WO1998000138A1 - Procedes et compositions pour traiter l'incontinence urinaire avec du (r)-clidinium enrichi par enantiomorphisme - Google Patents

Procedes et compositions pour traiter l'incontinence urinaire avec du (r)-clidinium enrichi par enantiomorphisme Download PDF

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Publication number
WO1998000138A1
WO1998000138A1 PCT/US1997/011258 US9711258W WO9800138A1 WO 1998000138 A1 WO1998000138 A1 WO 1998000138A1 US 9711258 W US9711258 W US 9711258W WO 9800138 A1 WO9800138 A1 WO 9800138A1
Authority
WO
WIPO (PCT)
Prior art keywords
clidinium
pharmaceutical composition
recited
enantiomerically enriched
pharmaceutically acceptable
Prior art date
Application number
PCT/US1997/011258
Other languages
English (en)
Inventor
Vincent L. Fabiano
John R. Mccullough
Original Assignee
Sepracor, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sepracor, Inc. filed Critical Sepracor, Inc.
Priority to EP97932349A priority Critical patent/EP0957916A4/fr
Publication of WO1998000138A1 publication Critical patent/WO1998000138A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine

Abstract

L'invention a pour objet un procédé pour traiter l'incontinence urinaire, telle l'incontinence résultant d'une instabilité du muscle vésical, utilisant du (R)-clidinium enrichi par énantiomorphisme. Le procédé comprend l'administration d'une quantité thérapeutiquement efficace de (R)-clidinium enrichi par énantiomorphisme, ou d'un sel de celui-ci acceptable selon des critères pharmaceutiques, pratiquement dépourvu de l'énantiomère (S)-clinidium. Ladite invention se réfère également à des compositions pharmaceutiques pour traiter l'incontinence urinaire, comportant du (R)-clinidium enrichi par énantiomorphisme, ou un sel de celui-ci acceptable selon des critères pharmaceutiques, et un excipient acceptable.
PCT/US1997/011258 1996-07-01 1997-06-27 Procedes et compositions pour traiter l'incontinence urinaire avec du (r)-clidinium enrichi par enantiomorphisme WO1998000138A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP97932349A EP0957916A4 (fr) 1996-07-01 1997-06-27 Procedes et compositions pour traiter l'incontinence urinaire avec du (r)-clidinium enrichi par enantiomorphisme

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2073096P 1996-07-01 1996-07-01
US60/020,730 1996-07-01

Publications (1)

Publication Number Publication Date
WO1998000138A1 true WO1998000138A1 (fr) 1998-01-08

Family

ID=21800231

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/011258 WO1998000138A1 (fr) 1996-07-01 1997-06-27 Procedes et compositions pour traiter l'incontinence urinaire avec du (r)-clidinium enrichi par enantiomorphisme

Country Status (2)

Country Link
EP (1) EP0957916A4 (fr)
WO (1) WO1998000138A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6482837B1 (en) * 1998-04-24 2002-11-19 University Of Rochester Antimuscarinic compounds and methods for treatment of bladder diseases
US8481518B2 (en) 2003-01-16 2013-07-09 University Of Rochester Quaternary antimuscarinic compounds for the treatment of bladder diseases

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3714357A (en) * 1968-07-15 1973-01-30 Rech D Applic Scient Sogeras S Pharmaceutical compositions comprising quinuclidinol derivatives
US4644003A (en) * 1985-04-03 1987-02-17 Research Corporation 3-quinuclidinol esters, useful as antagonists of muscarinic acetylcholine receptors
US5519033A (en) * 1993-02-04 1996-05-21 Pfizer Inc. Azabicyclo derivatives for treatment of urinary incontinence

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3714357A (en) * 1968-07-15 1973-01-30 Rech D Applic Scient Sogeras S Pharmaceutical compositions comprising quinuclidinol derivatives
US4644003A (en) * 1985-04-03 1987-02-17 Research Corporation 3-quinuclidinol esters, useful as antagonists of muscarinic acetylcholine receptors
US5519033A (en) * 1993-02-04 1996-05-21 Pfizer Inc. Azabicyclo derivatives for treatment of urinary incontinence

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of EP0957916A4 *
SUPPLEMENT TO UROLOGY, October 1990, Vol. 36, No. 4, WEIN A.J., "Pharmacologic Therapy for Incontinence", pages 36-43. *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6482837B1 (en) * 1998-04-24 2002-11-19 University Of Rochester Antimuscarinic compounds and methods for treatment of bladder diseases
US8481518B2 (en) 2003-01-16 2013-07-09 University Of Rochester Quaternary antimuscarinic compounds for the treatment of bladder diseases

Also Published As

Publication number Publication date
EP0957916A1 (fr) 1999-11-24
EP0957916A4 (fr) 2000-02-23

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