WO1997019375A1 - Dispositif de couplage optique et procede de production associe - Google Patents

Dispositif de couplage optique et procede de production associe Download PDF

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Publication number
WO1997019375A1
WO1997019375A1 PCT/SE1996/001522 SE9601522W WO9719375A1 WO 1997019375 A1 WO1997019375 A1 WO 1997019375A1 SE 9601522 W SE9601522 W SE 9601522W WO 9719375 A1 WO9719375 A1 WO 9719375A1
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WO
WIPO (PCT)
Prior art keywords
optical coupling
coupling device
convex
convex surface
plate
Prior art date
Application number
PCT/SE1996/001522
Other languages
English (en)
Inventor
Bengt Ivarsson
Henrik ÖSTLIN
Original Assignee
Biacore Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biacore Ab filed Critical Biacore Ab
Publication of WO1997019375A1 publication Critical patent/WO1997019375A1/fr

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Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24—Coupling light guides
    • G02B6/42—Coupling light guides with opto-electronic elements
    • G02B6/4201—Packages, e.g. shape, construction, internal or external details
    • G02B6/4204—Packages, e.g. shape, construction, internal or external details the coupling comprising intermediate optical elements, e.g. lenses, holograms
    • G02B6/4212—Packages, e.g. shape, construction, internal or external details the coupling comprising intermediate optical elements, e.g. lenses, holograms the intermediate optical element being a coupling medium interposed therebetween, e.g. epoxy resin, refractive index matching material, index grease, matching liquid or gel
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24—Coupling light guides
    • G02B6/36—Mechanical coupling means
    • G02B6/38—Mechanical coupling means having fibre to fibre mating means
    • G02B6/3807—Dismountable connectors, i.e. comprising plugs
    • G02B6/381—Dismountable connectors, i.e. comprising plugs of the ferrule type, e.g. fibre ends embedded in ferrules, connecting a pair of fibres
    • G02B6/3818—Dismountable connectors, i.e. comprising plugs of the ferrule type, e.g. fibre ends embedded in ferrules, connecting a pair of fibres of a low-reflection-loss type
    • G02B6/3821—Dismountable connectors, i.e. comprising plugs of the ferrule type, e.g. fibre ends embedded in ferrules, connecting a pair of fibres of a low-reflection-loss type with axial spring biasing or loading means

Definitions

  • the present invention relates to a replaceable and reusable coupling device for non-permanent coupling of light between two solid optically transparent media as well as to the production thereof.
  • the conventional way of making a non-permanent passive (i.e. not refracting or diffracting) light coupling between two light transmitting elements consists in sealingly connecting the two elements by an immersion oil, or in some applications, an uncured silicone rubber composition, having a suitable refractive index.
  • This requires an accurate amount of the coupling medium to be dispensed, making necessary either manual handling or mechanical equipment.
  • the drop-formed residues of immersion oil that remain after element separation must also be removed from one or both elements for each new coupling operation to obtain a good light coupling without disturbing enclosed air bubbles.
  • Such removal of the immersion oil by wiping it off or other cleaning is besides a messy and time-consuming procedure which in addition to involving the risk of scratching the optical surfaces is difficult to automate in, for example, a commercial measuring instrument.
  • WO 90/05317 discloses a reusable optical solid type interface means, or optointerface, for non-permanent passive coupling of light between two light transmitting media, which comprises at least one optically transparent elastic element attached to one or both sides of a solid support.
  • the elastic elements are adapted to contact the light transmitting media and have a matching refractive index with respect thereto.
  • the optointerface is a transparent plate having a transparent elastic material body attached to each side of the plate.
  • Such an optointerface may, for example, be inserted between a microscope lens and a slide for coupling light therebetween.
  • the elastic body has a planar contact surface for the lens, the convex shape of the latter providing for air exclusion when the elastic body is compressed for permitting light coupling.
  • the contact surface or surfaces of the elastic element (s) should preferably be dome-shaped or stepped to prevent the enclosure of air- bubbles when the elastic element (s) is (are) pressed against the respective light transmitting medium.
  • the optointerface is intended for light coupling in a biosensor system based on surface plasmon resonance (SPR) , and more particularly between a coupling prism or lens and a SPR sensor plate forming one wall of one or more flow channels.
  • SPR biosensor system uses total internal reflection (TIR) of light at a glass/metal interface on the sensor plate.
  • the optointerface consists of a glass or plastic plate having a number of transparent ridges (one for each sample flow channel) of transparent elastic material in an opposed relationship on each side of the plate.
  • Each ridge has a stepped configuration to prevent air pockets from being formed between each ridge and the sensor plate or prism, respectively. Otherwise, the total internal reflection would take place at the prism/air or ridge/air interface.
  • the ridges typically have a width of about 700 ⁇ m, a length of about 7 mm, and a spacing of about 500 ⁇ m.
  • Such an optointerface with a number of parallel ridges is, however, disadvantageous in that it will tend to scatter the light in the direction orthogonal to the ridges.
  • the positioning of the optointerface in relation to the sensor plate and flow channel is critical. It would therefore be desirable to replace the ridges by a single optical element.
  • the necessary width of such an elastic element (about 10 mm) is too large for a stepped surface configuration to be practically feasible, as it would require too great a compression (and compression force) due to the difficulty of producing sufficiently low steps.
  • the elastic coupling element has a convex contact surface with a specifically defined curvature which requires only a moderate compression to provide excellent light coupling with minimal light scattering, reflection losses and light refraction, as well as a minimal variation of the polarization and phase of the light wave.
  • the present invention therefore provides a replaceable and reusable optical coupling device, suitable for use in a biosensor, for the coupling of light from a first solid optically transparent medium to a second solid optically transparent medium, which device comprises opposite elastic contact portions for contacting said first and second solid media and has a refractive index matching with said media, at least one of said contact portions having a convex surface and being adapted to be compressed when pressed against one of said two solid media to provide an optically coupling contact area.
  • the coupling device is characterized in that (i) in its non-compressed state, said convex surface portion has a maximum height over its periphery in the range of about 5 to about 280 ⁇ m, particularly 5 to 280 ⁇ , preferably in the range of about 12 to about 140 ⁇ m, especially 12 to 140 ⁇ , and a ratio of maximum height to maximum lateral extension in the range of about 0.00008 to about 0.05, particularly 0.00008 to 0.05, preferably in the range of about 0.0001 to about 0.03, especially 0.0001 to 0.03; and (ii) , in its compressed state, said convex surface portion is elastically deformed to provide an optical coupling area with uniform transmission in the range of about 12 to about 5000 mm 2 , particularly 12 to 5000 mm 2 , preferably in the range of about 28 to about 1500 mm 2 , especially 28 to 1500 mm 2 .
  • matching with respect to refractive index as used herein is a relative one and means that the refractive index of the elastic material should be appropriately matched or adapted to the contacting media in accordance with each particular application. For instance, in case the incident light is normal to a planar interfacial contact surface between the light coupling means and the solid medium or media, rather “extensive" differences between the refractive indices of the respective material may be tolerated, whereas only moderate or small refractive index deviations may be allowed in case of applications with obliquely incident light.
  • the optically transparent elastic material may be any material meeting the specific requirements concerning elasticity, strength, refractive index, etc., for each particular application, and to find suitable materials for a particular application, in view of the disclosure herein, is within the skill of a person skilled in the art.
  • broad material classes may be mentioned transparent rubber or (cross-linked) elastomers, such as silicone rubber or polybutadiene; and transparent epoxy resins .
  • the necessary compression force for sufficiently contacting the elastic contact portions with the respective transparent solid medium depends, of course, on the particular elastic material, but is usually from about 0.1 to about 50 N, particularly 0.1 - 50 N, a suitable degree of compression being from about 30% to about 70%, particularly 30 - 70%, preferably from about 40% to about 60%, especially 40 - 60%, of the maximum height of the elastic element in its non-compressed state.
  • the convex surface is spherical and concentric, and the radius of curvature is constant.
  • the convex surface is aspherical and concentric, and the radius of curvature varies with the angle between the radius and the vertical center axis of the convex surface.
  • the convex surface is composed of several different concentric convex segments of different radii of curvature, the transition between the different convex segments being stepless (i.e. a continuous curvature) .
  • the convex surface is cylindrically spherical, and the radius of curvature is in a plane normal to the longitudinal axis of the cylinder.
  • the arc angle [2*arcsin(half edge chord/radius of curvature)] is in the range of about 0.02° to about 25°, particularly 0.02° to 25°, preferably in the range of about 0.03° to about 9°, especially 0.03° to 9°. This may, for example, be compared to the corresponding arc angle of 60° for a transparent elastic ball of 2 mm radius of curvature used in the prior art to couple light between two optical fiber ends.
  • r_ is the radius of the intermediate or optocoupling surface
  • A. is the area thereof
  • T_o_ is the total thickness, or height, of the elastic optocoupling material
  • £ is the force by which the solid optical medium is pressed against the elastic optocoupling material.
  • the present invention provides a method of producing an optical coupling component as described above by moulding the convex surface against a corresponding concave wall of a mould cavity.
  • the concave mould cavity wall has been produced by moulding against a membrane or plate deformed mechanically to a corresponding convex curvature.
  • the concave mould cavity wall may, of course, be produced by grinding or polishing a mould substrate surface.
  • the optical coupling device of the invention may suitably be used for coupling of light between an instrument-based stationary optical element and a replaceable or disposable optical sensor element for sensor principles based on total internal reflection (TIR) in, for example, absorbance reflectometry (detecting intensity of polarised light component) ; polarometry (detecting the polarisation state of the light) ; interferometry (detecting the phase or wavefront cooperation of the light) ; and fluorescence.
  • TIR total internal reflection
  • Reflectometry includes attenuated total reflection infrared spectroscopy (ATR-IR) , surface plasmon resonance reflectometry (SPR) (both angle- and wavelength-scanned) , long-range plasmon resonance (both angle- and wavelength- scanned) , internal Brewster angle reflectometry.
  • Polarometry includes internal reflection ellipsometry.
  • Fluorescence includes TIR fluorescence (TIRF) .
  • the optical coupling device of the invention may further be used for coupling between a first optical element and a replaceable or disposable second optical sensor element based on resonant guided mode detection including those based on frustrated total reflection (FTR) (resonant cavity); see e.g. Harrick, N.J., Internal Reflection Spectroscopy. Chapter 2, page 163. Harrick Scientific Corporation, New York 1987.
  • FTR frustrated total reflection
  • novel optical coupling component of the present invention offers several advantages in relation to those of the prior art.
  • the whole sensor area of a sensor chip may be monitored rather than being restricted to the parts of the sensor chip that the matrix photodetector actually "sees".
  • different sensor areas within a sensor chip may be positioned randomly and be monitored, provided that the sensor areas are imaged with appropriate size in relation to the matrix photodetector elements .
  • monitoring and visualization respectively, with a high lateral density of localized detection within a sensor area is made possible. Thereby it will be possible to monitor a large amount of individual sensor surface zones to provide for multi-analyte assays or multi-site monitoring.
  • the optical coupling component of the present invention has the advantages that disturbing light scattering and/or light refraction caused by refractive index steps and steep refractive index gradients are avoided.
  • the invention will de described in more detail with reference to some non-limiting embodiments, reference being made to the accompanying drawings.
  • FIGs . IA and IB are schematic side views of a first embodiment of the optical coupling device of the invention inserted between a prism and a sensor chip, before and after being pressed therebetween, respectively.
  • Fig. IC is an enlarged part of the view in Fig. IB.
  • Fig. 2 is a schematic partial view of a second embodiment of the optical coupling device compressed between a prism and a sensor chip.
  • Fig. 3 is a schematic partial view of a third embodiment of the optical coupling device attached to a sensor chip and compressed between a prism and a sensor chip.
  • Fig. 4 is a schematic partial view of a forth embodiment of the optical coupling device attached to a prism and compressed between the prism and a sensor chip.
  • Fig. 5 is a schematic partial view of a fifth embodiment of the optical coupling device, including immersion oil enclosed within a transparent cover, compressed between a prism and a sensor chip.
  • Figs. 6A and 6B are schematic side views of a sixth embodiment of the optical coupling device integral with a prism and a sensor chip, before and after, respectively, being pressed against a fluidic system.
  • Fig. 6C is an enlarged part of the view in Fig. 6B.
  • Figs. 7A to 7H are partial sectional views of two cooperating parts of a moulding apparatus at different stages of a process for producing a coupling device of the invention.
  • Fig. 8 is a partial sectional view of parts of another embodiment of moulding apparatus for producing a coupling device of the invention.
  • Fig. 9A is a schematic sectional view of parts of still another embodiment of moulding apparatus for producing a coupling device of the invention.
  • Fig. 9B is a section along A-A in Fig. 9A;
  • Fig. 10A is a varied arrangement of the moulding apparatus parts in Fig. 9; and Fig. 10B is a section along B-B in Fig. 10A.
  • identical parts are designated by the same reference numerals.
  • Fig. IA illustrates a coupling device 1, hereinafter often called optointerface, inserted between a prism 2 and a sensor element 3.
  • the optointerface 1 is compressed between the prism 2 and the sensor element 3.
  • the sensor element 3 includes a sensor chip 4, the lower face of which forms a sensing surface to be contacted with a sample.
  • the sensor chip 4 is docked against a fluidic block indicated at 5.
  • Light is coupled to the opposite side of the sensor chip 4 via the prism 2 and the optointerface 1 such that it is totally reflected at the sensor chip.
  • the sensor chip may, for example, be adapted to surface plasmon resonance (SPR) detection.
  • SPR surface plasmon resonance
  • the chip may be a glass plate having a thin layer of an SPR-supporting metal film thereon, e.g. gold.
  • the metal layer may have suitable ligands immobilized thereto to form the sensing surface of the sensor chip.
  • SPR-based detection systems to be used with the sensor element as well as on the sensor element and its sensing surface, it may be referred to WO 90/05295 (detection system) , WO 90/05305 (sensor element) and WO 90/05303 (sensing surface) , the full disclosures of which are incorporated by reference herein.
  • the optointerface 1 consists of a transparent plate la, e.g. of glass or plastic, which has respective layers 6, 7 of transparent elastic material, such as silicone, attached to each side thereof.
  • the elastic material has a matching refractive index with respect to the material of the transparent plate, the prism and the sensor chip.
  • the layers 6, 7 each have a convex surface of a curvature as defined above.
  • the optointerface in Figs. IA to IC may thus be said to form a bi-convex optical coupling component.
  • the optointerface shown in Figs. 1A-C may alternatively be made as an integral component of a single material. This is illustrated in Fig. 2 which shows an integral elastic optointerface 8 compressed between a prism 2 and a sensor chip 4.
  • Fig. 3 illustrates an optointerface variant where an elastic material body 9 with a convex surface is attached to a sensor chip 10 to provide an integral sensor chip/convex optocoupling component.
  • This variant has the advantage that the optointerface is replaced whenever the sensor chip is replaced, i.e. the use of a fresh optointerface is always insured.
  • FIG. 4 Another integral type optocoupling component is illustrated in Fig. 4 where an elastic material body 11 with a convex surface is attached to a replaceable TIR element, such as a prism 12, to provide an integral TIR element/convex optocoupling component.
  • a replaceable TIR element such as a prism 12
  • FIG. 5 Still another optointerface variant is shown in Fig. 5.
  • a separate optocoupling component is formed by a carrier structure 13 supporting a liquid transparent medium 14, such as a conventional type immersion oil, enclosed within a transparent cover 15.
  • a liquid transparent medium 14 such as a conventional type immersion oil
  • an expansion reservoir 16 is connected to the medium 15 via a conduit 17.
  • This optocoupling component has the advantage of requiring a low docking pressure to provide the desired optical coupling.
  • FIGs. 6A-C illustrate an embodiment where an integral sensor chip/optocoupling component 18, like that shown in Fig. 3, is resiliently mounted, via an elastic sealing or elastic pads 20, in a TIR element 19 to be docked against a fluidic block 5.
  • At least one of the two large contact surfaces of the optocoupling material is continuously convex in the non-compressed state.
  • each convex surface is microscopically deformed as the contact area or areas to the planar optical element in question (such as sensor chip and/or prism) are successively increased until the optocoupling component forms a planar homogenous structure with optical transmission within a homogeneous continuous area, typically of the size 0.3 cm 2 to 10 cm 2 .
  • the contact surface of the elastic optocoupling material successively "wets" the contacted prism or sensor chip such that air is displaced, a continuous optointerface thereby being formed.
  • the optical coupling contacting is reversible, i.e. when the applied compression force is sufficiently reduced, the elastic optocoupling material successively recovers its convex surface shape, the optocoupling material lifting itself from the contact surface. This release is propagated towards the center of the contact surface.
  • the light coupling obtained with the coupling device insures that a minimal disturbance of light ray angles, intensity, polarization and phase is obtained.
  • the elastic optocoupling material is attached to a chip or prism, it may as well be attached to other elements, such as e.g. a planesided lens, a cuvette, microcuvette array or a waveguide, such as e.g. an optical fiber, a rectangular slab type waveguide or a waveguide element integrated in a substrate.
  • one or more stops are provided on the surface or surfaces to which the elastic optocoupling material is attached so that compression thereof is only permitted down to the stop or stops, i.e. a fixed minimum compressed thickness of the optocoupling material is insured. In this way, further compression (and cold flow) of the optocoupling material in case of a temperaure rise is avoided.
  • a convenient method of producing the optointerfaces described above is by means of moulding cavities which are created by contacting curable low viscosity materials with a harder material of good surface fineness and flexed in a controlled fashion. These harder materials may, for example, be metal or glass plates or sheets or plastic films.
  • Exemplary curable materials are UV- or thermally curable silicone gels, 2-component curable plastics, and 1- component UV-curable acrylic plastics.
  • An example of such production of a biconvex optointerface is described below with reference to Figs. 7A to 7H.
  • a moulding apparatus comprising two vertically opposed tool parts, a lower tool part 21 and an upper tool part 22, is used (Fig. 7A) .
  • Such two tool parts may, for example, be part of a multiprocess chamber of the type described in Swedish patent application no. 9401961-9.
  • a multiprocess chamber comprises a number of blocks which can be assembled to form the walls of a closed cavity.
  • Each block includes a package of a number of bar members which together form a wall of the cavity. In each package the bar members are individually displaceable lengthwise to create any desired shape of the cavity.
  • the lower tool part 21 in Figs. 7A-D has a top recess 23 with a central protrusion 24, the rim 25 of recess 23 forming a stop frame.
  • the upper tool part 22 has an open cone-shaped cavity 26 connected to a material filling channel 27.
  • a flexible disc 28 is placed on the protrusion 25.
  • the height of the protrusion is from about 1 to about 5 times the desired compression of the elastic optocoupling material of the optical coupling device to be produced.
  • the two tool parts are then pressed against each other such that the bottom edge of the upper tool part 22 contacts the rim 25 of the lower tool part 21, as shown in Fig. 7C, the disc 28 thereby being bent to a convex configuration with a controlled radius of curvature.
  • Subsequent filling of a curable material, e.g. UV-curable PMMA, through the channel 27 results in the formation of a conical plug 29 in the upper tool part 22; see Fig. 7D.
  • This plug is then irradiated with UV light for curing thereof, either through the channel 27 or after the two tool parts 21 and 22 have been separated.
  • the deformed disc 28 is then removed from the plug 29. If necessary, a release agent is used on the top face of disc 28 to reduce the adherence of plug 29 thereto.
  • the above described procedure is repeated to produce another identical upper tool part 22 with a plug 29 therein.
  • the two tool parts, or mould halves, 22a and 22b are placed opposite each other with a glass plate 30 inserted between them as shown in Fig. 7E.
  • Predetermined volumes 31 and 32 of an optoelastic material such as e.g. a UV-curing silicone gel, are then placed on (i) the glass plate 30 and (ii) the lower mould half 22b.
  • the two mould halves 22a, 22b are then brought towards each other to close a moulding cavity 33 defined by the opposed curved surfaces of the respective plugs 29a and 29b, as shown in Fig. 7G, whereupon UV irradiation of the silicone gel parts 31, 32 is effected for curing thereof.
  • the tool parts 22a, 22b are then separated to release the moulded optointerface component 34 consisting of a glass plate 30 with a convex- surfaced optoelastomer body 31, 32 on either face thereof.
  • the moulded optointerface component 34 consisting of a glass plate 30 with a convex- surfaced optoelastomer body 31, 32 on either face thereof.
  • a similar technique to that described above may be used for moulding a convex elastic element body directly on a waveguide, e.g. in the form of an optical fiber of the same or another material, such as a conventional waveguide or optical fiber material.
  • FIG. 8 An alternative way of deforming the disc 28 to the shape shown in Figs. 7A-7D is illustrated in Fig. 8, which uses subpressure or overpressure to deform the disc.
  • disc 28 is pressed between the top of a lower tool part 35 having a central bore 36, and an upper tool part 37 similar to the upper tool part 22 in Figs. 7A-H.
  • a sealing element 38 is provided in an annular recess on the top edge of lower tool part 22.
  • An optional adjustable stop member for controlling the maximum deformation of disc 28 is indicated at 39.
  • a more controlled deformation of a disc or membrane may be obtained by deforming the latter between two blocks of bar members in the above-mentioned multiprocess chamber. This is schematically illustrated in Figs. 9A-B and 10A-B.
  • Figs. 9A and 9B illustrate controlled deformation of a disc or membrane 40 between two opposed sets of 5 x 5 bar members 41 and 42.
  • pegs or pins 43 By appropriate positioning of pegs or pins 43 on top of selected bar members and individual adjustment of the bar members, a well controlled deformation of the membrane 40 may be obtained, in the illustrated case of a spherical convexity.
  • Figs. 10A and 10B schematically illustrate an arrangement for obtaining a cylindrically convex deformation of the membrane 40 by loading the membrane by a number of parallel ridges 44 to obtain line-loading of the membrane rather than single-point loading as in the embodiment shown in Figs. 9A and 9B.
  • the invention is, of course, not restricted to the embodiments described above and specifically shown in the drawings, but many modifications and changes may be made within the scope of the present inventive concept as defined in the following claims.

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  • Physics & Mathematics (AREA)
  • Optical Measuring Cells (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

Ce dispositif de couplage optique remplaçable et réutilisable, conçu pour être utilisé dans un biocapteur, aux fins de coupler la lumière provenant d'un premier milieu solide (2), transparent sur le plan optique, à un second milieu solide (4), également transparent sur le plan optique, comprend des portions de contact élastiques opposées (6, 7), destinées à entrer en contact avec les premier et second milieux solides (2, 4), et possède un indice de réfraction s'adaptant à ces milieux. L'une au moins des portions de contact (6, 7) présente une surface convexe et elle est conçue pour se comprimer lorsqu'elle est pressée contre l'un des deux milieux solides (2, 4), afin de constituer une zone de contact de couplage optique. Dans son état non comprimé, la portion convexe possède une hauteur maximum, par rapport à sa périphérie, se situant entre environ 5 et 280νm, de préférence entre environ 12 et 140 νm, ainsi qu'un rapport hauteur maximum/extension latérale maximum de l'ordre d'environ 0,00008 à 0,05, préférablement de l'ordre de 0,0001 à 0,03. Dans son état comprimé, la portion de surface convexe est déformée de manière élastique, afin de constituer une zone de couplage optique présentant une transmission de lumière uniforme de l'ordre d'environ 12 à environ 5000 mm2, préférablement de l'ordre de 28 à 1500 mm2.
PCT/SE1996/001522 1995-11-24 1996-11-22 Dispositif de couplage optique et procede de production associe WO1997019375A1 (fr)

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Application Number Priority Date Filing Date Title
SE9504206A SE9504206D0 (sv) 1995-11-24 1995-11-24 Optical coupling device and method for its production
SE9504206-5 1995-11-24

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US6016348A (en) * 1996-11-27 2000-01-18 Thomson Consumer Electronics, Inc. Decoding system and data format for processing and storing encrypted broadcast, cable or satellite video data
SG81341A1 (en) * 1998-12-24 2001-06-19 Sony Corp Optical fiber connecting device, electronic equipment, network system and optical fiber connecting method
US6833920B2 (en) 2000-07-11 2004-12-21 Maven Technologies Llc Apparatus and method for imaging
US6859280B2 (en) 2000-07-11 2005-02-22 Maven Technologies Llc Imaging apparatus and method
US7023547B2 (en) 2000-07-11 2006-04-04 Maven Technologies, Llc Apparatus including a biochip for imaging of biological samples and method
US7193711B2 (en) 2000-07-11 2007-03-20 Maven Technologies, Llc Imaging method and apparatus
WO2008117087A2 (fr) 2007-03-23 2008-10-02 Attomarker Limited Réseaux de biodétecteurs photoniques
US7518724B2 (en) 2000-07-11 2009-04-14 Maven Technologies Image acquisition, processing, and display
WO2009066236A1 (fr) * 2007-11-22 2009-05-28 Koninklijke Philips Electronics N.V. Procédés et systèmes pour le couplage d'une bio-cartouche avec un lecteur optique
US7799558B1 (en) 2007-05-22 2010-09-21 Dultz Shane C Ligand binding assays on microarrays in closed multiwell plates
US7863037B1 (en) 2007-04-04 2011-01-04 Maven Technologies, Llc Ligand binding assays on microarrays in closed multiwell plates
US7867783B2 (en) 2007-02-22 2011-01-11 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US7981664B1 (en) 2008-05-22 2011-07-19 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US8039270B2 (en) 2008-05-22 2011-10-18 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
WO2016140890A1 (fr) * 2015-03-04 2016-09-09 Northwestern University Interface sur demande préfabriquée destinée à être utilisée pour assurer un couplage optique entre des éléments jetable et réutilisable d'une sonde à fibre optique
CN114720429A (zh) * 2022-04-12 2022-07-08 无锡简测生物科技有限公司 一种光学测量系统

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WO1990005317A1 (fr) * 1988-11-10 1990-05-17 Pharmacia Ab Organe d'interface optique

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6016348A (en) * 1996-11-27 2000-01-18 Thomson Consumer Electronics, Inc. Decoding system and data format for processing and storing encrypted broadcast, cable or satellite video data
SG81341A1 (en) * 1998-12-24 2001-06-19 Sony Corp Optical fiber connecting device, electronic equipment, network system and optical fiber connecting method
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