WO1996030016A2 - Low dose ridogrel formulations and their use for the treatment of inflammatory bowel diseases - Google Patents
Low dose ridogrel formulations and their use for the treatment of inflammatory bowel diseases Download PDFInfo
- Publication number
- WO1996030016A2 WO1996030016A2 PCT/EP1996/001229 EP9601229W WO9630016A2 WO 1996030016 A2 WO1996030016 A2 WO 1996030016A2 EP 9601229 W EP9601229 W EP 9601229W WO 9630016 A2 WO9630016 A2 WO 9630016A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ridogrel
- pharmaceutically acceptable
- body weight
- inflammatory bowel
- bowel diseases
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Definitions
- the present invention relates to the use of ridogrel at low dosages in the treatment of inflammatory bowel diseases and to corresponding low dose ridogrel formulations.
- EP-0,221,601 describes (E)-5-[[[(3-pyridinyl)[3-(trifluoromethyl)phenyl] methylene]amino)oxy]pentanoic acid (generically known as ridogrel) for use in various pathological conditions. This document also generically discloses pharmaceutical compositions comprising ridogrel.
- EP-0,448,274 describes a tablet formulation comprising 400 mg of ridogrel for use in ulcerative and inflammatory conditions of the gastrointestinal tract.
- ridogrel in the treatment of inflammatory bowel diseases as described in the prior-art shows limited clinical efficacy and displays undesired side-effects.
- the use as described in claim 1 solves this problem by administering ridogrel at low doses, thereby unexpectedly increasing the clinical efficacy in inflammatory bowel diseases and reducing adverse side-effects.
- Ridogrel as defined herein refers to (E)-5-[[[(3-pyridinyl)[3-(trifluoromethyl) phenyl]methylene]amino]oxy]pentanoic acid and can be prepared in accordance with the procedures described in EP-0,221,601. Ridogrel can also be used according to this invention as a pharmaceutically acceptable acid or base addition salt thereof. When a pharmaceutically acceptable acid or base addition salt is used, the dose referred to hereinabove and hereinunder is based upon the amount of ridogrel as such.
- the pharmaceutically acceptable acid addition salts as mentioned hereinabove are meant to comprise the acid addition salt forms which can conveniently be obtained by treating the base form of the compounds of formula (I) with appropriate acids such as inorganic acids, for example, hydrohalic acid, e.g. hydrochloric or hydrobromic, sulfuric. nitric, phosphoric and the like acids; or organic acids, such as, for example, acetic, hydroxyacetic, propanoic, lactic, pyruvic.
- acids such as inorganic acids, for example, hydrohalic acid, e.g. hydrochloric or hydrobromic, sulfuric. nitric, phosphoric and the like acids; or organic acids, such as, for example, acetic, hydroxyacetic, propanoic, lactic, pyruvic.
- acids to form acid addition salts are hydrochloric acid, which forms a ( 1 : 1 ) salt with ridogrel and nitric acid, which also forms a (1: 1) salt with ridogrel.
- said acid addition salt forms can be converted in the free base forms by treatment with an appropriate base.
- the compounds of formula (I) which are acidic may form base addition salt forms.
- the pharmaceutically acceptable base addition salts as mentioned hereinabove are meant to comprise the base addition salts forms which can conveniently be obtained by treating the acid form of the compounds of formula (I) with appropriate bases.
- bases may include lithium, sodium, potassium, calcium, aluminium, gold and silver salts.
- salts with pharmaceutically acceptable amines such as ammonia, primary, secondary and tertiary amines, such as alkyl amines, hydroxyalkylamines, N-methylglucamine and the like.
- said base addition salt forms can be converted in the free acid forms by treatment with an appropriate acid.
- Preferred counter ions in a base addition salt form are lithium and sodium.
- the present invention relates to the use of ridogrel or a pharmaceutically acceptable acid or base addition salt thereof for the manufacture of a medicament for treating inflammatory bowel diseases, wherein ridogrel or its pharmaceutically acceptable acid or base addition salt form is administered in a daily dose from 0.01 mg/kg body weight to 1 mg/kg body weight, suitably to 0.5 mg/kg body weight (the dose based upon the amount of ridogrel present as such).
- the invention relates to a method of treating humans suffering from inflammatory bowel diseases, said method comprising the administration to said humans of ridogrel or a pharmaceutically acceptable acid or base addition salt form thereof in an amount from 0.01 mg/kg body weight to 1 mg/kg body weight, suitably to 0.5 mg/kg body weight.
- ridogrel or a pharmaceutically acceptable acid or base addition salt form thereof is used in a daily dose from 0.02 mg/kg body weight to 0.1 mg/kg body weight, more particularly in a dose of about 0.05 mg/kg body weight.
- the above cited dose ranges in mg/kg body weight correspond to a dose range from about 1 mg/day to about 50 mg/day, in particular from about 2 mg/day to 10 mg/day, more in particular of about 5 mg/day.
- Inflammatory bowel diseases include, for example, ulcerative colitis, Crohn's disease and the like.
- ridogrel is used in the treatment of ulcerative colitis. Ulcerative colitis is characterized by the presence of lesions in the mucous membranes of the colon.
- thromboxane plays an active role in the development of these lesions.
- Ridogrel has been described to show both thromboxane synthetase inhibitory activity and thromboxane receptor antagonistic activity.
- ridogrel is a mere thromboxane synthetase inhibitor, lacking thromboxane receptor antagonistic activity.
- the treatment of inflammatory bowel diseases includes both the treatment of the acute disease state, thereby inducing remission of the disease or improvement of the lesions or clinical condition, as well as the use in maintenance therapy.
- a satisfactory treatment of inflammatory bowel diseases, in particular ulcerative colitis, is characterized by a good clinical efficacy and a low occurrence of adverse events.
- the following findings are desirable:
- Adverse events that may occur are e.g. nausea, vomiting, diarrhoea, abdominal cramps, oedema, paraesthesia, hematoma, ecchymoses, and the like.
- Ridogrel or its pharmaceutically acceptable acid or base addition salt form is suitably administered systemically, such as orally, rectally, intraperitoneally or parenterally.
- ridogrel is administered orally or rectally.
- ridogrel or a pharmaceutically acceptable acid or base addition salt form thereof is administered once daily (o.d.) or twice daily (b.i.d.), preferably formulated in an appropriate pharmaceutical composition.
- the invention relates to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and ridogrel or its pharmaceutically acceptable acid or base addition salt form in an amount effective to be used as defined hereinabove.
- the invention relates to a pharmaceutical composition comprising from 0.5 to 5 mg ridogrel per dosage unit form and a pharmaceutically acceptable carrier.
- Solid pharmaceutical compositions such as tablets, capsules, suppositories and the like, suitably comprise ridogrel in an amount from 0.5 to 5 mg per dosage unit form, in particular from 1 to 5 mg per dosage unit form.
- the active ingredient is preferably ridogrel as such.
- Liquid pharmaceutical compositions such as oral solutions, oral suspensions, oral syrups, injectable solutions, rectal enema's or rectal solutions, rectal foams and the like, suitably comprise ridogrel in an amount from 0.1 to 1 mg ml, preferably from 0.5 to 1 mg/ml.
- ridogrel is preferably present as the sodium salt of the ridogrel.
- Dosage unit form refers to physically discrete units suitable as unitary dosages, each unit containing a predetermined quantity of ridogrel.
- dosage unit forms are tablets (including scored or coated tablets), capsules, pills, powder packets, wafers, injectable solutions or suspensions, teaspoonfuls, tablespoonfuls and the like, and segregated multiples thereof.
- compositions there may be cited all compositions usually employed for systemically administering drugs.
- an effective amount of ridogrel is combined in intimate admixture with a pharmaceutically acceptable carrier, which carrier may take a wide variety of forms depending on the form of preparation desired for administration.
- Solid compositions according to the present invention will preferably comprise pharmaceutically acceptable carriers and excipients, such as fillers e.g. lactose, sucrose, mannitol, maize starch, microcrystalline cellulose or calcium hydrogen phosphate; lubricants e.g. stearic acid, polyethylene glycol, magnesium stearate, talc or silica; disintegrants e.g.
- compositions comprise by weight based on the total weight of the composition from 60% to 90% fillers, from 3% to 10% disintegrants and from 0.5% to 5% binding agents.
- ridogrel is blended with suitable excipients and granulated.
- ridogrel is granulated with the filler or fillers before admixture of the other excipients.
- Liquid compositions may comprise any of the usual pharmaceutical media such as water, glycols, oils, alcohols and the like. interesting liquid compositions are aqueous solutions or suspensions, in particular for rectal administration.
- Liquid oral compositions may comprise, apart from ridogrel or a pharmaceutically acceptable acid or preferably base addition salt form and water, flavouring substances; sweeteners; suspending agents, e.g. cellulose derivatives; wetting agents, e.g.
- the carrier will usually comprise sterile water, at least in large part, though other ingredients, for example, to aid solubility, may be included.
- injectable solutions for example, may be prepared in which the carrier comprises saline solution, glucose solution or a mixture of saline and glucose solution.
- injectable suspensions may also be prepared in which case appropriate liquid carriers, suspending agents and the like may be employed.
- convenuonal compositions such as suppositories or enemas may be used.
- rectal solutions may be used for rectal administration.
- Said rectal solutions comprise apart from the active ingredient ridogrel or its pharmaceutically acceptable acid or preferably base addition salt, water (suitably demineralised, preferably free of pyrogenics), a suitable buffer, such as the combination of disodium hydrogen phosphate and sodium dihydrogen phosphate, a thickening and stabilising agent such as for example hydroxyethyl cellulose, and an agent to make the solution isotonic, such as sodium chloride.
- a suitable buffer such as the combination of disodium hydrogen phosphate and sodium dihydrogen phosphate
- a thickening and stabilising agent such as for example hydroxyethyl cellulose
- an agent to make the solution isotonic such as sodium chloride.
- solid form preparations which are intended to be converted, shortly before use, to liquid form preparations.
- Particular pharmaceutical compositions are controlled release formulations, from which the active ingredient is gradually released after administration.
- micronized form of ridogrel is used in the present compositions.
- These micronized forms may be prepared by micronization techniques known in the art, e.g. by milling in appropriate mills and sieving through appropriate sieves.
- ridogrel may be administered in combination with another agent effective in the treatment of inflammatory bowel diseases, e.g. sulphasalazine, mesalazine, olsalazine, balsalazide, a corticosteroid and the like.
- Another agent effective in the treatment of inflammatory bowel diseases e.g. sulphasalazine, mesalazine, olsalazine, balsalazide, a corticosteroid and the like.
- the combined use includes the simultaneous, separate or sequential administration of the therapeutic agents.
- the invention relates to a product containing (a) ridogrel and (b) sulphasalazine, mesalazine or a corticosteroid, as a combined preparation for simultaneous, separate or sequential use in the treatment of inflammatory bowel diseases.
- compositions 1. 1 mg oral tablet
- Tablets having the composition shown hereinunder were prepared according to art-known formulation procedure.
- Croscarmellose sodiumO 2 mg 2.00 %
- Croscarmellose sodium is the British Approved Name of sodium carboxymethyllcellulose.
- Hypromellose 2910 15 mPa.s is the British Approved Name for methylhydroxypropylcellulose, the four digit number (2910) is an indication of the substitution on cellulose, i.e. the first two digits represent the approximate percentage composition of methoxyl groups, and the third and fourth digits the approximate percentage composition of hydroxypropyl groups.
- the grade used in this example is indicated by the viscosity of a 2 % solution at 20°C, i.e. 15 mPa.s
- Hypromellose 2910 15 mPa.s 2 2 mg 2.00 % w/w)
- colloidal anhydrous silica 0.3 mg 0.30 % ( ⁇ w/w)
- the percentages are based on the total weight of the tablet.
- the pH of the final solution should range between about 6.5 and 8.5, preferably the pH should be between 7.2 and 7.6.
- the solutions are packaged in enema bottles containing 40 ml or 80 ml of the above described solution.
- Analogous solutions containing 2.5 mg to 10 mg of ridogrel in 40 ml of rectal solution or 2.5 mg to 10 mg of ridogrel in 80 ml of rectal solution can be prepared according to the above described preparation.
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP96910921A EP0817631A2 (en) | 1995-03-28 | 1996-03-18 | Low dose ridogrel formulations and their use for the treatment of inflammatory bowel diseases |
AU53974/96A AU5397496A (en) | 1995-03-28 | 1996-03-18 | Low dose ridogrel formulations and their use for the treatme nt of inflammatory bowel diseases |
JP8528894A JPH10511097A (en) | 1995-03-28 | 1996-03-18 | Low-dose lidogrel formulations and their use for the treatment of inflammatory bowel disease |
MXPA/A/1997/007394A MXPA97007394A (en) | 1995-03-28 | 1997-09-26 | Formulations of low dose ridogrel and its use the treatment of inflamator intestinal diseases |
NO974486A NO974486L (en) | 1995-03-28 | 1997-09-29 | Low-dose "Ridogrel" formulations and their use in the treatment of intestinal inflammation |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP95200768.0 | 1995-03-28 | ||
EP95200768 | 1995-03-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1996030016A2 true WO1996030016A2 (en) | 1996-10-03 |
WO1996030016A3 WO1996030016A3 (en) | 1997-01-30 |
Family
ID=8220134
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1996/001229 WO1996030016A2 (en) | 1995-03-28 | 1996-03-18 | Low dose ridogrel formulations and their use for the treatment of inflammatory bowel diseases |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0817631A2 (en) |
JP (1) | JPH10511097A (en) |
AR (1) | AR002727A1 (en) |
AU (1) | AU5397496A (en) |
CA (1) | CA2215160A1 (en) |
HU (1) | HUP9900309A3 (en) |
IL (1) | IL117670A (en) |
NO (1) | NO974486L (en) |
WO (1) | WO1996030016A2 (en) |
ZA (1) | ZA962461B (en) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998015265A1 (en) * | 1996-10-04 | 1998-04-16 | Danbiosyst Uk Limited | Colonic delivery of weak acid drugs |
WO2002072069A1 (en) * | 2001-03-12 | 2002-09-19 | Novo Nordisk A/S | Novel tablets and capsules and a process for its preparation |
WO2017046343A1 (en) * | 2015-09-17 | 2017-03-23 | Nogra Pharma Limited | Compositions for rectal administration in the treatment of ulcerative colitis and methods of using same |
US9682050B2 (en) | 2012-04-18 | 2017-06-20 | Nogra Pharma Limited | Methods of treating lactose intolerance |
US9682923B2 (en) | 2012-02-09 | 2017-06-20 | Nogra Pharma Limited | Methods of treating fibrosis |
US9901557B2 (en) | 2009-02-16 | 2018-02-27 | Nogra Pharma Limited | Methods of treating hair related conditions |
US9913817B2 (en) | 2008-12-05 | 2018-03-13 | Nogra Pharma Limited | Methods for preventing or reducing colon carcinogenesis |
US10016381B2 (en) | 2005-07-22 | 2018-07-10 | Nogra Pharma Limited | Compounds and their salts specific to the PPAR receptors and the EGF receptors and their use in the medical field |
US11905232B2 (en) | 2019-02-08 | 2024-02-20 | Nogra Pharma Limited | Process of making 3-(4′-aminophenyl)-2-methoxypropionic acid, and analogs and intermediates thereof |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0221601A1 (en) * | 1985-11-04 | 1987-05-13 | Janssen Pharmaceutica N.V. | [[[(3-Pyridinyl)methylen]amino]oxy]alkanoic acids and esters |
-
1996
- 1996-03-18 WO PCT/EP1996/001229 patent/WO1996030016A2/en not_active Application Discontinuation
- 1996-03-18 CA CA002215160A patent/CA2215160A1/en not_active Abandoned
- 1996-03-18 EP EP96910921A patent/EP0817631A2/en not_active Withdrawn
- 1996-03-18 JP JP8528894A patent/JPH10511097A/en active Pending
- 1996-03-18 HU HU9900309A patent/HUP9900309A3/en unknown
- 1996-03-18 AU AU53974/96A patent/AU5397496A/en not_active Abandoned
- 1996-03-27 AR ARP960101944A patent/AR002727A1/en unknown
- 1996-03-27 ZA ZA9602461A patent/ZA962461B/en unknown
- 1996-03-27 IL IL11767096A patent/IL117670A/en active IP Right Grant
-
1997
- 1997-09-29 NO NO974486A patent/NO974486L/en unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0221601A1 (en) * | 1985-11-04 | 1987-05-13 | Janssen Pharmaceutica N.V. | [[[(3-Pyridinyl)methylen]amino]oxy]alkanoic acids and esters |
Non-Patent Citations (7)
Title |
---|
94TH ANNUAL MEETING OF THE AMERICAN GASTROENTEROLOGICAL ASSOCIATION, BOSTON, MASSACHUSETTS, USA, MAY 15-21, 1993. GASTROENTEROLOGY, 104 (4 SUPPL.). 1993. A677., XP000612204 CASELLAS F ET AL: "A SELECTIVE THROMBOXANE SYNTHETASE INHIBITOR IMPROVES CHRONIC ULCERATIVE COLITIS" cited in the application * |
CLIN. EXP. HYPERTENS. PART B HYPERTENS. PREGNANCY, 1991, 10/3 (371-383), USA, XP000612222 SPITZ B. ET AL: "Differential inhibition of vascular prostacyclin and platelet thromboxane synthesis by different doses aspirin and by the thromboxane inhibitor ridogrel (R 68070)" * |
DIGESTIVE DISEASE WEEK AND THE 93RD ANNUAL MEETING OF THE AMERICAN GASTROENTEROLOGICAL ASSOCIATION, SAN FRANCISCO, CALIFORNIA, USA, MAY 9-15, 1992. GASTROENTEROLOGY, 102 (4 PART 2). 1992. A601., XP000612207 CASELLAS F ET AL: "IN-VIVO QUANTIFICATION OF INTRACOLONIC EICOSANOID RELEASE IN ACTIVE CHRONIC ULCERATIVE COLITIS AFTER INHIBITION OF THROMBOXANE SYNTHETASE BY RIDOGREL" cited in the application * |
GASTROENTEROLOGY, FEB 1990, 98 (2) P269-77, UNITED STATES, XP000610998 VILASECA J ET AL: "Participation of thromboxane and other eicosanoid synthesis in the course of experimental inflammatory colitis." * |
J CARDIOVASC PHARMACOL, JAN 1993, 21 (1) P56-69, UNITED STATES, XP000611801 VANDEPLASSCHE G ET AL: "Interplay between platelet-derived 5-hydroxytryptamine and arachidonic acid metabolites limits the thrombolytic efficacy of streptokinase against canine platelet-rich coronary thrombosis." * |
PROSTAGLANDINS, JUN 1993, 45 (6) P547-55, UNITED STATES, XP000611801 KEITH JC JR ET AL: "Effects of ridogrel on the prostacyclin-thromboxane ratio in nulliparous third trimester-pregnant rhesus monkeys." * |
PROSTAGLANDINS, MAR 1994, 47 (3) P247-63, UNITED STATES, XP000611800 KEITH JC JR ET AL: "Ridogrel improves maternal/fetal homeostasis in an ovine model of pregnancy-induced hypertension." * |
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2333042A (en) * | 1996-10-04 | 1999-07-14 | Danbiosyst Uk | Colonic delivery of weak acid drugs |
GB2333042B (en) * | 1996-10-04 | 2000-10-18 | Danbiosyst Uk | Colonic delivery of weak acid drugs |
WO1998015265A1 (en) * | 1996-10-04 | 1998-04-16 | Danbiosyst Uk Limited | Colonic delivery of weak acid drugs |
WO2002072069A1 (en) * | 2001-03-12 | 2002-09-19 | Novo Nordisk A/S | Novel tablets and capsules and a process for its preparation |
US10016381B2 (en) | 2005-07-22 | 2018-07-10 | Nogra Pharma Limited | Compounds and their salts specific to the PPAR receptors and the EGF receptors and their use in the medical field |
US9913817B2 (en) | 2008-12-05 | 2018-03-13 | Nogra Pharma Limited | Methods for preventing or reducing colon carcinogenesis |
US10959970B2 (en) | 2009-02-16 | 2021-03-30 | Nogra Pharma Limited | Methods of treating hair related conditions |
US9901557B2 (en) | 2009-02-16 | 2018-02-27 | Nogra Pharma Limited | Methods of treating hair related conditions |
US10137101B2 (en) | 2009-02-16 | 2018-11-27 | Nogra Pharma Limited | Alkylamido compounds and uses thereof |
US10398667B2 (en) | 2009-02-16 | 2019-09-03 | Nogra Pharma Limited | Methods of treating hair related conditions |
US9682923B2 (en) | 2012-02-09 | 2017-06-20 | Nogra Pharma Limited | Methods of treating fibrosis |
US11046641B2 (en) | 2012-02-09 | 2021-06-29 | Nogra Pharma Limited | Methods of treating fibrosis |
US11753365B2 (en) | 2012-02-09 | 2023-09-12 | Nogra Pharma Limited | Methods of treating fibrosis |
US9682050B2 (en) | 2012-04-18 | 2017-06-20 | Nogra Pharma Limited | Methods of treating lactose intolerance |
WO2017046343A1 (en) * | 2015-09-17 | 2017-03-23 | Nogra Pharma Limited | Compositions for rectal administration in the treatment of ulcerative colitis and methods of using same |
US11905232B2 (en) | 2019-02-08 | 2024-02-20 | Nogra Pharma Limited | Process of making 3-(4′-aminophenyl)-2-methoxypropionic acid, and analogs and intermediates thereof |
Also Published As
Publication number | Publication date |
---|---|
AU5397496A (en) | 1996-10-16 |
IL117670A (en) | 2000-02-29 |
CA2215160A1 (en) | 1996-10-03 |
NO974486D0 (en) | 1997-09-29 |
JPH10511097A (en) | 1998-10-27 |
HUP9900309A2 (en) | 1999-05-28 |
MX9707394A (en) | 1997-11-29 |
HUP9900309A3 (en) | 1999-11-29 |
IL117670A0 (en) | 1996-07-23 |
NO974486L (en) | 1997-09-29 |
EP0817631A2 (en) | 1998-01-14 |
AR002727A1 (en) | 1998-04-29 |
ZA962461B (en) | 1997-09-29 |
WO1996030016A3 (en) | 1997-01-30 |
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