WO1998008866B1 - Bau, a bin1 interacting protein, and uses therefor - Google Patents
Bau, a bin1 interacting protein, and uses thereforInfo
- Publication number
- WO1998008866B1 WO1998008866B1 PCT/US1997/015298 US9715298W WO9808866B1 WO 1998008866 B1 WO1998008866 B1 WO 1998008866B1 US 9715298 W US9715298 W US 9715298W WO 9808866 B1 WO9808866 B1 WO 9808866B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- seq
- bau
- fragment
- antibody
- nucleotides
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title claims abstract 7
- 108090000623 proteins and genes Proteins 0.000 title claims abstract 7
- 108090001123 antibodies Proteins 0.000 claims abstract 10
- 102000004965 antibodies Human genes 0.000 claims abstract 10
- 229920001850 Nucleic acid sequence Polymers 0.000 claims abstract 7
- 229920001184 polypeptide Polymers 0.000 claims abstract 7
- 150000007523 nucleic acids Chemical group 0.000 claims abstract 6
- 229920002676 Complementary DNA Polymers 0.000 claims abstract 2
- 239000002299 complementary DNA Substances 0.000 claims abstract 2
- 239000002773 nucleotide Substances 0.000 claims 8
- 125000003729 nucleotide group Chemical group 0.000 claims 8
- 150000001413 amino acids Chemical class 0.000 claims 6
- 230000003302 anti-idiotype Effects 0.000 claims 2
- 230000001809 detectable Effects 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 108020005187 Oligonucleotide Probes Proteins 0.000 claims 1
- 230000001413 cellular Effects 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 108091006028 chimera Proteins 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 108010045030 monoclonal antibodies Proteins 0.000 claims 1
- 102000005614 monoclonal antibodies Human genes 0.000 claims 1
- 239000002751 oligonucleotide probe Substances 0.000 claims 1
- 108091008117 polyclonal antibodies Proteins 0.000 claims 1
- 230000001105 regulatory Effects 0.000 claims 1
- 206010053643 Neurodegenerative disease Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000002390 hyperplastic Effects 0.000 abstract 1
Abstract
A murine cDNA clone encoding a BIN1-Associated U1-specific protein (Bau) are provided. Also provided are methods of using the nucleic acid sequences, polypeptides, and antibodies directed against same in the diagnosis and treatment of cancers, hyperplastic disease states, or degenerative diseases.
Claims
1. A mammalian nucleic acid sequence encoding a BIN 1 -Associated Ul -specific protein (Bau) or a fragment thereof, isolated from cellular materials with which it is naturally associated, selected from the group consisting of:
(a) SEQ ID NO: 1;
(b) a nucleotide sequence comprising 50 nucleotides which hybridizes to SEQ ID NO:l under stringent conditions;
(c) an allelic variation of SEQ ID NO: 1 ; and
(d) a fragment of SEQ ID NO: 1 comprising 15 nucleotides selected from the sequences of nucleotides 1 to 300 and 325 to 926 of SEQ ID NO:l.
2. The mammalian nucleic acid sequence according to claim 1 which encodes murine Bau SEQ ID NO: 2 or a fragment thereof.
3. The mammalian nucleic acid sequence according to claim 1, wherein the fragment of (d) is selected from the group consisting of:
(a) nucleotides 231 to 674 of SEQ ID NO: 1 ;
(b) nucleotides 48 to 527 of SEQ ID NO:l;
(c) nucleotides 312 to 362 of SEQ ID NO: 1;
(d) nucleotides 294 to 356 of SEQ ID NO: 1; and
(e) nucleotides 540 to 554 of SEQ ID NO: 1.
4. A murine cDNA sequence SEQ ID NO: 1 which encodes a Bau polypeptide. 45
5. A mammalian BIN 1 -Associated Ul-specific protein (Bau) polypeptide, said polypeptide selected from the group consisting of:
(a) murine Bau, SEQ ID NO:2;
(b) human Bau;
(c) a fragment of (a) or (b) having biological activity; and
(d) analogues or homologs of (a) or (b) characterized by having at least 85% homology with SEQ ID NO: 2.
6. The Bau polypeptide according to claim 5, wherein the fragment is selected from the group consisting of:
(a) amino acids 62 to 209 of SEQ ID NO:2;
(b) amino acids 1 to 160 of SEQ ID NO:2;
(c) amino acids 89 to 105 of SEQ ID NO:2;
(d) amino acids 83 to 103 of SEQ ID NO:2; and
(e) amino acids 165 to 169 of SEQ ID NO:2.
7. A vector comprising a mammalian nucleic acid sequence encoding a BIN 1 -Associated Ul-specific protein (Bau) polypeptide under the control of suitable regulatory sequences, said polypeptide selected from the group consisting of:
(a) murine Bau SEQ ID NO:2;
(b) human Bau;
(c) a fragment of (a) or (b) having biological activity; and
(d) analogues or homologs of (a) or (b) characterized by having at least 90% homology with SEQ ID NO: 2.
8. A host cell transformed with the vector according to claim 6. 46
9. An oligonucleotide probe comprising a mammalian nucleic acid sequence encoding a BIN 1 -Associated Ul-specific protein (Bau) or a fragment thereof according to claim 1 and a detectable label which is associated with said sequence.
10. An anti-BINl-Associated Ul-specific protein (Bau) antibody.
11. The anti-Bau antibody according to claim 10 directed against a Bau peptide, said peptide selected from the group consisting of:
(a) SEQ ID NO:2; and
(b) a fragment of (a) comprising about 8 amino acids.
12. The antibody according to claim 10, selected from the group consisting of a chimeric antibody, a humanized antibody, a monoclonal antibody and a polyclonal antibody.
13. An anti-idiotype antibody specific for the antibody of claim 10.
14. A diagnostic reagent comprising the antibody according to claim 10 and a detectable label.
15. A pharmaceutical composition comprising the vector according to claim 7 and a pharmaceutically acceptable carrier.
16. A pharmaceutical composition comprising the anti-idiotype antibody according to claim 13 and a pharmaceutically acceptable carrier.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU41717/97A AU4171797A (en) | 1996-08-29 | 1997-08-28 | Bau, a bin1 interacting protein, and uses therefor |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2548296P | 1996-08-29 | 1996-08-29 | |
| US60/025,482 | 1996-08-29 | ||
| US08/919,145 US5958753A (en) | 1996-08-29 | 1997-08-27 | Nucleic acid sequences encoding Bau, a Bin1 interacting protein, and vectors and host cells containing same |
| US08/919,146 | 1997-08-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1998008866A1 WO1998008866A1 (en) | 1998-03-05 |
| WO1998008866B1 true WO1998008866B1 (en) | 1998-05-07 |
Family
ID=26699796
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1997/015298 WO1998008866A1 (en) | 1996-08-29 | 1997-08-28 | Bau, a bin1 interacting protein, and uses therefor |
Country Status (3)
| Country | Link |
|---|---|
| US (2) | US5958753A (en) |
| AU (1) | AU4171797A (en) |
| WO (1) | WO1998008866A1 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5958753A (en) * | 1996-08-29 | 1999-09-28 | The Wistar Institute Of Anatomy And Biology | Nucleic acid sequences encoding Bau, a Bin1 interacting protein, and vectors and host cells containing same |
| AU8571598A (en) * | 1997-07-17 | 1999-02-10 | Ludwig Institute For Cancer Research | Cancer associated nucleic acids and polypeptides |
| US6171790B1 (en) | 1998-05-01 | 2001-01-09 | Incyte Pharmaceuticals, Inc. | Human protease associated proteins |
| WO1999063091A1 (en) * | 1998-06-04 | 1999-12-09 | Zymogenetics, Inc. | Disulfide core polypeptides |
| US6686147B1 (en) | 1998-07-15 | 2004-02-03 | Ludwig Institute For Cancer Research | Cancer associated antigens and uses therefor |
| US6831063B1 (en) | 1999-08-31 | 2004-12-14 | The Wistar Institute Of Anatomy And Biology | Bridging Integrator-2(Bin2) nucleic acid molecules and proteins and uses therefor |
| AU7336700A (en) * | 1999-08-31 | 2001-03-26 | Wistar Institute Of Anatomy And Biology, The | Bridging integrator-2 (bin2) nucleic acid molecules and proteins and uses therefor |
| US20030064378A1 (en) * | 2000-10-26 | 2003-04-03 | Recipon Herve E. | Compositions and methods relating to lung specific genes and proteins |
| US20030068624A1 (en) * | 2000-10-26 | 2003-04-10 | Recipon Herve E. | Compositions and methods relating to lung specific genes and proteins |
| US20030235821A1 (en) * | 2001-06-04 | 2003-12-25 | Zerhusen Bryan D. | Novel Human proteins, polynucleotides encoding them and methods of using the same |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3316601A1 (en) * | 1983-05-06 | 1984-11-08 | Battelle-Institut E.V., 6000 Frankfurt | METHOD FOR IMMOBILIZING PROTEINS OR ENZYMES |
| US6048702A (en) * | 1995-05-05 | 2000-04-11 | The Wistar Institute Of Anatomy And Biology | Murine and human box-dependent myc-interacting protein (Bin1) and uses therefor |
| US5605830A (en) * | 1995-05-05 | 1997-02-25 | The Wistar Institute Of Anatomy & Biology | Murine and human c-Myc interacting protein |
| US5958753A (en) * | 1996-08-29 | 1999-09-28 | The Wistar Institute Of Anatomy And Biology | Nucleic acid sequences encoding Bau, a Bin1 interacting protein, and vectors and host cells containing same |
-
1997
- 1997-08-27 US US08/919,145 patent/US5958753A/en not_active Expired - Fee Related
- 1997-08-28 AU AU41717/97A patent/AU4171797A/en not_active Abandoned
- 1997-08-28 WO PCT/US1997/015298 patent/WO1998008866A1/en active Application Filing
-
1999
- 1999-06-25 US US09/344,889 patent/US6140465A/en not_active Expired - Fee Related
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