WO1998002189A3 - Method for preparing bioactive polymers - Google Patents

Method for preparing bioactive polymers Download PDF

Info

Publication number
WO1998002189A3
WO1998002189A3 PCT/IL1997/000239 IL9700239W WO9802189A3 WO 1998002189 A3 WO1998002189 A3 WO 1998002189A3 IL 9700239 W IL9700239 W IL 9700239W WO 9802189 A3 WO9802189 A3 WO 9802189A3
Authority
WO
WIPO (PCT)
Prior art keywords
polymer
reacting
iii
amino group
ligand
Prior art date
Application number
PCT/IL1997/000239
Other languages
French (fr)
Other versions
WO1998002189A2 (en
Inventor
Shlomo Margel
Irene Burdygin
Original Assignee
Univ Bar Ilan
Shlomo Margel
Irene Burdygin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Bar Ilan, Shlomo Margel, Irene Burdygin filed Critical Univ Bar Ilan
Priority to EP97929483A priority Critical patent/EP0938340A2/en
Priority to AU33574/97A priority patent/AU3357497A/en
Publication of WO1998002189A2 publication Critical patent/WO1998002189A2/en
Publication of WO1998002189A3 publication Critical patent/WO1998002189A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

A method to prepare a bioactive polymer by covalently binding at least one amino group containing ligand to at least one polymer containing a plurality of free hydroxyl groups, said method comprising the following steps: (i) reacting the at least one polymer with an appropriate activating agent; (ii) reacting the resultant activated polymer in aqueous solution with desired amino group containing ligands; (iii) blocking by reaction or removing by hydrolysis residual polymer bound-ligand unreacted, activating groups; and wherein the said activating agent and/or leaving by-products formed by step (i) and/or by step (ii) and/or by step (iii), are swelling agents of the support polymer.
PCT/IL1997/000239 1996-07-14 1997-07-14 Method for preparing bioactive polymers WO1998002189A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP97929483A EP0938340A2 (en) 1996-07-14 1997-07-14 Method for preparing bioactive polymers
AU33574/97A AU3357497A (en) 1996-07-14 1997-07-14 Method for preparing bioactive polymers

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL118848 1996-07-14
IL11884896A IL118848A0 (en) 1996-07-14 1996-07-14 Method for preparing bioactive polymers

Publications (2)

Publication Number Publication Date
WO1998002189A2 WO1998002189A2 (en) 1998-01-22
WO1998002189A3 true WO1998002189A3 (en) 1998-05-07

Family

ID=11069070

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL1997/000239 WO1998002189A2 (en) 1996-07-14 1997-07-14 Method for preparing bioactive polymers

Country Status (5)

Country Link
EP (1) EP0938340A2 (en)
AU (1) AU3357497A (en)
CA (1) CA2260324A1 (en)
IL (1) IL118848A0 (en)
WO (1) WO1998002189A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8595055B2 (en) 2001-03-27 2013-11-26 Points.Com Apparatus and method of facilitating the exchange of points between selected entities
US20060216267A1 (en) 2002-08-20 2006-09-28 Kovacs Stephen G Hydrophobic elastomeric polymer chemistry device for inhibiting the growth of onychomycosis and urushiol-induced allergic contact dermatitis
US7426775B2 (en) 2003-12-17 2008-09-23 The Procter + Gamble Company Polymeric structures comprising a hydrophile/lipophile system
US7714065B2 (en) 2003-12-17 2010-05-11 The Procter & Gamble Company Polymeric structures comprising a hydrophile/lipophile system
US7709439B2 (en) 2004-02-20 2010-05-04 Boston Scientific Scimed, Inc. Biomaterials for enhanced healing
WO2009040811A2 (en) 2007-09-24 2009-04-02 Bar-Ilan University Polymer nanoparticles coated by magnetic metal oxide and uses thereof
US8771725B2 (en) 2007-10-12 2014-07-08 Chesson Laboratory Associates, Inc. Poly(urea-urethane) compositions useful as topical medicaments and methods of using the same

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1257263A (en) * 1968-03-29 1971-12-15
WO1990006767A1 (en) * 1988-12-20 1990-06-28 La Jolla Cancer Research Foundation Polypeptide-polymer conjugates active in wound healing
JPH04183392A (en) * 1990-11-19 1992-06-30 Fuji Photo Film Co Ltd Production of membrane immobilizing physiologically active substance
EP0611573A2 (en) * 1993-02-15 1994-08-24 Bar Ilan University Bioactive conjugates of cellulose with amino compounds
WO1995015352A1 (en) * 1993-12-01 1995-06-08 Universite Du Quebec A Montreal Albumin based hydrogel
EP0680990A1 (en) * 1994-05-02 1995-11-08 Collagen Corporation Collagen-synthetic polymer matrices prepared using a multiple step reaction
WO1996015236A1 (en) * 1994-11-11 1996-05-23 Bar Ilan University Bioactive conjugates of polyhydroxy-polymers with amines

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1257263A (en) * 1968-03-29 1971-12-15
US4970156A (en) * 1968-03-29 1990-11-13 Agence Nationale De Valorisation De La Recherche Immobilization of active protein by cross-linking to inactive protein
WO1990006767A1 (en) * 1988-12-20 1990-06-28 La Jolla Cancer Research Foundation Polypeptide-polymer conjugates active in wound healing
JPH04183392A (en) * 1990-11-19 1992-06-30 Fuji Photo Film Co Ltd Production of membrane immobilizing physiologically active substance
EP0611573A2 (en) * 1993-02-15 1994-08-24 Bar Ilan University Bioactive conjugates of cellulose with amino compounds
WO1995015352A1 (en) * 1993-12-01 1995-06-08 Universite Du Quebec A Montreal Albumin based hydrogel
EP0680990A1 (en) * 1994-05-02 1995-11-08 Collagen Corporation Collagen-synthetic polymer matrices prepared using a multiple step reaction
WO1996015236A1 (en) * 1994-11-11 1996-05-23 Bar Ilan University Bioactive conjugates of polyhydroxy-polymers with amines

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
AVRAMEAS S. AND TERNYNCK T.: "The crosslinking of proteins with glutaraldehide and its use for the preparation of immunoadsorbents", IMMUNOCHEMISTRY, vol. 6, 30 April 1968 (1968-04-30), pages 53 - 66, XP002057181 *
BETHELL G S ET AL: "INVESTIGATION OF THE ACTIVATION OF VARIOUS INSOLUBLE POLY SACCHARIDES WITH 1 1' CARBONYL DI IMIDAZOLE AND OF THE PROPERTIES OF THE ACTIVATED MATRICES", J CHROMATOGR, 219 (3). 1981 (RECD. 1982). 361-372., XP002056902 *
CUATRECASAS P: "PROTEIN PURIFICATION BY AFFINITY CHROMATOGRAPHY DERIVATIZATIONS OF AGAROSE AND POLYACRYLAMIDE BEADS", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 245, no. 12, 25 June 1970 (1970-06-25), pages 3059 - 3065, XP000563603 *
HUBBELL J A: "Hydrogel systems for barriers and local drug delivery in the control of wound healing", JOURNAL OF CONTROLLED RELEASE, vol. 39, no. 2, May 1996 (1996-05-01), pages 305-313, XP004037336 *
PATENT ABSTRACTS OF JAPAN vol. 016, no. 496 (C - 0995) 14 October 1992 (1992-10-14) *

Also Published As

Publication number Publication date
AU3357497A (en) 1998-02-09
IL118848A0 (en) 1996-10-31
WO1998002189A2 (en) 1998-01-22
CA2260324A1 (en) 1998-01-22
EP0938340A2 (en) 1999-09-01

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