WO1997028821B1 - Immunological methods for the treatment of gastrointestinal cancer - Google Patents

Immunological methods for the treatment of gastrointestinal cancer

Info

Publication number
WO1997028821B1
WO1997028821B1 PCT/US1997/002029 US9702029W WO9728821B1 WO 1997028821 B1 WO1997028821 B1 WO 1997028821B1 US 9702029 W US9702029 W US 9702029W WO 9728821 B1 WO9728821 B1 WO 9728821B1
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
gastrin
amidated
mammal
glycine
Prior art date
Application number
PCT/US1997/002029
Other languages
French (fr)
Other versions
WO1997028821A1 (en
Filing date
Publication date
Application filed filed Critical
Priority to JP9528702A priority Critical patent/JP2000504692A/en
Priority to EP97905858A priority patent/EP0889735B1/en
Priority to AT97905858T priority patent/ATE505202T1/en
Priority to PT97905858T priority patent/PT889735E/en
Priority to DE69740173T priority patent/DE69740173D1/en
Priority to DK97905858.3T priority patent/DK0889735T3/en
Publication of WO1997028821A1 publication Critical patent/WO1997028821A1/en
Publication of WO1997028821B1 publication Critical patent/WO1997028821B1/en

Links

Abstract

A method of treating gastrointestinal cancers dependent on the prohormones amidated gastrin-17 and glycine extended G-17, comprising the administration to the patient of an anti-gastrin-17 immunogen which induces antibodies which bind and neutralize amidated and glycine-extended gastrin-17.

Claims

AMENDED CLAIMS [received by the International Bureau on 20 August 1997 (20.08.97); original claim 1 amended; remaining claims unchanged ( 1 page)]
1. A method for the treatment of amidated or glycine- extended gastrin-17-dependent gastrointestinal tumors, comprising administering to a mammal a therapeutically effective amount of an anti-G17 immunogenic composition.
2. The method of claim 1, wherein the immunogen induces anti-G17 antibodies of an effective titer in the immunized mammal which bind and neutralize amidated and glycine-extended gastrin-17.
3. The method of claim 1, wherein the gastrointestinal tumors contain gastrin/cholecystochinin 6 receptors.
4. The method of claim 1, wherein the gastrointestinal tumors are colorectal adenocarcinomas.
5. The method of claim 1, wherein the mammal is a human.
STATEMENT UNDER ARTICLE 19
Applicant's amendment of claim 1 is submitted to further define the preamble. Specifically the treatment of the invention includes amidated gastrin-17 dependent tumors. The amendment is fully supported by the description on page 4, lines 10-14 of the Specification.
Applicant asserts that this treatment is not taught or suggested by the references cited in the international search report dated June 20, 1997.
PCT/US1997/002029 1996-02-08 1997-02-07 Immunological methods for the treatment of gastrointestinal cancer WO1997028821A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP9528702A JP2000504692A (en) 1996-02-08 1997-02-07 Immunological methods for treating gastrointestinal cancer
EP97905858A EP0889735B1 (en) 1996-02-08 1997-02-07 Immunological methods for the treatment of gastrointestinal cancer
AT97905858T ATE505202T1 (en) 1996-02-08 1997-02-07 IMMUNOLOGICAL METHODS FOR TREATING GASTROINTESTINAL CANCER
PT97905858T PT889735E (en) 1996-02-08 1997-02-07 Immunological methods for the treatment of gastrointestinal cancer
DE69740173T DE69740173D1 (en) 1996-02-08 1997-02-07 IMMUNOLOGICAL METHODS FOR THE TREATMENT OF GASTROINTESTINAL CANCER
DK97905858.3T DK0889735T3 (en) 1996-02-08 1997-02-07 Immunogenic methods for the treatment of gastrointestinal cancer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1141196P 1996-02-08 1996-02-08
US60/011,411 1996-02-08

Publications (2)

Publication Number Publication Date
WO1997028821A1 WO1997028821A1 (en) 1997-08-14
WO1997028821B1 true WO1997028821B1 (en) 1997-10-02

Family

ID=21750270

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/002029 WO1997028821A1 (en) 1996-02-08 1997-02-07 Immunological methods for the treatment of gastrointestinal cancer

Country Status (9)

Country Link
US (1) US20050025770A1 (en)
EP (1) EP0889735B1 (en)
JP (3) JP2000504692A (en)
AT (1) ATE505202T1 (en)
DE (1) DE69740173D1 (en)
DK (1) DK0889735T3 (en)
ES (1) ES2361474T3 (en)
PT (1) PT889735E (en)
WO (1) WO1997028821A1 (en)

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