WO1997010055A1 - Tubulure a vide pour le traitement en laboratoire d'echantillons liquides multiples - Google Patents
Tubulure a vide pour le traitement en laboratoire d'echantillons liquides multiples Download PDFInfo
- Publication number
- WO1997010055A1 WO1997010055A1 PCT/US1996/013668 US9613668W WO9710055A1 WO 1997010055 A1 WO1997010055 A1 WO 1997010055A1 US 9613668 W US9613668 W US 9613668W WO 9710055 A1 WO9710055 A1 WO 9710055A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- receptacle
- base
- vacuum
- adapter frame
- dimensioned
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
- B01L3/50255—Multi-well filtration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/18—Apparatus therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
Definitions
- This invention relates generally to vacuum manifold devices, and specifically, to vacuum manifold devices useful in the simultaneous laboratory processing of multiple liquid samples.
- the simultaneous testing of multiple liquid samples in a single apparatus is conducted with apparatus especially designed for this purpose.
- the most common piece of apparatus is a disposable tray having multiple individual “wells. " These trays, commonly called “microtitre dishes,” are made by a large number of manufacturers in a variety of sizes and shapes.
- microtitre dishes are made by a large number of manufacturers in a variety of sizes and shapes.
- an individual liquid sample is placed within each of the wells, where it is manipulated as part of the testing process.
- a third problem is that, because of the relative inflexibility of present-day vacuum manifolds, and the excessive amount of area required by present-day multiple testing operations, present-day vacuum manifolds are not easily incorporated into fully automated machines capable of carrying out a multiplicity of laboratory procedures using a relatively small amount of work space.
- the invention satisfies these needs.
- the invention is a vacuum manifold useful in combination with first and second liquid receptacles, such as microtitre dishes.
- the invention comprises:
- a base which is sized and dimensioned to accept and retain the first receptacle, the base having a bottom wall and side walls, the side walls having uppermost portions which cooperate to form a base wall perimeter;
- an adapter frame which is sized and dimensioned to accept and retain the second receptacle, the adapter frame being further sized and dimensioned to attach to the base wall perimeter in substantially sealed relationship such that the first receptacle can be fully enclosed within a chamber formed by the base, the adapter frame and the second receptacle;
- the vacuum means comprises a port defined within the base.
- Both the base and the adapter frame can be sized and dimensioned to handle a wide variety of liquid receptacles.
- the second receptacle is adapted for filtration, its bottom comprising a filtration material.
- both the first and second liquid receptacles complies a plurality of separate "wells.” This facilitates the simultaneous processing of a large number of individual liquid samples in a single step.
- the invention can also comprise stacking trays for retaining unused liquid receptacles and frames when not in use.
- the invention is easily adaptable in a semi-automated or fully- automated machine having a computerized mechanical manipulator.
- the mechanical manipulator is programmed to robotically configure and reconfigure the various elements of the vacuum manifold to serially carry out a number of laboratory manipulations of a large number of individual liquid samples.
- the invention can be conveniently and easily used to perform a wide variety of vacuum-assisted laboratory procedures, such as filtration, drying, column purification and column chromatography.
- the invention is inexpensive and simple to manufacture and operate, and its use conserves valuable laboratory work space.
- FIGURE 1 is an exploded perspective view showing a vacuum manifold having features of the invention and adapted for use with a narrow dish microtitre tray;
- FIGURE 2 is an exploded cross-sectional view of the vacuum manifold shown in FIG. 1 ;
- FIGURE 3 is a cross-sectional side view of the fully assembled vacuum manifold shown in FIG. 1 ;
- FIGURE 4 is an exploded perspective view showing a vacuum manifold having features of the invention and adapted for use with a deep dish microtitre tray;
- FIGURE 5 is an exploded cross-sectional view of the vacuum manifold shown in FIG. 4;
- FIGURE 6 is a cross-sectional side view of the fully assembled vacuum manifold shown in FIG. 4;
- FIGURE 7 is an exploded perspective view of a stacking tray assembly having features of the invention.
- FIGURE 8 is an exploded cross-sectional view of the stacking tray assembly shown in FIG. 7;
- FIGURE 9 is a cross-sectional view of the fully assembled stacking tray assembly shown in FIG. 7;
- FIGURE 10 is a perspective view of a machine and a kit having features of the invention.
- the vacuum manifold of the invention 10 comprises a base 12, an adapter frame 14 and a means for drawing a vacuum.
- the base has a bottom wall 16 and side walls 18.
- the side walls 18 have uppermost portions 20 which cooperate to form a base wall perimeter 22.
- the base 12 is sized and dimensioned to accept and retain a first liquid receptacle 24.
- the base 12 has a foot print with an area smaller than about 200 square centimeters.
- footprint is meant to indicate the horizontal area and dimensions of various elements of the invention
- the base 12 further comprises a vacuum port 26 capable of attachment to an external source of vacuum, such as a laboratory vacuum line.
- the vacuum port 26 is defined in the side walls 18 proximate to the bottom wall 16.
- a discontinuous lip 28 is provided to support the first receptacle 24 above and spaced-apart from the bottom wall 16. This allows a vacuum generated using the vacuum port 26 to be uniform across the bottom wall 16.
- the base 12 can be made out of a wide variety of suitable materials, such as metals and plastics. For ease and inexpense of manufacture, the base 12 is typically made from a plastic.
- the base 12 has a rectangular footprint with the width between about 1 0 and about 1 3 centimeters and a length between about 1 2 and about 1 6 centimeters.
- the base 12 is inexpensively made with dimensions capable of accepting and retaining the footprint of any first receptacle 24 having a footprint smaller than the footprint of the base 12.
- the adapter frame 14 is sized and dimensioned to accept a second liquid receptacle 30. Typically, this is accomplished by providing the adapter frame 14 with an interior lip 32 capable of supporting the second receptacle 30 in a horizontal position. In the embodiments shown in the drawings, a sealing gasket 34 is disposed around the perimeter of the lip 28 to provide sufficient sealing of the second receptacle 30 to the adapter frame 14 when a vacuum is applied to the bottom side 36 of the second receptacle 30.
- the adapter frame 14 is further sized and dimensioned to attach to the base wall perimeter 22 of the base in a substantially sealed relationship such that, when a first receptacle 24 is disposed within the base 12 and a second receptacle 30 is disposed within the adapter frame 14, the first receptacle 24 is fully enclosed within a chamber 38 formed by the base 12, the adapter frame 14 and the second receptacle 30.
- the adapter frame 14 is rectangular with substantially the same footprint as that of the base 12.
- the adapter frame 14 defines a central opening 40 which is sized and dimensioned to accept and retain the footprint of a particular second receptacle 30.
- the invention allows the use of a second receptacle 30 which has a different footprint than that of the first receptacle 24. In the invention, this is easily accomplished by adapting the base 12 to accept and retain the footprint of the first receptacle 24 and adapting the adaptor frame 14 to accept and retain the different footprint of the second receptacle 30.
- the invention makes it easy to use liquid receptacles 24 and 30 of differing height.
- the base 12 is sized and dimensioned to accept and retain the first receptacle 24 having a given height while the adapter frame 14 is sized and dimensioned to accept a second receptacle 30 having a different height.
- Figures 4-6 illustrate the invention using an adapter frame 14 sized and dimensioned to accept and retain a typical deep well microtitre plate.
- the adapter frame 14 can be made from a wide variety of suitable materials. Metals and plastics are easily used. Plastics are generally the preferred material because of the ease and inexpense of its use in the manufacturing process.
- locator pins 42 are disposed within the base 12 and adapted to cooperate with matching holes 44 within the adapter frame 14 to facilitate the proper alignment and sealing of the adapter frame 14 to the base 12.
- the base 12 and the adapter frame 14 have matching beveled walls so that the adapter frame 14 "nests" with the base 12.
- the invention 10 can further comprise a first receptacle 24, such as a microtitre dish, disposed within the base 12.
- the invention 10 can comprise a second receptacle 30, such as a microtitre dish, disposed within the adapter frame 14 above the first receptacle 24.
- the receptacles 24 and 30 are microtitre dishes having a plurality of separate wells 46 disposed in fixed arrays.
- the fixed array of the second receptacle 30 is similar in layout to the fixed array of the first receptacle 24. This allows each well 46 in the second receptacle 30 to discharge liquid into a corresponding well 46 in the first receptacle 24.
- the bottoms 48 of each separate well 46 of the second receptacle 30 comprise a filter material, such as a filtering membrane. As liquid is filtered from a well 46 in the second receptacle 30 across the filter membrane in the well bottom 48, the liquid drops by gravity into the corresponding well 46 in the first receptacle 24.
- the vacuum means is for drawing a vacuum on the bottom side 36 of the second receptacle 30 when the second receptacle 30 is disposed within the adapter frame 14 and the first receptacle 24 is disposed within the base 12.
- the vacuum means is typically one or more ports disposed within the base 12 or adapter frame 14. As discussed above, the embodiments illustrated in the drawings define a vacuum port 26 near the bottom wall 16 of the base 12. In this embodiment, when the vacuum manifold of the invention 10 is fully assembled with first and second liquid receptacles 24 and 30 are in place, a uniform vacuum is drawn across the bottom wall 16 of the base 12. This uniform vacuum propagates around the first receptacle 24 so as to result in a uniform vacuum across the bottom side 36 of the second receptacle 30.
- the distance between the first receptacle 24 and the second receptacle 30 must be carefully chosen in conjunction with the degree of vacuum to be used within the vacuum manifold 10 so as not to horizontally divert liquid dripping from the second receptacle 30 to the first receptacle 24.
- the degree of vacuum must be sufficiently small, given the distance between the bottom side 36 of the second receptacle 30 and the uppermost portion of the first receptacle 24, so that liquid dripping from a specific well 46 in the second receptacle 30 falls precisely vertically into the corresponding well 46 within the first receptacle 24. Should the degree of vacuum be excessive, liquid falling from the second receptacle 30 towards the first receptacle 24 may be diverted horizontally into a non-corresponding well 46 within the first receptacle 24.
- the invention is also a kit 50 comprising the vacuum manifold 10 described above, together with one or more stacking trays 52 which are sized and dimensioned to accept at least one of the receptacles 24 and 30.
- the stacking trays 52 are similar in design and construction to the base 12. The stacking trays, however, have no vacuum ports 26.
- the purpose of the stacking trays 52 is to allow receptacles 24 and
- the kit can also provide additional adapter frames 14, each sized and dimensioned to accept and retain receptacles 24 and 30 having different footprints and/or differing heights.
- the invention 10 is conveniently used with semi-automated DNA purification equipment, such as BioMek 2000 purification equipment sold by Beckman Instruments, Inc. of Fullerton, California.
- the vacuum manifold of the invention 10 is also conveniently adapted to a fully automatic machine 54 capable of robotically carrying out a number of laboratory manipulations to a plurality of individual liquid samples.
- a machine 54 comprises the vacuum manifold 10 described above and a computerized mechanical manipulator 56 having a moveable gripper tool 58.
- the mechanical manipulator 56 is basically a computerized robotic device programmed to robotically manipulate the various elements of the vacuum manifold 10 to perform first one laboratory manipulation on a plurality of liquid samples, then reconfigure the vacuum manifold 10 to perform a second or more laboratory manipulations on those liquid samples.
- one or more stacking trays 52 described above can be conveniently used to stack various elements of the invention 10 in between use. For example, as shown in
- a machine of the invention 54 comprises a vacuum manifold 10 and two stacking trays 52. Such a machine 54 can conveniently perform five or more different laboratory manipulations using the vacuum manifold 10.
- One of skill in the art will appreciate the relative lack of space required by the machine 54 because of the stacking capabilities of the component elements.
- the machine of the invention 54 is relatively easy and inexpensive to construct and maintain. Because of the simplicity of its construction and operation, such a machine 54 has a very high reliability factor Any process that can use vacuum as a driving force can generally be adapted for use in the invention. Such processes include column chromatography, column-based purification methods, vacuum drawing and filtration. For example, the invention can be easily adapted to carrying out chromatography procedures. In this case, the second liquid receptacle would have a plurality of chromatography columns, each having a semi-permeable bottom to allow a vacuum below the bottom to operate on liquid within each column.
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9511968A JPH10510501A (ja) | 1995-09-15 | 1996-08-23 | 複数の液体試料の実験室処理のための真空マニホルド |
EP96930585A EP0792190A1 (fr) | 1995-09-15 | 1996-08-23 | Tubulure a vide pour le traitement en laboratoire d'echantillons liquides multiples |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52874195A | 1995-09-15 | 1995-09-15 | |
US08/528,741 | 1995-09-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1997010055A1 true WO1997010055A1 (fr) | 1997-03-20 |
WO1997010055A9 WO1997010055A9 (fr) | 1997-09-25 |
Family
ID=24106971
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1996/013668 WO1997010055A1 (fr) | 1995-09-15 | 1996-08-23 | Tubulure a vide pour le traitement en laboratoire d'echantillons liquides multiples |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0792190A1 (fr) |
JP (1) | JPH10510501A (fr) |
WO (1) | WO1997010055A1 (fr) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998057746A2 (fr) * | 1997-06-19 | 1998-12-23 | GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) | Chambre a vide differentielle destinee au transport dirige d'une substance |
WO2001006003A2 (fr) * | 1999-07-19 | 2001-01-25 | Mueller Werner E G | Procede et necessaire pour la determination de cassures bicatenaires ou monocatenaires d'adn, et dispositif pour la filtration controlee en particulier de molecules d'adn avec des plaques de filtration a puits |
GB2379012A (en) * | 2001-07-31 | 2003-02-26 | Macaulay Land Use Res Inst The | Detecting a component in a plurality of samples |
DE10238630A1 (de) * | 2002-08-19 | 2004-03-04 | Macherey, Nagel Gmbh & Co. Handelsgesellschaft | Verfahren zur Isolierung biologischer Makromoleküle sowie Vorrichtung zur Durchführung dieses Verfahrens |
EP1491258A3 (fr) * | 2003-06-24 | 2005-07-27 | Millipore Corporation | Systeme de vide multifonctionnelle |
EP1698845A2 (fr) * | 2000-03-13 | 2006-09-06 | Caliper Life Sciences, Inc. | Evaporateur avec bain d'air chaud |
EP1742064A2 (fr) * | 2005-07-06 | 2007-01-10 | Genetix Limited | Procédés et appareil d'imagerie et de traitement d'échantillons dans les conteneurs d'échantillons biologiques |
US7588728B2 (en) | 2003-06-24 | 2009-09-15 | Millipore Corporation | Multifunctional vacuum manifold |
CN110193216A (zh) * | 2019-06-12 | 2019-09-03 | 江苏睿玻生物科技有限公司 | 负压收集装置及负压收集方法 |
US11479808B2 (en) | 2015-03-24 | 2022-10-25 | Illumina Cambridge Limited | Methods, carrier assemblies, and systems for imaging samples for biological or chemical analysis |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102009040180A1 (de) * | 2009-09-07 | 2011-03-17 | Dionex Benelux B.V. | Strömungssteuerung bei der räumlichen Chromatografie |
JP2011209084A (ja) * | 2010-03-30 | 2011-10-20 | Sumitomo Bakelite Co Ltd | マイクロプレート |
JP6472698B2 (ja) * | 2015-03-30 | 2019-02-20 | テルモ株式会社 | 保持具ハンド、保持具移載装置、及び保持具の移載方法 |
CN106081368B (zh) * | 2016-06-07 | 2019-08-23 | 安徽宏远职业卫生技术服务有限公司 | 一种密封性好的食品检测样品保存装置 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4300423A (en) * | 1978-11-08 | 1981-11-17 | Paul Price | Apparatus for severing and separating cup-shaped object supports |
US4902481A (en) * | 1987-12-11 | 1990-02-20 | Millipore Corporation | Multi-well filtration test apparatus |
GB2246081A (en) * | 1990-07-18 | 1992-01-22 | Bio Rad Laboratories | Multi-sample filtration plate assembly |
WO1992002303A1 (fr) * | 1990-08-07 | 1992-02-20 | Pharmacia Lkb Biotechnology Ab | Appareil servant a effectuer des reactions biochimiques |
WO1992016294A1 (fr) * | 1991-03-19 | 1992-10-01 | Minnesota Mining And Manufacturing Company | Dispositif et procede destines a la separation d'echantillons de liquide |
WO1993019199A1 (fr) * | 1992-03-20 | 1993-09-30 | Celsis Limited | Procede et appareil d'analyse de substance biologique |
-
1996
- 1996-08-23 JP JP9511968A patent/JPH10510501A/ja active Pending
- 1996-08-23 WO PCT/US1996/013668 patent/WO1997010055A1/fr not_active Application Discontinuation
- 1996-08-23 EP EP96930585A patent/EP0792190A1/fr not_active Withdrawn
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4300423A (en) * | 1978-11-08 | 1981-11-17 | Paul Price | Apparatus for severing and separating cup-shaped object supports |
US4902481A (en) * | 1987-12-11 | 1990-02-20 | Millipore Corporation | Multi-well filtration test apparatus |
GB2246081A (en) * | 1990-07-18 | 1992-01-22 | Bio Rad Laboratories | Multi-sample filtration plate assembly |
WO1992002303A1 (fr) * | 1990-08-07 | 1992-02-20 | Pharmacia Lkb Biotechnology Ab | Appareil servant a effectuer des reactions biochimiques |
WO1992016294A1 (fr) * | 1991-03-19 | 1992-10-01 | Minnesota Mining And Manufacturing Company | Dispositif et procede destines a la separation d'echantillons de liquide |
WO1993019199A1 (fr) * | 1992-03-20 | 1993-09-30 | Celsis Limited | Procede et appareil d'analyse de substance biologique |
Cited By (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998057746A3 (fr) * | 1997-06-19 | 1999-06-03 | Biotechnolog Forschung Gmbh | Chambre a vide differentielle destinee au transport dirige d'une substance |
WO1998057746A2 (fr) * | 1997-06-19 | 1998-12-23 | GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) | Chambre a vide differentielle destinee au transport dirige d'une substance |
WO2001006003A2 (fr) * | 1999-07-19 | 2001-01-25 | Mueller Werner E G | Procede et necessaire pour la determination de cassures bicatenaires ou monocatenaires d'adn, et dispositif pour la filtration controlee en particulier de molecules d'adn avec des plaques de filtration a puits |
WO2001006003A3 (fr) * | 1999-07-19 | 2001-12-13 | Werner E G Mueller | Procede et necessaire pour la determination de cassures bicatenaires ou monocatenaires d'adn, et dispositif pour la filtration controlee en particulier de molecules d'adn avec des plaques de filtration a puits |
EP1698845A3 (fr) * | 2000-03-13 | 2009-11-11 | Caliper Life Sciences, Inc. | Evaporateur avec bain d'air chaud |
EP1698845A2 (fr) * | 2000-03-13 | 2006-09-06 | Caliper Life Sciences, Inc. | Evaporateur avec bain d'air chaud |
GB2379012A (en) * | 2001-07-31 | 2003-02-26 | Macaulay Land Use Res Inst The | Detecting a component in a plurality of samples |
GB2379012B (en) * | 2001-07-31 | 2005-07-13 | Macaulay Land Use Res Inst | Use of multi-well plates to detect fluid components emanating from a plurality of samples |
DE10238630A1 (de) * | 2002-08-19 | 2004-03-04 | Macherey, Nagel Gmbh & Co. Handelsgesellschaft | Verfahren zur Isolierung biologischer Makromoleküle sowie Vorrichtung zur Durchführung dieses Verfahrens |
US7824623B2 (en) | 2003-06-24 | 2010-11-02 | Millipore Corporation | Multifunctional vacuum manifold |
US7588728B2 (en) | 2003-06-24 | 2009-09-15 | Millipore Corporation | Multifunctional vacuum manifold |
EP1491258A3 (fr) * | 2003-06-24 | 2005-07-27 | Millipore Corporation | Systeme de vide multifonctionnelle |
EP2027925A3 (fr) * | 2003-06-24 | 2011-01-05 | Millipore Corporation | Ensemble collecteur |
US8007743B2 (en) | 2003-06-24 | 2011-08-30 | Millipore Corporation | Multifunctional vacuum manifold |
EP1742064A3 (fr) * | 2005-07-06 | 2007-03-21 | Genetix Limited | Procédés et appareil d'imagerie et de traitement d'échantillons dans les conteneurs d'échantillons biologiques |
EP1742064A2 (fr) * | 2005-07-06 | 2007-01-10 | Genetix Limited | Procédés et appareil d'imagerie et de traitement d'échantillons dans les conteneurs d'échantillons biologiques |
EP2182368A1 (fr) * | 2005-07-06 | 2010-05-05 | Genetix Limited | Procédés et appareil d'imagerie et de traitement d'échantillons dans les conteneurs d'échantillons biologiques |
US7718131B2 (en) | 2005-07-06 | 2010-05-18 | Genetix Limited | Methods and apparatus for imaging and processing of samples in biological sample containers |
US8414830B2 (en) | 2005-07-06 | 2013-04-09 | Molecular Devices (New Milton) Ltd. | Methods and apparatus for imaging and processing of samples in biological sample containers |
US11479808B2 (en) | 2015-03-24 | 2022-10-25 | Illumina Cambridge Limited | Methods, carrier assemblies, and systems for imaging samples for biological or chemical analysis |
CN110193216A (zh) * | 2019-06-12 | 2019-09-03 | 江苏睿玻生物科技有限公司 | 负压收集装置及负压收集方法 |
Also Published As
Publication number | Publication date |
---|---|
JPH10510501A (ja) | 1998-10-13 |
EP0792190A1 (fr) | 1997-09-03 |
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