327 A3 WO1998012327 A3 WO 1998012327A3 US 9716842 W US9716842 W US 9716842W WO 9812327 A3 WO9812327 A3 WO 9812327A3
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WO
WIPO (PCT)
Prior art keywords
bard1
brca1
protein
compositions
methods
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PCT/US1997/016842
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French (fr)
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WO1998012327A2 (en
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Priority to AU45866/97A priority Critical patent/AU4586697A/en
Publication of WO1998012327A2 publication Critical patent/WO1998012327A2/en
Publication of WO1998012327A3 publication Critical patent/WO1998012327A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Disclosed are several novel genes, identified in screening assays based upon binding to the breast cancer protein, BRCA1. The currently preferred gene and protein, termed BARD1, is a RING protein that interacts with BRCA1. The genes, proteins and other biological materials provided are envisioned for use in various cancer-related diagnostic and therapeutic methods, particularly those connected with breast, ovarian and uterine cancer.
PCT/US1997/016842 1996-09-20 1997-09-19 Compositions and methods comprising bard1 and other brca1 binding proteins WO1998012327A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU45866/97A AU4586697A (en) 1996-09-20 1997-09-19 Compositions and methods comprising bard1 and other brca1 binding proteins

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US2529696P 1996-09-20 1996-09-20
US60/025,296 1996-09-20
US4261197P 1997-04-03 1997-04-03
US60/042,611 1997-04-03
US4298597P 1997-04-04 1997-04-04
US60/042,985 1997-04-04

Publications (2)

Publication Number Publication Date
WO1998012327A2 WO1998012327A2 (en) 1998-03-26
WO1998012327A3 true WO1998012327A3 (en) 1998-09-03

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/016842 WO1998012327A2 (en) 1996-09-20 1997-09-19 Compositions and methods comprising bard1 and other brca1 binding proteins

Country Status (2)

Country Link
AU (1) AU4586697A (en)
WO (1) WO1998012327A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU728352B2 (en) 1996-08-02 2001-01-04 Wistar Institute Of Anatomy And Biology, The BRCA1 associated protein (BAP-1) and uses therefor
CA2335653A1 (en) * 1998-07-22 2000-02-03 Incyte Pharmaceuticals, Inc. Molecules associated with cell proliferation
CA2340796A1 (en) * 1998-08-26 2000-03-09 Trustees Of Boston University Novel irap-bp polypeptide and nucleic acid molecules and uses therefor
AU781437B2 (en) * 1999-06-25 2005-05-26 Serono Genetics Institute S.A. A novel BAP28 gene and protein
FR2813606B1 (en) * 2000-09-01 2004-04-30 Inst Nat Sante Rech Med TRUNKED PROTEIN BARD1, AND ITS DIAGNOSTIC AND THERAPEUTIC APPLICATIONS
DE10054639B4 (en) * 2000-11-03 2004-05-06 Jenapharm Gmbh & Co. Kg Use of RanBPM as a co-modulator of steroid hormone receptors
CA2681360A1 (en) * 2007-04-02 2008-10-09 Universite De Geneve Deletion bearing bard1 isoforms and use thereof
RU2013104137A (en) * 2010-08-17 2014-09-27 Университэ Де Женева BARD1 ISOFORMS IN LUNG AND COLORECTAL CANCER AND THEIR APPLICATION
EP2871480A1 (en) 2013-11-06 2015-05-13 Bard1Ag SA Lung Cancer Diagnosis
US10273475B2 (en) * 2014-07-12 2019-04-30 Bard1 Life Sciences Limited Regulation of BARD1 expression by non-coding RNA
KR20220079857A (en) * 2019-09-13 2022-06-14 루트거스, 더 스테이트 유니버시티 오브 뉴 저지 AAV-compatible laminin-linker polymeric protein

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996005306A2 (en) * 1994-08-12 1996-02-22 Myriad Genetics, Inc. IN VIVO MUTATIONS AND POLYMORPHISMS IN THE 17q-LINKED BREAST AND OVARIAN CANCER SUSCEPTIBILITY GENE
WO1996005308A1 (en) * 1994-08-12 1996-02-22 Myriad Genetics, Inc. Method for diagnosing a predisposition for breast and ovarian cancer
US5622829A (en) * 1993-12-08 1997-04-22 The Regents Of The University Of California Genetic markers for breast, ovarian, and prostatic cancer
US5654155A (en) * 1996-02-12 1997-08-05 Oncormed, Inc. Consensus sequence of the human BRCA1 gene
WO1997030108A1 (en) * 1996-02-20 1997-08-21 Vanderbilt University Characterized brca1 and brca2 proteins and screening and therapeutic methods based on characterized brca1 and brca2 proteins

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5622829A (en) * 1993-12-08 1997-04-22 The Regents Of The University Of California Genetic markers for breast, ovarian, and prostatic cancer
WO1996005306A2 (en) * 1994-08-12 1996-02-22 Myriad Genetics, Inc. IN VIVO MUTATIONS AND POLYMORPHISMS IN THE 17q-LINKED BREAST AND OVARIAN CANCER SUSCEPTIBILITY GENE
WO1996005308A1 (en) * 1994-08-12 1996-02-22 Myriad Genetics, Inc. Method for diagnosing a predisposition for breast and ovarian cancer
WO1996005307A2 (en) * 1994-08-12 1996-02-22 Myriad Genetics, Inc. 17q-LINKED BREAST AND OVARIAN CANCER SUSCEPTIBILITY GENE
US5654155A (en) * 1996-02-12 1997-08-05 Oncormed, Inc. Consensus sequence of the human BRCA1 gene
WO1997030108A1 (en) * 1996-02-20 1997-08-21 Vanderbilt University Characterized brca1 and brca2 proteins and screening and therapeutic methods based on characterized brca1 and brca2 proteins

Non-Patent Citations (21)

* Cited by examiner, † Cited by third party
Title
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A.N.A. MONTEIRO ET AL.: "Evidence for a transcriptional activation function of BRAC1 C-terminal region.", PROC. NATL. ACAD. SCI. USA, vol. 93, November 1996 (1996-11-01), pages 1395 - 13599, XP002067828 *
CLAVERIE ET AL.: "Alu-alert", NATURE, vol. 371, 1994, pages 752, XP002070602 *
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DATABASE EMBL accession number AF007217; 14 July 1997 (1997-07-14), CHANG ET AL.: "A novel thyroid hormone receptor coactivator negatively regulated by the retinoblastoma protein", XP002070604 *
DATABASE EMBL accession number AF015913; 23 August 1997 (1997-08-23), MARCUS ET AL.: "SKB1Hs, a human homolog of the fission yeast skb1 gene.", XP002070605 *
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WANG H ET AL: "BRCA1 PROTEINS ARE TRANSPORTED TO THE NUCLEUS IN THE ABSENCE OF SERUM AND SPLICE VARIANTS BRCA1A, BRCA1B ARE TYROSINE PHOSPHOPROTEINS THAT ASSOCIATE WITH E2F, CYCLINS AND CYCLIN DEPENDENT KINASES", ONCOGENE, vol. 15, no. 2, 10 July 1997 (1997-07-10), pages 143 - 157, XP002050114 *

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Publication number Publication date
AU4586697A (en) 1998-04-14
WO1998012327A2 (en) 1998-03-26

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