WO1995021637A1 - Membrane aux proprietes antivirales - Google Patents

Membrane aux proprietes antivirales

Info

Publication number
WO1995021637A1
WO1995021637A1 PCT/GB1995/000194 GB9500194W WO9521637A1 WO 1995021637 A1 WO1995021637 A1 WO 1995021637A1 GB 9500194 W GB9500194 W GB 9500194W WO 9521637 A1 WO9521637 A1 WO 9521637A1
Authority
WO
WIPO (PCT)
Prior art keywords
membrane
fullerene
coating
layers
langmuir
Prior art date
Application number
PCT/GB1995/000194
Other languages
English (en)
Inventor
Michael Charles Petty
Martin Robert Bryce
Geoffrey Williams
Original Assignee
British Technology Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Technology Group Limited filed Critical British Technology Group Limited
Publication of WO1995021637A1 publication Critical patent/WO1995021637A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2604/00—Fullerenes, e.g. C60 buckminsterfullerene or C70

Definitions

  • This invention relates to a membrane with anti-viral properties, to a method of imparting anti-viral properties to a membrane, and to products such as surgical gloves and condoms made of such a membrane, which itself may typically be of rubber, such as latex rubber, or polyurethane.
  • products such as surgical gloves and condoms made of such a membrane, which itself may typically be of rubber, such as latex rubber, or polyurethane.
  • An important virus whose activity it would be appropriate to curb with such products is the human immuno-deficiency virus HIV.
  • a membrane of for example polyurethane or rubber, e.g. latex rubber, according to the invention carries a coating of from one to ten, preferably 1 or 2, layers of one or more fullerenes.
  • the fullerene(s) may be applied by way of dispersion in a gel or lubrication layer, applied conventionally to the membrane, or as follows.
  • a method of coating a membrane comprises applying one or more Langmuir-Blodgett coatings of fullerene to the membrane.
  • the fullerene may be dissolved in an aromatic and/or hydrophobic compound on a hydrophilic (e.g. water) subphase.
  • the fullerene may be codissolved with a phospholipid or fatty acid, e.g. arachidic acid, in a mole proportion of 1 :(1-10) and/or may be substituted with alkyl chains C j -C j g or with functionalised chains containing amine, hydroxyl or carboxy lie acid groups, e.g. may be 1 -tertbutyl- 1.9-dihydrofullerene-60.
  • the invention extends to products such as surgical gloves and condoms made of a membrane which has a coating as set forth above.
  • a Langmuir-Blodgett trough of a constant perimeter design of floating boom was housed in a microelectronics-grade clean room.
  • the subphase in the trough was ultra-pure water (pH 5.7 ⁇ 0.1, temperature 20 ⁇ 2°C) obtained by reverse osmosis, deionization and
  • This arrangement is believed to be of vertically aligned fatty acid molecules in a close-packed ordered arrangement on the subphase (water) surface, with the fullerene molecules on tog. This arrangement is transferred "as is” to a solid substrate dipped into the Langmuir-Blodgett trough.
  • a substrate When a substrate is dipped into the trough and removed, it may have adhering to it a layer of aligned molecules which became attached: on the downstroke only (X-type deposition), on the downstroke and again on the upstroke (Y-type deposition), or on the upstroke only (Z-type deposition).
  • the thoroughness or efficiency of deposition is measured by the deposition ratio, defined as (change in enclosed surface area of trough)/(dipped area of substrate).

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nanotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Composite Materials (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Application Of Or Painting With Fluid Materials (AREA)

Abstract

L'invention se rapporte à un procédé consistant à appliquer un revêtement Langmuir-Blodgett d'une part molaire de fullerène C60 et de 4 parts molaires d'acide arachidique sur un préservatif de caoutchouc de latex afin de conférer à celui-ci des propriétés antivirales.
PCT/GB1995/000194 1994-02-10 1995-01-31 Membrane aux proprietes antivirales WO1995021637A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9402581.4 1994-02-10
GB9402581A GB9402581D0 (en) 1994-02-10 1994-02-10 Membrane with anti-viral properties

Publications (1)

Publication Number Publication Date
WO1995021637A1 true WO1995021637A1 (fr) 1995-08-17

Family

ID=10750183

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1995/000194 WO1995021637A1 (fr) 1994-02-10 1995-01-31 Membrane aux proprietes antivirales

Country Status (2)

Country Link
GB (1) GB9402581D0 (fr)
WO (1) WO1995021637A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000044357A2 (fr) * 1999-01-29 2000-08-03 Max-Delbrück-Centrum für Molekulare Medizin Moyen pour prevenir des restenoses intra-stent et des infections post-operatoires
EP1039944A1 (fr) * 1997-12-19 2000-10-04 Cordis Corporation Systeme de catheter avec fullerenes et procede associe
WO2015068174A2 (fr) 2013-11-11 2015-05-14 Hll Lifecare Limited Composites polymères à base de graphène pour la production de préservatifs présentant un transfert thermique élevé, une sensibilité améliorée et une capacité d'administration de médicament
US9376609B2 (en) 2010-12-21 2016-06-28 Halliburton Energy Services, Inc. Settable compositions comprising interground perlite and hydraulic cement

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994000552A1 (fr) * 1992-06-22 1994-01-06 The Trustees Of Dartmouth College Surfaces recouvertes de fullerene et utilisations de ces dernieres
EP0582221A1 (fr) * 1992-08-06 1994-02-09 Hoechst Aktiengesellschaft Laminé et méthode de fabrication

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994000552A1 (fr) * 1992-06-22 1994-01-06 The Trustees Of Dartmouth College Surfaces recouvertes de fullerene et utilisations de ces dernieres
EP0582221A1 (fr) * 1992-08-06 1994-02-09 Hoechst Aktiengesellschaft Laminé et méthode de fabrication

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
FRIEDMAN SH ET AL.: "INHIBITION OF THE HIV-1 PROTEASE BY FULLERENE DERIVATIVES: MODEL BUILDING STUDIES AND EXPERIMENTAL VERIFICATION.", J. AM. CHEM. SOC., vol. 115, no. 15, 1993, pages 6506 - 6509 *
G. WILLIAMS ET AL.: "LANGMUIR-BLODGETT FILMS OF THE FULLERENES C70 AND C60.", SYNTHETIC METALS, vol. 56, no. 2&3, 5 April 1993 (1993-04-05), pages 2955 - 2960 *
GOLDENBERG LM ET AL.: "ELECTROCHEMICAL STUDIES ON LANGMUIR-BLODGETT FILMS OF 1-TERT-BUTYL-1,9-DIHYDROFULLERENE-60.", J. CHEM. SOC., CHEM. COMMUN., 1993, pages 1310 - 1312 *
SCHINAZI RF ET AL.: "SYNTHESIS AND VIRUCIDAL ACTIVITY OF A WATER-SOLUBLE CONFIGURATIONALLY STABLE, DERIVATIZED C60 FULLERENE.", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 37, no. 8, August 1993 (1993-08-01), pages 1707 - 1710 *
SIJBESMA R. ET AL.: "SYNTHESIS OF A FULLERENE DERIVATIVE FOR THE INHIBITION OF HIV ENZYMES.", J. AM. CHEM. SOC., vol. 115, no. 5, 1993, pages 6510 - 6512 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1039944A1 (fr) * 1997-12-19 2000-10-04 Cordis Corporation Systeme de catheter avec fullerenes et procede associe
EP1039944A4 (fr) * 1997-12-19 2001-04-11 Cordis Corp Systeme de catheter avec fullerenes et procede associe
US6468244B1 (en) 1997-12-19 2002-10-22 James E. Leone Catheter system having fullerenes and method
WO2000044357A2 (fr) * 1999-01-29 2000-08-03 Max-Delbrück-Centrum für Molekulare Medizin Moyen pour prevenir des restenoses intra-stent et des infections post-operatoires
WO2000044357A3 (fr) * 1999-01-29 2001-04-26 Max Delbrueck Centrum Moyen pour prevenir des restenoses intra-stent et des infections post-operatoires
US9376609B2 (en) 2010-12-21 2016-06-28 Halliburton Energy Services, Inc. Settable compositions comprising interground perlite and hydraulic cement
WO2015068174A2 (fr) 2013-11-11 2015-05-14 Hll Lifecare Limited Composites polymères à base de graphène pour la production de préservatifs présentant un transfert thermique élevé, une sensibilité améliorée et une capacité d'administration de médicament

Also Published As

Publication number Publication date
GB9402581D0 (en) 1994-04-06

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