WO1997028821B1 - Immunological methods for the treatment of gastrointestinal cancer - Google Patents
Immunological methods for the treatment of gastrointestinal cancerInfo
- Publication number
- WO1997028821B1 WO1997028821B1 PCT/US1997/002029 US9702029W WO9728821B1 WO 1997028821 B1 WO1997028821 B1 WO 1997028821B1 US 9702029 W US9702029 W US 9702029W WO 9728821 B1 WO9728821 B1 WO 9728821B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- treatment
- gastrin
- amidated
- mammal
- glycine
- Prior art date
Links
- 230000002496 gastric Effects 0.000 title claims abstract 5
- 201000011510 cancer Diseases 0.000 title abstract 2
- 230000001900 immune effect Effects 0.000 title 1
- 230000001419 dependent Effects 0.000 claims abstract 3
- 108010066264 gastrin 17 Proteins 0.000 claims abstract 3
- 108010017400 glycine-extended gastrin 17 Proteins 0.000 claims abstract 3
- 230000002163 immunogen Effects 0.000 claims abstract 3
- 102400000921 Gastrin Human genes 0.000 claims abstract 2
- GKDWRERMBNGKCZ-RNXBIMIWSA-N Little gastrin I Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 GKDWRERMBNGKCZ-RNXBIMIWSA-N 0.000 claims abstract 2
- 102000004965 antibodies Human genes 0.000 claims abstract 2
- 108090001123 antibodies Proteins 0.000 claims abstract 2
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 3
- 206010052360 Colorectal adenocarcinoma Diseases 0.000 claims 1
- 102100001448 GAST Human genes 0.000 claims 1
- 101700005903 GAST Proteins 0.000 claims 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- 239000004471 Glycine Substances 0.000 abstract 1
Abstract
A method of treating gastrointestinal cancers dependent on the prohormones amidated gastrin-17 and glycine extended G-17, comprising the administration to the patient of an anti-gastrin-17 immunogen which induces antibodies which bind and neutralize amidated and glycine-extended gastrin-17.
Claims
1. A method for the treatment of amidated or glycine- extended gastrin-17-dependent gastrointestinal tumors, comprising administering to a mammal a therapeutically effective amount of an anti-G17 immunogenic composition.
2. The method of claim 1, wherein the immunogen induces anti-G17 antibodies of an effective titer in the immunized mammal which bind and neutralize amidated and glycine-extended gastrin-17.
3. The method of claim 1, wherein the gastrointestinal tumors contain gastrin/cholecystochinin 6 receptors.
4. The method of claim 1, wherein the gastrointestinal tumors are colorectal adenocarcinomas.
5. The method of claim 1, wherein the mammal is a human.
STATEMENT UNDER ARTICLE 19
Applicant's amendment of claim 1 is submitted to further define the preamble. Specifically the treatment of the invention includes amidated gastrin-17 dependent tumors. The amendment is fully supported by the description on page 4, lines 10-14 of the Specification.
Applicant asserts that this treatment is not taught or suggested by the references cited in the international search report dated June 20, 1997.
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9528702A JP2000504692A (en) | 1996-02-08 | 1997-02-07 | Immunological methods for treating gastrointestinal cancer |
EP97905858A EP0889735B1 (en) | 1996-02-08 | 1997-02-07 | Immunological methods for the treatment of gastrointestinal cancer |
AT97905858T ATE505202T1 (en) | 1996-02-08 | 1997-02-07 | IMMUNOLOGICAL METHODS FOR TREATING GASTROINTESTINAL CANCER |
PT97905858T PT889735E (en) | 1996-02-08 | 1997-02-07 | Immunological methods for the treatment of gastrointestinal cancer |
DE69740173T DE69740173D1 (en) | 1996-02-08 | 1997-02-07 | IMMUNOLOGICAL METHODS FOR THE TREATMENT OF GASTROINTESTINAL CANCER |
DK97905858.3T DK0889735T3 (en) | 1996-02-08 | 1997-02-07 | Immunogenic methods for the treatment of gastrointestinal cancer |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1141196P | 1996-02-08 | 1996-02-08 | |
US60/011,411 | 1996-02-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1997028821A1 WO1997028821A1 (en) | 1997-08-14 |
WO1997028821B1 true WO1997028821B1 (en) | 1997-10-02 |
Family
ID=21750270
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/002029 WO1997028821A1 (en) | 1996-02-08 | 1997-02-07 | Immunological methods for the treatment of gastrointestinal cancer |
Country Status (9)
Country | Link |
---|---|
US (1) | US20050025770A1 (en) |
EP (1) | EP0889735B1 (en) |
JP (3) | JP2000504692A (en) |
AT (1) | ATE505202T1 (en) |
DE (1) | DE69740173D1 (en) |
DK (1) | DK0889735T3 (en) |
ES (1) | ES2361474T3 (en) |
PT (1) | PT889735E (en) |
WO (1) | WO1997028821A1 (en) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2000504692A (en) * | 1996-02-08 | 2000-04-18 | アフトン・コーポレーション | Immunological methods for treating gastrointestinal cancer |
US20040001842A1 (en) * | 1997-05-12 | 2004-01-01 | Dov Michaeli | Immunogenic compositions to the CCK-B/gastrin receptor and methods for the treatment of tumors |
NZ500748A (en) * | 1997-05-12 | 2001-06-29 | Aphton Corp | Methods for the treatment of gastrin-dependent tumours comprising active or passive immunisation with an anti-CCK-B/gastrin receptor immunogen or anti-CCK-B/gastrin receptor antibodies |
EP1897556A1 (en) * | 1998-05-15 | 2008-03-12 | Receptor Biologix, Inc. | Prevention and treatment of hypergastrinemia |
JP2002515458A (en) * | 1998-05-15 | 2002-05-28 | アフトン・コーポレーシヨン | Prevention and treatment of hypergastrinemia |
US20030068326A1 (en) * | 1998-05-15 | 2003-04-10 | Aphton Corporation | Method for the treatment of gastroesophageal reflux disease |
JP2005508838A (en) * | 2001-03-23 | 2005-04-07 | アフトン コーポレーション | Combination therapy for pancreatic cancer |
US20090191232A1 (en) * | 2001-05-04 | 2009-07-30 | Gevas Philip C | Combination therapy for the treatment of tumors |
CN1525868A (en) * | 2001-07-09 | 2004-09-01 | 埃弗顿有限公司 | Treatment and prevention of cancerous and pre-cancerous conditions of the liver, lung and esophagus |
US20050169979A1 (en) * | 2002-07-03 | 2005-08-04 | Dov Michaeli | Liposomal vaccine |
CA2520010C (en) * | 2003-03-28 | 2012-07-10 | Aphton Corporation | Gastrin hormone immunoassays |
AU2005228897B2 (en) * | 2004-03-29 | 2009-12-10 | Cancer Advances, Inc. | Monoclonal antibodies to gastrin hormone |
CA2580965C (en) | 2004-09-22 | 2014-04-08 | Receptor Biologix, Inc. | Monoclonal antibodies to progastrin |
JP5558660B2 (en) | 2007-05-11 | 2014-07-23 | 日東電工株式会社 | Double-sided adhesive pressure-sensitive adhesive sheet |
US8674064B2 (en) * | 2010-03-03 | 2014-03-18 | Onkologix Ltd | Immunogenic compositions against human progastrin peptides |
CN101797382B (en) | 2010-03-03 | 2013-11-20 | 戚胜美 | Anti-human progastrin polypeptide immune composition |
CN105407919B (en) * | 2013-05-21 | 2019-08-06 | Tyg肿瘤学有限公司 | Gastrin Peptide Radioimmunoassay immunogenic composition |
JP6525909B2 (en) | 2016-03-15 | 2019-06-05 | 中外炉工業株式会社 | Industrial furnace |
CN111050789A (en) | 2017-06-15 | 2020-04-21 | 癌症进展有限公司 | Compositions and methods for inducing humoral and cellular immunity against tumors and cancers |
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US21786A (en) * | 1858-10-12 | Improvement in the manufacture of sugar | ||
US140962A (en) * | 1873-07-15 | Improvement in feeding paper to printing-presses | ||
US69966A (en) * | 1867-10-22 | Joseph chadwick | ||
US187152A (en) * | 1877-02-06 | Improvement in clothes-wringers | ||
US58040A (en) * | 1866-09-18 | Improvement in making bolts | ||
US91574A (en) * | 1869-06-22 | Improvement in water-closet valves | ||
US39911A (en) * | 1863-09-15 | Improvement in corset skirt-supporters | ||
US86941A (en) * | 1869-02-16 | Improvement in corn-planter | ||
US68326A (en) * | 1867-08-27 | Alcibiades j | ||
US1842A (en) * | 1840-10-31 | Machine fob cutting corks | ||
US95028A (en) * | 1869-09-21 | Improved process for preserving eggs | ||
US20119A (en) * | 1858-04-27 | Improvement in raking and delivering attachments to harvesters | ||
US4526716A (en) * | 1981-11-20 | 1985-07-02 | The Ohio State University | Antigenic modification of polypeptides |
US4691006A (en) * | 1983-03-04 | 1987-09-01 | Ohio State University | Antigenic modification of polypeptides |
US4384995A (en) * | 1980-01-16 | 1983-05-24 | The Ohio State University | Antigenic modification of polypeptides |
IT1179894B (en) * | 1984-12-27 | 1987-09-16 | Rotta Research Lab | PROGLUMIDE AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN IT FOR USE IN NEOPLASTIC AFFECTION THERAPY |
US6861510B1 (en) * | 1989-01-24 | 2005-03-01 | Aphton Corporation | Immunogenic compositions against gastrin peptides |
EP0380230B1 (en) * | 1989-01-24 | 1994-11-17 | Aphton Corporation | Immunogenic compositions against gastrin peptides |
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JP2000504692A (en) * | 1996-02-08 | 2000-04-18 | アフトン・コーポレーション | Immunological methods for treating gastrointestinal cancer |
NZ500748A (en) * | 1997-05-12 | 2001-06-29 | Aphton Corp | Methods for the treatment of gastrin-dependent tumours comprising active or passive immunisation with an anti-CCK-B/gastrin receptor immunogen or anti-CCK-B/gastrin receptor antibodies |
WO2000050059A1 (en) * | 1999-02-24 | 2000-08-31 | The Uab Research Foundation | Taxane derivatives for targeted therapy of cancer |
-
1997
- 1997-02-07 JP JP9528702A patent/JP2000504692A/en not_active Withdrawn
- 1997-02-07 ES ES97905858T patent/ES2361474T3/en not_active Expired - Lifetime
- 1997-02-07 DK DK97905858.3T patent/DK0889735T3/en active
- 1997-02-07 WO PCT/US1997/002029 patent/WO1997028821A1/en active Application Filing
- 1997-02-07 PT PT97905858T patent/PT889735E/en unknown
- 1997-02-07 EP EP97905858A patent/EP0889735B1/en not_active Expired - Lifetime
- 1997-02-07 AT AT97905858T patent/ATE505202T1/en active
- 1997-02-07 DE DE69740173T patent/DE69740173D1/en not_active Expired - Lifetime
-
2004
- 2004-01-20 US US10/762,226 patent/US20050025770A1/en not_active Abandoned
-
2006
- 2006-11-16 JP JP2006310647A patent/JP5200251B2/en not_active Expired - Lifetime
-
2011
- 2011-02-21 JP JP2011034753A patent/JP5200269B2/en not_active Expired - Lifetime
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