WO1995017915A3 - Prefilled syringe, tooling for preventing removal of a piston from the syringe, and sterilizing method using the tooling - Google Patents

Prefilled syringe, tooling for preventing removal of a piston from the syringe, and sterilizing method using the tooling Download PDF

Info

Publication number
WO1995017915A3
WO1995017915A3 PCT/JP1994/002295 JP9402295W WO9517915A3 WO 1995017915 A3 WO1995017915 A3 WO 1995017915A3 JP 9402295 W JP9402295 W JP 9402295W WO 9517915 A3 WO9517915 A3 WO 9517915A3
Authority
WO
WIPO (PCT)
Prior art keywords
piston
end side
tooling
syringe
outer cylinder
Prior art date
Application number
PCT/JP1994/002295
Other languages
French (fr)
Other versions
WO1995017915A2 (en
Inventor
Takeshi Watanabe
Takayuki Ikeuchi
Sumio Watanabe
Original Assignee
Eisai Co Ltd
Takeshi Watanabe
Takayuki Ikeuchi
Sumio Watanabe
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd, Takeshi Watanabe, Takayuki Ikeuchi, Sumio Watanabe filed Critical Eisai Co Ltd
Publication of WO1995017915A2 publication Critical patent/WO1995017915A2/en
Publication of WO1995017915A3 publication Critical patent/WO1995017915A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A61J1/062—Carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/04—Heat
    • A61L2/06—Hot gas
    • A61L2/07—Steam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/001—Apparatus specially adapted for cleaning or sterilising syringes or needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M2005/31516—Piston or piston-rod constructions, e.g. connection of piston with piston-rod reducing dead-space in the syringe barrel after delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31501—Means for blocking or restricting the movement of the rod or piston
    • A61M5/31505—Integral with the syringe barrel, i.e. connected to the barrel so as to make up a single complete piece or unit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M5/31515—Connection of piston with piston rod

Abstract

The present invention is directed towards climinating disadvantages of a prefilled syringe (1, 11, 15, 20, 25, 35, 40, 45, 50, 55, 100) including removal of a piston (6, 107) and leakage of a loaded liquid without disturbing the movement of the piston. A prefilled syringe according to the present invention having an outer cylinder (2, 105) which has a nozzle (4) provided in one end thereof and an opening (3, 103) provided in the other end thereof and accommodates therein a piston (6, 107) inserted from the other end, is characterized by a retainer (9, 13) disposed on the other end side of the piston in the outer cylinder (2, 105) for providing a tightness to an inner wall of the outer cylinder. Also, a tooling for preventing removal of the piston according to the present invention is provided comprising a spacer (71) for mounting on the other end side of the piston in the outer cylinder, an other end side retainer plate (72) attached to an other end side of the flange (104) for preventing removal of the piston from the outer cylinder, a one-end side retainer plate (73) attached to a one end side of the flange, and a tightening member (74) for sandwiching and tightening the flange of the prefilled syringe between the other end side retainer plate and the one end side retainer plate.
PCT/JP1994/002295 1993-12-30 1994-12-28 Prefilled syringe, tooling for preventing removal of a piston from the syringe, and sterilizing method using the tooling WO1995017915A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP5/353579 1993-12-30
JP35357993 1993-12-30
JP6/275690 1994-10-14
JP27569094 1994-10-14
JP6338188A JPH08164205A (en) 1993-12-30 1994-12-27 Prefilled syringe and gasket falling-off preventing jig and sterilization method using the jig
JP6/338188 1994-12-27

Publications (2)

Publication Number Publication Date
WO1995017915A2 WO1995017915A2 (en) 1995-07-06
WO1995017915A3 true WO1995017915A3 (en) 1995-09-08

Family

ID=27336284

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1994/002295 WO1995017915A2 (en) 1993-12-30 1994-12-28 Prefilled syringe, tooling for preventing removal of a piston from the syringe, and sterilizing method using the tooling

Country Status (2)

Country Link
JP (1) JPH08164205A (en)
WO (1) WO1995017915A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6802828B2 (en) * 2001-11-23 2004-10-12 Duoject Medical Systems, Inc. System for filling and assembling pharmaceutical delivery devices
JP4964976B2 (en) * 2003-12-26 2012-07-04 株式会社ウエットトラストジャパン Portable injection injector
JP2009240411A (en) * 2008-03-28 2009-10-22 Terumo Corp Drug container
US8162917B2 (en) * 2008-05-21 2012-04-24 Onpharma, Inc. Methods and apparatus for buffering anesthetics
US9345835B2 (en) 2008-07-18 2016-05-24 Becton, Dickinson And Company Cartridge stopper for an intradermal delivery system
PL2454012T3 (en) * 2009-07-09 2018-04-30 Onpharma, Inc. Method and device for sterilizing and holding buffering solution cartridges
CN102711875B (en) * 2009-10-30 2014-07-16 赛诺菲-安万特德国有限公司 Drug delivery devices and method of assembly
EP2332602A1 (en) * 2009-12-09 2011-06-15 F. Hoffmann-La Roche AG Container for receiving liquids
JP6199604B2 (en) * 2013-05-15 2017-09-20 住友ゴム工業株式会社 Medical gasket
WO2016014406A1 (en) * 2014-07-21 2016-01-28 Ge Healthcare As Deflectable plunger head
US20170354784A1 (en) * 2015-01-12 2017-12-14 Sanofi-Aventis Deutschland Gmbh Packaging for pre-filled drug cartridges with peg for pushing cartridge stopper for priming purposes
JP6589406B2 (en) * 2015-06-17 2019-10-16 住友ゴム工業株式会社 Prefilled syringe
FR3047903B1 (en) 2016-02-18 2018-03-23 Crossject INHIBITION DEVICE WITHOUT NEEDLE MEMBRANE HOLLOW

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH317306A (en) * 1953-08-18 1956-11-15 Dent Mischol Eduard Dr Med Injection syringe for cylindrical ampoules
DE1491834A1 (en) * 1966-01-29 1969-08-21 Wimmer Pharma Gummi Gmbh Injection ampoule
FR2258866A1 (en) * 1974-01-30 1975-08-22 Merieux Inst Sterilisation of syringes, pref. contg. medicaments - which does not require high degree of precision; overpressure being accommodated without expelling contents
DE2458004A1 (en) * 1974-12-07 1976-06-10 Vetter Arznei Ravensburg Disposable injection syringe package - formed by sterilising gas permeable foil and contg ampoule closed in air bubble free manner
US3987940A (en) * 1971-11-11 1976-10-26 Mpl, Inc. Glass tube and thermoplastic resin finger-grip and nose sleeve syringe body assembly
FR2330412A1 (en) * 1975-11-05 1977-06-03 Lezard Sa SYRINGE BULB
FR2353303A1 (en) * 1976-06-01 1977-12-30 Wimmer Pharma Gummi Gmbh Hypodermic syringe with separate piston and rod - rod end and piston end having segmental conical form
EP0107874A1 (en) * 1982-10-27 1984-05-09 Duphar International Research B.V Automatic injection device
WO1992001485A1 (en) * 1990-07-20 1992-02-06 Novo Nordisk A/S Two compartment syringe
WO1992008507A1 (en) * 1990-11-14 1992-05-29 Duoject Medical Systems Inc. Syringe
EP0555900A1 (en) * 1992-01-31 1993-08-18 Nycomed Imaging As Pre-filled plastic syringes, containers and vials and method of terminal sterilization thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1440270A (en) * 1970-04-28 1971-11-04 Ab SINGO Hypodermic syringe

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH317306A (en) * 1953-08-18 1956-11-15 Dent Mischol Eduard Dr Med Injection syringe for cylindrical ampoules
DE1491834A1 (en) * 1966-01-29 1969-08-21 Wimmer Pharma Gummi Gmbh Injection ampoule
US3987940A (en) * 1971-11-11 1976-10-26 Mpl, Inc. Glass tube and thermoplastic resin finger-grip and nose sleeve syringe body assembly
FR2258866A1 (en) * 1974-01-30 1975-08-22 Merieux Inst Sterilisation of syringes, pref. contg. medicaments - which does not require high degree of precision; overpressure being accommodated without expelling contents
DE2458004A1 (en) * 1974-12-07 1976-06-10 Vetter Arznei Ravensburg Disposable injection syringe package - formed by sterilising gas permeable foil and contg ampoule closed in air bubble free manner
FR2330412A1 (en) * 1975-11-05 1977-06-03 Lezard Sa SYRINGE BULB
FR2353303A1 (en) * 1976-06-01 1977-12-30 Wimmer Pharma Gummi Gmbh Hypodermic syringe with separate piston and rod - rod end and piston end having segmental conical form
EP0107874A1 (en) * 1982-10-27 1984-05-09 Duphar International Research B.V Automatic injection device
WO1992001485A1 (en) * 1990-07-20 1992-02-06 Novo Nordisk A/S Two compartment syringe
WO1992008507A1 (en) * 1990-11-14 1992-05-29 Duoject Medical Systems Inc. Syringe
EP0555900A1 (en) * 1992-01-31 1993-08-18 Nycomed Imaging As Pre-filled plastic syringes, containers and vials and method of terminal sterilization thereof

Also Published As

Publication number Publication date
WO1995017915A2 (en) 1995-07-06
JPH08164205A (en) 1996-06-25

Similar Documents

Publication Publication Date Title
WO1995017915A3 (en) Prefilled syringe, tooling for preventing removal of a piston from the syringe, and sterilizing method using the tooling
NZ318732A (en) Tamper evident syringe design
CA2173359A1 (en) Implant injection device
IL93881A0 (en) Pre-filled injection device
WO2001037903A3 (en) Front-loading medical injector and syringe
CA2387893A1 (en) Medical injector and medicament loading system for use therewith
CA2161632A1 (en) Seal Configuration for Aerosol Canister
AU1297795A (en) Low cost pressure transducer particularly for medical applications
SG43766A1 (en) Pressure isolator assembly for sanitary processing
EP0925798A3 (en) Easy-slip plunger/plunger rod assembly for a syringe or a cartridge
AU2365295A (en) Dispenser and method of its use
AU7267691A (en) Closure means for a cylindrical housing
EP0715861A4 (en) Liquid injection device
EP0390717A3 (en) A dispensing pump for a fluid contained in a container
AU5164993A (en) One-piece seal for high pressure applications
GB2276212B (en) An axial piston fluid translating unit with sealed barrel plate
AU3305089A (en) Closure device for a cylindrical housing
WO1998013084A8 (en) Pharmaceutical ampul
AUPO501897A0 (en) Hydraulically actuated electronic fuel injection system
AU6939791A (en) Welding gun assembly and fluid actuated cylinder
CA2179350A1 (en) Flexible tube with pump dispenser and method of making
GEP20053560B (en) Container for Dispensing Fluid, Comprising Pressure Control Device with Activation Step
EP0641604A3 (en) Spraying device for liquid container.
CA2147073A1 (en) Pump Sprayer with Stationary Discharge
GB2340191B (en) Low leakage plunger and barrel assembly for high pressure fluid system

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): CA US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU NL PT SE

AK Designated states

Kind code of ref document: A3

Designated state(s): CA US

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
NENP Non-entry into the national phase

Ref country code: CA

122 Ep: pct application non-entry in european phase