WO1994022911A3 - A PROCESS AND INTERMEDIATE COMPOUNDS USEFUL FOR THE PREPARATION OF PLATELET GLYCOPROTEIN IIb/IIIa INHIBITORS CONTAINING Nα-METHYLARGININE - Google Patents

A PROCESS AND INTERMEDIATE COMPOUNDS USEFUL FOR THE PREPARATION OF PLATELET GLYCOPROTEIN IIb/IIIa INHIBITORS CONTAINING Nα-METHYLARGININE Download PDF

Info

Publication number
WO1994022911A3
WO1994022911A3 PCT/US1994/003222 US9403222W WO9422911A3 WO 1994022911 A3 WO1994022911 A3 WO 1994022911A3 US 9403222 W US9403222 W US 9403222W WO 9422911 A3 WO9422911 A3 WO 9422911A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
intermediate compounds
glycoprotein iib
platelet glycoprotein
methylarginine
Prior art date
Application number
PCT/US1994/003222
Other languages
French (fr)
Other versions
WO1994022911A2 (en
Inventor
William Frank Degrado
Roberta Louise Dorow
Randall Kay Ward
Chu-Biao Xue
Original Assignee
Du Pont Merck Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Merck Pharma filed Critical Du Pont Merck Pharma
Priority to EP94914727A priority Critical patent/EP0694041A1/en
Priority to JP6522194A priority patent/JPH08509709A/en
Priority to AU66976/94A priority patent/AU6697694A/en
Publication of WO1994022911A2 publication Critical patent/WO1994022911A2/en
Publication of WO1994022911A3 publication Critical patent/WO1994022911A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/28—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups, amino groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention provides processes for the preparation of platelet glycoprotein IIb/IIIa inhibitors of formula (I). The present invention also provides processes for the preparation of intermediate compounds. Finally, the invention provides intermediate compounds useful in said processes for the preparation of platelet glycoprotein IIb/IIIa inhibitors.
PCT/US1994/003222 1993-03-29 1994-03-28 A PROCESS AND INTERMEDIATE COMPOUNDS USEFUL FOR THE PREPARATION OF PLATELET GLYCOPROTEIN IIb/IIIa INHIBITORS CONTAINING Nα-METHYLARGININE WO1994022911A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP94914727A EP0694041A1 (en) 1993-03-29 1994-03-28 A PROCESS AND INTERMEDIATE COMPOUNDS USEFUL FOR THE PREPARATION OF PLATELET GLYCOPROTEIN IIb/IIIa INHIBITORS CONTAINING N-ALPHA-METHYLARGININE
JP6522194A JPH08509709A (en) 1993-03-29 1994-03-28 Method for producing inhibitor of platelet glycoprotein (II) b / (IIIIIIa) containing N.sup.α-methylarginine and intermediate compound used therefor
AU66976/94A AU6697694A (en) 1993-03-29 1994-03-28 A process and intermediate compounds useful for the preparation of platelet glycoprotein IIb/IIIa inhibitors containing N alpha--methylarginine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3896193A 1993-03-29 1993-03-29
US08/038,961 1993-03-29

Publications (2)

Publication Number Publication Date
WO1994022911A2 WO1994022911A2 (en) 1994-10-13
WO1994022911A3 true WO1994022911A3 (en) 1995-01-12

Family

ID=21902917

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1994/003222 WO1994022911A2 (en) 1993-03-29 1994-03-28 A PROCESS AND INTERMEDIATE COMPOUNDS USEFUL FOR THE PREPARATION OF PLATELET GLYCOPROTEIN IIb/IIIa INHIBITORS CONTAINING Nα-METHYLARGININE

Country Status (6)

Country Link
EP (1) EP0694041A1 (en)
JP (1) JPH08509709A (en)
AU (1) AU6697694A (en)
CA (1) CA2159069A1 (en)
NZ (1) NZ265753A (en)
WO (1) WO1994022911A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2159072A1 (en) * 1993-03-29 1994-10-13 Lin-Hua Zhang Novel processes and intermediate compounds for the preparation of platelet glycoprotein iib/iiia inhibitors
ZA978758B (en) * 1996-10-02 1999-03-30 Du Pont Merck Pharma Technetium-99m-labeled chelator incorporated cyclic peptides that bind to the GPIIb/IIIa receptor as imaging agents
JP2002538151A (en) 1999-03-02 2002-11-12 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド Compounds useful as reversible inhibitors of cathepsin
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0422938A1 (en) * 1989-10-13 1991-04-17 Merck & Co. Inc. Fibrinogen receptor antagonists

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0422938A1 (en) * 1989-10-13 1991-04-17 Merck & Co. Inc. Fibrinogen receptor antagonists

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KIRIHATA, M. ET AL.: "Asymmetric Synthesis of alpha-Methylornithine", AGRIC. BIOL. CHEM., vol. 42, no. 1, 1978, pages 185 - 186 *
MEZO, I. ET AL.: "Labelled amino acids and their derivatives", ACTA CHIM. ACAD. SCI. HUNG., vol. 85, no. 2, 1975, pages 201 - 213 *

Also Published As

Publication number Publication date
AU6697694A (en) 1994-10-24
JPH08509709A (en) 1996-10-15
EP0694041A1 (en) 1996-01-31
CA2159069A1 (en) 1994-10-13
NZ265753A (en) 1996-11-26
WO1994022911A2 (en) 1994-10-13

Similar Documents

Publication Publication Date Title
EP0636617A3 (en) Process for the preparation of N-(2-hydromethyl)-piperazin.
AU1980997A (en) Synthetic Multimerizing Agents
CA2160137A1 (en) Bicyclic Ansamycins
HUP0003305A3 (en) Hiv protease inhibiting tetrahydro-pyrimid-2-on derivative, pharmaceutical compositions containing it and process for producing the compound
PL310896A1 (en) Cyclic compounds useful as platelet iib/iiia glycoprotein inhibitors
AU8974298A (en) 1,4,7,10-tetraazabicyclo{8.2.2}tetradecan-2-one, a process for the preparation thereof and the use thereof for the preparation of tetraazamacrocycles
CA2137748A1 (en) Amidinophenylalanine derivatives, a process for their preparation, their use and compositions containing these as anticoagulants
EP0632684A3 (en) Process for manufacturing metal-ceramic substrate.
EP0624620A3 (en) Process for the production of fibres containing polypropylene as main component.
MY117934A (en) Process for the preparation of n-methyl-3-(1-methyl-4- piperidinyl)-1h-indole-5-ethanesulphonamide
WO1994022911A3 (en) A PROCESS AND INTERMEDIATE COMPOUNDS USEFUL FOR THE PREPARATION OF PLATELET GLYCOPROTEIN IIb/IIIa INHIBITORS CONTAINING Nα-METHYLARGININE
EP0622384A3 (en) Process for the preparation of polymer-polyesterols.
AU673401B2 (en) 6,7-dialkoxy-3,4-dihydroisoquinolin-8-ol, process for preparation thereof and process for preparation of 6,7-dialkoxy-1,2,3,4-tetrahydroisoquinolin-8-ol using the compound
ZA961659B (en) A process for making 1,2-benzisothiazolin-3-ones, and the use of such compounds as industrial biocides
EP0628536A3 (en) Process for the preparation of amines.
HU9503959D0 (en) Process for the preparation of substituted 4,6-diamino-5-cyanopyrimidines
AU6534594A (en) A method of controlling the closing of a can or container, as well as a closing machine for carrying out the method
EP0635482A3 (en) Process for the preparation of polyfluoronitrobenzenes.
TW239124B (en) Process for the preparation of 2,4,5-tribromopyrrole-3-carbonitrile
AU8052994A (en) System for the stowrage of articles, in particular bicycles
GR3025168T3 (en) Process for the purification of 1,1,1,2-Tetrafluorethane.
EP0663207A3 (en) Process for preparation of bamboo-salt, bamboo-salt.
GR3024856T3 (en) Process for the preparation of dichloroacetylchloride.
EP0635486A3 (en) Process for the preparation of fluorobenzonitriles.
EP0621264A3 (en) Process for the preparation of 4-alkanoylaryl-benzylethers.

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU CA JP NZ

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AU CA JP NZ

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE

WWE Wipo information: entry into national phase

Ref document number: 265753

Country of ref document: NZ

WWE Wipo information: entry into national phase

Ref document number: 1994914727

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2159069

Country of ref document: CA

WWP Wipo information: published in national office

Ref document number: 1994914727

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1994914727

Country of ref document: EP