WO1996014368A1 - Colle biologique, procede de preparation et dispositif d'application pour colle biologique, et durcisseurs pour colle biologique - Google Patents
Colle biologique, procede de preparation et dispositif d'application pour colle biologique, et durcisseurs pour colle biologique Download PDFInfo
- Publication number
- WO1996014368A1 WO1996014368A1 PCT/FR1995/001420 FR9501420W WO9614368A1 WO 1996014368 A1 WO1996014368 A1 WO 1996014368A1 FR 9501420 W FR9501420 W FR 9501420W WO 9614368 A1 WO9614368 A1 WO 9614368A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- constituent
- gelatin
- aldehyde
- gelled
- weight
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/104—Gelatin
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J189/00—Adhesives based on proteins; Adhesives based on derivatives thereof
- C09J189/04—Products derived from waste materials, e.g. horn, hoof or hair
- C09J189/06—Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2666/00—Composition of polymers characterized by a further compound in the blend, being organic macromolecular compounds, natural resins, waxes or and bituminous materials, non-macromolecular organic substances, inorganic substances or characterized by their function in the composition
- C08L2666/02—Organic macromolecular compounds, natural resins, waxes or and bituminous materials
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2666/00—Composition of polymers characterized by a further compound in the blend, being organic macromolecular compounds, natural resins, waxes or and bituminous materials, non-macromolecular organic substances, inorganic substances or characterized by their function in the composition
- C08L2666/28—Non-macromolecular organic substances
Definitions
- Bio glue preparation process and application device for biological glue, and hardeners for biological glue.
- the present invention relates to biological adhesives based on gelatin and an aldehyde hardener, a process for preparing the biological adhesives and a device for their application, as well as hardeners for such adhesives.
- adhesives based on gelatin and resorcinol hardened by an aldehyde known under the name of GRA adhesives.
- GRF surgical glue gelatin resorcinol formaldehyde
- Gelatin was chosen in particular for its harmlessness and its hemostatic properties and moreover for its ability to react with certain so-called "hardener” aldehydes to form, by crosslinking, a sticky mass.
- Resorcinol moreover, makes it possible to reinforce the quality of this type of glue.
- GRF adhesives require on the part of the surgeon to spread the gelatin / resorcinol (GR) mixture on the dry surfaces of the organ to be bonded, then to spray, instill or deposit in small drops, using a syringe of the intradermal syringe type, the liquid hardener, stabilized aqueous solution of fonmaldehyde, on the spread GR mixture, and finally apply the glued surfaces one on the other (CNIMH file, November-December 1984, V .6).
- liquid hardener it is known to use aqueous solutions of formaldehyde, glutaraldehyde, glyceraldehyde, or mixtures thereof.
- the present invention relates to a biological adhesive comprising at least two constituents intended to be combined, for simultaneous, separate or spread over time,
- a semi-liquid constituent (A) comprising at least gelatin in aqueous solution
- constituent (B) gelled or not comprising at least one aldehyde, with the exception of non-gelled solutions of formaldehyde, glutaraldehyde or glyceraldehyde.
- the constituent (B) is gelled and the drawbacks presented above are avoided, according to the invention, because the hardening gels are easier to use than the hardening liquids and they avoid the risks of involuntary sprinkling and consequently necrosis and do not require the use of the same syringes.
- These adhesives apply to the bonding of human or animal tissues and in particular to the bonding of arteries and aortas.
- the first constituent (A) is usual in GRA adhesives; it is an aqueous gelatin solution, in semi-liquid form. It can contain from 5 to 20 g of gelatin, for 20 to 25 ml of distilled water. Usually, the semi-liquid component GR comprises approximately 15 g of gelatin for 20 ml of distilled water.
- the aqueous gelatin solution may also contain, mixed with gelatin, resorcinol or phloroglucinol.
- resorcinol usually, about 4 to 6 g of resorcinol can be used for 20 to 25 ml of water, and preferably, it can comprise about 5 g for about 15 g of gelatin and about 20 ml of water. Since the toxicity of resorcinol is not zero, it may be useful to have an adhesive containing little or none at all.
- the constituent (B) comprising the hardening aldehyde is in the form of a gel, preferably an aqueous gel.
- a gelling agent which can be used, mention may be made of all available, usual, biologically acceptable gelling agents which do not react with aldehydes.
- the gelling agents which can be used there may be mentioned in particular agar-agar, Karaya gum, silica powders, hydroxylated and carboxylated derivatives of cellulose, such as hydroxyethylcellulose, carboxy-methylcellulose and their mixtures.
- the preferred gelling agents are hydroxyethyl cellulose and carboxymethyl cellulose. These gelling agents are non-toxic.
- gelling agents are used in an amount of 0.5 to 4% by weight, preferably about 1.5 to 2% by weight in the aqueous gel.
- the aldehydes that can be used are chosen from officinal formaldehyde, glutaraldehyde, glyceraldehyde, succinic dialdehyde, sulfonyl-bis-acetaldehyde, octanedial-1,8, octene-4 dial-1,8 , oxy-bis-acetaldehyde, as well as mixtures of these aldehydes.
- the usual aldehydes are used in their usual concentrations for liquid hardeners, optionally as a mixture, as in liquid hardeners.
- the aldehydes succinic dialdehyde is preferred, the use of which as hardener for biological adhesives has not yet been described.
- This aldehyde is effective at very low concentrations, of the order of 5% by weight in the hardener, which has an advantage with regard to the toxicity of aldehydes.
- the succinic dialdehyde / glutaraldehyde mixtures (5 / 0.25) are preferred.
- the usual aldehyde concentrations in liquid hardeners can reach values of the order of 1 to 50% by weight of aldehydes and, for information, 1 to 40% by weight for glutaraldehyde, 1 to 50% by weight for l 'oxy-bis-acetaldehyde.
- succinic dialdehyde concentrations ranging from 1 to 40%, preferably around 5 to 20%, are provided.
- the gelling agent is optionally used, in aqueous solution, in proportions of the order of 1 to 5% by weight, preferably 2% by weight, this proportion depending, on the one hand, on the gelling agent used and, on the other hand, the viscosity of the semi-liquid constituent (A). Indeed, during application, it may be useful for the constituents (A) and (B) to have similar viscosities.
- the invention also relates to gelled aqueous solutions of these aldehydes or their mixtures, stabilized or not, useful in particular as a hardener for biological adhesives.
- the aldehyde gels obtained with these products are stable at room temperature for at least 1 year. Furthermore, the initial aldehyde content is maintained during this period.
- the invention also relates to the use of succinic dialdehyde as a hardener for biological adhesives.
- Biological adhesives which can be hardened by such a succinic dialdehyde, in aqueous solution or in gelled aqueous solution, comprise, on the one hand, a semi-liquid constituent comprising at least gelatin, and optionally resorcinol or phloroglucinol and , on the other hand, an aldehyde constituent, in liquid or gelled form, comprising, as hardener, at least succinic dialdehyde.
- the dialdehyde can optionally be mixed with another hardening aldehyde.
- this dialdehyde is particularly suitable for bonding the liver, lung, spleen, pericardium and kidney. Its effectiveness makes it possible to reduce the percentage of aldehyde used, and this up to approximately 5% by weight of aldehyde in the constituent (B).
- succinic dialdehyde biological adhesives the succinic dialdehyde, in the component (B) gelled or not, is used at concentrations ranging from approximately 1 to 40%, preferably 5 to 20% by weight.
- the present invention also relates to a process for the preparation of a biological glue, characterized in that a semi-liquid constituent (A) comprising at least gelatin in aqueous solution and, on the other hand, a constituent (B) gelled or not comprising at least one aldehyde, with the exception of aqueous solutions of formaldehyde, glutaraldehyde or glyceraldehyde.
- A semi-liquid constituent
- B constituent gelled or not comprising at least one aldehyde
- the two constituents are mixed just before use.
- the adhesive For the preparation of the adhesive, one proceeds by preparing, on the one hand, the semi-liquid constituent (A) by diluting the gelatin, possibly resorcinol, in distilled water and, on the other hand, by introducing the aldehyde and optionally the gelling agent in water.
- the semi-liquid constituent (A) by diluting the gelatin, possibly resorcinol, in distilled water and, on the other hand, by introducing the aldehyde and optionally the gelling agent in water.
- the component (A) is usually preheated to a temperature of the order of 28 to 40 °, in a water bath, preferably to a temperature of the order of 37 °.
- the aldehyde gels are used at room temperature, but can be used at temperatures of the order of human temperature, that is to say temperatures of the order of 28 to 40 °. .
- hardeners in the form of gel allows the use of a device of the syringe type with two bodies, or any other suitable means for mixing and dosing, in suitable proportion, the constituent (A) and the constituent (B) comprising the aldehyde chosen at the concentration most suitable for the type of bonding envisaged.
- the invention therefore relates to a device with two compartments, one of which comprises the constituent (A) and the other the constituent (B), as defined above.
- a suitable device is of the two-body syringe type, comprising, in one of its bodies, a component (A) comprising at least gelatin in aqueous solution and, in the other body, the component (B) gelled or not according to the present invention, comprising at least one aldehyde.
- a syringe with two bodies which allows the simultaneous application of the two components, or the mixing of the two components just at the outlet of the syringe.
- Bi-barrel syringes of this type are known in particular under the trade name "Duploject”.
- constituents (A) and (B) of similar viscosity are used.
- the biological adhesives prepared according to the invention have been shown to be particularly effective, in particular for aortic bonding, that of the pericardium, the lung, the liver, the spleen or the kidney.
- the adhesives of the invention can be used in bone, vascular, visceral and dental surgery.
- a GR paste is obtained by dissolving, in 20 to 25 ml of distilled water, kept in a water bath at 50 ° C, 20 g of a mixture of resorcinol and gelatin powder in respective proportions of 1/4 and 3/4. The proper consistency of the mixture is obtained in 30 minutes by mixing with a planetary type agitator which is handled slowly to avoid the formation of air bubbles.
- a preconditioned GR paste is used, coming from the gelatin-resorcinol-water mixture illustrated in Example 1, in a sterile tube ready for use, after heating for 5 to 10 minutes, in a sterile water bath at 45 ° C. .
- the mixture of constituents (A) and (B) is applied to the fabrics to be bonded and these fabrics are applied one on the other.
- Example 2 is repeated, but with a 5% aqueous solution of succinic dialdehyde, and without glutaraldehyde, as constituent (B).
- the mixture of constituents (A) and (B) is applied to the fabrics to be bonded and these fabrics are applied one on the other.
- Component (A) is identical to that of Example 1.
- An aqueous gel is prepared containing 36% by weight of formaldehyde and 4.5% by weight of succinic dialdehyde and 2% by weight of carboxymethylcellulose. The mixture is heated and stirred as in Example 1, to obtain the desired gel (B).
- the mixture of constituents (A) and (B) is applied to the fabrics to be bonded and these fabrics are applied one on the other.
- a layer of component (A) is applied to the fabrics to be bonded.
- the solution (B) is then injected into the layer of constituent (A).
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP95936614A EP0753033B1 (fr) | 1994-11-03 | 1995-10-27 | Colle chirurgicale, procede de preparation et dispositif d'application et de durcissement pour cette colle |
AU38480/95A AU3848095A (en) | 1994-11-03 | 1995-10-27 | Bioadhesive, method for preparing same and device for applying a bioadhesive, and hardening agents for a bioadhesive |
DE69528163T DE69528163T2 (de) | 1994-11-03 | 1995-10-27 | Chirurgischer klebstoff, verfahren zu deren herstellung, vorrichtung zur anwendung und härten dieses klebstoffes |
US08/860,769 US6007613A (en) | 1994-11-03 | 1995-10-27 | Bioadhesive; preparation procedure and device for the application of a bioadhesive; and hardeners for a bioadhesive |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR94/13136 | 1994-11-03 | ||
FR9413136A FR2726571B1 (fr) | 1994-11-03 | 1994-11-03 | Colle biologique, procede de preparation et dispositif d'application pour colle biologique, et durcisseurs pour colle biologique |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1996014368A1 true WO1996014368A1 (fr) | 1996-05-17 |
Family
ID=9468465
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR1995/001420 WO1996014368A1 (fr) | 1994-11-03 | 1995-10-27 | Colle biologique, procede de preparation et dispositif d'application pour colle biologique, et durcisseurs pour colle biologique |
Country Status (6)
Country | Link |
---|---|
US (1) | US6007613A (fr) |
EP (1) | EP0753033B1 (fr) |
AU (1) | AU3848095A (fr) |
DE (1) | DE69528163T2 (fr) |
FR (1) | FR2726571B1 (fr) |
WO (1) | WO1996014368A1 (fr) |
Cited By (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8834864B2 (en) | 2003-06-05 | 2014-09-16 | Baxter International Inc. | Methods for repairing and regenerating human dura mater |
US8940335B2 (en) | 2010-06-01 | 2015-01-27 | Baxter International Inc. | Process for making dry and stable hemostatic compositions |
US9005609B2 (en) | 2003-08-07 | 2015-04-14 | Ethicon, Inc. | Hemostatic compositions containing sterile thrombin |
US9039783B2 (en) | 2009-05-18 | 2015-05-26 | Baxter International, Inc. | Method for the improvement of mesh implant biocompatibility |
US9084728B2 (en) | 2010-06-01 | 2015-07-21 | Baxter International Inc. | Process for making dry and stable hemostatic compositions |
US9114172B2 (en) | 2006-08-02 | 2015-08-25 | Baxter International Inc. | Rapidly acting dry sealant and methods for use and manufacture |
US9162006B2 (en) | 2009-06-16 | 2015-10-20 | Baxter International Inc. | Hemostatic sponge |
US9265858B2 (en) | 2012-06-12 | 2016-02-23 | Ferrosan Medical Devices A/S | Dry haemostatic composition |
US9375505B2 (en) | 2010-04-07 | 2016-06-28 | Baxter International Inc. | Hemostatic sponge |
US9408945B2 (en) | 2010-06-01 | 2016-08-09 | Baxter International Inc. | Process for making dry and stable hemostatic compositions |
US9517287B2 (en) | 2009-12-16 | 2016-12-13 | Baxter International, Inc. | Hemostatic sponge |
US9533069B2 (en) | 2008-02-29 | 2017-01-03 | Ferrosan Medical Devices A/S | Device for promotion of hemostasis and/or wound healing |
US9724078B2 (en) | 2013-06-21 | 2017-08-08 | Ferrosan Medical Devices A/S | Vacuum expanded dry composition and syringe for retaining same |
US9821025B2 (en) | 2011-10-11 | 2017-11-21 | Baxter International Inc. | Hemostatic compositions |
US9833541B2 (en) | 2011-10-27 | 2017-12-05 | Baxter International Inc. | Hemostatic compositions |
US10111980B2 (en) | 2013-12-11 | 2018-10-30 | Ferrosan Medical Devices A/S | Dry composition comprising an extrusion enhancer |
US10322170B2 (en) | 2011-10-11 | 2019-06-18 | Baxter International Inc. | Hemostatic compositions |
US10653837B2 (en) | 2014-12-24 | 2020-05-19 | Ferrosan Medical Devices A/S | Syringe for retaining and mixing first and second substances |
US10918796B2 (en) | 2015-07-03 | 2021-02-16 | Ferrosan Medical Devices A/S | Syringe for mixing two components and for retaining a vacuum in a storage condition |
US11046818B2 (en) | 2014-10-13 | 2021-06-29 | Ferrosan Medical Devices A/S | Dry composition for use in haemostasis and wound healing |
US11109849B2 (en) | 2012-03-06 | 2021-09-07 | Ferrosan Medical Devices A/S | Pressurized container containing haemostatic paste |
US11801324B2 (en) | 2018-05-09 | 2023-10-31 | Ferrosan Medical Devices A/S | Method for preparing a haemostatic composition |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7883693B2 (en) | 1995-12-18 | 2011-02-08 | Angiodevice International Gmbh | Compositions and systems for forming crosslinked biomaterials and methods of preparation of use |
US6833408B2 (en) | 1995-12-18 | 2004-12-21 | Cohesion Technologies, Inc. | Methods for tissue repair using adhesive materials |
EP1704878B1 (fr) | 1995-12-18 | 2013-04-10 | AngioDevice International GmbH | Compositions de polyméres réticulés et leur procédé d'utilisation |
US6743248B2 (en) | 1996-12-18 | 2004-06-01 | Neomend, Inc. | Pretreatment method for enhancing tissue adhesion |
US20030191496A1 (en) | 1997-03-12 | 2003-10-09 | Neomend, Inc. | Vascular sealing device with microwave antenna |
US6371975B2 (en) | 1998-11-06 | 2002-04-16 | Neomend, Inc. | Compositions, systems, and methods for creating in situ, chemically cross-linked, mechanical barriers |
JP4205306B2 (ja) * | 1997-09-26 | 2009-01-07 | クリオライフ,インコーポレイティド | 縫合することなく生物接着剤を使用して吻合する技術及びそのための装置 |
US6994686B2 (en) | 1998-08-26 | 2006-02-07 | Neomend, Inc. | Systems for applying cross-linked mechanical barriers |
US6458147B1 (en) | 1998-11-06 | 2002-10-01 | Neomend, Inc. | Compositions, systems, and methods for arresting or controlling bleeding or fluid leakage in body tissue |
US7279001B2 (en) * | 1998-11-06 | 2007-10-09 | Neomend, Inc. | Systems, methods, and compositions for achieving closure of vascular puncture sites |
US6830756B2 (en) * | 1998-11-06 | 2004-12-14 | Neomend, Inc. | Systems, methods, and compositions for achieving closure of vascular puncture sites |
US6949114B2 (en) | 1998-11-06 | 2005-09-27 | Neomend, Inc. | Systems, methods, and compositions for achieving closure of vascular puncture sites |
US6899889B1 (en) * | 1998-11-06 | 2005-05-31 | Neomend, Inc. | Biocompatible material composition adaptable to diverse therapeutic indications |
US7923431B2 (en) | 2001-12-21 | 2011-04-12 | Ferrosan Medical Devices A/S | Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis |
US7648515B2 (en) * | 2002-04-16 | 2010-01-19 | Tyco Healthcare Group Lp | Method and apparatus for anastomosis including an expandable anchor |
US7135027B2 (en) | 2002-10-04 | 2006-11-14 | Baxter International, Inc. | Devices and methods for mixing and extruding medically useful compositions |
PL377477A1 (pl) | 2002-12-11 | 2006-02-06 | Ferrosan A/S | Materiały na bazie żelatyny jako waciki |
CA2554994C (fr) | 2004-01-30 | 2015-05-19 | Ferrosan A/S | Pulverisations et compositions hemostatiques |
CN101080246A (zh) | 2004-04-28 | 2007-11-28 | 安希奥设备国际有限责任公司 | 用于形成交联生物材料的组合物和系统及关联的制备方法与用途 |
US8021684B2 (en) | 2004-07-09 | 2011-09-20 | Ferrosan Medical Devices A/S | Haemostatic composition comprising hyaluronic acid |
CA2581093C (fr) | 2004-09-17 | 2014-11-18 | Angiotech Biomaterials Corporation | Composes multifonctionels pour la formation de biomateriaux reticules et leurs procedes de preparation et d'utilisation |
DE102006033168A1 (de) * | 2006-07-10 | 2008-01-17 | Gelita Ag | Verwendung von Gelatine und einem Vernetzungsmittel zur Herstellung einer vernetzenden therapeutischen Zusammensetzung |
DE102006033167A1 (de) * | 2006-07-10 | 2008-01-24 | Gelita Ag | Verwendung von Gelatine und einem Vernetzungsmittel zur Herstellung eines vernetzenden medizinischen Klebers |
US8133484B2 (en) * | 2006-12-15 | 2012-03-13 | Lifebond Ltd | Hemostatic materials and dressing |
CN102552967B (zh) * | 2006-12-15 | 2015-08-12 | 生命连结有限公司 | 明胶-转谷氨酰胺酶止血敷料和密封材料 |
WO2009153751A2 (fr) * | 2008-06-18 | 2009-12-23 | Lifebond Ltd | Procédé de réticulation enzymatique d'une protéine |
WO2009153748A2 (fr) * | 2008-06-18 | 2009-12-23 | Lifebond Ltd | Procédés et dispositifs à utiliser pour des matières de scellement |
CN104031393B (zh) | 2008-06-18 | 2017-08-01 | 生命连结有限公司 | 改进的交联组合物 |
US20100256671A1 (en) * | 2009-04-07 | 2010-10-07 | Biomedica Management Corporation | Tissue sealant for use in noncompressible hemorrhage |
WO2011077388A1 (fr) | 2009-12-22 | 2011-06-30 | Lifebond Ltd | Modification d'agents de réticulation enzymatiques pour la maîtrise des propriétés des matrices réticulées |
EP2600910B1 (fr) | 2010-08-05 | 2016-01-20 | Lifebond Ltd | Pansements et adhésifs contenant des compositions sèches |
WO2019003206A1 (fr) | 2017-06-30 | 2019-01-03 | Universidad De Los Andes | Biomatières comprenant de la gélatine dérivée d'espèces aquatiques adaptées au froid |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR620957A (fr) * | 1926-09-01 | 1927-05-03 | John Broadfoot & Sons Ltd Soc | Procédé d'assemblage de matériaux bruts ou ouvrés et nouveaux produits industriels qui en résultent |
US4187119A (en) * | 1976-05-13 | 1980-02-05 | Service D'exploitation Industrielle Des Tabacs Et Des Allumettes | Glue for articles in the tobacco industry |
WO1993004711A1 (fr) * | 1991-09-05 | 1993-03-18 | Beth Israel Hospital | Adhesion de tissus biologiques |
JPH0670972A (ja) * | 1992-06-30 | 1994-03-15 | Nippon B X I Kk | 生体組織接着用組成物及びその使用法 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3758660A (en) * | 1971-10-15 | 1973-09-11 | Avicon Inc | Method of forming structures from microcrystalline collagen |
US3917862A (en) * | 1974-04-08 | 1975-11-04 | Tee Pak Inc | Method for patching edible artificial collagen sausage casings |
US4292028A (en) * | 1979-07-13 | 1981-09-29 | Arthur Barr | Cosmetic breath freshener and palate coolant composition and method of use |
US4329333A (en) * | 1980-11-24 | 1982-05-11 | Arthur Barr | Method for the oral treatment of dogs and other animals |
US4394370A (en) * | 1981-09-21 | 1983-07-19 | Jefferies Steven R | Bone graft material for osseous defects and method of making same |
JPS61122222A (ja) * | 1984-11-19 | 1986-06-10 | Koken:Kk | コラ−ゲン又はゼラチンとプロタミンとよりなる止血剤 |
US5336616A (en) * | 1990-09-12 | 1994-08-09 | Lifecell Corporation | Method for processing and preserving collagen-based tissues for transplantation |
US5129882A (en) * | 1990-12-27 | 1992-07-14 | Novoste Corporation | Wound clotting device and method of using same |
CA2089487A1 (fr) * | 1991-06-14 | 1992-12-15 | Suk-Zu Song | Presentation du produit par pellicule de collagene pour proteines |
NL9101051A (nl) * | 1991-06-18 | 1993-01-18 | Ashridge Ag | Sluitinrichting voor een bloedvat of dergelijke. |
DK0591392T3 (da) * | 1991-06-21 | 1996-09-30 | Genetics Inst | Farmaceutiske formuleringer af osteogene proteiner |
WO1993021844A1 (fr) * | 1992-04-23 | 1993-11-11 | Scimed Life Systems, Inc. | Appareil et procede pour obturer des ponctions vasculaires |
US5385606A (en) * | 1992-07-06 | 1995-01-31 | Kowanko; Nicholas | Adhesive composition and method |
US5607590A (en) * | 1993-08-06 | 1997-03-04 | Shimizu; Yasuhiko | Material for medical use and process for preparing same |
JPH09122227A (ja) * | 1995-10-31 | 1997-05-13 | Bio Eng Lab:Kk | 医用材料およびその製造方法 |
US5755778A (en) * | 1996-10-16 | 1998-05-26 | Nitinol Medical Technologies, Inc. | Anastomosis device |
-
1994
- 1994-11-03 FR FR9413136A patent/FR2726571B1/fr not_active Expired - Fee Related
-
1995
- 1995-10-27 AU AU38480/95A patent/AU3848095A/en not_active Abandoned
- 1995-10-27 DE DE69528163T patent/DE69528163T2/de not_active Expired - Lifetime
- 1995-10-27 WO PCT/FR1995/001420 patent/WO1996014368A1/fr active IP Right Grant
- 1995-10-27 EP EP95936614A patent/EP0753033B1/fr not_active Expired - Lifetime
- 1995-10-27 US US08/860,769 patent/US6007613A/en not_active Expired - Lifetime
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR620957A (fr) * | 1926-09-01 | 1927-05-03 | John Broadfoot & Sons Ltd Soc | Procédé d'assemblage de matériaux bruts ou ouvrés et nouveaux produits industriels qui en résultent |
US4187119A (en) * | 1976-05-13 | 1980-02-05 | Service D'exploitation Industrielle Des Tabacs Et Des Allumettes | Glue for articles in the tobacco industry |
WO1993004711A1 (fr) * | 1991-09-05 | 1993-03-18 | Beth Israel Hospital | Adhesion de tissus biologiques |
JPH0670972A (ja) * | 1992-06-30 | 1994-03-15 | Nippon B X I Kk | 生体組織接着用組成物及びその使用法 |
Non-Patent Citations (2)
Title |
---|
DATABASE WPI Week 9415, Derwent World Patents Index; AN 123366 * |
PATENT ABSTRACTS OF JAPAN vol. 18, no. 316 (C - 1213) 16 June 1994 (1994-06-16) * |
Cited By (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8834864B2 (en) | 2003-06-05 | 2014-09-16 | Baxter International Inc. | Methods for repairing and regenerating human dura mater |
US9005609B2 (en) | 2003-08-07 | 2015-04-14 | Ethicon, Inc. | Hemostatic compositions containing sterile thrombin |
US9114172B2 (en) | 2006-08-02 | 2015-08-25 | Baxter International Inc. | Rapidly acting dry sealant and methods for use and manufacture |
US9533069B2 (en) | 2008-02-29 | 2017-01-03 | Ferrosan Medical Devices A/S | Device for promotion of hemostasis and/or wound healing |
US9993298B2 (en) | 2009-05-18 | 2018-06-12 | Baxter International Inc. | Method for the improvement of mesh implant biocompatibility |
US9039783B2 (en) | 2009-05-18 | 2015-05-26 | Baxter International, Inc. | Method for the improvement of mesh implant biocompatibility |
US9162006B2 (en) | 2009-06-16 | 2015-10-20 | Baxter International Inc. | Hemostatic sponge |
US9517287B2 (en) | 2009-12-16 | 2016-12-13 | Baxter International, Inc. | Hemostatic sponge |
US11478566B2 (en) | 2010-04-07 | 2022-10-25 | Baxter International Inc. | Hemostatic sponge |
US9375505B2 (en) | 2010-04-07 | 2016-06-28 | Baxter International Inc. | Hemostatic sponge |
US10441674B2 (en) | 2010-04-07 | 2019-10-15 | Baxter International Inc. | Hemostatic sponge |
US8940335B2 (en) | 2010-06-01 | 2015-01-27 | Baxter International Inc. | Process for making dry and stable hemostatic compositions |
US9084728B2 (en) | 2010-06-01 | 2015-07-21 | Baxter International Inc. | Process for making dry and stable hemostatic compositions |
US9408945B2 (en) | 2010-06-01 | 2016-08-09 | Baxter International Inc. | Process for making dry and stable hemostatic compositions |
US10994045B2 (en) | 2010-06-01 | 2021-05-04 | Baxter International Inc. | Process for making dry and stable hemostatic compositions |
US10245348B2 (en) | 2010-06-01 | 2019-04-02 | Baxter International Inc. | Process for making dry and stable hemostatic compositions |
US9821025B2 (en) | 2011-10-11 | 2017-11-21 | Baxter International Inc. | Hemostatic compositions |
US10322170B2 (en) | 2011-10-11 | 2019-06-18 | Baxter International Inc. | Hemostatic compositions |
US9833541B2 (en) | 2011-10-27 | 2017-12-05 | Baxter International Inc. | Hemostatic compositions |
US11109849B2 (en) | 2012-03-06 | 2021-09-07 | Ferrosan Medical Devices A/S | Pressurized container containing haemostatic paste |
US9265858B2 (en) | 2012-06-12 | 2016-02-23 | Ferrosan Medical Devices A/S | Dry haemostatic composition |
US10799611B2 (en) | 2012-06-12 | 2020-10-13 | Ferrosan Medical Devices A/S | Dry haemostatic composition |
US9999703B2 (en) | 2012-06-12 | 2018-06-19 | Ferrosan Medical Devices A/S | Dry haemostatic composition |
US10595837B2 (en) | 2013-06-21 | 2020-03-24 | Ferrosan Medical Devices A/S | Vacuum expanded dry composition and syringe for retaining same |
US9724078B2 (en) | 2013-06-21 | 2017-08-08 | Ferrosan Medical Devices A/S | Vacuum expanded dry composition and syringe for retaining same |
US10111980B2 (en) | 2013-12-11 | 2018-10-30 | Ferrosan Medical Devices A/S | Dry composition comprising an extrusion enhancer |
US11103616B2 (en) | 2013-12-11 | 2021-08-31 | Ferrosan Medical Devices A/S | Dry composition comprising an extrusion enhancer |
US11046818B2 (en) | 2014-10-13 | 2021-06-29 | Ferrosan Medical Devices A/S | Dry composition for use in haemostasis and wound healing |
US10653837B2 (en) | 2014-12-24 | 2020-05-19 | Ferrosan Medical Devices A/S | Syringe for retaining and mixing first and second substances |
US10918796B2 (en) | 2015-07-03 | 2021-02-16 | Ferrosan Medical Devices A/S | Syringe for mixing two components and for retaining a vacuum in a storage condition |
US11801324B2 (en) | 2018-05-09 | 2023-10-31 | Ferrosan Medical Devices A/S | Method for preparing a haemostatic composition |
Also Published As
Publication number | Publication date |
---|---|
EP0753033A1 (fr) | 1997-01-15 |
EP0753033B1 (fr) | 2002-09-11 |
FR2726571B1 (fr) | 1997-08-08 |
FR2726571A1 (fr) | 1996-05-10 |
DE69528163T2 (de) | 2003-04-30 |
US6007613A (en) | 1999-12-28 |
DE69528163D1 (de) | 2002-10-17 |
AU3848095A (en) | 1996-05-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0753033B1 (fr) | Colle chirurgicale, procede de preparation et dispositif d'application et de durcissement pour cette colle | |
EP1409033B1 (fr) | Adhesif renfermant un medicament | |
CN1075952C (zh) | 粘合剂组合物及其用法 | |
CA2344222C (fr) | Mousse proteique adhesive a usage chirurgical et/ou therapeutique | |
EP0843562B1 (fr) | Composition pour bio-materiau, procede de preparation | |
KR920003599B1 (ko) | 접착 촉진용 조성물 | |
EP0984902B1 (fr) | Procede de preparation d'un biomateriau a base d'hydroxyapatite, biomateriau obtenu et application chirurgicale ou dentaire | |
FR2653338A1 (fr) | Formulation pour des pansements a liberation prolongee de medicament et son utilisation. | |
EP0107526B1 (fr) | Pâte pour la protection de la peau | |
IE47606B1 (en) | Absorbable hemostatic composition | |
FR2479089A1 (fr) | Bande ou feuille adhesive autocollante contenant de la nitroglycerine et leurs procedes de preparation | |
FR2695311A1 (fr) | Support orthodontique plastique avec couche primaire adhésive et procédés de fabrication. | |
CH650405A5 (fr) | Produit pharmaceutique moule. | |
CA2401573C (fr) | Procede de preparation d'un materiau pateux phosphocalcique injectable | |
US4781913A (en) | Pharmaceutical composition for use in desensitizing hypersensitive dentin | |
Finger et al. | Does application of phase-separated self-etching adhesives affect bond strength? | |
FR2606022A1 (fr) | Composition adhesive liquide a un seul composant a base d'un phosphate et d'un monomere a insaturation ethylenique et son utilisation dans l'art dentaire | |
FR2805747A1 (fr) | Procede de preparation d'un materiau pateux phosphocalcique injectable en vue de former un biomateriau apatitique et application chirurgicale ou dentaire | |
AT509474B1 (de) | Haftmittel für zahnprothesen | |
FR2467873A1 (fr) | Pate adhesive protectrice pour utilisation dans les appareils d'ostomie | |
EP2788039B1 (fr) | Ciments polymeres pour la fixation de protheses, la reparation osseuse et la vertebroplastie obtenus a partir de formulations monophasiques liquides. | |
Aljifan et al. | An Overview of Dentin Conditioning and Its Effect on Bond Strength | |
EP3004216B1 (fr) | Procédé de préparation d'un polyamide ester de gélatine | |
FR2754267A1 (fr) | Procede de reticulation de collagene ou de gelatine a l'aide d'un polyaldehyde macromoleculaire et composition adhesive | |
FR2684003A1 (fr) | Formulation malleable implantable biodegradable avec phosphate de calcium. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AM AU BB BG BR BY CA CN CZ EE FI GE HU IS JP KG KP KR KZ LK LR LT LV MD MG MN MX NO NZ PL RO RU SG SI SK TJ TM TT UA US UZ VN |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): KE LS MW SD SZ UG AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 1995936614 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 1995936614 Country of ref document: EP |
|
NENP | Non-entry into the national phase |
Ref country code: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 08860769 Country of ref document: US |
|
WWG | Wipo information: grant in national office |
Ref document number: 1995936614 Country of ref document: EP |