WO1998006851A3 - DEFINING EPITOPES OF THE OUTER MEMBRANE PROTEIN CopB OF $i(MORAXELLA CATARRHALIS) - Google Patents

DEFINING EPITOPES OF THE OUTER MEMBRANE PROTEIN CopB OF $i(MORAXELLA CATARRHALIS) Download PDF

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Publication number
WO1998006851A3
WO1998006851A3 PCT/US1997/014221 US9714221W WO9806851A3 WO 1998006851 A3 WO1998006851 A3 WO 1998006851A3 US 9714221 W US9714221 W US 9714221W WO 9806851 A3 WO9806851 A3 WO 9806851A3
Authority
WO
WIPO (PCT)
Prior art keywords
copb
reactivity
membrane protein
outer membrane
moraxella catarrhalis
Prior art date
Application number
PCT/US1997/014221
Other languages
French (fr)
Other versions
WO1998006851A2 (en
Inventor
Eric J Hansen
Leslie D Cope
Christoph Aebi
Original Assignee
Univ Texas
Eric J Hansen
Leslie D Cope
Christoph Aebi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas, Eric J Hansen, Leslie D Cope, Christoph Aebi filed Critical Univ Texas
Priority to CA002262748A priority Critical patent/CA2262748A1/en
Priority to AU41500/97A priority patent/AU740481B2/en
Priority to EP97939404A priority patent/EP0920513A2/en
Publication of WO1998006851A2 publication Critical patent/WO1998006851A2/en
Publication of WO1998006851A3 publication Critical patent/WO1998006851A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
    • C07K14/212—Moraxellaceae, e.g. Acinetobacter, Moraxella, Oligella, Psychrobacter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention involves an analysis of the CopB outer membrane protein of M. catarrhalis. Four CopB antigens now have been sequenced and their predicted amino acid sequences compared. Regions of conservation and non-conservation have been identified in this antigen, including one non-conserved region that represents an antibody binding region from the strain 035E. A single amino acid change (N to D) in this epitope, at residue 295, abolishes reactivity of the antibody 10F3 with CopB. Peptides which only contain residues of this region that are C-terminal to residue 295 do retain reactivity but their reactivity is less than the maximal reactivity achieved in the presence of an asparagine at position 295. Compositions and both diagnostic and immunoprophylactic methods are disclosed.
PCT/US1997/014221 1996-08-12 1997-08-12 DEFINING EPITOPES OF THE OUTER MEMBRANE PROTEIN CopB OF $i(MORAXELLA CATARRHALIS) WO1998006851A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002262748A CA2262748A1 (en) 1996-08-12 1997-08-12 Defining epitopes of the outer membrane protein copb of moraxella catarrhalis
AU41500/97A AU740481B2 (en) 1996-08-12 1997-08-12 Defining epitopes of the outer membrane protein CopB of moraxella catarrhalis
EP97939404A EP0920513A2 (en) 1996-08-12 1997-08-12 DEFINING EPITOPES OF THE OUTER MEMBRANE PROTEIN CopB OF MORAXELLA CATARRHALIS

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2383296P 1996-08-12 1996-08-12
US60/023,832 1996-08-12

Publications (2)

Publication Number Publication Date
WO1998006851A2 WO1998006851A2 (en) 1998-02-19
WO1998006851A3 true WO1998006851A3 (en) 1998-05-07

Family

ID=21817463

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/014221 WO1998006851A2 (en) 1996-08-12 1997-08-12 DEFINING EPITOPES OF THE OUTER MEMBRANE PROTEIN CopB OF $i(MORAXELLA CATARRHALIS)

Country Status (4)

Country Link
EP (1) EP0920513A2 (en)
AU (1) AU740481B2 (en)
CA (1) CA2262748A1 (en)
WO (1) WO1998006851A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0998557A2 (en) * 1997-07-21 2000-05-10 North American Vaccine, Inc. Modified immunogenic pneumolysin, compositions and their use as vaccines
US6627728B1 (en) 1998-05-12 2003-09-30 Smithkline Beecham Biologicals S.A. Compounds from moraxella catarrhalis
GB9810285D0 (en) * 1998-05-13 1998-07-15 Smithkline Beecham Biolog Novel compounds
EP1185658B1 (en) * 1999-05-24 2008-06-04 GlaxoSmithKline Biologicals S.A. Novel compounds from moraxella catarrhalis
GB9915031D0 (en) * 1999-06-25 1999-08-25 Smithkline Beecham Biolog Novel compounds
CA2383081A1 (en) * 1999-09-14 2001-03-22 Smithkline Beecham Biologicals S.A. Polypeptides from moraxella (branhamella) catarrhalis
CN1745096A (en) * 2003-01-30 2006-03-08 惠氏控股公司 Cross-protective epitopes of moraxella catarrhalis and use thereof
CN111675753A (en) * 2020-05-19 2020-09-18 深圳市疾病预防控制中心 Avian influenza virus epitope screening method and application

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
AEBI C ET AL: "Moraxella catarrhalis outer membrane protein CopB: Identification of a peptide that contains a protective epitope.", 36TH ICAAC (INTERNATIONAL CONFERENCE OF ANTIMICROBIAL AGENTS AND CHEMOTHERAPY), NEW ORLEANS, LOUISIANA, USA, SEPTEMBER 15-18, 1996. ABSTRACTS OF THE INTERSCIENCE CONFERENCE ON ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 36 (0). 1996. 158., XP002048789 *
HELMINEN, MERJA E. ET AL: "Human immune response against outer membrane proteins of Moraxella (Branhamella) catarrhalis determined by immunoblotting and enzyme immunoassay", CLIN. DIAGN. LAB. IMMUNOL. (1995), 2(1), 35-9 CODEN: CDIMEN;ISSN: 1071-412X, 1995, XP002048788 *
MERJA E. HELMINEN: "A major outer membrane protein of Moraxella catarrhalis is a target for antibodies that enhance pulmonary clearance of the pathogen in an animal model", INFECTION AND IMMUNITY, vol. 61, no. 5, May 1993 (1993-05-01), WASHINGTON US, pages 2003 - 2010, XP002048787 *

Also Published As

Publication number Publication date
EP0920513A2 (en) 1999-06-09
WO1998006851A2 (en) 1998-02-19
AU740481B2 (en) 2001-11-08
AU4150097A (en) 1998-03-06
CA2262748A1 (en) 1998-02-19

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