WO1997046253A3 - Immunotherapie pour maladie auto-immune - Google Patents

Immunotherapie pour maladie auto-immune Download PDF

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Publication number
WO1997046253A3
WO1997046253A3 PCT/US1997/009427 US9709427W WO9746253A3 WO 1997046253 A3 WO1997046253 A3 WO 1997046253A3 US 9709427 W US9709427 W US 9709427W WO 9746253 A3 WO9746253 A3 WO 9746253A3
Authority
WO
WIPO (PCT)
Prior art keywords
delivery
antigen
autoimmune disease
mbp
antigens
Prior art date
Application number
PCT/US1997/009427
Other languages
English (en)
Other versions
WO1997046253A2 (fr
WO1997046253A9 (fr
Inventor
Joel R Haynes
Sudhirdas K Prayaga
Ian A Ramshaw
Original Assignee
Auragen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Auragen Inc filed Critical Auragen Inc
Priority to AU32250/97A priority Critical patent/AU3225097A/en
Publication of WO1997046253A2 publication Critical patent/WO1997046253A2/fr
Publication of WO1997046253A3 publication Critical patent/WO1997046253A3/fr
Publication of WO1997046253A9 publication Critical patent/WO1997046253A9/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

On décrit un traitement de maladies auto-immunes fondé sur l'apport dans la peau d'antigène à l'aide d'un pistolet à gènes, ou l'apport dans la peau d'ADN codant l'antigène. L'apport de collagène ou d'ADN codant le collagène est utile pour traiter l'arthrite rhumatoïde, l'apport de protéine de base de myéline (PBM) ou d'ADN codand le PBM étant quant à lui utile pour traiter la sclérose en plaques. Ces antigènes atténuent les réponses cytotoxiques et favorisent la désensibilisation aux antigènes. A l'aide d'autres antigènes on peut traiter d'autres maladies auto-immunes.
PCT/US1997/009427 1996-06-03 1997-06-03 Immunotherapie pour maladie auto-immune WO1997046253A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU32250/97A AU3225097A (en) 1996-06-03 1997-06-03 Immunotherapy for autoimmune disease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1910096P 1996-06-03 1996-06-03
US60/019,100 1996-06-03

Publications (3)

Publication Number Publication Date
WO1997046253A2 WO1997046253A2 (fr) 1997-12-11
WO1997046253A3 true WO1997046253A3 (fr) 1998-01-29
WO1997046253A9 WO1997046253A9 (fr) 1998-08-06

Family

ID=21791438

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/009427 WO1997046253A2 (fr) 1996-06-03 1997-06-03 Immunotherapie pour maladie auto-immune

Country Status (2)

Country Link
AU (1) AU3225097A (fr)
WO (1) WO1997046253A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7030098B2 (en) 1999-03-12 2006-04-18 The Board Of Trustees Of The Leland Stanford Junior University DNA vaccination for treatment of autoimmune disease
ES2338890T3 (es) 1999-03-12 2010-05-13 The Board Of Trustees Of The Leland Stanford Junior University Vacunacion por dna para el tratamiento de enfermedades autoinmunes.
US6884785B2 (en) * 1999-06-17 2005-04-26 The Scripps Research Institute Compositions and methods for the treatment or prevention of autoimmune diabetes
EP2322185A3 (fr) 2001-11-21 2011-08-10 The Board Of Trustees Of The Leland Stanford Junior University Thérapie à base de polynucléotides
CN101955976A (zh) 2002-11-21 2011-01-26 贝希尔治疗学股份有限公司 预防和治疗疾病的方法及免疫调节核酸组合物
SE535625C2 (sv) 2010-10-28 2012-10-16 Toleranzia Ab Nya kompositioner och förfaranden för behandling av autoimmuna och allergiska sjukdomar
WO2013160865A1 (fr) 2012-04-26 2013-10-31 Toleranzia Ab Protéines hybrides d'immuno-tolérisation pour le traitement de la sclérose en plaques

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992006708A1 (fr) * 1990-10-15 1992-04-30 Brigham And Women's Hospital Traitement de maladies auto-immunes par administration orale d'auto-antigenes
WO1993016724A1 (fr) * 1992-02-28 1993-09-02 Autoimmune, Inc. Suppression de maladies auto-immunes par des antigenes en attente
WO1995007096A1 (fr) * 1993-09-06 1995-03-16 La Trobe University Traitement de maladies auto-immunes
WO1996010039A1 (fr) * 1994-09-27 1996-04-04 Peptide Therapeutics Limited Polypeptides et leur utilisation dans le traitement et la prophylaxie de maladies auto-immunes

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992006708A1 (fr) * 1990-10-15 1992-04-30 Brigham And Women's Hospital Traitement de maladies auto-immunes par administration orale d'auto-antigenes
WO1993016724A1 (fr) * 1992-02-28 1993-09-02 Autoimmune, Inc. Suppression de maladies auto-immunes par des antigenes en attente
WO1995007096A1 (fr) * 1993-09-06 1995-03-16 La Trobe University Traitement de maladies auto-immunes
WO1996010039A1 (fr) * 1994-09-27 1996-04-04 Peptide Therapeutics Limited Polypeptides et leur utilisation dans le traitement et la prophylaxie de maladies auto-immunes

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JOEL R. HAYNES, DENNIS E. MCCABE, WILLIAM F. SWAIN, GEORG WIDERA, JAMES T. FULLER: "Particle-mediated nucleic acid immunization", JOURNAL OF BIOTECHNOLOGY, vol. 44, no. 1-3, 16 January 1996 (1996-01-16), pages 37 - 42, XP002043695 *
S. K. PRAYAGA AND J. R. HAYNES: "Particle-mediated delivery of type II collagen to the epidermis of mice prevents the development of collagen-induced arthritis", FASEB JOURNAL, vol. 10, no. 6, 30 April 1996 (1996-04-30), pages A1025, XP002043694 *
TAMERA M. PERTNER, MICHAEL D. EISENBRAUN, DENNIS MCCABE, SUDHIRDAS K. PRAYAGA, DEBORAH H. FULLER AND JOEL R. HAYNEST: "Gene gun-based nucleic acid immunization: elicitation of humoral and cytotoxic T lymphocyte responses following epidermal delivery of nanogram quantities of DNA", VACCINE, vol. 13, no. 15, 1995, pages 1427 - 1430, XP002043696 *

Also Published As

Publication number Publication date
AU3225097A (en) 1998-01-05
WO1997046253A2 (fr) 1997-12-11

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