WO1995009386A1 - Dispositif electronique pour informations de dosage - Google Patents

Dispositif electronique pour informations de dosage Download PDF

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Publication number
WO1995009386A1
WO1995009386A1 PCT/US1994/011035 US9411035W WO9509386A1 WO 1995009386 A1 WO1995009386 A1 WO 1995009386A1 US 9411035 W US9411035 W US 9411035W WO 9509386 A1 WO9509386 A1 WO 9509386A1
Authority
WO
WIPO (PCT)
Prior art keywords
patient
medication
indicating
time
events
Prior art date
Application number
PCT/US1994/011035
Other languages
English (en)
Inventor
Michael V. Ward
Robert C. Wedemeyer
Ned W. Witting
Tom Papanek
Original Assignee
Aprex Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aprex Corporation filed Critical Aprex Corporation
Priority to AU80735/94A priority Critical patent/AU698543B2/en
Priority to EP94931786A priority patent/EP0721610A4/fr
Publication of WO1995009386A1 publication Critical patent/WO1995009386A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • A61J7/0409—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers
    • A61J7/0427—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers with direct interaction with a dispensing or delivery system
    • A61J7/0436—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers with direct interaction with a dispensing or delivery system resulting from removing a drug from, or opening, a container
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J2205/00—General identification or selection means
    • A61J2205/70—Audible labels, e.g. for pre-recorded info or messages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • A61J7/0409—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • A61J7/0409—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers
    • A61J7/0418—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers with electronic history memory
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • A61J7/0409—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers
    • A61J7/0481—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers working on a schedule basis

Definitions

  • This invention is in the field of medication monitoring. More particularly it concerns devices and methods for monitoring and assisting patients in the timely use of medication.
  • United States Patent Number 2,853,182 of Bamett and United States Patent Number 3,369,697 of Glucksman. They also include devices which provide additional compliance information to the patient or the patient's healthcare professional. (See, for example. United States Patent Number 3,227,127 of Gayle and United States Patent Number 4,360,125 of Martindale.) Such compliance information can range from an overview of the dosing regimen to the time of day.
  • Other devices in the art provide signals if a dose is being requested too early or too late.
  • Yet other devices have timer-driven lockouts which regulate patient access to the drug and thus prevent improper dosing.
  • Another feature found in some devices of the art is memory for storing information on the patient's compliance. (See, for example, United States Patent Number 4, 588,303 of Locker and United States Patent Number 4,970,669 of Mclntosh. )
  • the present invention provides improvements in medication dosing information devices for patient use. It also provides methods which employ these devices.
  • the devices are simple and direct in operation and provide patients with combinations of information which can be most effective in promoting compliance with the medication regimen. This effectiveness is a result of the device providing patients those pieces of compliance information which they most keenly want to know. This compliance information can improve compliance with a regimen and can lower patient anxiety.
  • the devices of the present invention in their most fundamental form, note when the patient takes a dose of drug, tell the patient how many doses of drug have been taken on a daily basis and indicates how long it has been since the last dose was taken.
  • the devices include a memory which can record information on patient compliance. This information can be retrieved and used by the health care professionals monitoring the patient's condition.
  • the devices include a memory into which a regimen of desired drug dosing times is loaded. These times are retrieved out of memory and used to generate alerting signals to aid the patient's timely adherence to the dosing regimen.
  • the devices are equipped to determine the rate at which medication events are being detected and to compare this determined rate with previously provided acceptable or preferred medication event rate values. The patient can then be informed as to whether or not the determined rate fits within the acceptable/preferred rates. This information can help the patient adhere to the prescribed regimen.
  • the device focuses on patient overdosing and informs the patient if the determined medication event rate exceeds the acceptable/preferred rate.
  • this invention provides methods for monitoring and enhancing a patient's compliance with drug dosing regimens. In one general sense, these methods involve administering a drug dosing regimen with the assistance of one of the devices of the invention.
  • a patient's compliance with a drug dosing regimen is monitored and enhanced by providing the patient two pieces of information throughout the dosing period - the number of doses taken on a current daily basis and the length of time since the patient's last dose - and additionally compiling and storing a record of the patient's dosing events which can later be accessed by the patient's health care professionals.
  • This method can also provide alerts to the patient consistent with the desired drug dosing regimen.
  • FIG. 1 is a perspective illustration of an electronic dosing information device implemented in a medication bottle cap.
  • FIG. 2 is a top view of the electronic dosing information device of FIG. 1.
  • FIG. 3 is a schematic illustration of a generalized electronic section of an electronic dosing information device.
  • FIG. 4 is a more detailed schematic illustration of a generalized electronic section of an electronic dosing information device.
  • the devices of this invention detect when "medication events" occur. These medication events are the taking or accessing by the patient or dispensing to the patient of medication. This medication is usually provided in a discrete unit dosage form such as a pill, tablet, metered volume of aerosol or the like. It also can be in less discrete forms such as a bulk liquid or suspension, although this is usually less preferred in situations where the delivery of the amount of drug is to be controlled.
  • the medication event is detected inferentially such as by noting the removal of a dose of drug from a container, by noting an opening and/or closing of an openable/closable drug container or by noting some other handling of a drug container consistent with the taking of a dose of its drug from it, for example inverting the container.
  • These events can be detected electronically by the use of a motion sensitive switch or a drug-container closure-actuated switch providing a detectable electrical signal. Any other means for sensing a medication event and generating a detectable electrical signal as the result can be used as well.
  • the devices of the invention provide two pieces of compliance information to the patient. One piece of information is the time that has elapsed since the patient's last medication event (dose taking) . This information can be generated by a resettable running clock within the device with its output reset and controlled by medication event signals. It can also be derived from a continuous running clock signal with a suitable subtraction of the time of the detected medication events.
  • the other piece of information is the number of medication events which have occurred on a daily basis, i.e. the number of medication events that the device has detected during the given day.
  • These pieces of information are provided to the patient in any patient-recognizable form. This can include visual information displayed on LED or LCD arrays, audible signals indicative of the time and count values or information from a speech synthesizer provided through an annunciator, or the like.
  • the two pieces of information usually are presented sequentially, if presented audibly. If presented visually, they can be presented simultaneously on a pair of displays or sequentially on a single display.
  • the daily dose count information which the device provides to the patient can be generated in any of several ways.
  • a readable count memory stores the number of medication events detected. This value is displayed and this memory is reset to zero before or at the beginning of each day.
  • the memory is not reset to zero at the beginning of the day but instead the total number of doses is accumulated and this total is noted at the end of each day and a value for the difference between the running total and the preceding night's total is displayed to provide the daily dose information.
  • Other methods may be used as well.
  • FIGs. 1 and 2 A presently preferred embodiment of the invention is illustrated in FIGs. 1 and 2 in which it is shown incorporated in the closure 3 of a medication container, here shown as a pill bottle.
  • closure 3 and container 2 are connected by an interlocking mechanism of any of the various known types for use with the type of drug or medicament being delivered.
  • the device includes a display readable by the user at any time.
  • display 4 is located in the top area of closure 3.
  • Display 4 consists of a first display 5 for indicating the number of dosages taken since last reset, and a second display 6 showing the elapsed time since the last drug dosage taken. Both displays 5 and 6 can be multi-digit displays. Display 6 may include digits to show days, hours, minutes, and/or seconds.
  • the interlocking mechanism of closure 3 and container 2 include a switch (not shown in FIG. 1 or FIG. 2) which is activated each time the closure 3 is removed from the container 2 or replaced on the container.
  • This switch serves as a sensor (detector) and provides a signal to the electronic section of the medication reminder device.
  • This signal may be subjected to any of many filters or validation techniques to assure that it is in fact an accurate indication of actual medication events. Such techniques are taught in the art and do not, in and of themselves constitute an aspect of this invention.
  • the signal resulting from the detected medication event is electronically noted in the device and used to start the generation of an elapsed time signal within the device.
  • the device of the invention includes an elapsed time clock determining the time elapsed since the last medication event. This elapsed time signal is reset to zero whenever a medication event is detected. This can be done by zeroing the clock, by subtracting the most recent medication event time from a running real time value generated by the clock, or the like. This elapsed time signal is used to provide the "time since last dose" information provided to the patient through the display.
  • the device also includes a counter for recording the number of medication events detected. Each time the sensor detects that a medication event has occurred, this counter is advanced.
  • the clock provides a "day" signal which serves as a basis for determining the beginning of successive "day” or twenty four hour time periods. When this day signal is generated, once every 24 hours, the number provided by this counter is reset.
  • the reset time defines the medication day, a 24-hour time period. This reset time does not have to coincide with midnight or any other significant time instant during a 24 hour day.
  • Resetting of the 24 hour medication event counter preferably occurs while the user is normally sleeping, e.g. at 3 a.m.
  • the resetting can take the form of zeroing the counter or by recording a start value which will be subtracted from the counter value throughout the upcoming day.
  • the time signal may merely provide the information needed for the 24 hour day determination and the time since last dose determination. It may, if desired, also provide information on the time of day and the date such that when the time signal and detector signal are correlated or otherwise associated with one another it results in a notation of the date and time of day when the medication event occurred.
  • This information can be used in those embodiments of this invention in which the device further includes a readable memory for storing the dates and times when medication events occurred.
  • FIG. 3 is a schematic illustration of a generalized electronic section of the present invention.
  • the electronic section includes a clock 40 providing timing signals.
  • Memory 24 is used to store control information for processor 42, detected medication event information and other information to operate the device.
  • the display section consists of a display controller 43 and two displays 5 and 6.
  • An input/output interface 44 allows the health care professional to load data into the apparatus and to read data from the apparatus via port 46 in those embodiments which call for this function.
  • Sensor 20 signals to processor 42 when a medication event is detected.
  • a battery 45 supplies electrical power to the electronic section.
  • FIG. 3 is a more detailed schematic illustration of the electronic section of the apparatus of the present invention. Upon installation of the battery and initial setting of real-time clock 22 clock generator 40 provides clock pulses to operate real-time clock 22, 24 hour clock 25, and elapsed time counter 51. Electronic sensor 20 issues a signal whenever a medication event is sensed.
  • Elapsed time counter 21 may be a separate counter or may be implemented as read, increment and store operation using an internal register of processor 42 or a store location of memory 24.
  • Elapsed time counter 21 may be a separate counter or may be implemented as read, increment and store operation using an internal register of processor 42 or a store location of memory 24.
  • Display controller 43 interfaces with processor 42, which includes the function of elapsed time counter 51 and drug use counter 26.
  • Display controller 30 processes information from elapsed time counter 51 and drug use counter 26 for display on first display 5 and second display 6. Additional data, such as date and time of day, may be displayed in multiplex mode or selectively on the same displays or constantly on additional displays.
  • the electronic section includes an electronic interface 44 for communication with external devices.
  • an external device may provide certain data of a drug regimen for storage in memory 24 or may read compliance information from memory 24 for use in equipment external to the device of the present invention.
  • the functions of elapsed time counter 26, real-time clock 22, 24 hr clock 25, drug event counter 26, and display controller 43, as well as other data handling functions represented by block 49 in FIG. 3 may be implemented in software and performed by a microprocessor.
  • a number of additional or alternative functions can be provided to adapt the device to particular applications.
  • One of these additional or alternative functions is generating an indication if the rate of medication events deviates from a predetermined regimen. To achieve this function, the device must be provided with a value for the desired rate of dosing such as through interface 44.
  • Processor 42 can generate variance data and issue an indicator for display on displays 5 and 6.
  • processor 42 can cause the issue of an indicator for display on displays 5 and 6.
  • processor 42 can cause the issue of an indicator in audible format by controlling an acoustic device or via a speech synthesizer generate the appropriate message.
  • the devices for generating indicator information in audible format are known in the art and are shown in block diagram form in FIG. 3 an audible embodiment of display 43.
  • one sort of indication can be provided to the patient. If the detected rate falls outside the desired parameters another indication can be provided. These differing indications can be provided by a separate visual or audible message.
  • a visual indication may be identified by an alternating display of a character, like an "X”, and the variance information or actual dose information. The indication may also be given in audible format.
  • this warning signal may continue until reset by the patient's health care professional, may reset automatically when the rate returns to an acceptable level, may reset automatically after an appropriate period of time, such as the beginning of the next successive "day", or may be cancelled or acknowledged by the user using an acknowledge button.
  • the rate information is provided in the form of a daily maximum dose count and a rate deviation is detected if the daily dose count exceeds this maximum.
  • the above disclosure relates to doses of drug taken in a 24 hour period and the time elapsed since the last dose was taken.
  • the device is incorporated in the cover of the drug container such as a pill or liquid medication bottle. It recognizes when and how often the container is opened or accessed.
  • the device can be used in combination with other types of containers of medications and medicinal devices to provide compliance information by detecting when the contents of the container is accessed.
  • This device provides information for display to the user about the number of medication events and the time elapsed since the last medication event.
  • the function can be expanded to show variances detected between the actual medication events and the prescribed medication regimen, to show excess doses, and to provide indicators if predetermined variance situations are detected.
  • the device may issue dose time reminders which are initiated by processor 42 using regimen data stored in memory 24 via the IP/OP interface 44 by a health care professional.
  • the dose time reminder could be a visual display of a symbol or character, or as an audible alarm signal. Visual display of the reminder and the audible alarm can be adapted to particular conditions related to the type of container and medication.

Abstract

On décrit des dispositifs et procédés qui fournissent des informations de dosages de médicaments à des patients. Ces dispositifs enregistrent le moment où un patient prend une dose d'un médicament, lui montrent combien de doses de médicament ont été prises quotidiennement et indiquent depuis quand la dernière dose a été prise. Dans une variante, un tel dispositif comporte une mémoire (24) qui peut enregistrer des informations sur le respect des doses par le patient auxquelles peuvent accéder des professionnels de la santé qui surveillent l'état de ce patient. Dans certaines variantes, ces dispositifs comportent une mémoire (24) de posologie utilisable pour fournir des signaux d'alarme destinés au patient. Dans d'autres variantes, ces dispositifs comportent une mémoire (24) pour informations de débit de distribution utilisables par les dispositifs pour évaluer le respect des doses par les patients et leur indiquer si la fréquence ainsi déterminée correspond à la fréquence souhaitée.
PCT/US1994/011035 1993-09-30 1994-09-29 Dispositif electronique pour informations de dosage WO1995009386A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU80735/94A AU698543B2 (en) 1993-09-30 1994-09-29 Electronic dosing information device
EP94931786A EP0721610A4 (fr) 1993-09-30 1994-09-29 Dispositif electronique pour informations de dosage

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12996793A 1993-09-30 1993-09-30
US08/129,967 1993-09-30

Publications (1)

Publication Number Publication Date
WO1995009386A1 true WO1995009386A1 (fr) 1995-04-06

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1994/011035 WO1995009386A1 (fr) 1993-09-30 1994-09-29 Dispositif electronique pour informations de dosage

Country Status (4)

Country Link
EP (1) EP0721610A4 (fr)
AU (1) AU698543B2 (fr)
CA (1) CA2172981A1 (fr)
WO (1) WO1995009386A1 (fr)

Cited By (22)

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Publication number Priority date Publication date Assignee Title
WO1997003914A1 (fr) * 1995-07-21 1997-02-06 Julian Davidson Taylor Ensemble de pieces
WO1999027483A1 (fr) * 1997-11-21 1999-06-03 Health Hero Network, Inc. Systeme de recompense informatise destine a encourager la participation a un programme de gestion de la sante
US6101478A (en) * 1997-04-30 2000-08-08 Health Hero Network Multi-user remote health monitoring system
WO2000056264A1 (fr) * 1999-03-19 2000-09-28 Medical Compliance Systems As Distributeur de comprimes
US6248065B1 (en) 1997-04-30 2001-06-19 Health Hero Network, Inc. Monitoring system for remotely querying individuals
US6270455B1 (en) 1997-03-28 2001-08-07 Health Hero Network, Inc. Networked system for interactive communications and remote monitoring of drug delivery
WO2000019962A3 (fr) * 1998-10-01 2002-09-19 Walker Asset Man Ltd Partnersh Procede et appareil permettant de documenter des donnees relatives au retrait d'un capuchon
WO2003075823A1 (fr) * 2002-03-13 2003-09-18 Peter Joseph Ayre Pilulier electronique pour plaquette alveolee et aide-memoire detectant la sortie de la plaquette alveolee
US6751730B1 (en) 1995-11-22 2004-06-15 Walker Digital, Llc Method and apparatus for documenting cap removal data
US7295890B2 (en) 2002-09-26 2007-11-13 Stratamed Labs, Inc. Prescription drug compliance monitoring system
US7366675B1 (en) 2000-03-10 2008-04-29 Walker Digital, Llc Methods and apparatus for increasing, monitoring and/or rewarding a party's compliance with a schedule for taking medicines
US7553235B2 (en) 1995-11-22 2009-06-30 Walker Digital, Llc Method and apparatus for outputting a result of a game via a container
US7752056B2 (en) 1996-12-23 2010-07-06 Health Hero Network, Inc. Network media access control system for encouraging patient compliance with a treatment plan
US7801745B2 (en) 2000-03-10 2010-09-21 Walker Digital, Llc Methods and apparatus for increasing and/or monitoring a party's compliance with a schedule for taking medicines
USRE43316E1 (en) 1997-01-10 2012-04-17 Health Hero Network, Inc. Diabetes management system and method for controlling blood glucose
US8870762B2 (en) 1997-03-28 2014-10-28 Robert Bosch Gmbh Electronic data capture in clinical and pharmaceutical trials
US8945009B2 (en) 2003-05-08 2015-02-03 Robert Bosch Heathcare Systems, Inc. Remote health monitoring system
US9123083B2 (en) 1994-04-26 2015-09-01 Robert Bosch Healthcare Systems, Inc. Blood glucose monitoring system
US9215979B2 (en) 1992-11-17 2015-12-22 Robert Bosch Healthcare Systems, Inc. Multi-user remote health monitoring system
US9477939B2 (en) 1992-11-17 2016-10-25 Robert Bosch Healthcare Systems, Inc. Radio frequency based remote health monitoring
US10704944B2 (en) 2014-09-14 2020-07-07 Becton, Dickinson And Company System and method for capturing dose information
US10971260B2 (en) 2014-09-14 2021-04-06 Becton, Dickinson And Company System and method for capturing dose information

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Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9477939B2 (en) 1992-11-17 2016-10-25 Robert Bosch Healthcare Systems, Inc. Radio frequency based remote health monitoring
US9215979B2 (en) 1992-11-17 2015-12-22 Robert Bosch Healthcare Systems, Inc. Multi-user remote health monitoring system
US9123083B2 (en) 1994-04-26 2015-09-01 Robert Bosch Healthcare Systems, Inc. Blood glucose monitoring system
WO1997003914A1 (fr) * 1995-07-21 1997-02-06 Julian Davidson Taylor Ensemble de pieces
US6751730B1 (en) 1995-11-22 2004-06-15 Walker Digital, Llc Method and apparatus for documenting cap removal data
US7553234B2 (en) 1995-11-22 2009-06-30 Walker Digital, Llc Method and apparatus for outputting a result of a game via a container
US7553235B2 (en) 1995-11-22 2009-06-30 Walker Digital, Llc Method and apparatus for outputting a result of a game via a container
US6151586A (en) * 1996-12-23 2000-11-21 Health Hero Network, Inc. Computerized reward system for encouraging participation in a health management program
US7752056B2 (en) 1996-12-23 2010-07-06 Health Hero Network, Inc. Network media access control system for encouraging patient compliance with a treatment plan
USRE43316E1 (en) 1997-01-10 2012-04-17 Health Hero Network, Inc. Diabetes management system and method for controlling blood glucose
US6381577B1 (en) * 1997-03-28 2002-04-30 Health Hero Network, Inc. Multi-user remote health monitoring system
US6270455B1 (en) 1997-03-28 2001-08-07 Health Hero Network, Inc. Networked system for interactive communications and remote monitoring of drug delivery
US8990336B2 (en) 1997-03-28 2015-03-24 Robert Bosch Healthcare Systems, Inc. Networked system for interactive communication and remote monitoring of individuals
US8870762B2 (en) 1997-03-28 2014-10-28 Robert Bosch Gmbh Electronic data capture in clinical and pharmaceutical trials
US6248065B1 (en) 1997-04-30 2001-06-19 Health Hero Network, Inc. Monitoring system for remotely querying individuals
US6101478A (en) * 1997-04-30 2000-08-08 Health Hero Network Multi-user remote health monitoring system
WO1999027483A1 (fr) * 1997-11-21 1999-06-03 Health Hero Network, Inc. Systeme de recompense informatise destine a encourager la participation a un programme de gestion de la sante
WO2000019962A3 (fr) * 1998-10-01 2002-09-19 Walker Asset Man Ltd Partnersh Procede et appareil permettant de documenter des donnees relatives au retrait d'un capuchon
WO2000056264A1 (fr) * 1999-03-19 2000-09-28 Medical Compliance Systems As Distributeur de comprimes
US8069056B2 (en) 2000-03-10 2011-11-29 Walker Digital, Llc Methods and apparatus for increasing and/or for monitoring a party's compliance with a schedule for taking medicines
US7366675B1 (en) 2000-03-10 2008-04-29 Walker Digital, Llc Methods and apparatus for increasing, monitoring and/or rewarding a party's compliance with a schedule for taking medicines
US8055509B1 (en) 2000-03-10 2011-11-08 Walker Digital, Llc Methods and apparatus for increasing and/or for monitoring a party's compliance with a schedule for taking medicines
US7801745B2 (en) 2000-03-10 2010-09-21 Walker Digital, Llc Methods and apparatus for increasing and/or monitoring a party's compliance with a schedule for taking medicines
WO2003075823A1 (fr) * 2002-03-13 2003-09-18 Peter Joseph Ayre Pilulier electronique pour plaquette alveolee et aide-memoire detectant la sortie de la plaquette alveolee
US7295890B2 (en) 2002-09-26 2007-11-13 Stratamed Labs, Inc. Prescription drug compliance monitoring system
US8945009B2 (en) 2003-05-08 2015-02-03 Robert Bosch Heathcare Systems, Inc. Remote health monitoring system
US10704944B2 (en) 2014-09-14 2020-07-07 Becton, Dickinson And Company System and method for capturing dose information
US10971260B2 (en) 2014-09-14 2021-04-06 Becton, Dickinson And Company System and method for capturing dose information

Also Published As

Publication number Publication date
AU8073594A (en) 1995-04-18
AU698543B2 (en) 1998-10-29
CA2172981A1 (fr) 1995-04-06
EP0721610A4 (fr) 1996-11-27
EP0721610A1 (fr) 1996-07-17

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