WO1997028187A3 - Multivalent chimeric peptides as microbicides - Google Patents

Multivalent chimeric peptides as microbicides Download PDF

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Publication number
WO1997028187A3
WO1997028187A3 PCT/US1997/001726 US9701726W WO9728187A3 WO 1997028187 A3 WO1997028187 A3 WO 1997028187A3 US 9701726 W US9701726 W US 9701726W WO 9728187 A3 WO9728187 A3 WO 9728187A3
Authority
WO
WIPO (PCT)
Prior art keywords
mucin
immunoglobulin
loop
peptides
microbicides
Prior art date
Application number
PCT/US1997/001726
Other languages
French (fr)
Other versions
WO1997028187A2 (en
Inventor
James Darrell Fontenot
David M Phillips
Original Assignee
Population Council Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Population Council Inc filed Critical Population Council Inc
Priority to AU21164/97A priority Critical patent/AU2116497A/en
Publication of WO1997028187A2 publication Critical patent/WO1997028187A2/en
Publication of WO1997028187A3 publication Critical patent/WO1997028187A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4727—Mucins, e.g. human intestinal mucin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
    • C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

A proline rich, tandem repeat domain of human mucin MUC1 forms an extended structure containing large repeating loops that are crested by a turn. The repeating loop structure of MUC1 can be replaced by an Φ loop of an immunoglobulin-superfamily protein to create a chimeric, multivalent, mucin-like, compound. The mucin/Φ loop chimera retains the binding specificity of the parent immunoglobulin-superfamily protein. The design and construction of chimeric peptides are general, theoretically limited only by the size of the immunoglobulin superfamily. The peptides can be used for a variety of prophylactic and therapeutic applications.
PCT/US1997/001726 1996-01-31 1997-01-29 Multivalent chimeric peptides as microbicides WO1997028187A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU21164/97A AU2116497A (en) 1996-01-31 1997-01-29 Multivalent chimeric peptides as microbicides

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US594,403 1990-10-09
US730,244 1991-07-15
US59440396A 1996-01-31 1996-01-31
US73024496A 1996-10-15 1996-10-15

Publications (2)

Publication Number Publication Date
WO1997028187A2 WO1997028187A2 (en) 1997-08-07
WO1997028187A3 true WO1997028187A3 (en) 1997-10-23

Family

ID=27081965

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/001726 WO1997028187A2 (en) 1996-01-31 1997-01-29 Multivalent chimeric peptides as microbicides

Country Status (2)

Country Link
AU (1) AU2116497A (en)
WO (1) WO1997028187A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005272815A1 (en) 2004-08-13 2006-02-23 Genentech, Inc. Thiazole based inhibitors of ATP-utilizing enzymes

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995003825A1 (en) * 1993-07-30 1995-02-09 Finn Olivera J Synthetic multiple tandem repeat mucin and mucin-like peptides, and uses thereof
WO1995027505A1 (en) * 1994-04-12 1995-10-19 Biomira, Inc. Cellular immune response-specific antigens and uses therefor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995003825A1 (en) * 1993-07-30 1995-02-09 Finn Olivera J Synthetic multiple tandem repeat mucin and mucin-like peptides, and uses thereof
WO1995027505A1 (en) * 1994-04-12 1995-10-19 Biomira, Inc. Cellular immune response-specific antigens and uses therefor

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
J.D. FONTENOT ET AL.: "Presentation of HIV V3 loop epitopes for enhanced antigenicity, immunogenicity and diagnostic potential", AIDS, vol. 9, no. 10, October 1995 (1995-10-01), pages 1121 - 1129, XP002038638 *
M.J. BRISKIN ET AL.: "MAdCAM-1 has homology to immunoglobulin and mucin-like adhesion receptors and to IgA1", NATURE, vol. 363, no. 6428, 3 June 1993 (1993-06-03), LONDON GB, pages 461 - 464, XP002038639 *

Also Published As

Publication number Publication date
WO1997028187A2 (en) 1997-08-07
AU2116497A (en) 1997-08-22

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