WO1997049807A3 - A novel hypertension related calcium regulated gene (hcarg) - Google Patents

A novel hypertension related calcium regulated gene (hcarg) Download PDF

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Publication number
WO1997049807A3
WO1997049807A3 PCT/CA1997/000439 CA9700439W WO9749807A3 WO 1997049807 A3 WO1997049807 A3 WO 1997049807A3 CA 9700439 W CA9700439 W CA 9700439W WO 9749807 A3 WO9749807 A3 WO 9749807A3
Authority
WO
WIPO (PCT)
Prior art keywords
low
expression
parathyroid
levels
gene
Prior art date
Application number
PCT/CA1997/000439
Other languages
French (fr)
Other versions
WO1997049807A2 (en
Inventor
Johanne Tremblay
Pavel Hamet
Richard Lewanczuk
Francis Gossard
Original Assignee
Johanne Tremblay
Pavel Hamet
Richard Lewanczuk
Francis Gossard
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johanne Tremblay, Pavel Hamet, Richard Lewanczuk, Francis Gossard filed Critical Johanne Tremblay
Priority to CA002230088A priority Critical patent/CA2230088A1/en
Priority to AU31619/97A priority patent/AU3161997A/en
Publication of WO1997049807A2 publication Critical patent/WO1997049807A2/en
Publication of WO1997049807A3 publication Critical patent/WO1997049807A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

This invention relates to a novel gene that shows tissue specific expression and increased expression in a low calcium concentration medium. Low renin hypertension is characterized by decreased levels of serum ionized calcium in the presence of increased levels of parathyroid hormone. It is hypothesized that hypertensive factor(s) are co-secreted with PTH in SHR, a model of low renin hypertension, the parathyroid hypertensive factor being one of them. This invention identifies the genes differentially expressed in humans and in rat models of low renin hypertension (SHR) and in normotensive rat models (WKY) that are induced by low calcium levels in the parathyroid gland. A cDNA of a human gene and a cDNA of a rat gene expressed in parathyroid cells have been cloned and sequenced with no high score homology found in the gene banks. Their expression is higher in hypertensive models and their expression is enhanced by cell incubation in a low calcium concentration medium. In situ hybridization showed specific expression of the genes in adrenal medula and cortex, proximal tubules and parathyroid gland with very low levels in heart ventricles, kidney medulla and glomeruli and liver. These novel calcium regulated genes show tissue specific expression and increased expression in hypertension.
PCT/CA1997/000439 1996-06-21 1997-06-23 A NOVEL HYPERTENSION RELATED CALCIUM REGULATED GENE (HCaRG) WO1997049807A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002230088A CA2230088A1 (en) 1996-06-21 1997-06-23 A novel hypertension related calcium regulated gene (hcarg)
AU31619/97A AU3161997A (en) 1996-06-21 1997-06-23 A novel hypertension related calcium regulated gene (hcarg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66749596A 1996-06-21 1996-06-21
US08/667,495 1996-06-21

Publications (2)

Publication Number Publication Date
WO1997049807A2 WO1997049807A2 (en) 1997-12-31
WO1997049807A3 true WO1997049807A3 (en) 1998-02-26

Family

ID=24678455

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1997/000439 WO1997049807A2 (en) 1996-06-21 1997-06-23 A NOVEL HYPERTENSION RELATED CALCIUM REGULATED GENE (HCaRG)

Country Status (3)

Country Link
AU (1) AU3161997A (en)
CA (1) CA2230088A1 (en)
WO (1) WO1997049807A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6300055B1 (en) * 1998-08-20 2001-10-09 Trustees Of Boston University Diagnostic screens for type 1 diabetes (IDDM)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990011074A1 (en) * 1989-03-22 1990-10-04 Pang Peter K T Parathyroid hypertensive factor
EP0528271A1 (en) * 1991-08-07 1993-02-24 Takeda Chemical Industries, Ltd. Human parathyroid hormone muteins and production thereof
WO1993025577A2 (en) * 1992-06-12 1993-12-23 Zenyaku Kogyo Co., Ltd. Active component of parathyroid hypertensive factor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990011074A1 (en) * 1989-03-22 1990-10-04 Pang Peter K T Parathyroid hypertensive factor
EP0528271A1 (en) * 1991-08-07 1993-02-24 Takeda Chemical Industries, Ltd. Human parathyroid hormone muteins and production thereof
WO1993025577A2 (en) * 1992-06-12 1993-12-23 Zenyaku Kogyo Co., Ltd. Active component of parathyroid hypertensive factor

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
FUJII Y. ET AL.: "Endothelin as an autocrine factor in the regulation of parathyroid cells", PNAS, U.S.A, vol. 88, no. 10, 15 May 1991 (1991-05-15), pages 4235 - 4239, XP002048899 *
HILLIER L. ET AL.: "The WashU-Merck EST project, AC R20463", EMBL DATABASE, 23 April 1995 (1995-04-23), HEIDELBERG, XP002048902 *
KOYAMA K. ET AL.: "EST AC D38732", EMBL DATABASE, 16 May 1995 (1995-05-16), HEIDELBERG, XP002048903 *
MARRA M. ET AL.: "The WashU-HHMI mouse EST project, AC W67032", EMBL DATABASE, 15 June 1996 (1996-06-15), HEIDELBERG, XP002048901 *
TREMBLAY J. ET AL.: "Characterization of a novel hypertension related calcium regulated gene", HYPERTENSION, vol. 29, no. 3, March 1997 (1997-03-01), pages 204, XP002048904 *
VASICEK T. ET AL.: "Nucleotide sequence of the human parathyroid hormone gene", PNAS, U.S.A., vol. 80, no. 7, April 1983 (1983-04-01), pages 2127 - 2131, XP002048900 *

Also Published As

Publication number Publication date
AU3161997A (en) 1998-01-14
WO1997049807A2 (en) 1997-12-31
CA2230088A1 (en) 1997-12-31

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