WO1997043414A3 - A basal cell carcinoma tumor suppressor gene - Google Patents

A basal cell carcinoma tumor suppressor gene Download PDF

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Publication number
WO1997043414A3
WO1997043414A3 PCT/US1997/008433 US9708433W WO9743414A3 WO 1997043414 A3 WO1997043414 A3 WO 1997043414A3 US 9708433 W US9708433 W US 9708433W WO 9743414 A3 WO9743414 A3 WO 9743414A3
Authority
WO
WIPO (PCT)
Prior art keywords
basal cell
cell carcinoma
tumor suppressor
suppressor gene
carcinoma tumor
Prior art date
Application number
PCT/US1997/008433
Other languages
French (fr)
Other versions
WO1997043414A2 (en
Inventor
Michael Frederick Dean
Heidi Hahn
Carol Wicking
Jeffrey Christiansen
Peter Zaphiropoulos
Mae R Gailani
Susan Shanley
Abriami Chidambaram
Igor Vorechovsky
Erika Holmberg
Anne Birgitte Unden
Susan Gillies
Kylie Negus
Ian Smyth
Carol Pressman
David Leffell
Bernard Gerrard
Alisa Goldstein
Brandon Wainwright
Rune Toftgard
Georgia Chenevix-Trench
Allen E Bale
Original Assignee
Us Gov Health & Human Serv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AUPO0011A external-priority patent/AUPO001196A0/en
Priority claimed from AUPO0363A external-priority patent/AUPO036396A0/en
Application filed by Us Gov Health & Human Serv filed Critical Us Gov Health & Human Serv
Priority to JP54116497A priority Critical patent/JP2002504805A/en
Priority to CA002266408A priority patent/CA2266408A1/en
Priority to AU31314/97A priority patent/AU725404B2/en
Priority to EP97926586A priority patent/EP0964925B1/en
Priority to DE69737660T priority patent/DE69737660T2/en
Publication of WO1997043414A2 publication Critical patent/WO1997043414A2/en
Publication of WO1997043414A3 publication Critical patent/WO1997043414A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

This invention provides for a tumor suppressor gene inactivation of which is a causal factor in nevoid basal cell carcinoma syndrome and various sporadic basal cell carcinomas. The NBCCS gene is a homologue of the Drosophila patched (ptc) gene.
PCT/US1997/008433 1996-05-17 1997-05-16 A basal cell carcinoma tumor suppressor gene WO1997043414A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP54116497A JP2002504805A (en) 1996-05-17 1997-05-16 Basal cell carcinoma tumor suppressor gene
CA002266408A CA2266408A1 (en) 1996-05-17 1997-05-16 A basal cell carcinoma tumor suppressor gene
AU31314/97A AU725404B2 (en) 1996-05-17 1997-05-16 A basal cell carcinoma tumor suppressor gene
EP97926586A EP0964925B1 (en) 1996-05-17 1997-05-16 A basal cell carcinoma tumor suppressor gene
DE69737660T DE69737660T2 (en) 1996-05-17 1997-05-16 TUMOR SUPPRESSOR FROM BASAL CELL CARCINOMA

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US1790696P 1996-05-17 1996-05-17
US60/017,906 1996-05-17
AUPO0011 1996-05-21
AUPO0011A AUPO001196A0 (en) 1996-05-21 1996-05-21 A novel gene
AUPO0363 1996-06-07
AUPO0363A AUPO036396A0 (en) 1996-06-07 1996-06-07 A novel gene - ii
US1976596P 1996-06-14 1996-06-14
US60/019,765 1996-06-14

Publications (2)

Publication Number Publication Date
WO1997043414A2 WO1997043414A2 (en) 1997-11-20
WO1997043414A3 true WO1997043414A3 (en) 1998-02-12

Family

ID=56289769

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/008433 WO1997043414A2 (en) 1996-05-17 1997-05-16 A basal cell carcinoma tumor suppressor gene

Country Status (2)

Country Link
CA (1) CA2266408A1 (en)
WO (1) WO1997043414A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2151505A1 (en) 2008-08-05 2010-02-10 Institut Gustave Roussy Method for determining a predisposition to basal cell carcinoma and for screening treatments thereof
WO2013113761A1 (en) 2012-01-31 2013-08-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and kits for predicting the risk of having a basal cell carcinoma in a subject
WO2015036405A1 (en) 2013-09-10 2015-03-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for diagnosing and treating basal cell carcinoma

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996011260A1 (en) * 1994-10-07 1996-04-18 The Board Of Trustees Of The Leland Stanford Junior University Patched genes and their use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996011260A1 (en) * 1994-10-07 1996-04-18 The Board Of Trustees Of The Leland Stanford Junior University Patched genes and their use

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
GAILANI, M.R. ET AL.: "Developmental defects in Gorlin syndrome related to a putative tumor suppressor gene on chromosome 9", CELL, vol. 69, 3 April 1992 (1992-04-03), NA US, pages 111 - 117, XP002048319 *
GOODRICH, L.V. ET AL.: "Conservation of the Hedgehog/ patched signaling pathway from flies to mice: induction of a mouse patched gene by hedgehog", GENES & DEVELOPMENT, vol. 10, no. 3, 1 February 1996 (1996-02-01), pages 301 - 312, XP002048318 *
HAHN, H. ET AL.: "A mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalities", JOURNAL OF BIOLOGICAL CHEMISTRY. (MICROFILMS), vol. 271, no. 21, 24 May 1996 (1996-05-24), MD US, pages 12125 - 12128, XP002048320 *
HAHN, H. ET AL.: "Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome", CELL, vol. 85, no. 6, 14 June 1996 (1996-06-14), NA US, pages 841 - 851, XP002048321 *

Also Published As

Publication number Publication date
CA2266408A1 (en) 1997-11-20
WO1997043414A2 (en) 1997-11-20

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