WO1997008564A1 - Verfahren und vorrichtung zur bildung einer abbildung mit kernspinresonanz - Google Patents
Verfahren und vorrichtung zur bildung einer abbildung mit kernspinresonanz Download PDFInfo
- Publication number
- WO1997008564A1 WO1997008564A1 PCT/AT1996/000155 AT9600155W WO9708564A1 WO 1997008564 A1 WO1997008564 A1 WO 1997008564A1 AT 9600155 W AT9600155 W AT 9600155W WO 9708564 A1 WO9708564 A1 WO 9708564A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- magnetic field
- field
- gradiometer
- polarizing
- magnetic
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/445—MR involving a non-standard magnetic field B0, e.g. of low magnitude as in the earth's magnetic field or in nanoTesla spectroscopy, comprising a polarizing magnetic field for pre-polarisation, B0 with a temporal variation of its magnitude or direction such as field cycling of B0 or rotation of the direction of B0, or spatially inhomogeneous B0 like in fringe-field MR or in stray-field imaging
Definitions
- the invention relates to a method for forming an image of an area of a body by detecting magnetic fields arising from nuclear magnetic resonance with a gradiometer and processing the signals obtained with this gradiometer in a data processing device into an image, the body being exposed to a homogeneous magnetic field and another magnetic field, in which there are spatial gradients of the field strength, is brought to bear on the body.
- the inventive method of the type mentioned at the outset is characterized in that the body to be examined is first exposed to a homogeneous polarizing static magnetic field and then the field strength of this magnetic field is reduced, preferably brought to zero, and a further static magnetic field, the field lines of which are transverse to the field lines of the said polarizing magnetic field and in which there is a gradient, is brought into effect on the body, and the component of the magnetic fields thereby generated in the body by magnetic resonance with a highly sensitive gradiometer, the detection coils of which do not produce any signal ⁇ have inductive coupling with the polarizing magnetic field can be detected.
- the above objective can be met well by this method.
- the nuclear spin of the atoms of the body region to be imaged is polarized by the polarizing magnetic field, then this magnetic field is reduced or switched off and the further magnetic field, which is directed transversely to the polarizing magnetic field, is allowed to act, as a result of which a precessional movement of the nuclear spin occurs in the further magnetic field results, which in turn forms a magnetic field that is detected with the gradiometer.
- the precession movement results in an amplitude maximum of the magnetic field or signal which can be detected with the gradiometer in the direction of the polarizing magnetic field (z direction).
- the signals emitted by the gradiometer are processed into an image using a data processing device.
- a SQUID gradiometer is preferably used as the gradiometer. This results in a high sensitivity, particularly in the low-frequency range from direct current to approximately 10 kHz, which is important here.
- the configuration of the gradiometer which can be of the first, second or higher, in particular third, order is chosen such that the detection coils of the gradiometer have no inductive coupling with the polarizing magnetic field. It is preferably provided that a gradiometer is used, the detection coils of which also have no signal-giving inductive coupling with the further static magnetic field.
- the good sensitivity of the SQUID at low frequencies can be supported by filtering out the high frequency to eliminate interfering high-frequency influences.
- filtering out the high frequency With a corresponding configuration of the input coils of the magnetometer, one can ensure, with regard to disturbing external fields, that only the low-frequency components of the fields acting on the gradiometer are detected.
- the homogeneous polarizing magnetic field is kept constant for a period of approximately two to three times the longitudinal relaxation time T 1 and then reduced, preferably switched off.
- the invention also relates to a device for carrying out the method according to the invention.
- This device is characterized in that the device has a polarizing magnet forming a homogeneous static magnetic field, which is connected to a switching device for reducing or switching off the magnetic flux, and a spatial gradient which forms a further, vertical, transverse to the polarizing field Magnetic field suitable magnetic device, which is also connected to a switching device, and has a highly sensitive gradiometer, which is designed to detect field changes in the direction of the polarization field, and furthermore has a data processing device for producing an image from the gradiometer signals.
- the gradiometer is preferably a SQUID gradiometer. It is advantageous for the decoupling if the gradiometer has an adjustable compensation coil in addition to the input coils, to which a compensation current determined by the current of the polarization magnet and / or by the current of the magnet device can be supplied.
- the body to be examined is designated 1, the polarization magnet 2, the magnet system for forming the further magnetic field 3, a switching device for the polarization magnet 2 and the magnet system 3 with 4 and a gradiometer with 5.
- the gradiometer 5 is a SQUID gradiometer with a SQUID 6 and a non-magnetic cryostat 7.
- With 8 is a control device for the SQUID 6 and with 9 a data processing device designated to form an image from the gradiometer signals and to control the magnetic fields.
- a preferably provided adjustable compensation coil 10 is supplied with a compensation current which is dependent on the currents of the magnet devices 2 and 3.
- the arrow B shows the direction of the polarizing magnetic field and the arrow B r shows the direction of the above-mentioned further magnetic field.
Landscapes
- Physics & Mathematics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- High Energy & Nuclear Physics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE59611358T DE59611358D1 (de) | 1995-08-28 | 1996-08-27 | Verfahren und vorrichtung zur bildung einer abbildung mit kernspinresonanz |
EP96929120A EP0847535B1 (de) | 1995-08-28 | 1996-08-27 | Verfahren und vorrichtung zur bildung einer abbildung mit kernspinresonanz |
US09/029,338 US6031373A (en) | 1995-08-28 | 1996-08-27 | Nuclear magnetic resonance imaging process and device |
HU9900324A HU227171B1 (en) | 1995-08-28 | 1996-08-27 | Nuclear magnetic resonance imaging process and device |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ATA1449/95 | 1995-08-28 | ||
AT0144995A AT406092B (de) | 1995-08-28 | 1995-08-28 | Verfahren und vorrichtung zur bildung einer abbildung mit kernspinresonanz |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1997008564A1 true WO1997008564A1 (de) | 1997-03-06 |
Family
ID=3514136
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/AT1996/000155 WO1997008564A1 (de) | 1995-08-28 | 1996-08-27 | Verfahren und vorrichtung zur bildung einer abbildung mit kernspinresonanz |
Country Status (6)
Country | Link |
---|---|
US (1) | US6031373A (de) |
EP (1) | EP0847535B1 (de) |
AT (1) | AT406092B (de) |
DE (1) | DE59611358D1 (de) |
HU (1) | HU227171B1 (de) |
WO (1) | WO1997008564A1 (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AP2004003127A0 (en) * | 2002-02-06 | 2004-09-30 | Univ California | Squid detected NMR and MR1 at ultralow fields |
WO2004048991A1 (en) * | 2002-11-26 | 2004-06-10 | Koninklijke Philips Electronics N.V. | Determination of subencoding mri coil sensitivities in a lower order magnetic field |
US7187169B2 (en) * | 2004-11-03 | 2007-03-06 | The Regents Of The University Of California | NMR and MRI apparatus and method |
AU2007288138A1 (en) * | 2006-08-25 | 2008-02-28 | Commonwealth Scientific And Industrial Research Organisation | Method and apparatus for nano-scale SQUID |
WO2008137485A2 (en) * | 2007-05-04 | 2008-11-13 | California Institute Of Technology | Low field squid mri devices, components and methods |
US20090322324A1 (en) * | 2007-05-04 | 2009-12-31 | Penanen Konstantin I | Geometries for superconducting sensing coils for squid-based systems |
CN101334456B (zh) * | 2008-06-30 | 2012-07-25 | 东软飞利浦医疗设备系统有限责任公司 | 核磁共振射频接收信号数字向下转换的实现装置及方法 |
US8970217B1 (en) | 2010-04-14 | 2015-03-03 | Hypres, Inc. | System and method for noise reduction in magnetic resonance imaging |
US9459210B2 (en) | 2012-05-08 | 2016-10-04 | University Of Calcutta | Static magnetic field induced differential fluorescence emission |
WO2013167933A1 (en) * | 2012-05-08 | 2013-11-14 | University Of Calcutta | Static magnetic field induced differential fluorescence emission |
US10126438B2 (en) | 2014-09-19 | 2018-11-13 | University Of Virginia Patent Foundation | Systems and methods for polarized nuclear imaging and spectroscopy |
EP3513222A4 (de) | 2016-09-15 | 2020-05-20 | Yuan Zheng | Systeme und verfahren zur polarisierten nuklearen bildgebung und spektroskopie |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4442404A (en) * | 1978-12-19 | 1984-04-10 | Bergmann Wilfried H | Method and means for the noninvasive, local, in-vivo examination of endogeneous tissue, organs, bones, nerves and circulating blood on account of spin-echo techniques |
US5057776A (en) * | 1989-12-08 | 1991-10-15 | Albert Macovski | Pulsed field MRI system with non-resonant excitation |
EP0481211A2 (de) * | 1990-10-09 | 1992-04-22 | International Business Machines Corporation | Gradiometer mit einem Magnetometer zur Kompensation von der Magnetfeldhintergrund von anderen Magnetometern |
WO1995003550A1 (de) * | 1993-07-22 | 1995-02-02 | Josef Constantin Szeles | Verfahren und vorrichtung zur bildung einer abbildung von einem körper unter ausnützung der kernspinresonanz |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU439756A1 (ru) * | 1972-03-09 | 1974-08-15 | Ленинградский Ордена Ленина И Ордена Трудового Красного Знамени Государственный Университет Имени А.А.Жданова | Способ измерени скорости равномерного течени жидкости |
SU742839A1 (ru) * | 1978-04-11 | 1980-06-25 | Научно-Производственное Объединение "Геофизика" | Способ измерени магнитных полей с использованием мр |
GB2227095B (en) * | 1989-01-03 | 1993-01-27 | Instrumentarium Corp | Magnetic resonance imaging apparatus and method |
-
1995
- 1995-08-28 AT AT0144995A patent/AT406092B/de not_active IP Right Cessation
-
1996
- 1996-08-27 EP EP96929120A patent/EP0847535B1/de not_active Expired - Lifetime
- 1996-08-27 HU HU9900324A patent/HU227171B1/hu not_active IP Right Cessation
- 1996-08-27 US US09/029,338 patent/US6031373A/en not_active Expired - Lifetime
- 1996-08-27 WO PCT/AT1996/000155 patent/WO1997008564A1/de active IP Right Grant
- 1996-08-27 DE DE59611358T patent/DE59611358D1/de not_active Expired - Lifetime
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4442404A (en) * | 1978-12-19 | 1984-04-10 | Bergmann Wilfried H | Method and means for the noninvasive, local, in-vivo examination of endogeneous tissue, organs, bones, nerves and circulating blood on account of spin-echo techniques |
US5057776A (en) * | 1989-12-08 | 1991-10-15 | Albert Macovski | Pulsed field MRI system with non-resonant excitation |
EP0481211A2 (de) * | 1990-10-09 | 1992-04-22 | International Business Machines Corporation | Gradiometer mit einem Magnetometer zur Kompensation von der Magnetfeldhintergrund von anderen Magnetometern |
WO1995003550A1 (de) * | 1993-07-22 | 1995-02-02 | Josef Constantin Szeles | Verfahren und vorrichtung zur bildung einer abbildung von einem körper unter ausnützung der kernspinresonanz |
Non-Patent Citations (3)
Title |
---|
MACOVSKI A ET AL: "NOVEL APPROACHES TO LOW-COST MRI", MAGNETIC RESONANCE IN MEDICINE, vol. 30, no. 2, 1 August 1993 (1993-08-01), pages 221 - 230, XP000385356 * |
SETON H C ET AL: "DC SQUID-BASED NMR DETECTION FROM ROOM TEMPERATURE SAMPLES", PHYSICS IN MEDICINE AND BIOLOGY, vol. 37, no. 11, 1 November 1992 (1992-11-01), pages 2133 - 2138, XP000309569 * |
STEPISNIK J ET AL: "NMR IMAGING IN THE EARTH'S MAGNETIC FIELD", MAGNETIC RESONANCE IN MEDICINE, vol. 15, no. 3, 1 September 1990 (1990-09-01), pages 386 - 391, XP000170518 * |
Also Published As
Publication number | Publication date |
---|---|
DE59611358D1 (de) | 2006-08-03 |
US6031373A (en) | 2000-02-29 |
AT406092B (de) | 2000-02-25 |
EP0847535B1 (de) | 2006-06-21 |
HU227171B1 (en) | 2010-09-28 |
EP0847535A1 (de) | 1998-06-17 |
HUP9900324A2 (hu) | 1999-05-28 |
HUP9900324A3 (en) | 2002-11-28 |
ATA144995A (de) | 1999-06-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69732763T2 (de) | Magnetisches resonanzsystem für interventionelle verfahren | |
EP1304542B1 (de) | Verfahren zur Ermittlung der räumlichen Verteilung magnetischer Partikel | |
WO1997008564A1 (de) | Verfahren und vorrichtung zur bildung einer abbildung mit kernspinresonanz | |
DE19615254A1 (de) | Gerät zur höchstempfindlichen magnetischen Detektion von Analyten | |
DE102004022262A1 (de) | Magnetfeld-Messsystem | |
DE4432570A1 (de) | Verfahren und Vorrichtung für die Kernresonanzabbildung physiologischer Funktionsinformation | |
EP0695947A1 (de) | MR-Verfahren zur Bestimmung der Kernmagnetisierungsverteilung mit einer Oberflächenspulen-Anordnung | |
EP1304581A2 (de) | Verfahren zum Lokalisieren eines Gegenstandes in einer MR-Apparatur sowie Katheter und MR-Apparatur zur Durchführung des Verfahrens | |
DE112012002705B4 (de) | Magnetresonanz-Messgerät | |
DE102011086658B3 (de) | Von Gradienten unabhängige Shimspule für eine Lokalspule einer Magnetresonanzeinrichtung, Lokalspule, Magnetresonanzeinrichtung, sowie Verfahren zur Platzierung einer Shimspuleneinrichtung | |
DE4419061A1 (de) | Anordnung zur Messung und Regelung des Grundfeldes eines Magneten eines Kernspintomographiegerätes | |
DE19939626C2 (de) | Verfahren zur Erzeugung von Meßsignalen in Magnetfeldern mit einem NMR-Mouse-Gerät | |
DE3340337A1 (de) | Hochfrequenz-einrichtung einer kernspinresonanz-apparatur | |
US4398148A (en) | Electromagnetic coil system for examination of large objects by nuclear magnetic resonance and whole-body imaging machine using a system | |
DE19502374A1 (de) | MR-Verfahren mit induktiv gekoppelten Empfangsspulen-Anordnungen | |
EP0496447B1 (de) | Kernresonanzspektroskopieverfahren und Anordnung zur Durchführung des Verfahrens | |
DE69735617T2 (de) | Mr-gerät mit mitteln zur reduzierung des auswirkungen von begleitenden gradienten | |
EP0233675B1 (de) | Verfahren zur Ermittlung der spektralen Verteilung der Kernmagnetisierung in einem begrenzten Volumenbereich und Anordnung zur Durchführung des Verfahrens | |
DE3632738A1 (de) | Verfahren zum bestimmen der spektralen verteilung der kernmagnetisierung in einem begrenzten volumenbereich | |
EP0478030B1 (de) | Verfahren für die zweidimensionale Kernresonanzspektroskopie | |
EP0248469B1 (de) | Kernspintomographieverfahren | |
DE3908303C2 (de) | ||
DE1673037C3 (de) | ||
EP0237105A2 (de) | Verfahren zum Bestimmen der spektralen Verteilung der Kernmagnetisierung in einem begrenzten Volumenbereich | |
DE4304516A1 (en) | Determining characteristic field distribution of interference source - using measurement signal e.g. from multi-channel SQUID gradiometer to form average and correlation values, and normalising |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): HU JP US |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 1996929120 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 09029338 Country of ref document: US |
|
WWP | Wipo information: published in national office |
Ref document number: 1996929120 Country of ref document: EP |
|
WWG | Wipo information: grant in national office |
Ref document number: 1996929120 Country of ref document: EP |