WO1997039793A1 - Dispositif electrochimique de traitement contre le cancer - Google Patents

Dispositif electrochimique de traitement contre le cancer Download PDF

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Publication number
WO1997039793A1
WO1997039793A1 PCT/CN1997/000032 CN9700032W WO9739793A1 WO 1997039793 A1 WO1997039793 A1 WO 1997039793A1 CN 9700032 W CN9700032 W CN 9700032W WO 9739793 A1 WO9739793 A1 WO 9739793A1
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WO
WIPO (PCT)
Prior art keywords
circuit
current
computer
bus
current output
Prior art date
Application number
PCT/CN1997/000032
Other languages
English (en)
Chinese (zh)
Inventor
Yajun Ma
Runqiu Chen
Qingtai Guo
Original Assignee
Beijing Haidian Dadi Electronic Technology Development Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing Haidian Dadi Electronic Technology Development Corp. filed Critical Beijing Haidian Dadi Electronic Technology Development Corp.
Publication of WO1997039793A1 publication Critical patent/WO1997039793A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents

Definitions

  • the present invention relates to a medical instrument, in particular an electrochemical cancer treatment instrument that uses direct current as a treatment means to make a biochemical reaction of a diseased tissue, thereby destroying the diseased tissue (such as a tumor).
  • the purpose of the present invention is to provide an improved electrochemical cancer treatment instrument, which has good treatment effect, safety and reliability.
  • the electrochemical cancer treatment instrument includes a computer; a display and a keyboard supporting the computer; a bus conversion circuit board is inserted into the computer, and the bus conversion circuit is connected to the computer bus and the treatment host bus;
  • a treatment host and an electrode needle the treatment host includes: a DC current output unit composed of a multi-route D / A conversion circuit and a constant current output circuit; a multi-channel DC voltage stabilization unit, which is composed of a filter, a transformer, and a DC voltage regulator A plurality of negative current sharing circuits matching the constant current output circuit; an A / D conversion circuit, the constant current output circuit including an operational amplifier and a driver, and the current sharing circuit including three poles A tube, an upper bias resistor, an emitter resistor, and two diodes connected in series between the base and ground in a forward direction, the electrode needle includes a positive electrode A and a plurality of negative electrodes C.
  • Figure 1 Block diagram of the working principle of the therapeutic apparatus of the present invention
  • FIG. 2 is a circuit schematic diagram of a DC current output unit of the therapeutic apparatus of the present invention
  • Figure 3 Circuit schematic of the negative current sharing circuit of the therapeutic device of the present invention.
  • FIG. 1 is a computer, and 1 and 2 are a display and a keyboard supporting the computer.
  • a bus conversion circuit board 4 is inserted into the computer, which transmits signals between the computer and the treatment host, and is connected through the computer bus and the instrument bus 12. Between the computer and the treatment unit.
  • the treatment unit 5 includes: a DC current output unit composed of a D / A conversion circuit 6 and a constant current output circuit 7.
  • the output unit is multi-channel and can be selected according to needs; the host also includes Multi-channel DC voltage stabilizing unit 10, which includes a filter, a transformer, and a DC voltage stabilizer, can output a safety voltage below 36 V, and the current (milliampere level) under the safety voltage is regulated by the circuit of each part of the instrument and converted into the required treatment Current is drawn out; 9 in FIG. 1 is a negative current sharing circuit, which constitutes a treatment unit with the constant current output circuit 7 (see FIG. 3 for details), and FIG. 1 also includes an electrode needle 8 which adopts corrosion resistance and good conductivity. Made of metal materials, preferably a platinum group metal, the subject to be treated is connected in series between the positive and negative electrodes, and the host also includes an A / D conversion circuit.
  • Multi-channel DC voltage stabilizing unit 10 which includes a filter, a transformer, and a DC voltage stabilizer, can output a safety voltage below 36 V, and the current (milliampere level) under the safety voltage is regulated by the circuit of each
  • the above bus conversion circuit includes: an address latch, a write data latch, an address buffer, a data write buffer, a read data buffer, a data read buffer, and a control signal generator.
  • the control signal generator is used to generate the control signals required by the treatment unit, and these control signals are transmitted to the treatment unit via the control signal driver.
  • a control signal generator which is used for buffers and registers in the bus conversion circuit, etc. Provide chip select signal.
  • the A / D conversion circuit includes: a channel selection controller connected to the data bus, a multi-way conversion switch, an A / D conversion chip, and a digital data output end of the output terminal connected to the data bus and the input terminal of the A / D conversion chip.
  • the data receiver, the output end of the multiplexer is connected to the input end of the A / D conversion chip, and the channel controller is used to select the channel of the multiplexer.
  • 6 is a D / A conversion circuit, and the circuit includes a data buffer, an address decoder, a D / A conversion chip, and an operational amplifier 13. Among them, there are multiple D / A conversion chips and operational amplifiers, depending on the output The number of groups depends.
  • the output of the D / A conversion chip is connected to an operational amplifier.
  • the reference voltage VREF of the chip is directly provided by the voltage regulator of the voltage stabilization unit.
  • the model of the operational amplifier is ⁇ A741.
  • the operational amplifier 13 is connected to another operational amplifier. 14 (shared ⁇ A741), the output of the operational amplifier 14 is connected to the driver (S8050) 15, where the collector of the triode is connected to + 24V adjustable voltage.
  • the positive current of each constant current output circuit is between 20mA-100mA, which is lower than 20mA. The effect is not obvious, higher than 100mA is not conducive to patient treatment and safety.
  • the triode collector of driver 15 of the therapy device is connected with an adjustable voltage of + 24V, and an adjustable potentiometer is used, and the potentiometer is fixed on the front panel of the treatment host.
  • the potentiometer can be Adjust to zero to make the positive output current close to zero to ensure patient safety.
  • the positive treatment current la enters the tumor.
  • the negative current Iki of a certain path increases to make the
  • the negative current sharing circuit of this circuit works in a saturated state. In this state, the increase of Vci is large and the increase of I w is small, so the increased therapeutic current flowing to the negative electrode of this channel will pass through the cancer tissue between the negative electrodes. Flow to the negative electrode with a lower V ci value, so that the treatment current is evenly distributed among the various negative electrodes.
  • the constant current circuit satisfies the following formula
  • VREF Reference voltage for D / A conversion circuit 6, provided by the regulator.
  • the working process of the therapeutic instrument After the computer is set by the software, the therapeutic data representing the treatment channel number, the therapeutic current intensity and the corresponding control commands are sent to the instrument bus through the bus conversion unit, which is converted into simulation by D / A on the treatment host. The voltage is then output from the positive pole of the corresponding channel through constant current. The voltage presented at the output end is returned to the computer via A / D, conversion bus conversion, and computer bus. The computer processes and displays these data, and the remaining channels proceed in sequence. During the treatment process, the size of the treatment current is adjusted and controlled by the computer. Generally, the treatment current can be changed in a trapezoidal wave shape, that is, it gradually rises from a small value to a set current value. After maintaining for a period of time, it slowly decreases to zero. The computer regulates, controls and manages the entire process of treatment.
  • the therapy device adopts direct current as the main control parameter, which is beneficial to the treatment, and the current value is controlled in the range of 20mA-100mA, which greatly improves the treatment effect.
  • the therapy device is also provided with a treatment device in an emergency state (0 ⁇ + 24V output adjustable voltage), so that the output treatment current is close to zero, the safety and reliability of the therapy device is improved, and personal safety is guaranteed.
  • the use of metal materials such as platinum as electrodes also ensures the reliability of the instrument and extends Service life.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Electrotherapy Devices (AREA)

Abstract

Cette invention concerne un dispositif électrochimique de traitement contre le cancer, lequel comprend un ordinateur, un clavier, un affichage, une carte de circuit de transfert par bus insérée dans l'ordinateur, une machine de thérapie principale, ainsi qu'une d'électrode de type aiguille. La machine de thérapie principale comprend, quant à elle, les éléments suivants: une unité de sortie de courant continu multiplex se composant d'un circuit de conversion Num./Anal. et d'un circuit de sortie de courant constant; une unité à tension stable, à courant continu et multiplex; un circuit de courant équilibré, à polarité négative et multiplex qui correspond à un circuit à courant de sortie constant; et enfin, un circuit de conversion Anal./Num. Le courant représente le paramètre de commande principal de ce dispositif de traitement, et sa valeur est ajustée de manière à rester dans la fourchette allant de zom à 100 mA, ce qui permet d'améliorer sensiblement l'effet thérapeutique. Le dispositif de traitement comporte également un système de traitement qui, en cas d'urgence, permet d'améliorer sa sécurité et sa fiabilité.
PCT/CN1997/000032 1996-04-22 1997-04-22 Dispositif electrochimique de traitement contre le cancer WO1997039793A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN 96104718 CN1163150A (zh) 1996-04-22 1996-04-22 电化学癌肿治疗仪
CN96104718.6 1996-04-22

Publications (1)

Publication Number Publication Date
WO1997039793A1 true WO1997039793A1 (fr) 1997-10-30

Family

ID=5118476

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN1997/000032 WO1997039793A1 (fr) 1996-04-22 1997-04-22 Dispositif electrochimique de traitement contre le cancer

Country Status (2)

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CN (1) CN1163150A (fr)
WO (1) WO1997039793A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6712840B2 (en) 1999-04-23 2004-03-30 Caijin Sun Tumor electrochemical-therapeutic device using electrothermal needles
KR100503882B1 (ko) * 2001-07-16 2005-07-29 주식회사 솔고 바이오메디칼 전기화학적 치료기

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1066346C (zh) * 1997-11-17 2001-05-30 北京计然电子科技公司 金属离子电化学治疗仪

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1078649A (zh) * 1993-06-12 1993-11-24 北京市海淀区大地电子技术开发公司 智能癌肿治疗仪
CN1086444A (zh) * 1993-06-12 1994-05-11 北京市海淀区大地电子技术开发公司 电化学癌肿治疗仪
CN1103319A (zh) * 1993-12-03 1995-06-07 北京市海淀区大地电子技术开发公司 电化学癌肿治疗仪
US5470347A (en) * 1994-12-13 1995-11-28 Somatics, Inc. Safety monitor circuit for an ECT device and method

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1078649A (zh) * 1993-06-12 1993-11-24 北京市海淀区大地电子技术开发公司 智能癌肿治疗仪
CN1086444A (zh) * 1993-06-12 1994-05-11 北京市海淀区大地电子技术开发公司 电化学癌肿治疗仪
CN1103319A (zh) * 1993-12-03 1995-06-07 北京市海淀区大地电子技术开发公司 电化学癌肿治疗仪
US5470347A (en) * 1994-12-13 1995-11-28 Somatics, Inc. Safety monitor circuit for an ECT device and method

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6712840B2 (en) 1999-04-23 2004-03-30 Caijin Sun Tumor electrochemical-therapeutic device using electrothermal needles
KR100503882B1 (ko) * 2001-07-16 2005-07-29 주식회사 솔고 바이오메디칼 전기화학적 치료기

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Publication number Publication date
CN1163150A (zh) 1997-10-29

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