WO1997005258A3 - Rekombinantes 60 kda pflanzliches panallergen (kofaktor-unabhängige phosphoglyceratmutase; e.c. 5.4.2.1.) - Google Patents

Rekombinantes 60 kda pflanzliches panallergen (kofaktor-unabhängige phosphoglyceratmutase; e.c. 5.4.2.1.) Download PDF

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Publication number
WO1997005258A3
WO1997005258A3 PCT/AT1996/000141 AT9600141W WO9705258A3 WO 1997005258 A3 WO1997005258 A3 WO 1997005258A3 AT 9600141 W AT9600141 W AT 9600141W WO 9705258 A3 WO9705258 A3 WO 9705258A3
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WO
WIPO (PCT)
Prior art keywords
recombinant
factor
phosphoglycerate mutase
molecule
independent phosphoglycerate
Prior art date
Application number
PCT/AT1996/000141
Other languages
English (en)
French (fr)
Other versions
WO1997005258A2 (de
Inventor
Fatima Ferreira
Klaus Richter
Edwin Engel
Christof Ebner
Alexander Jilek
Hans-Joerg Rheinberger
Dietrich Kraft
Michael Breitenbach
Original Assignee
Biomay Prod & Handel
Fatima Ferreira
Klaus Richter
Edwin Engel
Christof Ebner
Alexander Jilek
Rheinberger Hans Joerg
Dietrich Kraft
Michael Breitenbach
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomay Prod & Handel, Fatima Ferreira, Klaus Richter, Edwin Engel, Christof Ebner, Alexander Jilek, Rheinberger Hans Joerg, Dietrich Kraft, Michael Breitenbach filed Critical Biomay Prod & Handel
Priority to AU66059/96A priority Critical patent/AU6605996A/en
Publication of WO1997005258A2 publication Critical patent/WO1997005258A2/de
Publication of WO1997005258A3 publication Critical patent/WO1997005258A3/de

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Wir zeigen ein rekombinantes DNA Molekül, das für ein Polypeptid mit der Antigenität der Kofaktor-unabhängigen Phosphoglyceratmutase (E.C. 5.4.2.1.) des Birken-, Beifuß- oder Lieschgraspollen kodiert. Dieses Allergen des Birkenpollens ist in Sequenz und Antigenität in allen Pflanzen (aber nicht in tierischen Organismen) hoch konserviert. Die Aminosäuresequenz und die wichtigsten B-Zell- und T-Zell-Epitope des Moleküls werden abgeleitet und gezeigt. Das rekombinante Allergen wurde in Escherichia coli exprimiert und bindet Serum IgE von Patienten, die gegen Pollen von Bäumen, Gräsern und Unkräutern sowie gegen verschiedene Nahrungsmittel allergisch sind. Ein monoklonaler Antikörper (BIP 3) bindet spezifisch an dieses hochkonservierte Protein aus allen untersuchten Pflanzen. Die Bedeutung der Kofaktor-unabhängigen Phosphoglyceratmutase (E.C. 5.4.2.1.) liegt darin, daß sie zur Kreuzsensibilisierung von Patienten führt. Das rekombinante Molekül und seine Teilpeptide kann zu diagnostischen und therapeutischen Verfahren herangezogen werden, die z.B. auf Antigen-Antikörper Wechselwirkung, Mediatorfreisetzung, oder T-Zell-Reaktivität beruhen.
PCT/AT1996/000141 1995-08-02 1996-08-02 Rekombinantes 60 kda pflanzliches panallergen (kofaktor-unabhängige phosphoglyceratmutase; e.c. 5.4.2.1.) WO1997005258A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU66059/96A AU6605996A (en) 1995-08-02 1996-08-02 Recombinant 60kda vegetable panallergen (co-factor-independent phosphoglycerate mutase; e.c. 5.4.2.1.)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0132095A AT402505B (de) 1995-08-02 1995-08-02 Rekombinantes 60 kda pflanzliches panallergen (kofaktor-unabhängige phosphoglyceratmutase; e.c. 5.4.2.1.)
ATA1320/95 1995-08-02

Publications (2)

Publication Number Publication Date
WO1997005258A2 WO1997005258A2 (de) 1997-02-13
WO1997005258A3 true WO1997005258A3 (de) 1997-03-27

Family

ID=3511346

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AT1996/000141 WO1997005258A2 (de) 1995-08-02 1996-08-02 Rekombinantes 60 kda pflanzliches panallergen (kofaktor-unabhängige phosphoglyceratmutase; e.c. 5.4.2.1.)

Country Status (3)

Country Link
AT (1) AT402505B (de)
AU (1) AU6605996A (de)
WO (1) WO1997005258A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT407048B (de) 1998-03-26 2000-11-27 Biomay Prod & Handel Rekombinantes hauptallergen des pollens von artemisia vulgaris (beifuss)
EP0981050A1 (de) * 1998-08-14 2000-02-23 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Immuntest für Haselnussallergene
US6767889B1 (en) * 1998-11-10 2004-07-27 Temple University Of The Commonwealth System Of Higher Education Inhibition of angiogenesis by high molecular weight kininogen and peptide analogs thereof
US6994852B1 (en) 1999-11-12 2006-02-07 Temple University-Of The Commonwealth System Of Higher Education Inhibition of angiogenesis by antibodies against high molecular weight kininogen domain 5
DK1219299T4 (da) 2000-12-28 2011-02-14 Biomay Ag Allergivacciner og fremstilling deraf
AU2003213861B2 (en) * 2002-04-02 2010-04-29 Circassia Limited Immunotherapeutic and immunoprophylactic reagents
AUPS148202A0 (en) * 2002-04-02 2002-05-09 Monash University Immunotherapeutic and immunoprophylactic reagents
CN103784952B (zh) 2009-02-05 2016-08-17 切尔卡西亚有限公司 用于疫苗的草肽

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992003551A1 (en) * 1990-08-13 1992-03-05 Biomay Biotechnik Produktions- Und Handelsgesellschaft M.B.H. Birch pollen allergen p14 for diagnosis and therapy of allergic diseases
WO1995006728A2 (en) * 1993-08-13 1995-03-09 Immulogic Pharmaceutical Corporation T cell epitopes of ryegrass pollen allergen

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992003551A1 (en) * 1990-08-13 1992-03-05 Biomay Biotechnik Produktions- Und Handelsgesellschaft M.B.H. Birch pollen allergen p14 for diagnosis and therapy of allergic diseases
WO1995006728A2 (en) * 1993-08-13 1995-03-09 Immulogic Pharmaceutical Corporation T cell epitopes of ryegrass pollen allergen

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GRANA X. ET AL.: "Cloning and sequencing of a cDNA encoding 2,3-biphosphoglycerate-independent phosphoglycerate mutase from maize.", J.BIOL.CHEM., vol. 267, no. 18, 25 June 1992 (1992-06-25), pages 12797 - 12803, XP002024349 *
HUANG Y. ET AL.: "Higher-plant cofactor-independent phosphoglycermutase: purification, molecular characterization and expression.", PLANT MOL BIOL, vol. 23, 1993, pages 1039 - 1053, XP000616028 *

Also Published As

Publication number Publication date
WO1997005258A2 (de) 1997-02-13
AT402505B (de) 1997-06-25
ATA132095A (de) 1996-10-15
AU6605996A (en) 1997-02-26

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