WO1995003841A1 - Robinet de remplissage d'une poche a solution de type iv - Google Patents
Robinet de remplissage d'une poche a solution de type iv Download PDFInfo
- Publication number
- WO1995003841A1 WO1995003841A1 PCT/US1994/008245 US9408245W WO9503841A1 WO 1995003841 A1 WO1995003841 A1 WO 1995003841A1 US 9408245 W US9408245 W US 9408245W WO 9503841 A1 WO9503841 A1 WO 9503841A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- diaphragm
- syringe
- valve
- downstream
- upstream
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/02—Access sites
- A61M39/04—Access sites having pierceable self-sealing members
- A61M39/045—Access sites having pierceable self-sealing members pre-slit to be pierced by blunt instrument
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/10—Bag-type containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1475—Inlet or outlet ports
- A61J1/1487—Inlet or outlet ports with friction fit, e.g. connecting tubes directly to a protruding port
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/202—Separating means
- A61J1/2044—Separating means having slits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2048—Connecting means
- A61J1/2058—Connecting means having multiple connecting ports
Definitions
- the present invention relates generally to the field of syringe-actuated valves used in medical applications for filling intravenous solution bags and like containers with a liquid medicament solution. More specifically, the present invention relates to a syringe-actuated valve that permits (a) the filling of such containers with a first liquid medicament by means of a syringe; (b) the withdrawal of air or excess liquid from the container during the filling process by means of the syringe; and (c) the introduction, by means of a syringe, of a second liquid medicament into the infusion line during the intravenous administration of the first medicament from the bag into the patient.
- IV bag collapsible container
- One method of filling an IV bag comprises the steps of withdrawing a volume of the medicament from the supply container with a syringe, and then injecting the medicament into the bag through an infusion line, by means of a valve that permits the liquid to flow into the bag from the syringe, but which prevents backflow out of the valve when the syringe is removed.
- the valve is opened in response to the introduction of the syringe, and closed in response to the withdrawal of the syringe.
- the bag may be filled by serial applications of the syringe without leakage or backflow out of the valve, and the valve may be left in the infusion line after the filling is completed, and the infusion line is introduced into the patient's vein.
- valves used in such an application may fall short of meeting one or more of the criteria that should be advantageously met by a valve used in such an application.
- the valve typically would remain in the IV line (or "administration set") during the administration of medicament to the patient. the valve would need to remain closed in response to back pressures received from the patient's vascular system or from the flow of liquid from the IV bag.
- the valve must permit both the introduction of a liquid into the bag through the IV line, and the withdrawal of gas (air) or liquid from the bag, by means of a syringe.
- the valve must be opened only in response to the introduction of the syringe into the valve, and, when open, the valve must allow bi-directional flow.
- the valve should have few, if any, moving parts, other than a valving element that is displaced from a closed position to a- ⁇ open position by direct contact with the Luer tip of the syringe. Ease of use would dictate that minimal contact force be required to open the valve, thereby allowing the valve to be opened by a minimal degree of insertion of the Luer tip.
- the valve would need to provide excellent sealing integrity when closed, so that leakage is substantially prevented when the administration set is used to deliver the contents of the IV bag to the patient.
- the present invention is a syringe- actuated valve for filling an IV bag or the like from a syringe having a male Luer tip surrounded by a Luer lock fitting, as is normally found on the end of a syringe for the attachment of a needle, wherein the valve comprises a housing having an upstream portion and a downstream portion. Captured between the two housing portions is a resilient, deformable diaphragm having a normally-closed slit.
- the upstream portion of the housing includes a syringe-receiving port formed as a female Luer fitting adapted to receive the male Luer tip of the syringe and to lock with the Luer lock fitting on the syringe.
- the downstream portion of the housing defines a funnel-shaped internal valve passage extending from the downstream side of the diaphragm, and terminating at an entry orifice into a main flow passage defined between first and second opposed tube connection ports.
- a syringe filled with a liquid medicament and having a male Luer tip, as described above, is inserted into the syringe-receiving port and locked therein by the engagement between the female Luer fitting and the Luer lock fitting.
- the axial dimension of the syringe- receiving port is such that, when the Luer tip is locked into place, the end of the tip presses against the upstream side of the diaphragm so as to open the slit.
- the syringe is emptied, so that the medicament flows through the slit and the internal valve passage downstream therefrom, entering the main flow passage via the entry orifice. Flow then proceeds through the first tube connection port and the first tube, and then into the bag.
- the syringe When the syringe is empty, it is unlocked from the syringe-receiving port and withdrawn therefrom.
- the si t closes as a result of the resilience of the diaphragm, thereby preventing back flow through the valve.
- Additional syringes filled with medicament can then be successively inserted into the syringe- receiving port to continue the bag filling process until the bag is filled to the desired level. At selected intervals during the filling process, it may be necessary or desirable to remove air or excess liquid from the bag. '. is is accomplished by locking an empty syringe into tne syringe-receiving port so as to open the slit, as describe above.
- the syringe p anger is then withdrawn t amove the air or liquid from the bag via the first tuoe, the first tube connection port, the internal valve passage, and the slit.
- a second or supplemental medicament can be introduced into the main flow passage during infusion by means of a syringe inserted into the syringe-receiving port, in the manner described above.
- the syringe can be used to withdraw liquid from the main flow passage during infusion.
- the valve remains closed, due to the closure of the slit from the resilience of the diaphragm, as long as it is not pressed on its upstream side by the end of the syringe tip.
- the diaphragm is seated in the housing so that its upst-.sa side is supported closer to the diaphragm's center, and through a larger proportion of its radial dimension, than is its downstream side, thereby providing a valve seat on the upstream side of the diaphragm that is closer to the center of the diaphragm than is the valve seat on the downstream side of the diaphragm.
- This structure allows the diaphragm to flex relatively easily to open its slit when physically urged in the downstream direction (i.e., toward the -internal passage) by downstream-directed forces applied against its upstream surface, while restraining the diaphragm from flexing in response to upstream-directed forces applied against its downstream surface.
- the valve remains closed in response to back pressures generated by the flow from the IV bag, as well as those resulting from the transmission, via the second tube and the second tube connection port, of the vascular pressure of the patient during infusion, thereby further ensuring against leakage.
- the instant invention provides a valve mechanism that permits both the introduction of liquid into an IV bag (or the like) and the withdrawal of gas or liquid from the bag, by means of a syringe, thus allowing bidirectional fluid flow, but only in response to the introduction of a syringe into the valve housing.
- a syringe is not locked into the housing so as to displace the diaphragm, the valve remains closed, resisting back flow and back pressures with excellent sealing integrity.
- the valve is simple and economical to construct and use, employing only a single moving part, namely, the diaphragm. The economy and simplicity of construction allow the valve to be manufactured as a disposable item, yet one that is highly reliable despite its low cost.
- Figure 1 is an idealized view of an intravenous administration set incorporating a syringe-actuated IV bag filling valve in accordance with the present invention, showing the use of the valve in filling the bag with a liquid medicament;
- Figure 2 is a cross-sectional view of a syringe- actuated IV bag filling valve in accordance with a preferred embodiment of the present invention, showing the valve in its closed position;
- Figure 3 is a cross-sectional view, similar to that of Figure 2, showing the valve being opened by the engagement of a syringe Luer tip against the diaphragm valving element in the valve.
- FIG. 1 shows an intravenous (IV) administration set 10 incorporating an IV bag filling valve 12 in accordance with the present invention.
- the set includes an IV bag 14 fluidly connected by a first tube 16 to the valve 12, and an IV needle 18 fluidly connected by a second tube 20 to the valve 12.
- the administration set 10 is shown in Figure in use during the filling of the bag 14 with a liquid medicament solution 22 by means of a syringe 24 that is coupled to the valve 12 in the manner to be described below.
- the second tube 20 is closed by a clamp 26, of conventional design.
- An IV bag filling valve 12 in accordance with a preferred embodiment of the invention, is shown in cross section in Figures 2 and 3, Figure 2 showing the valve in its closed state, and Figure 3 in the open state.
- the valve 12 includes an upper or upstream housing portion 28 and a lower or downstream housing portion 30, both of which may be formed of a molded biocompatible polymeric plastic, such as polycarbonate, for example.
- the upstream housing portion 28 includes a first annular base 32 from which extends a downwardly-depending peripheral flange 34 that is internally threaded.
- the downstream housing portion 30 includes a second annular base 36 from which extends an upwardly-extending peripheral rim 38 that is externally threaded to mate with the flange 34 with a sealing fit.
- the seal between the rim 38 and the flange 34 may be strengthened by an adhesive (not shown) , or by ultrasonic welding.
- the threads on the flange 34 and the rim 38 may be omitted, and the sealing attachment of the two housing portions 28, 30 may be achieved by an adhesive or (preferably) ultrasonic welding alone.
- the two housing portions 28, 30 form a structure resembling a "T"-fitting.
- a tubular syringe-receiving port 40 Extending upwardly (as shown in the drawings) from the first annular base 32 of the upstream housing portion is a tubular syringe-receiving port 40, terminating in an open end having a pair of radially- outwardly extending lips 42. As will be described below, the lips 42 allow the exterior of the syringe- receiving port to function as a female Luer fitting.
- a truncated conical portion defining a funnel-shaped internal valve passage 44 that is wider at its upper (upstream) end than at its lower (downstream) end.
- the downstream end of the valve passage 44 terminates in an entry orifice 46, through which the valve passage 44 communicates with a main flow passage 48.
- the main flow passage 48 extends between the interior of a first tube connection port 50 and the interior of a second tube connection port 52.
- the first tube connection port 50 is configured for removable fluid connection with one end of the first tube 16, while the second tube connection port 52 is configured for removable fluid connection with one end of the second tube 20.
- a resilient, deformable diaphragm 54 having a normally-closed central slit 56, is provided as the valving element.
- the slit 56 is preferably a simple linear slit, but alternative configurations, such as a "Y"-shaped slit or an "X"-shaped slit, may be workable.
- the diaphragm 54 which may be made of a biocompatible elasto eric material, such as silicone or latex, is captured between the upstream housing portion 28 and the downstream housing portion 30 so as to be allowed to flex only in the downstream direction, that is, in response to downstream-directed forces applied against its upstream surface.
- a peripheral portion of the upstream side of the diaphragm 54 is seated against the first annular base 32 on the upstream housing portion 28, while a peripheral portion of the downstream side of the diaphragm is seated against the second annular base 36 on the downstream housing portion 30.
- Retention of the diaphragm 54, especially against lateral slippage, is enhanced by first and second opposed annular beads 58, 60 on the first and second annular bases 32, 36, respectively.
- the first annular base 32 is wider in the radial dimension than is the second annular base 36.
- the upstream side of the diaphragm 54 is supported closer to the diaphragm's center, and through a greater proportion of its radial dimension, than is its downstream side, thereby providing a valve seat on the upstream side of the diaphragm that is closer to the diaphragm's center than is the valve seat on the downstream side.
- This structure allows the diaphragm 54 to flex relatively easily to open its slit 56 when physically urged in the downstream direction (i.e., toward the internal valve passage 44) by downstream-directed forces applied against its upstream surface, while restraining the diaphragm from flexing in response to upstream-directed forces applied against its downstream surface.
- the slit 56 is normally closed.
- the normal closure of the slit 56 is almost purely the result of the physical characteristics (i.e., material and configuration) of the diaphragm 54, and is not significantly the result of biasing by other structure in the valve assembly.
- the diaphragm is essentially internally self-biased closed, rather than externally biased.
- the outside diameter of the diaphragm is made less than the inside diameter of the downstream housing portion 30 across the peripheral rim 38 that concentrically surrounds the peripheral edge of the diaphragm.
- annular space 62 separating the diaphragm 54 from the rim 38, leaving the edge of the diaphragm free of contact with any adjacent structure.
- the diaphragm 54 is thus physically unconstrained except by the first and second annular bases 32, 36.
- the lack of significant external diaphragm bias contributes to the diaphragm's ease of flexing in the downstream direction, while providing enhanced sealing integrity when subjected to upstream-directed forces applied to its downstream surface.
- Figure 3 illustrates the opening of the diaphragm's slit 56 by means of the syringe 24.
- the syringe 24 has a male Luer tip 64 concentrically surrounded by a Luer lock fitting 66 of conventional design.
- Th Luer lock fitting 66 includes an internal thread 68 that engages the lips 42 on the exterior of the syringe-receiving port 40 when the syringe tip 64 is inserted into the interior of the syringe-receiving port, thereby locking the syringe 24 into the syringe receiving port 40.
- the exterior of the syringe-receiving port 40 with its radially-outwardly extending lips 42, provides a female Luer fitting that locks, in the conventional manner, with the Luer lock fi ⁇ ting 66 on the syringe.
- the syringe tip 4 has an outside diameter that is advantageously just s-iightly less than the inside diameter of the syringe-receiving port 40, so that there is only a small clearance between the tip 64 and the interior surface of the syringe-receiving port 40 when the tip is inserted therein.
- the relative axial lengths of the tip 64 and the syringe-receiving port 40 are such that when the tip 64 is fully inserted into the syringe-receiving port 40, the distal end of the tip extends slightly past the first annular base 32, thereby engaging the upstream surface of the diaphragm 54 around the slit 56.
- the administration set 10 is configured as shown in Figure 1.
- the first tube 16 is connected between the bag 14 and the first tube connection port 50, and the second tube 20, closed by the clamp 26, is connected at one end to the second tube connection port 52, and at the opposite end to the IV needle 18.
- the syringe 24, filled with a liquid medicament and having the Luer lock fitting 66 around its tip 64, as described above, is inserted into the syringe- receiving port 40 and locked therein by the engagement between the fema ' ..e Luer fitting and the Luer lock fitting 66.
- the syringe tip 64 against the upstream surface of the diaphragm 54, as described above, the syringe is emptied, so that the medicament flows through the open slit and the internal valve passage 44 " ownstream therefrom, entering the main flow passage 48 via the entry orifice 46. Flow then proceeds through the first tube connection port 50 and the first tube 16, and then into the bag 14.
- tc remove air or excess liquid from the bag 14. This is accomplished by locking an empty syringe 24 into the syringe-receiving port 40 so as to open the slit 56, as described above. The syringe plunger is then withdrawn to remove the air or liquid from the bag 14 via the first tube 16, the first tube connection port 50, the internal valve passage 44, and the slit 56.
- a second or supplemental medicament can be introduced into patient through the main flow passage 48, the second tube connection port 52, the second tube 20, and the needle 18 during infusion by means of a syringe 24 inserted into the syringe-receiving port 40, in the manner described above.
- a syringe 24 can be used to withdraw liquid from the main flow passage 48 during infusion.
- valve 12 remains closed, due to the closure of the slit 56 from the resilience of the diaphragm 54, as long as no actuating force is applied to its upstream side, either by the physical contact of the distal end of the syringe tip 64, or by the pressure of the fluid exiting therefrom.
- the slit 56 although easily opened by downstream-directed forces applied to the upstream surface of the diaphragm, strongly resists opening in response to upstream-directed forces applied to the downstream diaphragm surface.
- valve 12 remains closed in response to back pressures generated by the flow from the IV bag 14, as well as those resulting from the transmission, via the second tube 20 and the second tube connection port 52, of the vascular pressure of the patient during infusion, thereby further ensuring against leakage.
- the syringe tip 64 in withdrawing air or liquid from the bag 14 during the bag filling procedure, or in withdrawing liquid from the main flow passage 48 during infusion, the syringe tip 64 must extend past the first annular base 32 so as to open the slit 56 by physically pressing against the diaphragm 54.
- valve cannot be opened simply reducing the fluid pressure on the upstream surface of the diaphragm to less than the pressure on its downstream surface, since, as previously discussed, the seating structure of the diaphragm is such as to resist strongly any significant slit opening in response to such a reverse or back pressure.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Pulmonology (AREA)
- Pharmacology & Pharmacy (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Robinet (12) commandé par seringue et servant au remplissage d'une poche de type IV destiné à recevoir une solution ou autre liquide et comprenant une partie de logement amont (28), en forme de raccord Luer femelle, dans laquelle s'emboîte un embout Luer mâle, et vient se fixer le verrou Luer d'une seringue standard (24), et une partie de logement aval (30) pourvue d'un passage interne (48). La partie amont est pourvue d'une première base annulaire (32) et la partie aval, d'une seconde base annulaire (36), la première base (32) ayant un rayon supérieur à celui de la seconde (36). Un diaphragme souple (54) pourvu d'une fente centrale (56) normalement fermée présente un côté amont reposant sur la première base et un côté aval reposant sur la seconde base (36), le côté amont du diaphragme (56) reposant plus près de son centre et sur une plus grande portion de rayon que le côté aval.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU74740/94A AU7474094A (en) | 1993-08-03 | 1994-07-22 | Valve for filling iv solution bag |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10214193A | 1993-08-03 | 1993-08-03 | |
US08/102,141 | 1993-08-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1995003841A1 true WO1995003841A1 (fr) | 1995-02-09 |
Family
ID=22288324
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1994/008245 WO1995003841A1 (fr) | 1993-08-03 | 1994-07-22 | Robinet de remplissage d'une poche a solution de type iv |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU7474094A (fr) |
WO (1) | WO1995003841A1 (fr) |
Cited By (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0765653A1 (fr) * | 1995-09-27 | 1997-04-02 | Becton, Dickinson and Company | Fiole ayant un ensemble à membrane refermable activée par un dispositif de distribution médical |
WO1998037855A1 (fr) * | 1997-02-28 | 1998-09-03 | Abbott Laboratories | Fermeture de recipient avec joint cassable et connecteur de dispositif de transfert de fluide |
US5871110A (en) * | 1996-09-13 | 1999-02-16 | Grimard; Jean-Pierre | Transfer assembly for a medicament container having a splashless valve |
US5873872A (en) * | 1996-09-17 | 1999-02-23 | Becton Dickinson And Company | Multipositional resealable vial connector assembly for efficient transfer of liquid |
US5925029A (en) * | 1997-09-25 | 1999-07-20 | Becton, Dickinson And Company | Method and apparatus for fixing a connector assembly onto a vial with a crimp cap |
US6003702A (en) * | 1995-09-27 | 1999-12-21 | Becton Dickinson France, S.A. | Vial with resealable connector assembly having a membrane and a multi-configuration fluid access device |
US6003566A (en) * | 1998-02-26 | 1999-12-21 | Becton Dickinson And Company | Vial transferset and method |
US6090093A (en) * | 1997-09-25 | 2000-07-18 | Becton Dickinson And Company | Connector assembly for a vial having a flexible collar |
EP1040845A1 (fr) * | 1997-10-23 | 2000-10-04 | JMS Co., Ltd. | Dispositif d'entree de melange/administration de traitement medical |
US6168037B1 (en) | 1995-09-27 | 2001-01-02 | Becton Dickinson France, S.A. | Resealable vial with connector assembly having a membrane and pusher |
US6213994B1 (en) | 1997-09-25 | 2001-04-10 | Becton Dickinson France, S.A. | Method and apparatus for fixing a connector assembly onto a vial |
US6319236B1 (en) | 1998-11-06 | 2001-11-20 | Millipore Corporation | Universal outlet for filter units |
EP1190734A1 (fr) * | 2000-09-26 | 2002-03-27 | JMS Co., Ltd. | Dispositif d'entrée de mélange/administration de traitement médical |
EP1211184A1 (fr) * | 1999-04-20 | 2002-06-05 | JMS Co., Ltd. | Couvercle pour recipient et adaptateur pour communication liquide |
US6699225B2 (en) | 2000-09-26 | 2004-03-02 | Jms Co., Ltd. | Mixing/charging port for medical treatment |
US6699215B2 (en) | 2000-09-26 | 2004-03-02 | Jms Co., Ltd. | Mixing/charging port for medical treatment |
WO2004020037A1 (fr) * | 2002-08-12 | 2004-03-11 | Jms Co., Ltd. | Orifice sans aiguille et procede de fabrication associe |
EP1562657A2 (fr) * | 2002-10-04 | 2005-08-17 | DSU Medical Corporation | Site d'injection pour connecteur luer male ou autre connecteur tubulaire |
EP1584346A1 (fr) * | 2003-01-09 | 2005-10-12 | Fukai Kogyo Kabushiki Kaisha | Soupape d'etancheite, port de connexion, tube d'alimentation de melange, dispositif de connexion pour circuits de perfusion de liquides, et systeme de connexion pour circuits de perfusion de liquides destines a un dispositif medical |
JP2006055452A (ja) * | 2004-08-20 | 2006-03-02 | Terumo Corp | 薬剤収納容器 |
WO2008095665A1 (fr) * | 2007-02-03 | 2008-08-14 | Fresenius Kabi Deutschland Gmbh | Capuchon de fermeture pour un récipient destiné à recevoir des liquides médicaux et récipient destiné à recevoir des liquides médicaux |
EP2083900A4 (fr) * | 2006-10-05 | 2012-10-03 | Becton Dickinson Co | Dispositifs d'accès vasculaires comprenant un septum résistant à la déchirure |
CN102755677A (zh) * | 2012-06-21 | 2012-10-31 | 浙江润强医疗器械股份有限公司 | 防药液反流的加药装置 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4857062A (en) * | 1988-03-09 | 1989-08-15 | Medical Parameters, Inc. | Catheter introducer valve |
US4895346A (en) * | 1988-05-02 | 1990-01-23 | The Kendall Company | Valve assembly |
US4932633A (en) * | 1988-11-21 | 1990-06-12 | Schneider-Shiley (U.S.A.) Inc. | Hemostasis valve |
US5000745A (en) * | 1988-11-18 | 1991-03-19 | Edward Weck Incorporated | Hemostatis valve |
-
1994
- 1994-07-22 AU AU74740/94A patent/AU7474094A/en not_active Abandoned
- 1994-07-22 WO PCT/US1994/008245 patent/WO1995003841A1/fr active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4857062A (en) * | 1988-03-09 | 1989-08-15 | Medical Parameters, Inc. | Catheter introducer valve |
US4895346A (en) * | 1988-05-02 | 1990-01-23 | The Kendall Company | Valve assembly |
US5000745A (en) * | 1988-11-18 | 1991-03-19 | Edward Weck Incorporated | Hemostatis valve |
US4932633A (en) * | 1988-11-21 | 1990-06-12 | Schneider-Shiley (U.S.A.) Inc. | Hemostasis valve |
Cited By (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6168037B1 (en) | 1995-09-27 | 2001-01-02 | Becton Dickinson France, S.A. | Resealable vial with connector assembly having a membrane and pusher |
US5702019A (en) * | 1995-09-27 | 1997-12-30 | Becton Dickinson France S.A. | Vial having resealable membrane assembly activated by a medical delivery device |
US6003702A (en) * | 1995-09-27 | 1999-12-21 | Becton Dickinson France, S.A. | Vial with resealable connector assembly having a membrane and a multi-configuration fluid access device |
EP0765653A1 (fr) * | 1995-09-27 | 1997-04-02 | Becton, Dickinson and Company | Fiole ayant un ensemble à membrane refermable activée par un dispositif de distribution médical |
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