WO1998002551A3 - Process for the production of adipoyl cephalosporins - Google Patents

Process for the production of adipoyl cephalosporins Download PDF

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Publication number
WO1998002551A3
WO1998002551A3 PCT/EP1997/003879 EP9703879W WO9802551A3 WO 1998002551 A3 WO1998002551 A3 WO 1998002551A3 EP 9703879 W EP9703879 W EP 9703879W WO 9802551 A3 WO9802551 A3 WO 9802551A3
Authority
WO
WIPO (PCT)
Prior art keywords
adipoyl
cephalosporins
production
preparation
improved process
Prior art date
Application number
PCT/EP1997/003879
Other languages
French (fr)
Other versions
WO1998002551A2 (en
Inventor
Roelof Ary Lans Bovenberg
Der Laan Jan Metske Van
Richard Kerkman
Maarten Nieboer
Original Assignee
Gist Brocades Bv
Roelof Ary Lans Bovenberg
Laan Jan Metske V D
Richard Kerkman
Maarten Nieboer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades Bv, Roelof Ary Lans Bovenberg, Laan Jan Metske V D, Richard Kerkman, Maarten Nieboer filed Critical Gist Brocades Bv
Priority to AU41146/97A priority Critical patent/AU4114697A/en
Publication of WO1998002551A2 publication Critical patent/WO1998002551A2/en
Publication of WO1998002551A3 publication Critical patent/WO1998002551A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/02—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by desacylation of the substituent in the 7 position

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

An improved process for the preparation of adipoyl cephalosporins via enzymatic ring expansion of adipoyl-6-aminopenicillinic acid, using a Penicillium chrysogenum transformant strain expressing modified expandase enzyme.
PCT/EP1997/003879 1996-07-16 1997-07-15 Process for the production of adipoyl cephalosporins WO1998002551A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU41146/97A AU4114697A (en) 1996-07-16 1997-07-15 Improved process for the production of adipoyl cephalosporins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96201988 1996-07-16
EP96201988.1 1996-07-16

Publications (2)

Publication Number Publication Date
WO1998002551A2 WO1998002551A2 (en) 1998-01-22
WO1998002551A3 true WO1998002551A3 (en) 1998-02-19

Family

ID=8224186

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1997/003879 WO1998002551A2 (en) 1996-07-16 1997-07-15 Process for the production of adipoyl cephalosporins

Country Status (3)

Country Link
AU (1) AU4114697A (en)
WO (1) WO1998002551A2 (en)
ZA (1) ZA976295B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0924180A4 (en) 1996-07-02 2005-04-20 Toray Finechemicals Co Ltd Processes for the preparation of optically active ketones
CN1224471A (en) * 1997-04-22 1999-07-28 吉斯特-布罗卡迪斯有限公司 Method for preparing beta-lactam antibiotic
WO1998048037A1 (en) * 1997-04-22 1998-10-29 Dsm N.V. A METHOD FOR CONTROLLING THE SOLUBILITY OF A β-LACTAM NUCLEUS
BR9910532A (en) 1998-05-19 2001-10-16 Dsm Nv Improved in vivo cephalosporin production
US6699699B2 (en) 2002-03-26 2004-03-02 Synmax Biochemical Co., Ltd. Mutated penicillin expandases
WO2005103261A1 (en) * 2004-04-22 2005-11-03 Orchid Chemicals & Pharmaceuticals Ltd. Modified expandase enzyme and its use
BRPI0515976A (en) * 2004-10-13 2008-08-12 Dsm Ip Assets Bv mutant expandases
CN107304418B (en) * 2016-04-18 2022-08-26 百瑞全球有限公司 Penicillin expandase mutant, DNA encoding the mutant, kit containing the mutant and use thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0341892A1 (en) * 1988-05-09 1989-11-15 Eli Lilly And Company Recombinant DNA expression vectors and DNA compounds that encode deacetoxycephalosporin C synthetase
EP0366354A2 (en) * 1988-10-24 1990-05-02 Eli Lilly And Company Purified deacetoxycephalosporin C synthase
WO1997020053A2 (en) * 1995-11-27 1997-06-05 Gist-Brocades B.V. Improved process for the production of semi-synthetic cephalosporins via expandase activity on penicillin g

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0341892A1 (en) * 1988-05-09 1989-11-15 Eli Lilly And Company Recombinant DNA expression vectors and DNA compounds that encode deacetoxycephalosporin C synthetase
EP0366354A2 (en) * 1988-10-24 1990-05-02 Eli Lilly And Company Purified deacetoxycephalosporin C synthase
WO1997020053A2 (en) * 1995-11-27 1997-06-05 Gist-Brocades B.V. Improved process for the production of semi-synthetic cephalosporins via expandase activity on penicillin g

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BALDWIN J E ET AL: "GENETIC ENGINEERING OF CEPHALOSPORIN BIOSYNTHESIS", PROCEEDINGS OF THE INTERNATIONAL SYMPOSIUM ON THE GENETICS OF INDUSTRIAL MICROORGANISMS, 1994, pages 184, XP000646621 *
CANTWELL C A ET AL: "CLONING AND EXPRESSION OF A HYBRID STREPTOMYCES CLAVULIGERUS CEFE GENE IN PENICILLIUM CHRYSOGENUM", CURRENT GENETICS, vol. 17, 1990, pages 213 - 221, XP000606288 *
CANTWELL C ET AL: "ISOLATION OF DEACETOXYCEPHALOSPORIN C FROM FERMENTATION BROTHS OF PENICILLIUM-CHRYSOGENUM TRANSFORMANTS CONSTRUCTION OF A NEW FUNGAL BIOSYNTHETIC PATHWAY", PROC R SOC LOND SER B BIOL SCI, 248 (1323). 1992. 283-289., XP002049879 *
SKATRUD PL: "GENETIC-ENGINEERING OF BETA-LACTAM ANTIBIOTIC BIOSYNTHETIC PATHWAYS IN FILAMENTOUS FUNGI", TRENDS IN BIOTECHNOLOGY, 1992, 10, 324-329, XP002049880 *

Also Published As

Publication number Publication date
ZA976295B (en) 1998-09-01
WO1998002551A2 (en) 1998-01-22
AU4114697A (en) 1998-02-09

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