WO1997031533A1 - Composition anti-microbienne, notamment destinee a l'antiseptie et/ou la desinfection - Google Patents
Composition anti-microbienne, notamment destinee a l'antiseptie et/ou la desinfection Download PDFInfo
- Publication number
- WO1997031533A1 WO1997031533A1 PCT/FR1997/000372 FR9700372W WO9731533A1 WO 1997031533 A1 WO1997031533 A1 WO 1997031533A1 FR 9700372 W FR9700372 W FR 9700372W WO 9731533 A1 WO9731533 A1 WO 9731533A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- composition according
- agents
- composition
- microbial
- biguanide salts
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
Definitions
- Anti-microbial composition in particular intended for 1 antiseptic and / or disinfection.
- the subject of the present invention is an anti-microbial composition, in particular intended for antiseptics and / or for disinfection.
- this composition its use in the field of medical hygiene, in particular for cleaning and / or disinfecting objects, surfaces or premises as well as antiseptic ia skin, and mucous membranes.
- compositions in most cases contain a single active ingredient and, in practice, do not always provide satisfaction. Indeed, they have drawbacks in terms of toxicology and / or antimicrobial efficacy. In addition, they are not always well suited according to the desired applications and often require the use of a high concentration of active agents. Also known are compounds such as polyhexamethylene biguanide used, in particular, as an anti-infectious agent, as a topical treatment for herpetic conditions, as a treatment for acne, as a treatment for surgical wounds and / or in compositions for veterinary use for prevent the appearance of mastitis in ruminants.
- polyhexamethylene biguanide used, in particular, as an anti-infectious agent, as a topical treatment for herpetic conditions, as a treatment for acne, as a treatment for surgical wounds and / or in compositions for veterinary use for prevent the appearance of mastitis in ruminants.
- this compound must be used at relatively high concentrations to have a satisfactory anti-microbial action and is likely to cause allergic reactions. In addition, it provides a spectrum of relatively narrow activity. In antiseptics, we also know the use of phenoxyethanol, we even lend it a therapeutic activity.
- SUBSTITUTE SHEET (RULE 26) phenoxyethanol was thus used, a long time ago, in clinical practice, for example, as an anti-bacterial agent, in particular in the prophylactic treatment of burns and in intravesical instillations. Although rather used for infected open wounds, this agent is also used on intact skin. It is best known as a preservative, particularly in the field of cosmetics.
- the object of the present invention is to provide an antimicrobial composition which overcomes the aforementioned drawbacks and offers a broader spectrum of antimicrobial activity.
- Another object of the present invention is to provide an anti-microbial composition whose concentration of active agents can be optimized.
- Another object of the present invention is to provide an anti-microbial composition which meets the tolerance criteria and makes it possible to limit, in particular, allergic reactions.
- Another object of the present invention is to provide an anti-microbial composition which can be used for washing and / or disinfecting the hands, and / or the cutaneous and mucous tissues.
- Another object of the present invention is to provide an anti-microbial composition which can also be used in therapeutic treatments and thus makes it possible to limit the use of antibiotics in the treatment of infections, especially skin infections.
- the present invention relates to an anti ⁇ microbial composition, in particular intended for antiseptic and / or disinfection, characterized in that it comprises at least, in combination, one or more biguanide salts and one or more aromatic alcohols.
- the present invention also relates to a support element impregnated with the anti-microbial composition described above. - 3 -
- the present invention further relates to a use of said antimicrobial composition for obtaining a medicament for the therapeutic treatment of cutaneous-mucosal infections.
- the present invention relates to an anti ⁇ microbial composition, in particular intended for antiseptic and / or disinfection.
- the anti-microbial composition in accordance with the invention comprises at least one or more biguanide salts and / or one or more aromatic alcohols. They may be, for example, respectively, polyhexamethylene biguanide salts and phenoxyalkyl alcohols.
- the anti-microbial composition according to the invention has a broad spectrum of activity.
- it allows the use of said compounds at reduced concentrations. It thus limits toxicological risks.
- the composition according to the invention thus comprises from 0.1 to 10% of polyhexamethylene biguanide and from 0.05 to 5% of phenoxyethanol, the proportions being given in% by weight.
- the pH of the anti-microbial composition according to the invention is included, in particular, between 4 and 8.
- the anti-microbial composition according to the invention is, for example, in the form of an aqueous, alcoholic and / or hydroalcoholic solution.
- It also comprises, optionally, aliphatic alcohols such as, in particular, ethanol, isopropanol and / or n-propanol.
- It can also include other anti-microbial agents, and / or anti-infectives in order to specifically broaden the spectrum of activity, such as in particular antiviral active principles to obtain, for example, a complementary anti-herpetic activity.
- agents with therapeutic properties such as in particular local anesthetics and / or anti-inflammatories in order to confer properties complementary to the antiseptic effect.
- the antimicrobial composition according to the invention further comprises, for example, agents with a buffering effect, pH correctors, and / or surfactants. It may also contain, in particular, thickeners, gelling agents, humectant softening agents and / or superfats.
- healing agents for example, healing agents, skin protective agents, dyes and / or perfumes.
- the anti-microbial composition according to the invention is thus presented, in particular, in liquid form, gel, foaming composition, alcoholic lotion, cream, ointment and / or ointment, capable of determining, by example, a delayed and / or prolonged action.
- the present invention also relates to a support element such as, for example, a woven or nonwoven wipe, impregnated with the antimicrobial composition described above.
- the invention relates, in addition, to the use of said composition for obtaining a medicament intended for the therapeutic treatment of cutaneous-mucosal infections such as superinfections of wounds, burns , dermatoses.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Environmental Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Pest Control & Pesticides (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Agronomy & Crop Science (AREA)
- Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU19310/97A AU1931097A (en) | 1996-02-29 | 1997-02-28 | Antimicrobial composition, particularly for antisepsis and/or disinfection |
EP97907162A EP0884949A1 (fr) | 1996-02-29 | 1997-02-28 | Composition anti-microbienne, notamment destinee a l'antiseptie et/ou la desinfection |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR96/02784 | 1996-02-29 | ||
FR9602784A FR2745497B1 (fr) | 1996-02-29 | 1996-02-29 | Composition anti-microbienne, notamment destinee a l'antiseptie et/ou la desinfection |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1997031533A1 true WO1997031533A1 (fr) | 1997-09-04 |
Family
ID=9489895
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR1997/000372 WO1997031533A1 (fr) | 1996-02-29 | 1997-02-28 | Composition anti-microbienne, notamment destinee a l'antiseptie et/ou la desinfection |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0884949A1 (fr) |
AU (1) | AU1931097A (fr) |
FR (1) | FR2745497B1 (fr) |
WO (1) | WO1997031533A1 (fr) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001041567A1 (fr) * | 1999-12-13 | 2001-06-14 | Ethicon, Inc. | Compositions antimicrobiennes a forte penetration |
FR2830240A1 (fr) | 2001-10-01 | 2003-04-04 | Oreal | Dispositif de conditionnement d'un produit, notamment un produit cosmetique et/ou de soins |
CN111032060A (zh) * | 2017-06-28 | 2020-04-17 | 科利迪恩公司 | 用于清洁、消毒和/或灭菌的组合物、方法和用途 |
US11910797B2 (en) | 2018-01-14 | 2024-02-27 | Collidion, Inc. | Compositions, kits, methods and uses for cleaning, disinfecting, sterilizing and/or treating |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005115417A2 (fr) * | 2004-05-03 | 2005-12-08 | Neosil, Inc. | Medicament antimicrobien polycationique |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0231080A1 (fr) * | 1986-01-16 | 1987-08-05 | Imperial Chemical Industries Plc | Compositions antiseptiques |
GB2186486A (en) * | 1986-02-13 | 1987-08-19 | Smith & Nephew Ass | Antibacterial dressing |
-
1996
- 1996-02-29 FR FR9602784A patent/FR2745497B1/fr not_active Expired - Fee Related
-
1997
- 1997-02-28 AU AU19310/97A patent/AU1931097A/en not_active Abandoned
- 1997-02-28 EP EP97907162A patent/EP0884949A1/fr not_active Withdrawn
- 1997-02-28 WO PCT/FR1997/000372 patent/WO1997031533A1/fr not_active Application Discontinuation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0231080A1 (fr) * | 1986-01-16 | 1987-08-05 | Imperial Chemical Industries Plc | Compositions antiseptiques |
GB2186486A (en) * | 1986-02-13 | 1987-08-19 | Smith & Nephew Ass | Antibacterial dressing |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001041567A1 (fr) * | 1999-12-13 | 2001-06-14 | Ethicon, Inc. | Compositions antimicrobiennes a forte penetration |
FR2830240A1 (fr) | 2001-10-01 | 2003-04-04 | Oreal | Dispositif de conditionnement d'un produit, notamment un produit cosmetique et/ou de soins |
CN111032060A (zh) * | 2017-06-28 | 2020-04-17 | 科利迪恩公司 | 用于清洁、消毒和/或灭菌的组合物、方法和用途 |
EP3645017A4 (fr) * | 2017-06-28 | 2021-05-19 | Collidion, Inc. | Compositions, procédés et utilisations pour le nettoyage, la désinfection et/ou la stérilisation |
US11910797B2 (en) | 2018-01-14 | 2024-02-27 | Collidion, Inc. | Compositions, kits, methods and uses for cleaning, disinfecting, sterilizing and/or treating |
Also Published As
Publication number | Publication date |
---|---|
AU1931097A (en) | 1997-09-16 |
FR2745497A1 (fr) | 1997-09-05 |
EP0884949A1 (fr) | 1998-12-23 |
FR2745497B1 (fr) | 2002-09-06 |
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