WO1997035969A3 - Peptide ligands of the urokinase receptor - Google Patents
Peptide ligands of the urokinase receptor Download PDFInfo
- Publication number
- WO1997035969A3 WO1997035969A3 PCT/US1997/005199 US9705199W WO9735969A3 WO 1997035969 A3 WO1997035969 A3 WO 1997035969A3 US 9705199 W US9705199 W US 9705199W WO 9735969 A3 WO9735969 A3 WO 9735969A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- peptides
- upar
- binding
- peptide ligands
- urokinase receptor
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 title abstract 2
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 229960005356 urokinase Drugs 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 102000009816 urokinase plasminogen activator receptor activity proteins Human genes 0.000 abstract 3
- 108040001269 urokinase plasminogen activator receptor activity proteins Proteins 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 102000006495 integrins Human genes 0.000 abstract 2
- 108010044426 integrins Proteins 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 108010043958 Peptoids Proteins 0.000 abstract 1
- 102100035140 Vitronectin Human genes 0.000 abstract 1
- 108010031318 Vitronectin Proteins 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000012292 cell migration Effects 0.000 abstract 1
- 208000037976 chronic inflammation Diseases 0.000 abstract 1
- 230000006020 chronic inflammation Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000003278 mimic effect Effects 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 150000003384 small molecules Chemical class 0.000 abstract 1
- 230000003827 upregulation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70546—Integrin superfamily
- C07K14/7055—Integrin beta1-subunit-containing molecules, e.g. CD29, CD49
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP53466697A JP4088344B2 (en) | 1996-03-28 | 1997-03-28 | Peptide ligand of urokinase receptor |
US09/155,260 US6794358B1 (en) | 1997-03-28 | 1997-03-28 | Peptide ligands of the urokinase receptor |
EP97917723A EP0906419A2 (en) | 1996-03-28 | 1997-03-28 | Peptide ligands of the urokinase receptor |
AU25978/97A AU2597897A (en) | 1996-03-28 | 1997-03-28 | Peptide ligands of the urokinase receptor |
US10/821,544 US7094752B2 (en) | 1997-03-28 | 2004-04-09 | Peptide ligands of the urokinase receptor |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62336196A | 1996-03-28 | 1996-03-28 | |
US08/623,361 | 1996-03-28 |
Related Child Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/155,260 A-371-Of-International US6794358B1 (en) | 1997-03-28 | 1997-03-28 | Peptide ligands of the urokinase receptor |
US09155260 A-371-Of-International | 1997-03-28 | ||
US10/821,544 Division US7094752B2 (en) | 1997-03-28 | 2004-04-09 | Peptide ligands of the urokinase receptor |
Publications (3)
Publication Number | Publication Date |
---|---|
WO1997035969A2 WO1997035969A2 (en) | 1997-10-02 |
WO1997035969A3 true WO1997035969A3 (en) | 1997-11-06 |
WO1997035969A9 WO1997035969A9 (en) | 1997-12-31 |
Family
ID=24497795
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/005199 WO1997035969A2 (en) | 1996-03-28 | 1997-03-28 | Peptide ligands of the urokinase receptor |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0906419A2 (en) |
JP (2) | JP4088344B2 (en) |
AU (1) | AU2597897A (en) |
WO (1) | WO1997035969A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9114175B2 (en) | 2005-08-12 | 2015-08-25 | Amgen Inc. | Modified Fc molecules |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR020101A1 (en) * | 1998-07-01 | 2002-04-10 | Cancerforskingsfonden Af 1989 | A PEPTIDE ANTAGONIST OF THE HUMAN UROQUINASE RECEPTOR, PHARMACEUTICAL COMPOSITION CONTAINING HIM, ITS USE FOR THE MANUFACTURE OF A MEDICINAL PRODUCT AND METHODOPARA TO SELECT AN ADEQUATE PEPTIDE ANTAGONIST. |
EP0982036A1 (en) * | 1998-08-28 | 2000-03-01 | Wilex Biotechnology GmbH | Modulation of Beta2 -integrin-mediated cell adhesion |
US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
ES2388341T3 (en) | 1998-10-23 | 2012-10-11 | Kirin-Amgen Inc. | Dimeric thrombopoietin mimetic peptides that bind to the MPL receptor and that have thrombopoietic activity |
US7488590B2 (en) | 1998-10-23 | 2009-02-10 | Amgen Inc. | Modified peptides as therapeutic agents |
JP2003530871A (en) * | 2000-04-21 | 2003-10-21 | アムジエン・インコーポレーテツド | Integrin / adhesion factor antagonist |
CA2408812A1 (en) * | 2000-05-09 | 2001-11-15 | Dgi Biotechnologies, Inc. | Methods of identifying the activity of gene products |
AU2002358158A1 (en) * | 2001-12-19 | 2003-06-30 | D. Collen Research Foundation | Use of urokinase receptor antagonists to modulate ischemiareperfusion injury |
JP2008505928A (en) | 2004-07-08 | 2008-02-28 | アムジェン インコーポレーテッド | Therapeutic peptide |
TW200813091A (en) * | 2006-04-10 | 2008-03-16 | Amgen Fremont Inc | Targeted binding agents directed to uPAR and uses thereof |
US9283260B2 (en) | 2006-04-21 | 2016-03-15 | Amgen Inc. | Lyophilized therapeutic peptibody formulations |
BR112013016107A2 (en) * | 2010-12-22 | 2017-04-04 | Ifom Fond Inst Firc Di Oncologia Molecolare | dimeric molecule, cancer treatment method, pharmaceutical composition and kit for the diagnosis of an upar-mediated pathology or tumor |
CA2842281A1 (en) | 2011-08-05 | 2013-02-14 | Ifom Fondazione Istituto Firc Di Oncologia Molecolare | Constitutively active upar variants and their use for the generation and isolation of inhibitory antibodies |
WO2015004148A1 (en) | 2013-07-08 | 2015-01-15 | Ifom Fondazione Istituto Firc Di Oncologia Molecolare | Biomarker of plasminogen activation system and/or of upar/vn interaction and uses thereof |
WO2019165105A1 (en) * | 2018-02-26 | 2019-08-29 | The Board Of Trustees Of The Leland Stanford Junior University | Ligands of the urokinase receptor and their use in treating, detecting, and imaging cancer |
-
1997
- 1997-03-28 EP EP97917723A patent/EP0906419A2/en not_active Withdrawn
- 1997-03-28 AU AU25978/97A patent/AU2597897A/en not_active Abandoned
- 1997-03-28 WO PCT/US1997/005199 patent/WO1997035969A2/en not_active Application Discontinuation
- 1997-03-28 JP JP53466697A patent/JP4088344B2/en not_active Expired - Fee Related
-
2007
- 2007-11-13 JP JP2007294871A patent/JP2008109934A/en not_active Withdrawn
Non-Patent Citations (5)
Title |
---|
DOYLE M V ET AL: "The discovery of novel urokinase receptor ligands by bacteriophage display and combinatorial chemistry", FIBRINOLYSIS, 10 (SUPPL. 3). 1996. 21., XP002040489 * |
GOODSON RJ ET AL: "High-affinity urokinase receptor antagonists identified with bacteriophage peptide display.", PROC NATL ACAD SCI U S A, JUL 19 1994, 91 (15) P7129-33, UNITED STATES, XP000574761 * |
STRATTON-THOMAS JR ET AL: "Yeast expression and phagemid display of the human urokinase plasminogen activator epidermal growth factor-like domain.", PROTEIN ENG, MAY 1995, 8 (5) P463-70, ENGLAND, XP000574760 * |
WALTZ DA ET AL: "Reversible cellular adhesion to vitronectin linked to urokinase receptor occupancy.", J BIOL CHEM, MAY 20 1994, 269 (20) P14746-50, UNITED STATES, XP002040491 * |
WEI Y ET AL: "Identification of the urokinase receptor as an adhesion receptor for vitronectin.", J BIOL CHEM, DEC 23 1994, 269 (51) P32380-8, UNITED STATES, XP002040490 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9114175B2 (en) | 2005-08-12 | 2015-08-25 | Amgen Inc. | Modified Fc molecules |
Also Published As
Publication number | Publication date |
---|---|
EP0906419A2 (en) | 1999-04-07 |
JP2000509968A (en) | 2000-08-08 |
JP4088344B2 (en) | 2008-05-21 |
AU2597897A (en) | 1997-10-17 |
JP2008109934A (en) | 2008-05-15 |
WO1997035969A2 (en) | 1997-10-02 |
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