WO1997046679A9 - Variantes de cycline-c, leurs utilisations diagnostiques et therapeutiques - Google Patents
Variantes de cycline-c, leurs utilisations diagnostiques et therapeutiquesInfo
- Publication number
- WO1997046679A9 WO1997046679A9 PCT/US1997/009709 US9709709W WO9746679A9 WO 1997046679 A9 WO1997046679 A9 WO 1997046679A9 US 9709709 W US9709709 W US 9709709W WO 9746679 A9 WO9746679 A9 WO 9746679A9
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cyclin
- amino acid
- seq
- cell
- acid polymer
- Prior art date
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Abstract
L'invention concerne des ARNm de cycline C à épissage alternatif et partiel, de l'ADN recombiné et la protéine tronquée (cycline C tronquée) qu'ils codent. Les ARNm à épissage alternatif résultent de l'insertion d'exons uniques renfermant des codons à terminaison prématurée. Les ARNm à épissage partiel résultent de l'insertion d'une séquence de codage additionnel issue des exons. On démontre notamment qu'au moins l'un des ARNm de cycline C à épissage alternatif est produit en fonction d'un cycle cellulaire, comme la nouvelle protéine à séquence de cycline tronquée qu'il code. La cycline C tronquée tient lieu d'inhibiteur de cycline C à codage endogène par régulation négative de l'activité complexe cycline C/cdk8, par analogie avec les inhibiteurs de kinase de protéine dépendant de la cycline qui inhibent les cyclines de type D, la cyline A et la cycline E.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU33003/97A AU3300397A (en) | 1996-06-03 | 1997-06-03 | Cyclin-c variants, and diagnostic and therapeutic uses thereof |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1861496P | 1996-06-03 | 1996-06-03 | |
| US65713996A | 1996-06-03 | 1996-06-03 | |
| US60/018,614 | 1996-06-03 | ||
| US08/657,139 | 1996-06-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1997046679A1 WO1997046679A1 (fr) | 1997-12-11 |
| WO1997046679A9 true WO1997046679A9 (fr) | 1998-02-19 |
Family
ID=26691297
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1997/009709 WO1997046679A1 (fr) | 1996-06-03 | 1997-06-03 | Variantes de cycline-c, leurs utilisations diagnostiques et therapeutiques |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU3300397A (fr) |
| WO (1) | WO1997046679A1 (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6881571B1 (en) | 1998-03-11 | 2005-04-19 | Exonhit Therapeutics S.A. | Qualitative differential screening |
| FR2775984B1 (fr) * | 1998-03-11 | 2006-09-15 | Bioscreen Therapeutics Sa | Criblage differentiel qualitatif |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993024514A1 (fr) * | 1992-05-26 | 1993-12-09 | Mitotix | Cycline de type d et utilisations correspondantes |
| US5625031A (en) * | 1994-02-08 | 1997-04-29 | Bristol-Myers Squibb Company | Peptide inhibitors of the p33cdk2 and p34cdc2 cell cycle regulatory kinases and human papillomavirus E7 oncoprotein |
-
1997
- 1997-06-03 WO PCT/US1997/009709 patent/WO1997046679A1/fr active Application Filing
- 1997-06-03 AU AU33003/97A patent/AU3300397A/en not_active Abandoned
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