WO1997044059A3 - Collagene de type ii de cartilage utilise en tant que facteur angiogenique - Google Patents

Collagene de type ii de cartilage utilise en tant que facteur angiogenique Download PDF

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Publication number
WO1997044059A3
WO1997044059A3 PCT/US1997/009861 US9709861W WO9744059A3 WO 1997044059 A3 WO1997044059 A3 WO 1997044059A3 US 9709861 W US9709861 W US 9709861W WO 9744059 A3 WO9744059 A3 WO 9744059A3
Authority
WO
WIPO (PCT)
Prior art keywords
collagen
angiogenesis
angiogenic factor
cartilage type
methods
Prior art date
Application number
PCT/US1997/009861
Other languages
English (en)
Other versions
WO1997044059A2 (fr
Inventor
A Robin Poole
Anne Marriott
Mauro Alini
Original Assignee
Shriner S Hospitals For Childr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shriner S Hospitals For Childr filed Critical Shriner S Hospitals For Childr
Priority to AU33045/97A priority Critical patent/AU3304597A/en
Publication of WO1997044059A2 publication Critical patent/WO1997044059A2/fr
Publication of WO1997044059A3 publication Critical patent/WO1997044059A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention se rapporte à des matières et à des procédés permettant d'inhiber ou de favoriser l'angiogénèse. On a établit que le collagène de type II de cartilage est un promoteur d'angiogénèse. L'invention se rapporte également à des procédés visant à réduire l'angiogénèse non désirée ainsi qu'à des procédés visant à favoriser une angiogénèse appropriée, notamment pour la cicatrisation.
PCT/US1997/009861 1996-05-23 1997-05-23 Collagene de type ii de cartilage utilise en tant que facteur angiogenique WO1997044059A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU33045/97A AU3304597A (en) 1996-05-23 1997-05-23 Cartilage type ii collagen as an angiogenic factor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1815996P 1996-05-23 1996-05-23
US60/018,159 1996-05-23

Publications (2)

Publication Number Publication Date
WO1997044059A2 WO1997044059A2 (fr) 1997-11-27
WO1997044059A3 true WO1997044059A3 (fr) 1997-12-24

Family

ID=21786559

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/009861 WO1997044059A2 (fr) 1996-05-23 1997-05-23 Collagene de type ii de cartilage utilise en tant que facteur angiogenique

Country Status (2)

Country Link
AU (1) AU3304597A (fr)
WO (1) WO1997044059A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7122635B2 (en) 1999-01-06 2006-10-17 University Of Southern California Method and composition for angiogenesis inhibition
ATE435031T1 (de) 1999-07-13 2009-07-15 Univ Southern California Methode und zusammensetzung zur angiogenese- inhibierung mit antagonisten gegen mmp-9 und beta1-integrine
US7365167B2 (en) 2001-11-26 2008-04-29 Cell Matrix, Inc. Humanized collagen antibodies and related methods
US7390885B2 (en) 2001-11-26 2008-06-24 Cell Matrix, Inc. Humanized collagen antibodies and related methods
US7488792B2 (en) 2002-08-28 2009-02-10 Burnham Institute For Medical Research Collagen-binding molecules that selectively home to tumor vasculature and methods of using same
JP2007191467A (ja) * 2005-12-20 2007-08-02 Pentax Corp 肥大化能を有する軟骨細胞の産生する新しい細胞機能調節因子

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994007520A1 (fr) * 1992-09-25 1994-04-14 Autoimmune, Inc. Procede de traitement de la polyarthrite rhumatoide avec du collagene de type ii
WO1994018563A1 (fr) * 1993-02-12 1994-08-18 Rhode Island Hospital Detection de collagene de type ii et de ses peptides

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994007520A1 (fr) * 1992-09-25 1994-04-14 Autoimmune, Inc. Procede de traitement de la polyarthrite rhumatoide avec du collagene de type ii
WO1994018563A1 (fr) * 1993-02-12 1994-08-18 Rhode Island Hospital Detection de collagene de type ii et de ses peptides

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ALINI M. ET AL: "A novel angiogenic molecule produced at the time of chondrocyte hypertrophy during endochondral bone formation", DEVELOPMENTAL BIOLOGY, vol. 176, no. 1, 1996 - 1996, pages 124 - 132, XP002044392 *
HOLLANDER, A.P. ET AL: "Increased damage to type II collagen in osteoarthritic articular cartilage detected by a new immunoassay", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 93, no. 4, 1994, pages 1722 - 1732, XP002044391 *
OLIVER S.J. ET AL: "Suppression of collagen-induced Arthritis using an angiogenesis inhibitor, AGM-1470 and a microtubule stabilizer, Taxol", CELLULAR IMMUNOLOGY, vol. 157, 1994, pages 291 - 299, XP002044393 *
POSTLETHWAITE A. ET AL: "Chemotactic attraction of human fibroblasts to type I, II, and III collagens and collagen-derived peptides", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 75, no. 2, 1978, WASHINGTON US, pages 871 - 875, XP002044394 *

Also Published As

Publication number Publication date
WO1997044059A2 (fr) 1997-11-27
AU3304597A (en) 1997-12-09

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