WO1997038085A3 - Genes amplifies dans des cellules cancereuses - Google Patents

Genes amplifies dans des cellules cancereuses Download PDF

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Publication number
WO1997038085A3
WO1997038085A3 PCT/US1997/005930 US9705930W WO9738085A3 WO 1997038085 A3 WO1997038085 A3 WO 1997038085A3 US 9705930 W US9705930 W US 9705930W WO 9738085 A3 WO9738085 A3 WO 9738085A3
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WO
WIPO (PCT)
Prior art keywords
rna
cancer
gene
cells
genes
Prior art date
Application number
PCT/US1997/005930
Other languages
English (en)
Other versions
WO1997038085A2 (fr
Inventor
Helene Smith
Ling-Chun Chen
Original Assignee
California Pacific Med Center
Helene Smith
Chen Ling Chun
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1996/009286 external-priority patent/WO1996039516A2/fr
Priority claimed from US08/678,280 external-priority patent/US5776683A/en
Application filed by California Pacific Med Center, Helene Smith, Chen Ling Chun filed Critical California Pacific Med Center
Priority to EP97920293A priority Critical patent/EP0944651A2/fr
Priority to AU24521/97A priority patent/AU2452197A/en
Priority to JP9536486A priority patent/JP2000509256A/ja
Publication of WO1997038085A2 publication Critical patent/WO1997038085A2/fr
Publication of WO1997038085A3 publication Critical patent/WO1997038085A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne des nouveaux procédés pour détecter des gènes associés au cancer et produire des séquences d'ADNc correspondantes. Lesdits procédés consistent à produire des préparations d'ARN à partir de cellules de régulation et de plusieurs cellules cancéreuses différentes partageant un gène dupliqué ou modifié dans la même région d'un chromosome. Des copies d'ADNc amplifié sont visualisées puis sélectionnées en fonction des différences d'abondance d'ARN entre les préparations. Les étapes de criblages supplémentaires optionnelles consistent à rechercher dans des séries de cellules cancéreuses au moyen de l'ADNc la surabondance d'ARN avec ou sans duplication génique. Les gènes identifiés peuvent être utilisés à leur tour pour mettre au point des matériaux et des techniques de traitement et de diagnostic du cancer sous-jacent. On a identifié quatre nouveaux gènes associés au cancer. Dans environ 60 % des lignées de cellules du cancer du sein testées, l'ARN s'hybridant avec les ADN était sensiblement plus abondant que dans des cellules normales. La plupart des lignées cellulaires présentaient également une duplication du gène correspondant, ce qui semble avoir contribué au fait que le niveau d'ARN dans la cellule est accru. Néanmoins, pour chacun des quatre gènes, certaines cellules présentaient une surabondance sans duplication génique, ce qui semble indiquer que le produit génique est suffisamment important dans le processus cancéreux pour que les cellules utilisent plusieurs mécanismes différents pour amplifier leur expression.
PCT/US1997/005930 1996-04-10 1997-04-09 Genes amplifies dans des cellules cancereuses WO1997038085A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP97920293A EP0944651A2 (fr) 1996-04-10 1997-04-09 Genes amplifies dans des cellules cancereuses
AU24521/97A AU2452197A (en) 1996-04-10 1997-04-09 Genes amplified in cancer cells
JP9536486A JP2000509256A (ja) 1996-04-10 1997-04-09 ガン細胞において増幅される遺伝子

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US1516796P 1996-04-10 1996-04-10
USPCT/US96/09286 1996-06-05
PCT/US1996/009286 WO1996039516A2 (fr) 1995-06-05 1996-06-05 Cibles pour le diagnostic et le traitement du cancer du sein
US1920296P 1996-06-06 1996-06-06
US08/678,280 US5776683A (en) 1996-07-11 1996-07-11 Methods for identifying genes amplified in cancer cells
US60/019,202 1996-07-11
US60/015,167 1996-07-11
US08/678,280 1996-07-11

Publications (2)

Publication Number Publication Date
WO1997038085A2 WO1997038085A2 (fr) 1997-10-16
WO1997038085A3 true WO1997038085A3 (fr) 1998-02-19

Family

ID=27486464

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/005930 WO1997038085A2 (fr) 1996-04-10 1997-04-09 Genes amplifies dans des cellules cancereuses

Country Status (4)

Country Link
EP (1) EP0944651A2 (fr)
JP (1) JP2000509256A (fr)
AU (1) AU2452197A (fr)
WO (1) WO1997038085A2 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030170864A1 (en) 2000-05-30 2003-09-11 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US7160985B2 (en) 1997-10-29 2007-01-09 Genentech, Inc. Pro180 polypeptide
US20030105298A1 (en) 1998-06-16 2003-06-05 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US7351543B2 (en) 1998-06-02 2008-04-01 Genentech, Inc. Antibodies to a polypeptide encoded by a nucleic acid underexpressed in melanoma
US7319008B2 (en) 1998-06-02 2008-01-15 Genentech, Inc. Nucleic acid underexpressed in melanoma
US7244817B2 (en) 1998-09-10 2007-07-17 Genentech, Inc. Pro1357 polypeptide
US7244428B2 (en) 1998-09-10 2007-07-17 Genentech, Inc. PRO1357 antibodies
US7399828B2 (en) 1998-09-24 2008-07-15 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US7402661B2 (en) 1998-10-06 2008-07-22 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
GB9827430D0 (en) * 1998-12-11 1999-02-03 Ludwig Inst Cancer Res Differential expression in primary breast cancer
US20030187196A1 (en) 1998-12-30 2003-10-02 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US7507404B2 (en) 1999-03-08 2009-03-24 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US7423127B2 (en) 1999-12-09 2008-09-09 Genentech, Inc. Antibodies to a polypeptide encoded by a nucleic acid overexpressed in melanoma
US7300758B2 (en) 1999-12-09 2007-11-27 Genetech, Inc. Nucleic acid underexpressed in esophageal tumor
US7288384B2 (en) 1999-12-09 2007-10-30 Genentech, Inc. Antibodies to polypeptides encoded by a nucleic acid underexpressed in esophageal tumor
US20030018172A1 (en) 2001-12-06 2003-01-23 Genentech, Inc. Secreted transmembrane polypeptides and nucleic acids encoding the same
US7989167B2 (en) * 2006-11-13 2011-08-02 Val-Chum L.P. Method of prognosing and diagnosing hereditary spastic paraplegia, mutant nucleic acid molecules and polypeptides

Citations (3)

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WO1991002062A2 (fr) * 1989-08-04 1991-02-21 Triton Biosciences, Inc. Domaine externe du c-erbb-2: gp75
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Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
US4968603A (en) * 1986-12-31 1990-11-06 The Regents Of The University Of California Determination of status in neoplastic disease
WO1991002062A2 (fr) * 1989-08-04 1991-02-21 Triton Biosciences, Inc. Domaine externe du c-erbb-2: gp75
WO1992021771A1 (fr) * 1991-06-03 1992-12-10 Triton Diagnostics, Inc. Ectodomaine de recepteur du facteur de croissance epidermique

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Also Published As

Publication number Publication date
WO1997038085A2 (fr) 1997-10-16
JP2000509256A (ja) 2000-07-25
EP0944651A2 (fr) 1999-09-29
AU2452197A (en) 1997-10-29

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