WO1996007318B1 - Systeme de tampons ameliorant le rendement de seroconversion - Google Patents
Systeme de tampons ameliorant le rendement de seroconversionInfo
- Publication number
- WO1996007318B1 WO1996007318B1 PCT/US1995/011462 US9511462W WO9607318B1 WO 1996007318 B1 WO1996007318 B1 WO 1996007318B1 US 9511462 W US9511462 W US 9511462W WO 9607318 B1 WO9607318 B1 WO 9607318B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- deantigenation
- efficiency
- seroconversion
- erythrocytes
- increasing
- Prior art date
Links
- 239000007853 buffer solution Substances 0.000 title abstract 2
- 210000003743 Erythrocytes Anatomy 0.000 claims abstract 3
- UIIMBOGNXHQVGW-UHFFFAOYSA-M buffer Substances [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims abstract 3
- 210000004369 Blood Anatomy 0.000 claims abstract 2
- 239000008280 blood Substances 0.000 claims abstract 2
- 102000005840 alpha-Galactosidase Human genes 0.000 claims 2
- 108010030291 alpha-Galactosidase Proteins 0.000 claims 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K 2qpq Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- 241000723377 Coffea Species 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- 229920001850 Nucleic acid sequence Polymers 0.000 claims 1
- 210000004027 cells Anatomy 0.000 claims 1
- 238000000684 flow cytometry Methods 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
Abstract
Procédé permettant d'améliorer le rendement de désantigénation d'épitopes de groupe sanguin sur les érythrocites (séroconversion) par les exoglycosidases en procédant à ladite désantigénation dans un tampon zwitterionique. Le procédé recourt à un système de tampons et d'exoglycosidase tel que la masse totale des enzymes se trouve réduite dans un rapport de 1/20 à 1/100 par rapport aux techniques antérieures.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU36291/95A AU3629195A (en) | 1994-09-08 | 1995-09-07 | Buffer system for increasing seroconversion efficiency |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/303,156 US5633130A (en) | 1994-09-08 | 1994-09-08 | Buffer system for increasing seroconversion efficiency |
| US08/303,156 | 1994-09-08 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1996007318A1 WO1996007318A1 (fr) | 1996-03-14 |
| WO1996007318B1 true WO1996007318B1 (fr) | 1996-05-09 |
Family
ID=23170766
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1995/011462 WO1996007318A1 (fr) | 1994-09-08 | 1995-09-07 | Systeme de tampons ameliorant le rendement de seroconversion |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US5633130A (fr) |
| AU (1) | AU3629195A (fr) |
| WO (1) | WO1996007318A1 (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998021944A1 (fr) * | 1996-11-21 | 1998-05-28 | New York Blood Center | Methode pour convertir le type sanguin |
| DE69834397T2 (de) * | 1997-05-20 | 2007-06-06 | Zymequest, Inc., Beverly | Vorrichtung zum Austreiben von Fluiden |
| US6630339B1 (en) * | 2000-08-04 | 2003-10-07 | The Curators Of The University Of Missouri | Glycine and phaseolus α-D-galactosidases |
| US7767415B2 (en) * | 2001-09-25 | 2010-08-03 | Velico Medical, Inc. | Compositions and methods for modifying blood cell carbohydrates |
| EP1524989B1 (fr) | 2002-08-01 | 2013-11-06 | Yeda Research And Development Co., Ltd. | Methode et composition pour la protection du tissu neuronal contre une lesion induite par des taux de glutamate eleves |
| EA011481B1 (ru) * | 2003-02-17 | 2009-04-28 | Коуд Биотек Лимитид | Эритроциты, имеющие ферментативно уменьшенный уровень экспрессии антигена группы крови системы аво, способ их получения и применение |
| EP2502491B1 (fr) * | 2005-10-31 | 2017-05-10 | Velico Medical, Inc. | Nouvelles a-galactosidases |
| EP2502492A3 (fr) | 2005-10-31 | 2012-12-19 | Velico Medical, Inc. | Nouvelles a-galactosidases |
| US11162079B2 (en) | 2019-05-10 | 2021-11-02 | The Regents Of The University Of California | Blood type O Rh-hypo-immunogenic pluripotent cells |
| WO2020263880A1 (fr) | 2019-06-26 | 2020-12-30 | The Regents Of The University Of California | Cellules tueuses naturelles (nk) à fonction sirp alpha inactivée |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4330619A (en) * | 1980-08-14 | 1982-05-18 | New York Blood Center, Inc. | Enzymatic conversion of red cells for transfusion |
| US4427777A (en) * | 1980-08-14 | 1984-01-24 | New York Blood Center, Inc. | Enzymatic conversion of red cells for transfusion |
| US4407961A (en) * | 1981-03-16 | 1983-10-04 | Sanders James L | Ion-exchange system and method for isolation and determination of glycosylated hemoglobin in human blood |
| US4609627A (en) * | 1983-08-01 | 1986-09-02 | New York Blood Center, Inc. | Enzymatic conversion of certain sub-type A and AB erythrocytes |
| US4965203A (en) * | 1987-01-28 | 1990-10-23 | Warner-Lambert Company | Purified thrombin preparations |
-
1994
- 1994-09-08 US US08/303,156 patent/US5633130A/en not_active Expired - Lifetime
-
1995
- 1995-09-07 WO PCT/US1995/011462 patent/WO1996007318A1/fr active Application Filing
- 1995-09-07 AU AU36291/95A patent/AU3629195A/en not_active Abandoned
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