WO1996025136A1

WO1996025136A1 - Transfusion container

Info

Publication number: WO1996025136A1
Application number: PCT/JP1996/000308
Authority: WO
Inventors: Seizo Sunago; Akira Kagayama; Osamu Takahata; Hitoshi Futagawa; Mitsuo Murakami; Tomohiko Kubo
Original assignee: Fujisawa Pharmaceutical Co., Ltd.; Nissho Corporation
Priority date: 1995-02-13
Filing date: 1996-02-09
Publication date: 1996-08-22
Also published as: EP0809994B1; EP0809994A4; EP0809994A1

Abstract

A transfusion container provided with a drug chamber, a capping member for hermetically sealing the mouth of the drug chamber, and a solvent chamber joined to the bottom of the drug chamber, wherein the drug chamber is provided with a through hole at the bottom thereof and has a protruding piece which hermetically seals the through hole and is movable so as to open the through hole protruding into the drug chamber, while the capping member has an engaging part to be engaged with the tip of the protruding piece and the protruding piece is movable to open the through hole by the rotation of the capping member. This container serves to simplify the process steps and reduce the number of the parts, is ready to dispose of, facilitates mixing the drug with the solvent, and is easy to maintain and handle in hospitals and other facilities.

Description

Description Technical field for infusion containers

The present invention relates to an infusion container, and more specifically, a dry drug such as a powdered preparation or a lyophilized preparation, and a solution thereof are stored in a separated state, and the dried drug and the solution are stored in the container immediately before use. The present invention relates to an infusion container for aseptically mixing and supplying as an infusion solution. Kyokyo technology

2. Description of the Related Art Conventionally, in medical institutions such as hospitals, dried drugs in drug containers such as vials are dissolved in a dissolving solution such as distilled water, physiological saline, or glucose solution, and used for infusion.

To facilitate use in such cases, a vial containing the dried drug is connected in series to a dissolution solution container containing the dissolution solution, and the two containers are aseptically connected during use. Infusion containers have been proposed.

For example, as shown in FIG. 35, an infusion container 4 10 disclosed in Japanese Patent Application Laid-Open No. 2-12777 has a medicine container 4 12 and a dissolution container 4 11 1 containing a dissolution solution. A hollow puncture needle 417 having a hub in the middle and having a cutting edge at both ends is interposed therebetween, and the puncture needle 417 pierces the drug container 412 first, and then the lyse solution container 411 And the drug container 4 1 2 and the lysis solution container 4 1 1 The communication between the drug and the dissolving solution after the communication can be performed aseptically in a short time.

The drug container 4 12 is usually sealed with a self-sealing rubber stopper that can be pierced by a puncture needle 4 17, and a glass vial, which is a general distribution form of a dry drug, is used. I have. The rubber stopper is fastened by a cover member 413 made of aluminum or the like and fixed to the mouth of the container.

Further, as shown in FIG. 36, a flexible double container has been proposed in which a plurality of chambers for accommodating a liquid agent, a powder agent, or a solid agent are partitioned by partition means capable of communicating with each other. (Japanese Patent Application Laid-Open No. Hei 4-364850). This container 510 is composed of a plurality of chambers composed of flexible sheets, and stores a chemical solution storage room 501 and an oxygen absorber 504 and a desiccant 505 covered with an outer wall 502. A storage room 506 for storing the medicine and a medicine storage room 503 covered with the inner wall 508 for storing the medicine are connected via a weak seal portion 507. In use, the weak seal portion 507 is configured to be easily separated by applying an external pressure to the chemical solution storage room 501. Therefore, communication between the chemical storage room 501 and the chemical storage room 503 is easy, and disposal is easy.

The former transfusion container 410 uses a vial and is integrated, so it has high versatility and excellent operability. However, since glass and aluminum are used for vials, it takes time to remove and separate components when separately disposing of used infusion containers. In addition, puncture needle 4 1 7 The components such as the communication means between the drug container 4 1 2 and the solution container 4 1 1 are complicated and the number of components is large as a whole.

In the latter transfusion container 5110, the manufacturing process is complicated because a seal is formed with a plurality of films. In addition, since the entire container is made of a flexible sheet, there is no independence and space for storage is provided.

As shown in Fig. 34, each of the above-mentioned infusion containers is usually provided with a puncture needle 5 61 and a puncture needle 5 61 which can be inserted into the liquid outlet 560 at the bottom of the infusion container 55. The tube 5 6 2 connected to the tube 5 and the needle 5 6 3 attached to the tip of the tube 5 6 2 It is then offered for infusion. Normally, the flow rate adjuster 566 can be adjusted arbitrarily by pressing the tube 562 stored in the adjuster case with the roller 566 skewed in the case. .

As described above, in these infusion containers, the infusion can be easily adjusted.However, in order to instill the adjusted infusion into the patient, the above-described infusion device 570 was separately prepared and kept aseptically. It must be taken out of the bag and the puncture needle 561 must be inserted into the liquid outlet 560 at the bottom of the infusion container, which is not only time-consuming, but also has a problem with sterility. Also, there is no danger of accidentally injuring the hand with the puncture needle 56 1 during the operation.

The present invention has been made in view of the above-mentioned circumstances, and its purpose is to simplify the manufacturing process, facilitate disposal, and further improve the pharmaceutical properties. The present invention has been made in view of the circumstances described above, to provide an infusion device which can mix an agent and a dissolving solution satisfactorily, and which makes the infusion device aseptically safe and easy to attach. Its main purpose is to simplify the manufacturing process, facilitate disposal, facilitate mixing of drug and solution, and facilitate storage and handling in hospitals, etc. It is an object of the present invention to provide an infusion container and an infusion device that can assure sterile, safe, and easy mounting of a device. Disclosure of the invention

The present invention includes a medicine storage chamber, a cap member for sealing an opening of the medicine storage chamber, and a lysis solution chamber connected to a bottom of the medicine storage chamber. A communication hole with the dissolution liquid chamber is provided in the cap member, and the cap member has a protruding piece that seals the communication hole and is movable to open the communication hole protruding into the medicine storage chamber. Has an engaging portion to be engaged with the tip of the projecting piece, and the projecting piece is configured to be opened and moved to the communication hole by a rotation operation of a cap member. In other words, the present invention provides a transfusion container having a projecting piece that seals a communication hole with a dissolving solution chamber provided at the bottom of a medicine storage chamber, and that the cap member is rotated to operate the cap. The communication hole is opened by moving the projecting piece that engages with the Anything that tries to communicate. Examples of the drug stored in the drug storage chamber of the ring fluid container of the present invention include dry preparations such as powdery or granular preparations and freeze-dried preparations. Specific examples of the active ingredient of the dry preparation include the following.

Antibiotics include cefabrina sodium, ceftizoxim sodium, cefotiam hydrochloride, cef menoxime hydrochloride, cefacetrin sodium, cef amandol natrium, Cefaro lysine, Cef otaximina trium, Cefotena natrium, Cefopera buna trium, Cefsurojinna trium. Ceftebourna trium, Sefviramidona trium, Sefmeta Cefem antibiotics such as borunatium, cefloquinnatrium, and cefocless sulfate, as well as ampinlinatotrium, lupenicinlinatodium, sulpenicillinatonium, and ticarcinnatriton And penicillin antibiotics, and vancomycin hydrochloride. Examples of anti-tumor agents include mitomycin (:, fluorouracil, tegafur, and shihurabin). Examples of anti-excipients include famotidine, ranitidine hydrochloride, and cimetidine.

The dissolving solution contained in the dissolving solution chamber of the wheel solution container according to the present invention includes physiological saline, glucose solution, or amino to which cysteine, triptophan or the like is added. Examples thereof include an acid solution, but are not particularly limited.

In the present invention, the cap member specifically includes a plug that can be pierced, and a lid that is optionally attached to the body. Has an engaging portion to be engaged with the tip of the protruding piece.

According to a preferred aspect of the present invention, a drug-deterioration preventing agent storage chamber is formed on a cap member that seals the mouth of the drug storage chamber, specifically, preferably on the lid described above. It may be configured such that a desiccant and a deoxygenating agent or a desiccant can be stored therein as a chemical deterioration preventing agent. The desiccant is intended to stabilize a drug that is denatured by moisture, and examples thereof include those containing silica gel, zeolite, or the like as a component. The oxygen scavenger is used to prevent denaturation of the easily oxidizable drug, and examples thereof include those using active iron oxide, amorphous copper and the like. The desiccant and the oxygen scavenger are appropriately used depending on the type of the drug stored in the drug storage chamber, and may be used alone or both at the same time.

The solution chamber in the present invention is preferably a flexible container formed by fusing a relatively soft synthetic resin sheet such as polyethylene, polypropylene or polyvinyl chloride to form a bag.

At the bottom of the medicine storage chamber in the present invention, a communication hole for communicating the medicine storage chamber with the solution chamber is provided, and the communication hole is hermetically sealed, and a projecting piece projecting into the medicine storage chamber is provided.

Here, the communication hole is sealed by the close contact of the protruding pieces (contact while maintaining the liquid-tight state), and the communication hole is closed by the sliding movement of the protruding piece accompanying the rotation operation of the cap member. You may make it open. For example, a communication hole is two holes that are formed axisymmetrically or one hole that is semi-circular (semicircular). It may be configured to have a bottom portion that seals the hole so that it can be opened and moved. Openings or notches are formed in the bottoms of these protruding pieces corresponding to the shapes of the communication holes, so that they are opened in the communication holes by sliding movement accompanying rotation of the cap member. <Further, the projecting piece is provided eccentrically from the center of the medicine storage chamber, and the engaging portion is correspondingly formed as an engaging hole formed in the bottom portion of the body, and the tip of the projecting piece is formed therein. You may be engaged. Specifically, a circular bottom plate having an opening in which the protruding piece is slidably and rotatably in contact with the bottom of the medicine storage chamber, and eccentrically projects from the center into the medicine storage chamber from this bottom plate as an engagement part. The cap member or a tower-like portion that engages with the engagement hole of the plug body formed, and the opening of the bottom plate is formed by the movement of the protruding piece accompanying the rotation operation of the cap member or the lid portion. It is preferable that the communication hole is overlapped with the portion or notch to open the communication hole.

Further, the communication hole can be sealed by integral joining of the projecting pieces, and the projecting pieces can be forcibly removed and the communication holes can be opened by rotating the cap member.

For example, the communication hole is not opened (or formed) because the protruding piece (root) is fitted and integrally joined in a state before the use of the orifice container, but the protruding piece becomes ( It may be opened (or formed) when twisted from the bottom (along with the base).

The protruding piece is formed of resin (preferably integrally molded) at the bottom of the medicine storage chamber so as to be eccentric from the center of the medicine storage chamber and protrude into the medicine storage chamber. Or welding), and is preferably a solid or hollow molded member. The protruding piece is not particularly limited, but is formed of a material having poor compatibility with the material forming the (bottom) of the medicine storage chamber so that the communication hole can be easily formed when the protruding piece is twisted. It is preferable to make a cut at the joint.

For example, the drug storage chamber is formed of polypropylene, and the protruding piece is formed of a mixture of polyethylene and polypropylene, a copolymer or graft of polyethylene, as main components, respectively. It is preferred that both are welded.

Here, as described above, the cap member seals the mouth of the medicine storage chamber and has a pierceable plug having an engagement portion that engages with the projecting piece of the medicine storage chamber, for example, a stopper made of a rubber elastic material. A body is provided, and an engagement hole is preferably used as an engagement portion of the plug. Preferably, a pair of the engagement holes are formed opposite to each other with respect to the axis of the medicine storage chamber, and a pair of towering portions are formed in the protruding pieces correspondingly. When the cap member is rotated, it is rotated accordingly, whereby the projecting piece is twisted from the bottom of the medicine storage chamber via the engaging portion, thereby forming a communication hole.

Further, the cap member is provided with the above-mentioned medicine alteration preventing agent storage chamber in a detachable manner, and has a thin tube portion for communicating the storage room and the medicine storage chamber via a hydrophobic filter. (If the cover member is provided with a cover portion, the cover portion includes the cover portion). Here, as the hydrophobic filter, for example, polyethylene, Preferred examples include sintered bodies such as polypropylene and borotetrafluoroethylene, and membrane filters.

According to a preferred aspect of the present invention, the cap member (or a member mounted on the cap member, for example, a chemical-deterioration preventing agent storage chamber, hereinafter represented by a cap member) is a container. It is preferable to use a device provided with a self-supporting means capable of maintaining a self-supporting state. It is preferable that the self-supporting means form a flat portion or a support leg on the head of the cap member. The self-supporting means may be formed integrally with the cap member, or may be provided on the cap member.

In summary, according to the infusion container of the present invention, when the cap member is rotated in a state in which the medicine accommodating chamber is closed, the stopper rotates with the cap member and the engaging portion of the body is rotated. The protruding piece that engages with is twisted. At this time, the projecting piece is completely twisted off from the bottom of the medicine storage chamber together with its base, thereby forming (opening) a large communication hole, and the medicine storage chamber and the solution chamber communicate with each other. This allows the drug and dissolution solution to be easily mixed in the container.

It is preferable to provide a chemical solution take-out part on the top surface of the cap member and a hanging support part in the solution chamber.

One end of the puncture needle of the drip device is connected (pierced) through the body of the chemical solution take-out part on the top surface of the cap member, and the suspension is provided using the hanging support provided in the solution chamber. When the liquid is suspended with the cap member side down, the chemical solution obtained by mixing the chemical and the solution can be taken out as a wheel solution.

In the present invention, the projecting portion is communicated with the bottom of the medicine storage chamber. The hole may be formed so as to protrude integrally into the medicine storage chamber through a fragile portion that can be broken by a rotation operation of the cap member at a peripheral portion of the hole. Here, the cap member preferably has a leg extending into the medicine storage chamber, and the tip of the protruding piece is preferably engaged (eg, engaged by insertion) with this leg. If the portion is inserted into the protruding piece, the medicine storage chamber and the dissolving solution chamber can be communicated only by rotating the cap member at the time of cycling.

The fragile portion at the bottom of the drug storage chamber according to the present invention comprises a thin film portion or a groove (hollow portion) formed at the bottom of the drug storage chamber, and is easily broken by an external force and melts with the drug storage chamber. Refers to a portion that allows communication with the lysis chamber.

In the present invention, the projecting piece at the bottom of the medicine storage chamber refers to a resin molded (preferably integrally formed) at the bottom of the medicine storage chamber together with the fragile part, and is a solid or hollow molded member. Is preferred.

The legs of the cap member rotate integrally with the main body when the cap member rotates.

According to a preferred aspect of the present invention, the leg portion of the cap member has a bulging portion bulging in a radial direction on a part of the peripheral surface thereof, and the cap member is provided at the bottom of the drug storage chamber. After the fragile portion at the bottom of the medicine storage chamber is broken by the rotation of the stopper member, a contact portion is provided which can contact the bulging portion to move the protruding piece.

The bulge is formed at least partially on the outer peripheral surface of the leg, and is not easily deformed by the force that breaks the fragile part without a groove. It is desirable to do so. The contact portion is formed at the position where the lever force acts on the contact point with the bulging portion when the cap member is rotated, preferably near the protruding piece, and easily deformed. I prefer not to.

Here, the phrase “the projecting piece can be moved” means that the projecting piece can be moved outward on the bottom of the medicine storage chamber in a direction substantially perpendicular to its axis.

Further, in the present invention, the main body portion and the leg portion of the cap member are formed so as to be offset from each other, and the leg portion is inserted into the upper portion of the protruding piece by 0 mm, so that the cap member is formed. It is preferable that the upper portion of the protruding piece be moved in the tangential direction of the cap member main body by rotating to break the fragile portion.

Here, “moving the upper part of the projecting piece in the tangential direction of the cap member main body” means rotating the upper part of the projecting piece with a radius of 5 that is eccentric from the cap member main body. .

Further, a screw portion is formed inside the leg portion of the cap member, and a screw portion to be screwed with the screw is formed on a projecting piece at the bottom of the medicine storage chamber, and the cap member is rotated. Therefore, it is preferable that the protruding piece be moved upward to break the fragile portion.0 The cap member has a bulging portion at the leg and a contact portion at the bottom of the medicine storage chamber. With this configuration, after the fragile portion is broken, the projecting piece covering the broken portion can be moved in the radial direction, so that the flow of the solution between the drug storage chamber and the solution chamber can be reduced. It can be easier. If the main body and the leg of the cap member are formed so that their centers are shifted from each other, and the leg is inserted into the upper part of the protruding piece, the cap member is first rotated to rotate the protruding piece. The upper part is twisted to break the fragile part, and the upper part of the protruding piece moves while being tilted in the tangential direction of the cap member main part, so that the broken part can be enlarged and between the drug storage chamber and the solution chamber. The flow of the dissolving solution can be made easier.

If screws are formed on the inside of the legs of the cap member and on the protruding piece, when the cap member is rotated, both screws are screwed and the protruding piece moves upward. When the cap member is further rotated and the screwing of both screws reaches the limit, the protruding piece is twisted and the fragile portion is broken. Furthermore, the projecting piece covering the broken portion moves upward while screwing into the leg of the cap member, so that the flow of the solution between the drug storage chamber and the solution chamber is made easier. Can be

According to another aspect of the present invention, there is provided a medicine storage chamber, a cap member including a main body and a leg, which hermetically seals an opening of the medicine storage chamber and is capable of rotating itself. A solution chamber which is connected in a liquid-tight manner and has a chemical solution outlet having a pierceable thin film portion or 拴 at the lower end, a needle portion at one end and a stopper or thin film of the lysis solution chamber at the other end. A drip tool having a puncture needle that can penetrate the part,

The bottom of the medicine storage chamber has a fragile part and a projecting piece that projects at least partially into the medicine storage chamber in contact with the fragile part, and the leg part of the cap member has the protrusion. Engage the piece and The fragile portion can be broken by rotating the material, and the dissolving solution chamber is engaged with an outer cylinder with a bottom that can receive and displaceably displace the drip device and break the fragile portion. After mixing the drug and the dissolving solution, the outer ring is displaced relative to the dissolving solution chamber, thereby providing a wheel fluid device in which the puncture needle of the infusion device penetrates the hole or the thin film portion of the dissolving solution chamber.

The infusion device according to the present invention is a device for injecting a drug solution (infusion) prepared by mixing a drug and a solution into a living body, and the puncture held near the infusion outlet of the solution chamber. A needle, a tube that guides the infusion from the puncture needle, an intravenous needle connected to one end of the tube, and a flow control unit that adjusts the drop flow rate connected between the puncture needle and the intravenous needle. Have. The tube is usually composed of a transparent tube made of a synthetic resin such as polyvinyl chloride and having transparency.

The outer part is a member that constitutes the infusion device of the present invention together with the medicine storage chamber, the solution chamber, and the infusion device, and engages with the solution solution chamber to enable the infusion device to be stored in an aseptic state.

The displacement of the outer cylinder with respect to the solution chamber in the present invention means that the infusion device housed in the outer casing and the ring fluid outlet of the solution chamber are brought close to each other, and the infusion device is further moved through the puncture needle to the solution chamber. The change in the relative position between the two, which is performed manually by the operator to communicate with the user. Therefore, the displacement of the outer cylinder described above includes that caused by fitting such as pushing, and that caused by screwing of both.

According to a preferred embodiment of the present invention, the outer surface is slidable in the solution chamber. After the fragile part is broken and the drug and the dissolving liquid are mixed, the dissolving liquid chamber is pushed into the outer cylinder, and the puncture needle of the drip device penetrates the stopper or thin film part of the dissolving liquid chamber. .

According to a further preferred aspect of the present invention, the infusion device includes a cock for adjusting the amount of liquid flowing through the pipe by switching a plurality of flow paths.

In the infusion device according to the present invention, the solution chamber has an infusion outlet at the lower end thereof. The chemical solution outlet is an opening for taking out a chemical solution obtained by mixing a drug and a solution as an infusion.

According to the wheel fluid device of the present invention, when the cap member is rotated in a state in which the medicine storage chamber is sealed, the leg of the cap member rotates and the protruding piece engaging with the leg is twisted. . At this time, the fragile portion formed at the bottom of the medicine storage chamber in contact with the protruding piece is broken by twisting the protruding piece, and the medicine storage chamber and the solution chamber communicate with each other. Then, by shaking the dissolution solution chamber upward, the drug and the dissolution solution are mixed and prepared as an infusion solution.

Next, by displacing the outer cylinder with respect to the solution chamber, for example, by squeezing the solution chamber into the outer cylinder, the puncture of the drip device housed in the outer chamber and held near the chemical solution outlet is performed. The needle or the thin film portion of the solution chamber is pierced by the needle. As a result, the infusion device is connected to the solution chamber, so that the outer cylinder is removed from the solution chamber, the cock is opened, and the intravenous needle is inserted into the patient's blood vessel to perform the infusion.

The infusion rate is adjusted by the cock. The cock adjusts the amount of liquid flowing through the pipeline by switching between multiple flow paths. As described above, deformation of the pipeline and poor restoration due to the pressing of the pipeline do not occur. BRIEF DESCRIPTION OF THE FIGURES

FIG. 1 is a cross-sectional view of a main part of the front of an infusion container according to Embodiment 1 of the present invention.

FIG. 2 is a cross-sectional view of a main part of a side surface of the ring fluid container of FIG.

FIG. 3 is a perspective view of the protruding piece and the leg of FIG. 1 (when the medicine storage chamber is assembled).

FIG. 4 is a plan sectional view (before communication) of the engaged protruding piece and the leg.

FIG. 5 is a cross-sectional plan view of the engaged protruding piece and the leg (after communication).

FIG. 6 is a cross-sectional view of main parts of a projecting piece and a leg of an infusion container according to Embodiment 2 of the present invention (when assembling a medicine storage chamber).

FIG. 7 is a sectional view taken along line AA of FIG.

FIG. 8 is a perspective view showing a state in which the fragile portion of FIG. 6 has been broken, and FIG. 9 is a perspective view of a protruding piece and a leg of the annular fluid container according to Embodiment 3 of the present invention. (When assembling the room).

FIG. 10 is a perspective view illustrating the communication operation by the legs in FIG.

FIG. 11 is a perspective view (after communication) showing a prone state in which the fragile portion of FIG. 9 is broken.

Fig. 12 is a cross-sectional view (before communication) showing the protruding state of the cap member.

Fig. 13 is a cross-sectional view showing the cap member protruding (at the time of communication operation). It is.

FIG. 14 is a cross-sectional view of a principal part of the front surface of an embodiment of the self-supporting means provided in the chemical solution take-out section.

FIG. 15 is a cross-sectional view of a principal part of the front surface of a container for wheel fluid according to Embodiment 4 of the present invention.

FIG. 16 is a sectional view taken along line AA of FIG.

FIG. 17 is a perspective view showing a state in which the fragile portion of FIG. 15 is broken.

FIG. 18 is a front view of a wheel fluid device according to Embodiment 5 of the present invention.

FIG. 19 is a cross-sectional view of a main part of the infusion device of FIG.

FIG. 20 is a perspective view of the protruding pieces and legs of FIG.

FIG. 21 is a plan sectional view (before communication) of the engaged protruding piece and the leg.

FIG. 22 is a plan cross-sectional view (after communication) of the engaged protruding piece and the leg.

FIG. 23 is a cross-sectional view of a main part (at the time of infusion) showing a state where the infusion device is connected to the solution chamber.

FIG. 24 is a cross-sectional view of a main part of the flow control device of FIG.

FIG. 25 is a cross-sectional view of a main part of the front of the infusion device corresponding to FIG. 19, showing a state in which the fragile portion of FIG. 19 is broken and the infusion device and the solution chamber are in communication.

FIG. 26 is a front view including a cross-sectional view of a main part of a container for wheel fluid according to Embodiment 6 of the present invention. FIG. 27 is a sectional view taken along line AA of FIG.

FIG. 28 is a schematic diagram illustrating a state in which the projecting pieces of FIG. 26 are pushed down to form a communication hole.

FIG. 29 is a front view including a longitudinal cross-sectional view of a main part of the container for wheel fluid according to the seventh embodiment.

FIG. 30 is a sectional view taken along the line A-A in FIG.

FIG. 31 is a diagram corresponding to FIG. 28 showing a different state.

FIG. 32 is a longitudinal sectional view of a main part showing a different state.

FIG. 33 is a diagram corresponding to FIG. 31 according to the eighth embodiment.

FIG. 34 is an explanatory diagram showing an example of a conventional infusion device connected to an infusion device.

FIG. 35 is a cross-sectional view of a main part showing an example of a conventional infusion container.

FIG. 36 is a cross-sectional view of a main part showing another example of a conventional container for a wheel fluid. 0 BEST MODE FOR CARRYING OUT THE INVENTION

Some embodiments of the present invention will be described with reference to the drawings. However, this does not limit the present invention.

(Example 1)

The infusion container 10 shown in FIGS. 1 and 2 is mainly composed of a drug storage chamber 1, a dissolution liquid chamber 2, a cap member 3 installed in the drug storage chamber 1, and a drug outlet 4. Is configured.

The medicine storage room 1 has an opening at the upper end where a cap member 3 can be attached.

-1 It is a wide-mouthed container having a part 1a and a bottom part 6 having a fragile part 5 described later. The medicine storage chamber 1 and the solution chamber 2 are integrally formed of, for example, polyethylene resin. Solution chamber 2 is the upper part of the _c solution chamber 2 are possible pressed and deformed is formed at a relatively small wall thickness than the drug storing chamber 1 lower end of the medicine container chamber 1 is embedded integrally.

A hollow protruding piece 7 that is in contact with the thin film-shaped fragile portion 5 and protrudes toward the drug storage chamber 1 is provided at the bottom 6 of the drug storage chamber that connects the drug storage chamber 1 and the solution chamber 2 in a liquid-tight manner. . The fragile portion 5 and the projecting piece 7 are formed integrally with the bottom 6 as a part of the medicine storage chamber 1 (FIG. 3). The protruding piece 7 is formed in a hexagonal prism shape having a corner portion on the top surface. In the vicinity of the protruding piece 7, a solid contact portion 8 protruding from the bottom 6 is formed integrally with the bottom 6. The contact portion 8 is installed obliquely with respect to the axis of the projecting piece 7 so that the bulging portion 21 described later contacts the projecting piece 7 and does not come off from between the projecting piece 7 and the contacting portion 8 (FIG. 4). . The cap member 3 is composed of a cap body 9 and legs 11 at the lower part thereof, which engage with the protruding pieces 7. The cap body 9 has a substantially T-shaped cross section, and its upper part is fitted with the outer wall of the medicine storage room 1 so that the mouth of the medicine storage room 1 can rotate itself. 1a is sealed. The inside of the cap body 9 is hollow. It is kept liquid-tight and non-airtight, and contains a desiccant and an oxygen scavenger. Since the inside of the cap body 9 is kept liquid-tight, even when the medicine storage chamber 1 and the solution chamber 2 communicate with each other, the solution does not enter the inside of the cap body 9. Leg 1 1 is a hollow part with a hexagonal cross section A concave portion 12 corresponding to the protruding piece 7 and nesting is formed at the inner lower end thereof. Further, a bulge 21 is formed at the lower end of the outer periphery of the leg 11. As shown in FIG. 4, when the leg 11 is rotated by the cap body 9 in the direction of the arrow as shown in FIG. 4, the protruding piece 7 engaging with the recess 12 rotates. After the fragile portion 5 is broken, it has a function of moving the protruding piece 7 out of contact with the abutting portion 8 in a direction substantially perpendicular to its axis, thereby moving the protruding piece 7 away from the broken portion. .

The medicine filling section 15 for accommodating the medicine is composed of the outer peripheral surface of the cap body 9 and the leg 11 and the outer peripheral surface of the medicine storage chamber 1. Moisture and oxygen permeating through the part 15 are adsorbed by the desiccant and oxygen scavenger stored in the non-hermetic cap body 9. After a desiccant or an oxygen scavenger is stored in the cap body 9, a lid 16a having a suspending tool 16 is attached to the opening edge of the cap body 9 by heat welding or the like, and sealed.

At the lower end of the solution chamber 2, a chemical solution outlet 4 is provided. The chemical solution take-out part 4 has the same configuration as that of a normal bottle for ring fluid. For example, as shown in FIG. 1, a holding member 33 having a knob and a rubber member 3 attached thereto are provided. A configuration in which a sealing member made of 4 is covered is adopted. The sealing member is attached to the solution chamber 2 by inserting rubber 拴 34 into the chemical solution outlet 31 and welding a flange 31a formed on the outer wall of the outlet. The rubber stopper 3 4 of the sealing member is protected from contamination on its surface. When the knob is twisted off, the surface of the rubber 拴 34 comes to appear.

With such a configuration, when the leg 11 is rotated by the cap body 9, the recess 12 rotates and the protruding piece 7 is twisted to break the fragile portion 5 (FIG. 4). . As a result, the drug storage chamber 1 communicates with the lysis chamber 2 to press the lysis chamber 2 so that the drug and the lysis liquid are mixed and can be supplied as an infusion. Further, the bulging portion 21 comes into contact with the contact portion 8, and a “leverage force” acting at the contact point between the bulging portion 21 and the contact portion 8 acts on the projecting piece 7, Since the projecting piece 7 covering the break is moved, the opening 5a of the weak part 5 is widened (FIG. 5).

In addition, in the container for wheel fluid of this embodiment, the bulging portion 21 and the contact portion 8 are provided, and the projecting piece 7 is moved in the radial direction to widen the opening 5a formed. The bulging portion 21 and the contact portion 8 may be omitted, and the leg 11 may be simply rotated to twist the projecting piece 7 to break the fragile portion 5.

(Example 2)

6 to 8 show an example in which the main body 9 and the leg 41 of the cap member 3 are formed with their respective axes shifted from each other. The center of the leg 41 is formed outside the center of the main body 9. The leg portion 41 is a hollow cylindrical member, and a concave portion 42 corresponding to the protruding piece 47 is formed inside the leg portion 41.

The thin film-shaped fragile portion 45 is formed integrally with the bottom portion 46 of the medicine storage chamber 1. The bottom 4 6 of the medicine storage chamber is in contact with the fragile section 4 5 A solid protruding piece 47 protruding toward the medicine storage chamber 1 is provided. The protruding piece 47 includes a large-diameter base 44 and a small-diameter end 43. The leg 41 of the cap member 3 is inserted into the upper part of the projecting piece 47, that is, near the base of the small diameter tip 43 of the projecting piece 47.

With such a configuration, when the leg 41 is rotated by the cap body 9, the upper part of the protruding piece 47 is first twisted and the fragile portion 45 is broken. Since the centers of the axes of the legs 41 and the main body 9 are shifted from each other, and the legs 41 are inserted above the protruding pieces 47, when the main body 9 is further rotated, the protruding pieces 47 are formed. Since the distal end portion 4 3 moves while being tilted in the diagonal direction of the cap member main body portion 9, the broken portion is enlarged and a large communication port (opening 4) is provided between the medicine storage chamber 1 and the solution chamber 2. 5a) can be easily formed.

(Example 3)

Figures 9 to 13 show an example in which a female screw 52 is formed inside the leg 51 of the cap member 3, and this female screw 52 is screwed into a male screw 54 formed on the projecting piece 57. Is shown. The leg 51 is a hollow cylindrical member, and the female screw 52 formed therein is a single thread. At the bottom of the drug storage chamber 56, a solid protruding piece 57 is provided, which comes into contact with the thin film-shaped weakened portion 55 and protrudes toward the drug storage chamber 1, and the male screw 54 is formed around the protruding piece 57. Formed on the surface. The fragile part 55 and the bottom part 56 are integrally formed as a part of the medicine storage chamber 1. When assembling the fluid container, the cap member 3 is rotated so that the ftl screw 52 and the male screw 54 are engaged with each other, and as shown in FIG. Is held in a position that is almost horizontal.

In such a configuration, when the leg 51 is rotated by the cap body 9, the projecting piece 57 extends upward as the female screw 52 and the male screw 54 deepen. I'm pulled. Next, when the lower end of the leg 51 approaches the vicinity of the bottom 56 (FIG. 10), the female screw 52 reaches the end of the male screw 54 and the screwing of the screws 52 and 54 stops. You. At this time, the step 53 changes from a substantially horizontal state to a downwardly inclined state (see FIG. 13). Further, when the cap body 9 is rotated, the projecting piece 57 is twisted.

At this time, since the fragile portion 55 is pulled upward in the axial direction, the fragile portion 55 can be easily cut by twisting the protruding piece 57 (FIG. 12). ). Further, the cut-out protruding piece 57 is lifted upward by the rebound of the step 53 while being screwed into the female screw 52 inside the leg 51, so that the protruding piece 57 is located between the opening 55a. Space is created in Therefore, a relatively large communication port (opening 55a) can be formed between the medicine storage chamber 1 and the solution chamber 2, and the medicine and the solution can be mixed smoothly.

In order to make the infusion containers of Examples 1 to 3 self-supporting, it is preferable to use a stand 35 as shown in FIG. The stand 35 is attached to the knob of the holding member 33 by, for example, press-fitting.

As described above, in the present invention, the communication operation between the medicine storage chamber 1 and the solution chamber 2 can be achieved very easily by rotating the cap member or pressing the lid member or the solubility container. As described above, in the infusion container of the present invention, when the cap member is rotated at the mouth of the drug storage chamber, the fragile portion in contact with the projecting piece can be broken, so that the drug storage chamber and the solution chamber can be easily communicated. The drug and the dissolving solution can be mixed.

If the leg of the cap member is formed so as to be inserted into the protruding piece, the fragile portion can be reliably broken at once by simply rotating the cap member at the time of infusion.

If the leg portion of the cap member has a bulging portion and a contact portion that comes into contact with the bulging portion, the protruding piece covering the broken portion after the fragile portion is broken is moved. Therefore, a larger communication port can be formed between the medicine storage chamber and the solution chamber. Therefore, the mixing of the drug and the solution can be performed more easily.

If the main body and the leg of the cap member are formed so that their centers are shifted from each other, and the leg is inserted into the upper part of the protruding piece, the cap member is first rotated to rotate the protruding piece. The tip of the projection is twisted to break the fragile portion, and after the fragile portion is further broken, the tip of the protruding piece moves while being tilted in the tangential direction of the cap member main body. Therefore, the breaking portion can be enlarged, a larger communication port can be formed between the medicine storage chamber and the solution chamber, and the medicine and the solution can be easily mixed.

If a screw thread is formed between the leg of the cap member and the projecting piece, the projecting piece covering the broken portion after the fragile portion is broken is screwed to the leg of the cap member. And move it upward be able to. Therefore, a large communication port can be formed by the W of the medicine storage chamber and the dissolution liquid chamber, and the mixing of the medicine and the dissolution liquid can be easily performed.

If a desiccant and / or a deoxidizing agent is stored inside the main body of the cap member, the dry state of the drug denatured by moisture is maintained, and the oxidizable drug is prevented from changing over time. be able to.

If the dissolving solution chamber of the infusion container has a drug solution extracting portion at the lower end thereof, the drug solution obtained by mixing the drug and the dissolving solution can be easily taken out as an infusion solution.

If the medicine storage room of the infusion container has a self-supporting means for making the container self-supporting, the infusion container can be aligned and stored or put on standby, so that handling of the infusion container becomes easy.

According to the infusion container of the present invention, the integral molding is possible, so that not only the manufacturing process is simplified, but also a complicated structure for connecting the drug storage chamber and the solution chamber can be omitted. In addition, the number of parts can be reduced, so that an infusion container can be provided at low cost. In addition, transportation costs can be reduced and storage space can be easily secured. In addition, since glass vials and double-ended needles are not used, hands are not injured by mistake. In addition, since no glass or aluminum is used, there is no need for a separate operation when disposing the infusion container, thereby simplifying the disposal process.

(Example 4)

The ring fluid container 110 shown in FIGS. 15 and 16 is the drug storage chamber 1 0, a solution chamber 102, a capping member 103 installed in the solution storage chamber 101, and a chemical solution extraction section 104.

The medicine storage room 101 has a mouth 101 a at the upper end to which a cap member 103 can be attached, and a wide mouth having a fragile part 105 described later at the bottom 106. Container. The medicine storage chamber 101 is integrally molded of, for example, polyethylene resin.

The dissolving solution chamber 102 is formed in a liquid-tight bag form by laminating a transparent polyethylene resin sheet and fusing the edge portion 102a, and has sufficient flexibility. In the upper part of the solution chamber 102, an opening 102b connected to a boat 10lb formed at the lower end of the medicine storage chamber 101 is formed. At the lower end 102 a at the lower end of the solution chamber 102, a suspension hole 121 as a suspension support is formed. For example, the medicine storage chamber 101 and the dissolution liquid chamber 102 are bonded by heat welding the boat 101 b of the medicine storage chamber 101 and the mouth 102 b of the dissolution liquid chamber 102. Are concatenated. The medicine storage chamber 101 and the solution chamber 102 may be integrally molded with a resin. The medicine storage chamber 101 and the solution chamber 102 are connected in a liquid-tight manner. At the bottom 106, a solid, round-shaped protruding piece 107 projecting into the medicine storage chamber 101 in contact with the thin film-shaped weakened part 105 is provided at the center of the container. ing. The projecting piece 107 is formed integrally with the bottom 106 as a part of the medicine storage chamber 101 (FIGS. 16 and 17).

The cap member 103 is composed of a cap body 109 and its lid. And a leg portion 1 1 1 protruding inward from the outer peripheral portion 109 a, and a lower end portion engaging with the protruding piece 1 U 7. The cap main body 109 fits into the outer wall of the medicine storage room 101 at the lower part of the inner wall, and the mouth 101 a of the medicine storage room 101 is sealed so that it can rotate itself. ing. A notch hole 109 b through which a puncture needle connected to one end of the infusion device can pass is formed in the lid 109 a of the cap body 109. In addition, the upper surface of the lid portion 109 a has a flat surface that is self-supporting, and the infusion container 110 filled with a drug and a solution.

A rubber stopper 20 for hermetically sealing the medicine storage chamber 101 is inserted between the cap body 109 and the mouth 101a. At the approximate center of the rubber stopper 10, a recess 120 a that facilitates the penetration of the puncture needle is formed corresponding to the notch hole 109 b. The recessed part 120a is exposed at the cut-out hole 109b, but the cut-out hole 109b of the lid 109a is filmed so that the surface of the rubber stopper 120 is not contaminated. The film 109c is protected by removing the film 109c so that a concave portion 120a appears.

The leg portion 111 is a hollow member formed in a substantially cylindrical shape, and is connected to the lid portion 109 a and extends downward so as to store the drug deterioration preventing agent storage chamber 111 and the drug deterioration preventing agent storage room. It is composed of an engaging portion 111b extending further downward from the lower end of the chamber 111a. The lid at the upper end of the storage compartment 1 1 a is open and contains a desiccant and a deoxidizer. The engaging portion 111b is formed with a recess 112 corresponding to the projecting piece 107. Tip of protruding piece 107 The end is inserted into the recess 1 1 2 of the leg 1 1 1.

The drug deterioration preventing agent storage chamber 115 for storing a drug is formed by an inner peripheral surface of the cap body 109, a rubber layer 120, and a bottom 106. Moisture and oxygen permeating from the outside and the solution chamber into the drug filling section 1 15 are not stored in the desiccant filling section 1 1 la inside the non-airtight footprint 1 1 1 la. Adsorbed by chemicals and oxygen scavengers. The medicine storage room 101 fills the medicine filling section 115 with the medicine. The cap member 103 into which the rubber stopper 120 is inserted is fitted into the mouth part 10 ia, and then After storing the desiccant and oxygen scavenger inside the chemical-deterioration-prevention-agent storage chamber 111a, a cover film 109d is attached to the opening edge by heat welding or the like, and sealed.

When the leg portion 111 is rotated by the cap body 109 in use with such a configuration, first, the upper portion of the projecting piece 107 is twisted to break the fragile portion 105. Since the centers of the axes of the legs 111 and the main body 109 are shifted from each other, and the legs 111 are inserted into the upper part of the projecting piece 107, the main body 109 is further moved. When rotated, the upper part of the projecting piece 107 moves while being tilted in the tangential direction of the cap member main body. As a result, the broken portion is enlarged, and a large communication port (opening 105a) can be easily formed between the medicine storage chamber 101 and the dissolution liquid chamber 102.

After the medicine and the dissolution liquid are mixed by pressing the dissolution liquid chamber 102, the film 109c is peeled off, and a drip is injected into the notch hole 109b of the liquid discharge section 104. Insert the puncture needle connected to one end of the tool, pierce the rubber stopper 120, and then suspend the solution chamber 102

-2 When the hole 121 is hung on the stand, the drug solution obtained by mixing the drug and the dissolving solution can be taken out to the other end of the infusion device as a wheel solution ₍ note that the lid 109 a If the container 110 is free standing with its flat surface facing down, it can be aligned and stored or kept on standby.

Thus, in the above embodiment, the communication operation between the medicine storage chamber 101 and the solution chamber 102 can be achieved very easily by the rotation of the cap member 103.

The upper surface of the lid 109 a has a flat surface for self-supporting the container 110 filled with the drug and the dissolving solution, so that the infusion containers can be aligned and stored or put on standby. The handling of container 110 is considered to be acceptable.

Since the chemical solution take-out section 104 is formed integrally with the cap member 103, a separate step of attaching the chemical solution take-out section to the lower portion of the solution chamber by fusion or the like as in the related art is not required.

Further, it is not necessary to form the suspension support unit integrally with the cap member or to install the suspension support unit by bonding, and the container 111 can be formed simply by opening the hole 121 in the lower part of the solution chamber 102. O

As described above, in the infusion container of the present invention, when the cap member is rotated at the mouth of the drug storage chamber, the fragile portion in contact with the protruding piece can be broken, so that the drug storage chamber and the solution chamber are easily connected. The drug and the dissolving solution can be mixed.

If the leg of the cap member is formed so that it can be inserted into the protruding piece, the fragile portion can be reliably formed at once by simply rotating the cap member during use. Can be broken.

If the center of the leg of the cap member is formed so as to be offset from the center of the main body and the leg is inserted into the upper part of the protruding piece, the cap member is first rotated to rotate the protruding piece. After the upper part is twisted to break the fragile part and the fragile part is further broken, the tip of the protruding piece moves while being tilted in the tangential direction of the body of the cap member. Therefore, the broken portion can be enlarged, a larger communication port can be formed between the medicine storage chamber and the solution chamber, and the medicine and the solution can be easily mixed.

According to this invention, since the chemical solution take-out portion is formed integrally with the cap member, the step of separately attaching the chemical solution take-out portion to the lower portion of the solution chamber as in the related art is unnecessary. In addition, it is not necessary to integrally form or attach the hanging support section to the cap member, and it is not necessary to install the hanging support section at the lower part of the solution chamber, for example, by opening a hole for hanging, the container can be provided. Can be suspended and used for infusion.

According to the infusion container of the present invention, not only the manufacturing process is simplified, but also a complicated structure for connecting the drug storage chamber and the dissolution liquid chamber can be omitted and the number of parts can be reduced. A container for wheel fluid can be provided at low cost. In addition, transportation costs can be reduced and storage space can be easily secured.

In addition, since glass vials and double-ended needles are not used, hands are not injured by mistake. Furthermore, since no glass or aluminum is used, there is no need for sorting when disposing of the wheel fluid container. Therefore, disposal processing is simplified.

(Example 5)

The infusion device 210 shown in FIG. 18 and FIG. 19 is mainly composed of a medicine storage room 201, a dissolution solution room 202, a drip device 204, and an outer cylinder 205. ing.

The medicine storage room 201 has a mouth portion 201 a at the upper end to which a cap member 203 can be attached, and a wide mouth having a fragile portion 211 described later at the bottom portion 211. Container. The medicine storage chamber 201 and the dissolution liquid chamber 202 are cylindrical containers integrally molded with bolylene resin, and are formed with a thickness that does not easily deform when pressed from the outside. The bottom of the drug storage chamber 2 1 1, which connects the drug storage chamber 201 and the dissolution liquid chamber 202 in a liquid-tight manner, comes into contact with the thin film-shaped fragile portion 212 and protrudes toward the drug storage chamber 201. A hollow protruding piece 2 13 is provided. The fragile portion 2 12 and the protruding piece 2 13 are formed integrally with the bottom portion 211 as a part of the medicine storage chamber 201 (FIG. 20). The protruding pieces 2 13 are formed in a hexagonal column shape having a corner portion on the top surface. In the vicinity of the protruding piece 2 13, a solid contact portion 2 14 protruding from the bottom 2 11 is integrally formed with the bottom 206. The abutting portion 2 14 has a protruding portion 2 13 having a narrow end so that a protruding portion 2 18 described later abuts and one end of the abutting portion 2 14 does not come off between the protruding portion 2 13 and the abutting portion 2 14. It is installed obliquely to the axis of the protruding piece 2 13 to form a passage (Fig. 21).

The cap member 203 is composed of a cap body portion 215 and a leg portion 216 at a lower portion thereof which engages with the protruding piece 213. I have. The cap body 2 15 has a substantially T-shaped cross section, and its upper part is fitted to the outer wall of the medicine storage chamber 201 so that the cap itself can rotate. 0 1 The mouth 2 0 1a is sealed. The inside of the cap body 215 is hollow, is kept liquid-tight and non-hermetic, and contains a desiccant and an oxygen scavenger. Since the inside of the cap body 215 is kept liquid-tight, even if the medicine storage chamber 201 and the dissolution chamber 202 communicate with each other, the inside of the cap body 215 is dissolved. No lysate enters.

The leg portion 2 16 is a hollow member having a hexagonal cross section, and a concave portion 2 17 nested with the protruding piece 2 13 is formed at an inner lower end thereof. Further, a bulging portion 218 is formed at a lower end portion of the outer peripheral surface of the leg portion 216. The protruding piece 2 13 engages with the recess 2 17 when the leg 2 16 is rotated by the cap body 2 15 in the direction of the arrow in FIG. 21. After the fragile portion 2 12 is broken, the protruding piece 2 13 is moved in contact with the abutting portion 2 14 to move the protruding piece 2 13 away from the broken portion and dissolve with the drug. Has a function to facilitate mixing.

The medicine filling section 2 19 for accommodating a medicine is composed of an outer peripheral surface of the cap main body 2 15 and the legs 2 16 and an inner peripheral surface of the medicine storage chamber 201. Moisture and oxygen permeating from the outside and from the solution chamber 202 to the drug-filled part 219 are the desiccant stored inside the non-hermetic cap body 215 And adsorbed by oxygen scavenger. The cap main body 2 15 is provided with a desiccant or an oxygen scavenger therein, and a lid having a suspending tool 220 at an opening edge thereof. Attach body 220a by heat welding etc. _c Seal.

At the lower end of the dissolution liquid chamber 202, a wheel liquid outlet 2 21 capable of surrounding a drip device 204 described later is formed. For example, as shown in FIG. 19, a rubber 拴 223 having a thin film portion 222 in the center is attached to the infusion outlet 221 as shown in FIG. . The rubber 拴 2 23 supports the tip of a puncture needle 241, which will be described later, and protects the thin-film portion 222 from being pierced by the puncture needle 241 during storage. When the needle 202 is pushed into the outer cylinder 205, the puncture needle 241 penetrates the thin film part 222 of the rubber stopper 223, so that the drip device 224 dissolves. It is now connected to room 202.

The rubber stopper 223 may have no thin film part 222 in the center.

Further, instead of the rubber 22 3, a thin film portion may be provided in the ring fluid outlet 2 21 by resin molding integrally with the solution chamber 202.

As shown in Fig. 23, the drip device 204 has a puncture that can penetrate the thin film part 222 of the infusion outlet 2211 at the bottom of the solution chamber 202 as shown in Fig. 23. Needle 2 41, Cock 2 42 as a flow rate regulator, Tube 2 4 4 connected to Cock 2 4 2, Needle section 2 4 5, Filter 1 2 4 Consists of six.

The puncture needle 241 is a synthetic resin needle having one end fixed to the upper part of the cock 242. As the synthetic resin, a hard material such as high-density polyethylene, ABS resin, or polypropylene resin is preferable. As shown in Figure 24, the cock 2442 is formed by an opening / closing cock that can switch the internal port by turning the knob 247 to open and close the pipeline and adjust the infusion fluid flow in multiple stages. Have been. For example, the cock 242 shown in Fig. 24 can adjust the flow rate in three stages. The tube 244 is connected to the lower part of the cock 242. The tube 244 is a synthetic resin tube having a total length of about 1 m and having flexibility and transparency. Examples of soft synthetic resins include polyvinyl chloride, polyvinyl propylene, and teflon. Ron and polyethylene resins are preferred. One end of a needle portion 245 is connected to the other end of the tube 244 via a filter 246. The needle portion 245 has a fixed portion 249 at the lower end to which an intravenous needle 245 a to be inserted into the human body is fixed, and an upper end to which the other end of the tube 244 is fixed. Intravenous needle 2 45 a is covered with protective cap 250.

The filter 246 removes, during the infusion, fine particles that may be generated when the puncture needle 241 of the infusion device 204 is brought into contact with the medicine storage chamber 201 during the infusion described later. It is provided with a filter made of synthetic resin, which is provided to remove foreign substances of 1 micron or more. The infusion device 204 in which the puncture needle 241 is held in the infusion outlet 222 is stored in the outer cylinder 205 in an aseptic state.

The outer shell 205 is a cylindrical bottomed container integrally formed of a synthetic resin, and has a thickness that does not easily deform when pressed from the outside. The outer surface 205 is slidably fitted to the lower portion of the outer peripheral surface of the solution chamber 202, and the solution chamber 204 is housed with the drip device 204 stored therein. It can be attached to and detached from the lower outer peripheral surface of 202. As the synthetic resin, a hard resin such as polypropylene, polystyrene, high-density polyethylene, or polycarbonate resin is preferable.

The outer cylinder 205 is engaged with the solution chamber 202 so that the drip device 204 can be stored in an airtight manner. The outer cylinder 205 has a cock 2 for holding the tip of the puncture needle 241, in the vicinity of the thin film portion 222 of the rubber 拴 223 in the wheel fluid outlet 222. A part for fixing the members of the fixed seat 25 of the second and the other drip device 204 is formed (see FIG. 18). The intravenous needle 24 a covered with the protective cap 250 is formed by a recess 24 formed in a part of the outer periphery of the solution chamber 202 and a part of the upper end of the outer part 205. It is housed between the rising wall portion 25 2 rising upward from the upper side.

With such a configuration, when the cap main body 2 15 of the cap member 203 is rotated in the direction of the arrow in FIG. 4, the protrusion 2 16 rotates and engages with the leg 2 16. The piece 2 13 is twisted and the fragile portion 2 1 2 is broken. In addition, the bulging portion 2 18 comes into contact with the contact portion 2 14. The lever J is a projecting piece whose fulcrum is at the contact point between the bulging portion 2 18 and the contact portion 2 14. Acting on 2 13, the projecting piece 2 1 3 covering the break is moved, so that the opening 2 12 a of the fragile section 2 12 is widened (Fig. 2 2). 0 1 communicates with the solution chamber 202, and the solution and the solution are mixed by shaking with the solution chamber 2 up, whereby the solution is prepared as an infusion.

In addition, in the wheel fluid device of this embodiment, the swelling portion 2 18 and the contact portion 2 14 are provided, and the projecting piece 2 13 is moved in the radial direction. The opening 2 1 2a was widened, but the above-mentioned bulging portion 2 18 and contact portion 2 14 were omitted, and the hole of the leg 2 16 was simply rotated to protrude. A configuration in which the fragile portion 2 12 is broken by twisting 2 13 may be adopted.

Next, by pushing the solution chamber 202 into the outer circumference 205, the outer cylinder 205 slides on the outer peripheral surface of the lower part of the solution chamber 202, and is inserted into the outer circumference 205. The thin film part 2 2 2 of the rubber stopper 2 2 3 is pierced from the puncture needle 2 4 1 of the contained drip device 204, and the drip device 204 is aseptically communicated with the solution chamber 202. Infusion can be supplied (Fig. 25). This operation can be performed, for example, by simply standing the container on a desk with the bottom of the outer cylinder 205 facing down, and pressing the solution chamber 202 from above.

At the time of infusion, remove the outer cylinder 205 from the dissolution chamber 202, open the cock 242 contained in the outer cylinder, and attach the intravenous needle 245a of the drip device 204 to the patient. Intravenous injection is performed by inserting into a blood vessel. At this time, the infusion rate is adjusted by the cock 24. Since the liquid volume of the cock 242 is adjusted by switching the flow path, when the infusion device is stored before use, the tube 244 is pressed and blocked like a conventional flow control device. There is no loss of resilience. Even if fine particles generated when the infusion device 204 is put into the infusion are mixed, the fine particles can be removed by the filter 246.

In addition, since the outer cylinder 205 has a bottom and the wheel fluid device 210 can be made independent, a drip device is used for storing or waiting for containers. They can be lined up on their own.

As described above, in the present invention, the communication operation between the medicine storage chamber 201 and the solution chamber 202 can be achieved very easily by the rotation of the cap member 203. Also, the solution chamber 202 and the infusion device 204 are extremely easily communicated by pressing the solution chamber 202 against the outer cylinder 205.

As described above, in the wheel fluid device of the present invention, when the cap member is rotated, the weak portion in contact with the protruding piece can be broken, so that the medicine storage chamber and the solution chamber can be easily communicated, and the drug and the solution can be mixed. can do.

Furthermore, after mixing the drug and the dissolving solution, by displacing the outer cylinder with respect to the dissolving solution chamber, the puncture needle of the infusion device penetrates the stopper or thin film portion of the dissolving solution chamber. The connection of the infusion device is easily performed.

If the tube of the drip device can be communicated with the solution chamber by pushing the solution chamber into the outer cylinder, the connection of the drip device becomes easier.

If the infusion device has a cock that adjusts the liquid volume by switching a plurality of flow paths, the deformation and restoration failure of the pipeline due to the pressing of the pipeline do not occur as in the related art.

According to this infusion device, not only the manufacturing process can be simplified because it can be integrally molded, but also a complicated structure for connecting the drug storage chamber and the solution chamber can be omitted, and the number of parts can be reduced. Therefore, the infusion device can be provided at low cost. Also, transportation costs can be reduced and storage space can be easily secured. In addition, since glass vials and double-ended needles are not used, hands are not injured by mistake. Furthermore, since no glass or aluminum is used, there is no need for a separation operation when disposing the infusion device, thereby simplifying the disposal process.

In addition, the drip device is housed in the outer surface that engages with the lysis solution chamber, and by displacing the outer surface with respect to the lysis solution chamber, the puncture needle of the drip device is plugged into the lysis solution chamber or Since the thin film portion is pierced, the infusion device can be easily and aseptically connected to the solution chamber without injuring the hand.

(Example 6)

The infusion container 3 10 shown in FIG. 26 and FIG. 27 has a drug storage chamber 301, a dissolution liquid chamber 302, and a drug solution extraction section 304 mounted in the drug storage chamber 301. It is mainly composed of a cap member 303.

The medicine storage room 301 has a wide mouth having a mouth portion 301 a at the top end to which a cap member 303 can be attached, and a communication hole 300 to be described later at the bottom portion 303. Container. The medicine storage room 301 is integrally molded with polypropylene.

The dissolution solution chamber 302 is formed in a liquid-tight bag shape from transparent polypropylene or a copolymer sheet of polypropylene and polyethylene, and has sufficient interchangeability. In the upper part of the solution chamber 302, an opening 302b connected to a boat 301b formed at the lower end of the medicine storage chamber 301 is formed. In the lower part 302a of the lower end of the solution chamber 302, there is a hanging hole part 32 as a hanging support part. 1 is formed. The port 301 of the drug storage chamber 301 and the mouth 302 b of the solution chamber 302 are heat-welded, for example, to the drug storage chamber 301 and the solution chamber. 302 is concatenated. The medicine storage chamber 301 and the solution chamber 302 may be integrally molded.

The bottom of the drug storage chamber, which connects the drug storage chamber 301 and the solution chamber 302 in a liquid-tight manner, is connected to the drug storage chamber 301 and the solution chamber 302, respectively. A communication hole 305 is formed, and the communication hole 305 seals the communication hole 305 and has a solid, substantially conical projecting piece 307 projecting into the medicine storage chamber 301. Joined with the center X of the container shifted (eccentric). The protruding piece 307 is formed of a mixture of polyethylene and polypropylene, which are forming materials having poor compatibility with the borobrovirene, which is a material for forming the drug storage chamber 301, and Slightly more fragile than 301, but substantially formed integrally with the bottom portion 360 as a part of the medicine storage chamber 301 c For example, a preformed protruding piece 3007 is formed Attach it to the mold, then pour the resin in the medicine storage room 301 part, and make the bottom part 300 of the medicine storage room 301 and the protruding piece 307 as one part integrally connected. Can be molded. The size of the communication hole 305 is preferably 5 to 15 mm in diameter.

The cap member 303 fits with the outer wall of the medicine storage chamber 301 at the lower part of the inner wall, and itself seals the mouth 310 a of the medicine storage chamber 301 so as to be rotatable. . The lid portion 303 of the cap member 303 has a chemical solution outlet through which a puncture needle connected to one end of the infusion device can penetrate. Notched hole 303b is formed as shown in FIG. In addition, the upper surface of the lid portion 303 a has a flat surface for self-standing the wheel fluid container 310 filled with the drug and the dissolving solution.

The rubber member (plug) 320 of the cap member 303 is inserted into the mouth portion 301a of the medicine storage room 301 to make the medicine storage room 301 airtight. I have. At the approximate center of the rubber plug 320, a concave portion 320a for facilitating the penetration of the puncture needle is formed corresponding to the cutout hole 303b. The recesses 320a are exposed by the cutout holes 303b, but the cutout holes 303b are formed so that the surface of the rubber layer 320 is not contaminated. When the storage chamber 309 is removed, a concave portion 320a appears through the cutout hole 303b.

The lower surface of the rubber piece 320 has an engaging hole 320c which engages with the lower concave part 32Ob and the upper end part of the protruding piece 3107 for facilitating the penetration of the puncture needle. Are formed. Engagement hole diameter 2-5 m

ΙΏ

On the other hand, a chemical-deterioration preventing agent storage chamber 309 is connected to the lid part 303 a of the cap member 303 so as to cover it, and a desiccant (eg, silica gel) 310 a is provided inside. An oxygen scavenger (eg, activated iron oxide) 309 b is stored. In addition, 309 c is an upper lid of the storage room 309, and 309 d is a tension piece for removing the storage room 309 from the cap member 303.

The cap portion 303 has a lid portion 303 and a rubber member 320 which are provided with a thin tube portion 311 which contributes to the above. It is formed of polyethylene or polypropylene, and has a hydrophobic filter (for example, a sintered body of polypropylene) inserted underneath. The diameter of the tube is 1 to 3 mm.

The medicine filling section 3 15 for accommodating a medicine is substantially a space partitioned by a rubber stopper 3 20 and a medicine storage chamber 3 0 1. Moisture and oxygen permeating into the drug filling section 3 15 from the outside or the solution chamber are passed through the pipe section 3 1 1 1 which is kept non-hermetic by the water filter 3 1 a. It is adsorbed by the desiccant 309a and the oxygen scavenger 309b stored in the deterioration preventing agent storage room 309 to prevent the deterioration of the chemical.

The medicine storage room 301 fills the medicine filling part 3 15 with the medicine, and inserts the rubber stopper 3 20 of the cap member 303 into the opening 301 a to engage the hole 3. 20 c is engaged with the protruding piece 3 07, the cap (outer frame) 303 a of the cap member is fitted, and then the cap 303 a of the cap member and the rubber After attaching the thin tube section 311 through the stopper 3220 (the cap section 3103a and the rubber stopper 3200 have a thin section to allow the pipe section 311 to penetrate in advance. A hole is formed on the cap member 303 so as to cover the opening at the upper end of the tube part 311 and the cutout hole 303b of the cap member 303. Deterioration prevention agent storage room 309 is easily detachable by heat welding.

In this embodiment, the medicine alteration preventing agent storage chamber 309 is provided. However, it is not always necessary to provide the medicine depending on the type of the medicine stored in the medicine storage chamber 301, and the cap member 303 is provided in the cap member 303. Tensile piece 3 0 It is only necessary to provide an upper lid 309c with 9d.

With such a configuration, when the cap member 303 is rotated during use, the rubber member 320 is rotated accordingly, and the rubber stopper 3 is rotated.

The projecting piece 3 07 rotating through the engagement hole 3 2 0 c is twisted off from the bottom 3 0 6 of the drug storage chamber 3 0 1, and the drug storage chamber 3 0 1 and the solution chamber 3 0 A large communication hole 305 can be easily formed between the two (see FIG. 28 in particular).

Then, the solution is allowed to flow into the drug storage chamber 301 through the communication hole 305 by standing the medicine deterioration preventing agent storage chamber 309 side down or pressing the lysis liquid chamber 302. The drug and the solution are mixed. After that, the chemical-deterioration-prevention-agent storage chamber 309 is removed by its tension piece 310 d, the notch hole 303 b serving as the chemical solution discharge section 304 is opened, and it is connected to one end of the drip device.镜 Insert the puncture needle into the exposed rubber stopper 3 2 0 a 3 2 0 a, pierce the rubber stopper 3 2 0 a, and then hang the suspension hole 3 2 1 of the solution chamber 3 0 2. When placed on the infusion, the drug solution obtained by mixing the drug and the dissolving solution can be taken out to the other end of the infusion device as an infusion solution. In addition, the chemical deterioration preventing agent storage room 309 or the lid after removing this storage room

If the container 310 is made to stand by itself with the flat surface of 303a facing down, it can be aligned and stored or waited.

Thus, in the above embodiment, the communication operation between the medicine storage chamber 301 and the solution chamber 302 can be achieved very easily by the rotation of the cap member 303.

As described above, in the ring fluid container 310, the cap member 303 is used. When the mouth of the medicine storage chamber 301 rotates at the opening 301a, the rubber stopper 320 rotates with the rotation, and the protruding piece 3107 which engages with the engaging portion of the rubber 拴 3 The communication hole 300 can be opened by twisting it off from the bottom portion 303 of the storage room 301, whereby the medicine storage room 301 and the dissolution solution room 302 can be easily communicated, and the medicine and the solution Can be mixed.

As described above, according to this infusion container, the protruding piece seals the communication hole provided at the bottom of the medicine storage chamber, and the cap member is rotated by the cap member through the plug to rotate the plug. The projecting piece to be engaged is twisted off from the bottom to open the communication hole, so that the drug storage chamber and the solution chamber can communicate with each other to easily and aseptically provide an infusion.

If an engaging hole is formed as an engaging portion of the stopper, and the engaging hole and the projecting piece engaging with the engaging hole are formed eccentrically from the center of the medicine storage chamber, the cap can be used during use. The communication hole can be reliably opened at once by simply rotating the member.

According to this infusion container, since the drug solution take-out portion is formed in the cap member, a step of separately attaching the drug solution take-out portion to the lower portion of the solution chamber as in the related art is not required. In addition, it is not necessary to form the suspension support part integrally with the cap member or install it by bonding, and the container can be suspended simply by opening the suspension hole at the lower part of the solution chamber as the suspension support part. It can be used for ring fluid.

Furthermore, this annular fluid container not only simplifies the manufacturing process, but also has a complicated structure for connecting the drug storage chamber and the solution chamber. Can be omitted and the number of parts can be reduced, so that an infusion container can be provided at low cost. In addition, transportation costs can be reduced, and storage space can be easily secured.

In addition, since glass vials and double-ended needles are not used, hands are not accidentally hurt during sorting at the time of disposal. Furthermore, since no glass or aluminum is used, no separate operation is required when discarding the infusion container, so that disposal is simplified.

(Example 7)

Unlike Example 6 described above, as shown in Figs. 29 to 32, a projecting piece 3557 having a fan-shaped notch (or opening) 3557a Close the bottom 3 56 of the medicine storage chamber 3 5 1, and rotate the protruding piece 3 5 7, so that the notch 3 5 7 a It is also possible to overlap the pair of fan-shaped communication holes 35.5a and 3.55b formed in the bottom 35.6 of 1 to communicate the drug storage chamber 351 with the solution chamber 35.2 . Here, 357c and 357d are the tower-like portions of the projecting pieces 357, the ends of which are formed in the rubber plugs 370 of the cap member 353. 0 d · 370 e. Therefore, before use as shown in Fig. 29, the communication holes 3555a and 3555b are liquid-tightly closed by the bottom 3557e of the projecting piece 3557, but as shown in Fig. 31 The protruding piece 3557 rotates through the engagement hole 37 0d37 0e and the tower-like portion 357c However, as shown in FIG. 32, the communication holes 35 55 a · 35 55 b can be communicated with the notches 35 57 a · 35 57 b by being overlapped. The protruding piece 357 is a mixture of 10 to 30% of polypropylene resin and 90 to 70% of polyethylene resin, and the drug storage chamber 351 is a mixture of propylene resin. Each is molded at 100%, and both are resin-bonded (temporarily fixed) until the drug and the dissolving solution are mixed, ensuring the tightness of the communication holes 355a '355b ing. In addition, the fan-shaped communication holes 355a and 3555b formed in the bottom 3556 of the medicine storage chamber 3551 are formed to face each other at the center of the bottom 3556, and the center angles are all approximately equal. 90 °. On the other hand, the fan-shaped cutouts 35 7a and 35 7b formed at the bottom 35 7 e of the projecting piece 35 57 are the same as the communication holes 35 5 a and 35 55 b described above. It is formed in shape and arrangement.

As described above, the ring fluid containers shown in Figs. 29 to 32 have notches 35 7a and 35 57b in advance corresponding to the communication holes 35 5a-35 55b. The opening can be set large, so that the mixing of the drug and the dissolving solution is ensured in a short time. In addition, since little resin fragments are generated by twisting, it is possible to safely provide wheel fluid.

Furthermore, a semicircular opening 357f is formed as shown in Fig. 33 in place of the notch 3557a and 357b of the projecting piece 3557, and the bottom of the drug storage chamber is correspondingly formed. The pair of communication holes formed in the hole 356a may be a semicircular communication hole 355c.

As described above, according to this infusion container, the projecting piece seals the communication hole provided in the bottom of the medicine storage chamber, and engages with the body by rotating the lid of the cap member. Slide and rotate the protruding piece, As a result, the communication hole can be opened through the notch or opening formed in the protruding piece, so that the medicine storage chamber and the solution chamber can be reliably and quickly connected to each other in an easy, safe, and easy manner. An infusion can be provided aseptically.

Claims

The scope of the claims

1. A drug storage chamber, a cap member for sealing the mouth of the drug storage chamber, and a dissolution liquid chamber connected to the bottom of the drug storage chamber. A communication hole with the chamber; and a protruding piece that seals the communication hole and is movable so as to open the communication hole protruding into the medicine storage chamber.

The cap member has an engaging portion to be engaged with a tip end of the projecting piece, and the projecting piece is configured to be opened and moved to the communication hole by a rotation operation of the cap member. Characteristic infusion volume

2. The cap member is composed of a penetrable body and a lid part arbitrarily attached to the stopper body, and the body has an engaging portion that is engaged with the tip of the protruding piece. The infusion container according to claim 1.

3. The infusion container according to claim 1, wherein the communication hole comprises two axisymmetrically formed holes, and the projecting piece has a bottom portion that seals the holes so that the holes can be opened and moved.

4. The infusion container according to claim 1, wherein the communication hole comprises a single semicircular arc-shaped hole, and the projecting piece has a bottom portion for sealing the hole so that the hole can be opened and moved.

5. The bottom portion of the protruding piece has an opening or notch formed corresponding to the shape of the communication hole and opened to the communication hole by sliding movement accompanying rotation of the cap member. The volume for wheel fluid according to paragraph 3 or 4.

6. The projecting piece according to claim 1, wherein the projecting piece projects integrally into the medicine storage chamber して through a fragile portion that can be broken by a rotation operation of the cap member at a peripheral portion of the communication hole at the bottom of the medicine storage chamber. Container for wheel fluid.

7. The projecting piece is provided eccentrically from the center of the medicine storage chamber, and the engaging part is an engaging hole formed correspondingly on the bottom surface of the plug to engage the tip of the projecting piece. 2. The container for wheel fluid according to item 2.

8. The first claim, wherein the protruding piece is formed of a material having poor compatibility with the material forming the medicine storage chamber, and is welded to the communication hole so as to be able to be twisted off by rotating the cap member. Item.

9. The chemical storage chamber is mainly composed of polypropylene, and the protruding piece is mainly composed of a mixture of polyethylene and borobrovirene, a copolymer or graphitized polyethylene, and both are welded. Infusion container of clause 8.

10. The container for wheel fluid according to claim 6, wherein the cap member has a leg extending into the medicine storage chamber.

11. The container for annular fluid according to claim 10, wherein the protruding piece is engaged by inserting its tip into the leg of the cap member.

12. The lower part of the leg part has a bulging part on a part of the peripheral surface, and the medicine storage chamber bulges after the fragile part is broken by the rotation of the cap member at the bottom part. 2. The infusion container according to claim 1, further comprising: a contact portion capable of releasing and moving the protruding piece with respect to the communication hole in contact with the portion.

13. The wheel fluid container according to claim 12, wherein the legs are eccentric from the center of the lid.

1 4. The leg has a thread inside, and the protruding piece

- Four 10. The annular fluid container according to claim 10, further comprising a threaded screw portion screwed with said threaded portion, wherein said projecting piece is opened upward by rotating said cap member.

15. The cap member is provided with a drug-deterioration-preventing agent storage chamber detachably on its lid, and a pipe section that connects the drug-deterioration-preventing agent storage chamber and the drug storage chamber via a hydrophobic filter. 3. The wheel fluid container according to claim 2, wherein said container is provided with a plug penetrating therethrough.

16. The infusion container according to claim 15, wherein a desiccant and / or an oxygen scavenger is stored in the drug deterioration preventing agent storage chamber.

17. The container for wheel fluid according to claim 1, wherein the drug is stored in the drug storage chamber and the dissolving solution is stored in the dissolving solution chamber.

18. The container for infusion according to claim 1, wherein the cap member includes a self-standing means capable of holding the container in a self-standing state.

19. The infusion solution according to claim 1, wherein the solution chamber has a hanging support portion at its lower end capable of hanging with the cap member side down.

20. The infusion container according to claim 1, further comprising a transfusion taking-out portion having a thin-film portion or a body through which a lower end portion of the solution chamber can be pierced. A drip device having a needle portion at one end and a puncture needle at the other end capable of penetrating the body or thin film portion of the solution chamber; and storing the drip device, which can be displaceably attached to and detached from the solution chamber. The medicine storage chamber and the dissolution liquid chamber are communicated by rotating the cap member, and after mixing the medicine and the dissolution liquid, the dissolution is performed by displacing the dissolution liquid chamber with respect to the puncture needle of the drip device. Penetrate the body or thin film part of the liquid chamber An infusion device with a bottomed outer cylinder that enables it.

2 1. The outer cylinder is slidably engaged with the solution chamber, and after mixing the drug and the solution, the solution chamber is pushed into the outer cylinder, whereby the puncture needle of the drip device is moved to the thin film section of the solution chamber. 20. The wheel fluid device according to claim 20, wherein the body fluid penetrates the body.

22. The infusion solution according to claim 21, wherein the infusion device is provided with a cock for adjusting an amount of the liquid flowing through the conduit by switching a plurality of flow paths.