WO1995003786A3 - New pharmaceutical compositions for topical use containing hyaluronic acid and its derivatives - Google Patents
New pharmaceutical compositions for topical use containing hyaluronic acid and its derivatives Download PDFInfo
- Publication number
- WO1995003786A3 WO1995003786A3 PCT/EP1994/002536 EP9402536W WO9503786A3 WO 1995003786 A3 WO1995003786 A3 WO 1995003786A3 EP 9402536 W EP9402536 W EP 9402536W WO 9503786 A3 WO9503786 A3 WO 9503786A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ester
- hyaluronic acid
- acid
- derivative
- partial
- Prior art date
Links
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 7
- 229920002674 hyaluronan Polymers 0.000 title abstract 7
- 229960003160 hyaluronic acid Drugs 0.000 title abstract 7
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 230000000699 topical effect Effects 0.000 title abstract 3
- 150000002148 esters Chemical class 0.000 abstract 10
- 229920001284 acidic polysaccharide Polymers 0.000 abstract 3
- 150000004805 acidic polysaccharides Chemical class 0.000 abstract 3
- 229920002148 Gellan gum Polymers 0.000 abstract 2
- -1 alginic acid ester Chemical class 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 2
- 239000007921 spray Substances 0.000 abstract 2
- 239000003981 vehicle Substances 0.000 abstract 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 229920002230 Pectic acid Polymers 0.000 abstract 1
- 229920002472 Starch Polymers 0.000 abstract 1
- 208000025865 Ulcer Diseases 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 230000001133 acceleration Effects 0.000 abstract 1
- 239000000443 aerosol Substances 0.000 abstract 1
- 239000000783 alginic acid Substances 0.000 abstract 1
- 229920000615 alginic acid Polymers 0.000 abstract 1
- 235000010443 alginic acid Nutrition 0.000 abstract 1
- 229960001126 alginic acid Drugs 0.000 abstract 1
- 239000001768 carboxy methyl cellulose Substances 0.000 abstract 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 abstract 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 abstract 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000006260 foam Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 229920003175 pectinic acid Polymers 0.000 abstract 1
- 239000010318 polygalacturonic acid Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000008107 starch Substances 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 230000017423 tissue regeneration Effects 0.000 abstract 1
- 230000036269 ulceration Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0076—Sprayable compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A61K9/122—Foams; Dry foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Provided is a pharmaceutical composition, comprising a pharmaceutically effective amount of an acidic polysaccharide and/or a derivative thereof, a gaseous vehicle, and a pharmaceutically acceptable carrier or excipient. Said acidic polysaccharide or derivative thereof can be hyaluronic acid, a pharmaceutically acceptable salt of hyaluronic acid, a partial or total ester of hyaluronic acid with an alcohol, a partial or total intermolecular ester of hyaluronic acid, a partial or total intramolecular ester of hyaluronic acid, a cross-linked ester of hyaluronic acid, an alginic acid ester, an ester of carboxymethylcellulose, an ester of carboxymethylchitin, an ester of carboxymethyl starch, a gellan ester, a cross-linked gellan ester, a pectic acid ester, and a pectinic acid ester. The composition can contain one or more topical drugs, and can be in the form of an aerosol or liquid spray, a foam, or a dry spray. The composition is useful in the treatment of a variety of pathological situations requiring the acceleration of tissue repair, for example in the treatment of burns, sores, ulcerations, and wounds. Also provided is a therapeutic method, comprising topically administering a pharmaceutical composition comprising a pharmaceutically effective amount of an acidic polysaccharide and/or a derivative thereof in association with a gaseous vehicle and a pharmacologically acceptable excipient, and optionally, one or more topical drugs.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU75341/94A AU7534194A (en) | 1993-07-30 | 1994-07-29 | New pharmaceutical compositions for topical use containing hyaluronic acid and its derivatives |
| EP94925418A EP0716596B8 (en) | 1993-07-30 | 1994-07-29 | New pharmaceutical compositions for topical use containing hyaluronic acid and its derivatives |
| DE69434992T DE69434992T2 (en) | 1993-07-30 | 1994-07-29 | HYALURONIC ACID AND ITS DERIVATIVES FOR TOPICAL APPLICATION |
| US09/290,873 US6509322B2 (en) | 1993-07-30 | 1999-04-14 | Pharmaceutical compositions for topical use containing hyaluronic acid and its derivatives |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITPD93A000165 | 1993-07-30 | ||
| ITPD930165A IT1263394B (en) | 1993-07-30 | 1993-07-30 | PHARMACEUTICAL COMPOSITIONS FOR TOPICAL USE BASED ON HYALURONIC ACID AND ITS DERIVATIVES |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US09/290,873 Division US6509322B2 (en) | 1993-07-30 | 1999-04-14 | Pharmaceutical compositions for topical use containing hyaluronic acid and its derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1995003786A2 WO1995003786A2 (en) | 1995-02-09 |
| WO1995003786A3 true WO1995003786A3 (en) | 1995-03-16 |
Family
ID=11390425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP1994/002536 WO1995003786A2 (en) | 1993-07-30 | 1994-07-29 | New pharmaceutical compositions for topical use containing hyaluronic acid and its derivatives |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6509322B2 (en) |
| EP (1) | EP0716596B8 (en) |
| AT (1) | ATE365033T1 (en) |
| AU (1) | AU7534194A (en) |
| DE (1) | DE69434992T2 (en) |
| ES (1) | ES2288298T3 (en) |
| IT (1) | IT1263394B (en) |
| PT (1) | PT716596E (en) |
| WO (1) | WO1995003786A2 (en) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2322864A (en) * | 1997-03-07 | 1998-09-09 | Polybiomed Ltd | Gel for application to the human or animal body |
| US6872819B1 (en) * | 1998-05-27 | 2005-03-29 | Fidia Advanced Biopolymers S.R.L. | Biomaterials containing hyaluronic acid derivatives in the form of three-dimensional structures free from cellular components or products thereof for the in vivo regeneration of tissue cells |
| GB0015682D0 (en) * | 2000-06-28 | 2000-08-16 | Bristol Myers Squibb Co | Sprayable wound care composition |
| EP1443944A1 (en) * | 2001-11-12 | 2004-08-11 | Johannes Reinmüller | Pharmaceutical applications of hyaluronic acid preparations |
| RU2308954C2 (en) * | 2002-05-09 | 2007-10-27 | Медиджинез | Pharmaceutical composition containing blood plasma or serum for treatment of wounds |
| US7262179B2 (en) | 2003-05-28 | 2007-08-28 | Bristol-Myers Squibb Company | Wound care compositions |
| KR101244519B1 (en) * | 2004-03-17 | 2013-03-18 | 젠자임 코포레이션 | Anti-adhesion spraying |
| US20050272695A1 (en) * | 2004-05-27 | 2005-12-08 | Novozymes Biopolymer A/S | Fast dissolving dried hyaluronic acid product |
| US7323184B2 (en) * | 2005-08-22 | 2008-01-29 | Healagenics, Inc. | Compositions and methods for the treatment of wounds and the reduction of scar formation |
| CN101522164B (en) * | 2006-09-13 | 2014-03-26 | 提升肤质产品公司 | Cosmetic composition for the treatment of skin and methods thereof |
| DE102006049580A1 (en) * | 2006-10-20 | 2008-04-24 | Rochel, Michael, Dr. med. | Topical composition for the treatment of eczema |
| US8759321B2 (en) * | 2007-06-13 | 2014-06-24 | Bausch & Lomb Incorporated | Ophthalmic composition with hyaluronic acid and polymeric biguanide |
| US20090062233A1 (en) | 2007-08-09 | 2009-03-05 | Xin Ji | Modified starch material of biocompatible hemostasis |
| CN101455857B (en) * | 2007-12-11 | 2014-03-12 | 纪欣 | Biocompatibility modified starch sponges |
| US9096819B2 (en) | 2008-01-31 | 2015-08-04 | Bausch & Lomb Incorporated | Ophthalmic compositions with an amphoteric surfactant and an anionic biopolymer |
| US8679470B2 (en) * | 2008-11-28 | 2014-03-25 | Luromed Llc | Composition using cross-linked hyaluronic acid for topical cosmetic and therapeutic applications |
| PL2387390T3 (en) * | 2009-01-13 | 2013-12-31 | Pergamum Ab | Hylauronic acid containing compositions for treatment of wounds, scars, post-surgical adhesion formation |
| US8247390B2 (en) * | 2009-09-28 | 2012-08-21 | Luromed Llc | Modified hydrophilic polymers containing hydrophobic groups |
| US20140163217A1 (en) * | 2010-07-29 | 2014-06-12 | Universite De Geneve | Process for the esterification of hyaluronic acid with hydrophobic organic compounds |
| IT1402786B1 (en) * | 2010-11-19 | 2013-09-18 | Fidia Farmaceutici | PHARMACEUTICAL COMPOSITIONS WITH ANTIBACTERIAL AND CICATRIZING ACTIVITIES |
| BR122021017027B1 (en) | 2011-04-27 | 2022-05-17 | Biom'up France SAS | Hemostatic composition, method for preparing a hemostatic composition, composition and kit |
| US9956387B2 (en) * | 2011-07-08 | 2018-05-01 | Timothy Brown | Article of clothing for applying a pharmaceutical, a pharmaceutical delivery kit and method |
| US10400105B2 (en) | 2015-06-19 | 2019-09-03 | The Research Foundation For The State University Of New York | Extruded starch-lignin foams |
| US11052172B2 (en) | 2016-08-12 | 2021-07-06 | Biom'up France SAS | Hemostatic flowable |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0251905A2 (en) * | 1986-06-30 | 1988-01-07 | FIDIA S.p.A. | Esters of alginic acid |
| EP0265116A2 (en) * | 1986-10-13 | 1988-04-27 | FIDIA S.p.A. | Cross-linked esters of hyaluronic acid |
| EP0342557A1 (en) * | 1988-05-13 | 1989-11-23 | FIDIA S.p.A. | New polysaccharide esters |
| JPH02101010A (en) * | 1988-10-07 | 1990-04-12 | Kashiwa Kagaku Kogyo:Kk | Drug for spraying to human skin |
| WO1993014129A1 (en) * | 1992-01-13 | 1993-07-22 | M.U.R.S.T. | Esters of pectic and pectinic acid |
| JPH05320055A (en) * | 1991-07-03 | 1993-12-03 | Denki Kagaku Kogyo Kk | Allergy therapeutic agent |
| WO1994015623A1 (en) * | 1992-12-30 | 1994-07-21 | Patent Biopharmaceutics Inc. | Hyaluronic acid-urea pharmaceutical compositions and uses |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3482812D1 (en) | 1983-10-11 | 1990-08-30 | Fidia Spa | FRACTIONS OF HYALURONIC ACID WITH PHARMACEUTICAL ACTIVITY, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME. |
| US4851521A (en) | 1985-07-08 | 1989-07-25 | Fidia, S.P.A. | Esters of hyaluronic acid |
| IT1219587B (en) | 1988-05-13 | 1990-05-18 | Fidia Farmaceutici | SELF-CROSS-LINKED CARBOXYLY POLYSACCHARIDES |
| EP0518710B1 (en) | 1991-02-11 | 1996-05-22 | FIDIA S.p.A. | Gellan esters |
| IT1264322B (en) | 1992-07-30 | 1996-09-23 | Lanfranco Callegaro | SELF-CROSS-LINKED GELLANO ESTERS, PREPARATION PROCEDURE AND THEIR PHARMACEUTICAL AND BIOMEDICAL-SANITARY APPLICATIONS |
-
1993
- 1993-07-30 IT ITPD930165A patent/IT1263394B/en active IP Right Grant
-
1994
- 1994-07-29 AT AT94925418T patent/ATE365033T1/en active
- 1994-07-29 PT PT94925418T patent/PT716596E/en unknown
- 1994-07-29 EP EP94925418A patent/EP0716596B8/en not_active Revoked
- 1994-07-29 DE DE69434992T patent/DE69434992T2/en not_active Expired - Lifetime
- 1994-07-29 AU AU75341/94A patent/AU7534194A/en not_active Abandoned
- 1994-07-29 ES ES94925418T patent/ES2288298T3/en not_active Expired - Lifetime
- 1994-07-29 WO PCT/EP1994/002536 patent/WO1995003786A2/en active IP Right Grant
-
1999
- 1999-04-14 US US09/290,873 patent/US6509322B2/en not_active Expired - Fee Related
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0251905A2 (en) * | 1986-06-30 | 1988-01-07 | FIDIA S.p.A. | Esters of alginic acid |
| EP0265116A2 (en) * | 1986-10-13 | 1988-04-27 | FIDIA S.p.A. | Cross-linked esters of hyaluronic acid |
| EP0342557A1 (en) * | 1988-05-13 | 1989-11-23 | FIDIA S.p.A. | New polysaccharide esters |
| JPH02101010A (en) * | 1988-10-07 | 1990-04-12 | Kashiwa Kagaku Kogyo:Kk | Drug for spraying to human skin |
| JPH05320055A (en) * | 1991-07-03 | 1993-12-03 | Denki Kagaku Kogyo Kk | Allergy therapeutic agent |
| WO1993014129A1 (en) * | 1992-01-13 | 1993-07-22 | M.U.R.S.T. | Esters of pectic and pectinic acid |
| WO1994015623A1 (en) * | 1992-12-30 | 1994-07-21 | Patent Biopharmaceutics Inc. | Hyaluronic acid-urea pharmaceutical compositions and uses |
Non-Patent Citations (2)
| Title |
|---|
| CHEMICAL ABSTRACTS, vol. 113, no. 26, 24 December 1990, Columbus, Ohio, US; abstract no. 237840 * |
| PATENT ABSTRACTS OF JAPAN vol. 018, no. 140 (C - 1177) 8 March 1994 (1994-03-08) * |
Also Published As
| Publication number | Publication date |
|---|---|
| DE69434992T2 (en) | 2007-12-06 |
| US20020132790A1 (en) | 2002-09-19 |
| PT716596E (en) | 2007-08-20 |
| EP0716596B8 (en) | 2007-10-03 |
| EP0716596B1 (en) | 2007-06-20 |
| AU7534194A (en) | 1995-02-28 |
| ES2288298T3 (en) | 2008-01-01 |
| ITPD930165A0 (en) | 1993-07-30 |
| IT1263394B (en) | 1996-08-05 |
| ITPD930165A1 (en) | 1995-01-30 |
| EP0716596A1 (en) | 1996-06-19 |
| ATE365033T1 (en) | 2007-07-15 |
| US6509322B2 (en) | 2003-01-21 |
| DE69434992D1 (en) | 2007-08-02 |
| WO1995003786A2 (en) | 1995-02-09 |
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