WO1998000697A1 - Analyseur de dosages immunologiques automatise - Google Patents

Analyseur de dosages immunologiques automatise Download PDF

Info

Publication number
WO1998000697A1
WO1998000697A1 PCT/US1997/011245 US9711245W WO9800697A1 WO 1998000697 A1 WO1998000697 A1 WO 1998000697A1 US 9711245 W US9711245 W US 9711245W WO 9800697 A1 WO9800697 A1 WO 9800697A1
Authority
WO
WIPO (PCT)
Prior art keywords
tube
sample
bead
chamber
reagent
Prior art date
Application number
PCT/US1997/011245
Other languages
English (en)
Inventor
Arthur L. Babson
Thomas Palmieri
Anthony P. Montalbano
Chris P. Montalbano
Greg A. Montalbano
Eric A. Fleischer
Original Assignee
Dpc Cirrus, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/670,995 external-priority patent/US5773296A/en
Priority claimed from US08/672,653 external-priority patent/US5723092A/en
Priority claimed from US08/670,996 external-priority patent/US5721141A/en
Priority claimed from US08/672,654 external-priority patent/US5885529A/en
Priority claimed from US08/670,994 external-priority patent/US5632399A/en
Application filed by Dpc Cirrus, Inc. filed Critical Dpc Cirrus, Inc.
Priority to DE19781837T priority Critical patent/DE19781837T1/de
Priority to AU35827/97A priority patent/AU3582797A/en
Publication of WO1998000697A1 publication Critical patent/WO1998000697A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50853—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates with covers or lids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1002—Reagent dispensers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00457—Dispensing or evacuation of the solid phase support
    • B01J2219/00459—Beads
    • B01J2219/00468—Beads by manipulation of individual beads
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346—Heating or cooling arrangements
    • G01N2035/00435—Refrigerated reagent storage
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G01N2035/0403—Sample carriers with closing or sealing means
    • G01N2035/0405—Sample carriers with closing or sealing means manipulating closing or opening means, e.g. stoppers, screw caps, lids or covers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0439—Rotary sample carriers, i.e. carousels
    • G01N2035/0451—Rotary sample carriers, i.e. carousels composed of interchangeable sectors

Definitions

  • a sample is mixed with a reagent and a solid support having a bound antigen or antibody, the sample is incubated such that the corresponding antigen or antibody in the sample and a labeled antigen or antibody provided in the reagent can be bound to the antigen or antibody on the solid support, then the solid support is thoroughly washed and the label (fluorescent, radioactive, chemiluminescent, or the like) is detected by an appropriate mechanism, and finally the analyte of interest (antigen or antibody) is quantified from the detected label.
  • the label fluorescent, radioactive, chemiluminescent, or the like
  • the removable dilution well cover 613 has a central opening 614 for pipette access. Concentric projections 614' and 614" extending from the lower side 613' of the cover 613 help direct a pipette into the mouth 631 of the dilution well 625 and channel waste fluids during well cleaning, respectively.
  • the chamber body 615 includes flange 617 retaining O-ring 616 which forms a seal with the rim 618 of the cover 613.
  • the dilution well 625 shown as a test tube-like insert configuration in the FIG., is nested in the rotatable spindle 622 during a dilution and mixing mode and a cleaning high speed spinning mode, but it is a separate removable piece from the system in a preferred embodiment.
  • the spindle 622 and nested dilution well 625 are centered in the chamber 611 relative to imaginary longitudinal axis ⁇ .
  • the dilution well 625 is a non-wettable material, such as polypropylene, to facilitate water removal from the well 625.
  • the dilution well 625 can be formed integrally with the spindle 622.
  • exit opening 708 of the dispenser device is positioned directly over a mouth of a reaction tube, then an external force (not shown) is applied to the outer end of section 702e of plunger 702 that is sufficient in magnitude to overcome the internal opposing biasing force of spring 704, so as to displace the plunger 702 leftward (in the view of FIG. 7A) a distance sufficient to align bead chamber 702b of the plunger with exit opening 708, at which point the bead contained and waiting in bead chamber 702b drops by the force of gravity out of the bead chamber, through exit opening 708, and into a reaction tube (or to intermediary means such as tubing used to transport the bead to a reaction tube) .
  • FIG. 8A there generally is shown a tube washing system 810 provided with a high speed spinning station 820 having an angled, grooved chuck 822 housed within and surrounded by a waste chamber 823. Further details on the configuration of chuck 822 will be developed hereinafter where suitable.
  • the high speed spinning station 820 is shown in its nonengaged position relative to tube 840.
  • the waste chamber 823 serves as a receptacle for collecting and draining wash water fluid spun out of a tube 840.
  • the tube 840 is rotated on its vertical axes z-z by driving the chuck 822 in rotation while the tube is supported at the bottom of the tube (847, 849) via freely rotatable holder 851 which rotates as dictated by the movement of the chuck.
  • the tube spin rate will generally range from about 3,000 to about 10,000 rpm.
  • the analytical instrument of this invention produces reportable assay results through the processing of specimens and various other components of the chemistry system. This processing involves the control and timing of various internal operations as well as the acquisition and processing of data generated internally or through interaction with an external computer system such as LIS.
  • the analytic instrument is an integrated electromechanical apparatus which processes specimens in order to generate test results. It is comprised of all the mechanical hardware, electronic hardware and software required to perform immunoassays described herein. It is anticipated that many different constituents in the sample can be tested by immunoassay by the inventive instrument depending on the selection of the biomaterial bound to the inert support (e.g., bead) in the assay tube.
  • the automated design allows reduced user interface (e.g., tests are performed automatically from computer input) including the ability to order, perform and reassay tests reflexively based on test results without operator intervention.

Abstract

L'invention a pour objet un instrument (10) d'analyse de dosages immunologiques automatisé, à haut rendement, susceptible de réaliser des tests en grandes quantités sur une large gamme d'analytes, tout en opérant une sélection parmi un ensemble de divers dosages immunologiques pour chaque échantillon donné. L'instrument (10) d'analyse comporte un sous-système, lequel consiste en un système de distribution de billes (203, 203a-c), permettant le stockage et l'attribution d'une bille unique enrobée de biomatériau compatible avec le type sélectionné de dosage immunologique pour un échantillon donné. L'instrument (10) d'analyse comporte un autre sous-système, consistant en un moyen (209, 209a-c) de stocker des lots de réactifs, et permettant le stockage et le retrait, d'une manière auto-scellante, d'un réactif donné parmi une gamme de différents réactifs stockés. De plus, l'invention porte également sur un système combiné réutilisable de dilution d'échantillon et de puits de dilution d'échantillon (211), et sur un sous-système de poste de lavage de tubes (214) à grande vitesse, permettant de supprimer les besoins en tubes d'échantillonnage ou de dosage possédant des chambres intégrées de collecte de fluides résiduaires.
PCT/US1997/011245 1996-06-28 1997-06-27 Analyseur de dosages immunologiques automatise WO1998000697A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE19781837T DE19781837T1 (de) 1996-06-28 1997-06-27 Automatischer Immunoassay-Analysator
AU35827/97A AU3582797A (en) 1996-06-28 1997-06-27 Automated immunoassay analyzer

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US67099396A 1996-06-28 1996-06-28
US08/670,995 1996-06-28
US08/670,995 US5773296A (en) 1996-06-28 1996-06-28 Bead dispenser and bead dispenser system for immunoassay analysis
US08/672,654 1996-06-28
US08/672,653 US5723092A (en) 1996-06-28 1996-06-28 Sample dilution system and dilution well insert therefor
US08/670,996 US5721141A (en) 1996-06-28 1996-06-28 Tube washing system
US08/672,653 1996-06-28
US08/670,994 1996-06-28
US08/672,654 US5885529A (en) 1996-06-28 1996-06-28 Automated immunoassay analyzer
US08/670,996 1996-06-28
US08/670,993 1996-06-28
US08/670,994 US5632399A (en) 1996-06-28 1996-06-28 Self-sealing reagent container and reagent container system

Publications (1)

Publication Number Publication Date
WO1998000697A1 true WO1998000697A1 (fr) 1998-01-08

Family

ID=27560226

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/011245 WO1998000697A1 (fr) 1996-06-28 1997-06-27 Analyseur de dosages immunologiques automatise

Country Status (3)

Country Link
AU (1) AU3582797A (fr)
DE (1) DE19781837T1 (fr)
WO (1) WO1998000697A1 (fr)

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0962186A1 (fr) * 1998-06-02 1999-12-08 Bayer Corporation Système de diagnostic automatisé pour mettre en oeuvre des dosages immunologiques et des dosages de chimie-cliniques selon un algorithme réflexe
EP0994355A1 (fr) * 1998-09-23 2000-04-19 Randox Laboratories Ltd. Appareil pur traitement d'un dispositif d'essai
EP1355160A1 (fr) * 2001-01-23 2003-10-22 Hitachi, Ltd. Analyseur automatique
US6649128B1 (en) 1998-09-23 2003-11-18 Randox Laboratories Ltd Assay device processing instrument
AU2003200182B2 (en) * 1998-09-23 2005-02-10 Randox Laboratories Ltd. Assay device washing module
EP1614473A2 (fr) * 1998-05-01 2006-01-11 Gen-Probe Incorporated Carousel multiple pour la livraison d'échantillons aux récipients de réaction dans une analysateur automatique
US7250303B2 (en) 2001-07-20 2007-07-31 Ortho-Clinical Diagnostics, Inc. Chemistry system for a clinical analyzer
EP1914556A2 (fr) * 2006-10-10 2008-04-23 Sysmex Corporation Analyseur, ensemble contenant un réactif et procédé d'aspiration de réactif
EP1918721A1 (fr) * 2006-10-10 2008-05-07 Sysmex Corporation Ensemble contenant de réactif
AU2006230728B2 (en) * 1998-05-01 2008-09-25 Gen-Probe Incorporated Incubator for use in an automated diagnostic analyzer
AU2006230720B2 (en) * 1998-05-01 2008-10-09 Gen-Probe Incorporated Instrument for detecting light emitted by the contents of a reaction receptacle
US7794659B2 (en) 2005-03-10 2010-09-14 Gen-Probe Incorporated Signal measuring system having a movable signal measuring device
US8192992B2 (en) 1998-05-01 2012-06-05 Gen-Probe Incorporated System and method for incubating the contents of a reaction receptacle
CN102608340A (zh) * 2010-08-24 2012-07-25 西门子医疗诊断产品有限责任公司 用于试剂容器的封闭装置
US8718948B2 (en) 2011-02-24 2014-05-06 Gen-Probe Incorporated Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector
US9046507B2 (en) 2010-07-29 2015-06-02 Gen-Probe Incorporated Method, system and apparatus for incorporating capacitive proximity sensing in an automated fluid transfer procedure
EP2212686A4 (fr) * 2007-11-13 2017-11-08 LifeAssays AB (Publ) Mécanisme de bobine pour détecteur magnétique
EP2306205B1 (fr) * 2009-09-30 2019-04-03 Sysmex Corporation Analyseur d'échantillon et procédé d'analyse d'échantillon
CN109791161A (zh) * 2016-07-21 2019-05-21 西门子医疗保健诊断公司 自动临床分析器系统和方法
US10928399B2 (en) 2015-07-15 2021-02-23 Hycor Biomedical, Llc Customizable instrument
CN114460320A (zh) * 2022-04-14 2022-05-10 深圳市帝迈生物技术有限公司 样本分析仪及其样本检测流程

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DE10018876A1 (de) * 2000-04-14 2001-10-25 Mettler Toledo Gmbh Analysenvorrichtung und Analysiereinrichtung
DE102004047822B4 (de) * 2004-09-29 2007-04-05 Scil Animal Care Company Gmbh Reagenzträger sowie Transportbehältnis mit einem Reagenzträger

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Cited By (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8221682B2 (en) 1998-05-01 2012-07-17 Gen-Probe Incorporated System for incubating the contents of a reaction receptacle
US8569020B2 (en) 1998-05-01 2013-10-29 Gen-Probe Incorporated Method for simultaneously performing multiple amplification reactions
US8309358B2 (en) 1998-05-01 2012-11-13 Gen-Probe Incorporated Method for introducing a fluid into a reaction receptacle contained within a temperature-controlled environment
US8137620B2 (en) 1998-05-01 2012-03-20 Gen-Probe Incorporated Temperature-controlled incubator having an arcuate closure panel
US8192992B2 (en) 1998-05-01 2012-06-05 Gen-Probe Incorporated System and method for incubating the contents of a reaction receptacle
US9598723B2 (en) 1998-05-01 2017-03-21 Gen-Probe Incorporated Automated analyzer for performing a nucleic acid-based assay
EP1614473A2 (fr) * 1998-05-01 2006-01-11 Gen-Probe Incorporated Carousel multiple pour la livraison d'échantillons aux récipients de réaction dans une analysateur automatique
EP1614472A2 (fr) * 1998-05-01 2006-01-11 Gen-Probe Incorporated Luminomètre pour analysateur automatique
EP1614473A3 (fr) * 1998-05-01 2007-03-14 Gen-Probe Incorporated Carousel multiple pour la livraison d'échantillons aux récipients de réaction dans une analysateur automatique
EP1614472A3 (fr) * 1998-05-01 2007-03-14 Gen-Probe Incorporated Luminomètre pour analysateur automatique
US9150908B2 (en) 1998-05-01 2015-10-06 Gen-Probe Incorporated Method for detecting the presence of a nucleic acid in a sample
US8883455B2 (en) 1998-05-01 2014-11-11 Gen-Probe Incorporated Method for detecting the presence of a nucleic acid in a sample
US8709814B2 (en) 1998-05-01 2014-04-29 Gen-Probe Incorporated Method for incubating the contents of a receptacle
US8012419B2 (en) 1998-05-01 2011-09-06 Gen-Probe Incorporated Temperature-controlled incubator having rotatable door
AU2006230728B2 (en) * 1998-05-01 2008-09-25 Gen-Probe Incorporated Incubator for use in an automated diagnostic analyzer
AU2006230728B8 (en) * 1998-05-01 2008-10-02 Gen-Probe Incorporated Incubator for use in an automated diagnostic analyzer
AU2006230720B2 (en) * 1998-05-01 2008-10-09 Gen-Probe Incorporated Instrument for detecting light emitted by the contents of a reaction receptacle
US7666681B2 (en) 1998-05-01 2010-02-23 Gen-Probe Incorporated Method for agitating the fluid contents of a container
US7666602B2 (en) 1998-05-01 2010-02-23 Gen-Probe Incorporated Method for agitating the fluid contents of a container
US8569019B2 (en) 1998-05-01 2013-10-29 Gen-Probe Incorporated Method for performing an assay with a nucleic acid present in a specimen
US8546110B2 (en) 1998-05-01 2013-10-01 Gen-Probe Incorporated Method for detecting the presence of a nucleic acid in a sample
US8337753B2 (en) 1998-05-01 2012-12-25 Gen-Probe Incorporated Temperature-controlled incubator having a receptacle mixing mechanism
US8318500B2 (en) 1998-05-01 2012-11-27 Gen-Probe, Incorporated Method for agitating the contents of a reaction receptacle within a temperature-controlled environment
AU755041B2 (en) * 1998-06-02 2002-11-28 Bayer Corporation Automated diagnostic system implementing immunoassays and clinical chemistry assays according to a reflex algorithm
EP0962186A1 (fr) * 1998-06-02 1999-12-08 Bayer Corporation Système de diagnostic automatisé pour mettre en oeuvre des dosages immunologiques et des dosages de chimie-cliniques selon un algorithme réflexe
US6649128B1 (en) 1998-09-23 2003-11-18 Randox Laboratories Ltd Assay device processing instrument
EP0994355A1 (fr) * 1998-09-23 2000-04-19 Randox Laboratories Ltd. Appareil pur traitement d'un dispositif d'essai
US7270788B2 (en) 1998-09-23 2007-09-18 Randox Laboratories Ltd. Assay device processing instrument
AU2003200182B2 (en) * 1998-09-23 2005-02-10 Randox Laboratories Ltd. Assay device washing module
EP1355160A1 (fr) * 2001-01-23 2003-10-22 Hitachi, Ltd. Analyseur automatique
EP1355160A4 (fr) * 2001-01-23 2010-08-04 Hitachi Ltd Analyseur automatique
US7855084B2 (en) 2001-07-20 2010-12-21 Ortho-Clinical Diagnostics, Inc. Chemistry system for clinical analyzer
US7250303B2 (en) 2001-07-20 2007-07-31 Ortho-Clinical Diagnostics, Inc. Chemistry system for a clinical analyzer
US8501461B2 (en) 2005-03-10 2013-08-06 Gen-Probe Incorporated System for performing multi-formatted assays
US7932081B2 (en) 2005-03-10 2011-04-26 Gen-Probe Incorporated Signal measuring system for conducting real-time amplification assays
US8349564B2 (en) 2005-03-10 2013-01-08 Gen-Probe Incorporated Method for continuous mode processing of the contents of multiple reaction receptacles in a real-time amplification assay
US7897337B2 (en) 2005-03-10 2011-03-01 Gen-Probe Incorporated Method for performing multi-formatted assays
US9372156B2 (en) 2005-03-10 2016-06-21 Gen-Probe Incorporated System for processing contents of a receptacle to detect an optical signal emitted by the contents
US10006862B2 (en) 2005-03-10 2018-06-26 Gen-Probe Incorporated Continuous process for performing multiple nucleic acid amplification assays
US7964413B2 (en) 2005-03-10 2011-06-21 Gen-Probe Incorporated Method for continuous mode processing of multiple reaction receptacles in a real-time amplification assay
US8663922B2 (en) 2005-03-10 2014-03-04 Gen-Probe Incorporated Systems and methods for detecting multiple optical signals
US9726607B2 (en) 2005-03-10 2017-08-08 Gen-Probe Incorporated Systems and methods for detecting multiple optical signals
US8008066B2 (en) 2005-03-10 2011-08-30 Gen-Probe Incorporated System for performing multi-formatted assays
US7794659B2 (en) 2005-03-10 2010-09-14 Gen-Probe Incorporated Signal measuring system having a movable signal measuring device
EP1914556A3 (fr) * 2006-10-10 2015-02-18 Sysmex Corporation Analyseur, ensemble contenant un réactif et procédé d'aspiration de réactif
EP1914556A2 (fr) * 2006-10-10 2008-04-23 Sysmex Corporation Analyseur, ensemble contenant un réactif et procédé d'aspiration de réactif
EP1918721A1 (fr) * 2006-10-10 2008-05-07 Sysmex Corporation Ensemble contenant de réactif
US7790114B2 (en) 2006-10-10 2010-09-07 Sysmex Corporation Reagent-containing assembly
EP2212686A4 (fr) * 2007-11-13 2017-11-08 LifeAssays AB (Publ) Mécanisme de bobine pour détecteur magnétique
EP2306205B1 (fr) * 2009-09-30 2019-04-03 Sysmex Corporation Analyseur d'échantillon et procédé d'analyse d'échantillon
US9046507B2 (en) 2010-07-29 2015-06-02 Gen-Probe Incorporated Method, system and apparatus for incorporating capacitive proximity sensing in an automated fluid transfer procedure
CN102608340A (zh) * 2010-08-24 2012-07-25 西门子医疗诊断产品有限责任公司 用于试剂容器的封闭装置
US8718948B2 (en) 2011-02-24 2014-05-06 Gen-Probe Incorporated Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector
US9915613B2 (en) 2011-02-24 2018-03-13 Gen-Probe Incorporated Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector
US10641707B2 (en) 2011-02-24 2020-05-05 Gen-Probe Incorporated Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector
US10928399B2 (en) 2015-07-15 2021-02-23 Hycor Biomedical, Llc Customizable instrument
CN109791161A (zh) * 2016-07-21 2019-05-21 西门子医疗保健诊断公司 自动临床分析器系统和方法
US11927598B2 (en) 2016-07-21 2024-03-12 Siemens Healthcare Diagnostics Inc. Automated clinical analyzer system and method
CN114460320A (zh) * 2022-04-14 2022-05-10 深圳市帝迈生物技术有限公司 样本分析仪及其样本检测流程
CN114460320B (zh) * 2022-04-14 2022-06-21 深圳市帝迈生物技术有限公司 样本分析仪及其样本检测流程

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AU3582797A (en) 1998-01-21
DE19781837T1 (de) 1999-09-09

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