WO1994014479B1 - Controlled release composition for active substances into an aqueous medium - Google Patents
Controlled release composition for active substances into an aqueous mediumInfo
- Publication number
- WO1994014479B1 WO1994014479B1 PCT/US1993/012494 US9312494W WO9414479B1 WO 1994014479 B1 WO1994014479 B1 WO 1994014479B1 US 9312494 W US9312494 W US 9312494W WO 9414479 B1 WO9414479 B1 WO 9414479B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- capsule
- composition
- release
- neutralizer
- solution
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract 20
- 239000000126 substance Substances 0.000 title 1
- 239000002775 capsule Substances 0.000 claims abstract 35
- MHAJPDPJQMAIIY-UHFFFAOYSA-N hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims abstract 22
- 239000011780 sodium chloride Substances 0.000 claims abstract 15
- 239000003795 chemical substances by application Substances 0.000 claims abstract 13
- 102000004190 Enzymes Human genes 0.000 claims abstract 11
- 108090000790 Enzymes Proteins 0.000 claims abstract 11
- 230000002797 proteolythic Effects 0.000 claims abstract 11
- 230000000249 desinfective Effects 0.000 claims abstract 10
- 230000003472 neutralizing Effects 0.000 claims abstract 10
- 230000003111 delayed Effects 0.000 claims abstract 8
- 150000003839 salts Chemical class 0.000 claims abstract 5
- 108010010803 Gelatin Proteins 0.000 claims abstract 2
- 229920000159 gelatin Polymers 0.000 claims abstract 2
- 239000008273 gelatin Substances 0.000 claims abstract 2
- 235000019322 gelatine Nutrition 0.000 claims abstract 2
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 18
- 238000000034 method Methods 0.000 claims 11
- 102000016938 EC 1.11.1.6 Human genes 0.000 claims 10
- 108010053835 EC 1.11.1.6 Proteins 0.000 claims 10
- 229940088598 Enzyme Drugs 0.000 claims 9
- 239000007903 gelatin capsule Substances 0.000 claims 7
- 229940105657 CATALASE Drugs 0.000 claims 6
- 108090000787 Subtilisin Proteins 0.000 claims 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 5
- 239000007787 solid Substances 0.000 claims 4
- 238000004140 cleaning Methods 0.000 claims 2
- 230000029087 digestion Effects 0.000 claims 2
- 239000012530 fluid Substances 0.000 abstract 3
- 239000007963 capsule composition Substances 0.000 abstract 1
- 230000005591 charge neutralization Effects 0.000 abstract 1
- 230000001264 neutralization Effects 0.000 abstract 1
- 238000006386 neutralization reaction Methods 0.000 abstract 1
- 230000003204 osmotic Effects 0.000 abstract 1
Abstract
A composition for delaying release of an active component into an aqueous fluid is taught which includes a capsule that swells in the presence of an aqueous fluid allowing moisture to enter the capsule into contact with a capsule decomposing agent activated by the entering moisture such that the agent decomposes the capsule sufficiently to release the active agent at a predetermined delayed time after the capsule contacts the aqueous fluid. A preferred capsule composition is gelatin and decomposing agents are a proteolytic enzyme or a salt that affects the osmotic gradient of the system. The controlled release composition of the invention is preferably utilized in a soft contact lens disinfecting system wherein a solution of hydrogen peroxide disinfects the lenses followed by neutralization of residual hydrogen peroxide wherein release of the neutralizing agent is delayed by means of the capsule proteolytic enzyme or salt composition.
Claims
1. A composition for delaying release of a neutralizing composition into a solution of hydrogen peroxide for disinfecting contact lenses, comprising:
a gelatin capsule that swells in said solution allowing moisture to enter said capsule; a capsule decomposing agent that is a proteolytic enzyme or a water soluble inorganic or organic salt that is activated by said entering moisture wherein said agent decomposes said capsule sufficient to release said neutralizing component into said solution, wherein release of the neutralizer is delayed until after the disinfecting step is completed and then neutralize residual hydrogen peroxide.
2. The composition of claim 1 wherein said neutralizer component further comprises a proteolytic enzyme within said capsule wherein the capsule in the aqueous medium swells, transmitting sufficient water into the capsule to activate the proteolytic enzyme to digest the capsule, releasing the neutralizer into the aqueous medium whereby residual H2O2 is neutralized.
3. The composition of claim 2 wherein said proteolytic enzyme is subtilisin.
4. The composition of claim 2 wherein said neutralizer is a catalase enzyme.
5. The composition of claim 10 wherein the amount of subtilisin is adjusted to delay digestion of said capsule to provide sufficient time for disinfecting by said H2O2 solution.
6. The composition of claim 5 wherein said subtilisin is present in the amount of about 0.05-3.00 milligrams per capsule and said catalase release is substantially delayed for about 1-2 hours.
7. The composition of claim 1 wherein said means for delaying release of said catalase enzyme comprises sodium chloride within said capsule.
8. The composition of claim 7 wherein said NaCl is present in said capsule in a range of about 5-100 milligrams per capsule.
9. The composition of claim 7 wherein said NaCl is present in less than about 70 milligrams per capsule.
10. The composition of claim 7 wherein said NaCl is about 10 milligrams per capsule and said catalase release is substantially delayed for about 2-3 hours.
11. A process for delaying release of a neutralizing composition into a solution of hydrogen peroxide for disinfecting contact lenses, comprising: placing a gelatin capsule that swells in said solution and allowing moisture to enter said capsule; said gelatin capsule containing a decomposing agent that is a proteolytic enzyme or a water soluble inorganic or organic salt that is activated by said entering moisture wherein said agent decomposes said capsule sufficient to release said neutralizing component into said solution, wherein release of the neutralizer is delayed until after the disinfecting step is completed and then neutralize residual hydrogen peroxide.
12. The process of claim 11 wherein said neutralizer component further comprises a proteolytic enzyme within said capsule wherein the capsule in the aqueous medium swells, transmitting sufficient water into the capsule to activate the proteolytic enzyme to digest the capsule, releasing the neutralizer into the aqueous medium whereby residual H2O2 is neutralized.
13. The process of claim 12 wherein said proteolytic enzyme is subtilisin.
14. The process of claim 12 wherein said .neutralizer is a catalase enzyme.
15. The process of claim 14 wherein the amount of subtilisin is adjusted to delay digestion of said capsule to provide sufficient time for disinfecting by said H2O2 solution.
16. The process of claim 15 wherein said subtilisin is present in the amount of about 0.05-3.00 milligrams per capsule and said catalase release is substantially delayed for aobut 1-2 hours.
17. The process of claim 11 wherein said means for delaying release of said neutralizer comprises sodium chloride within said capsule.
18. The process of claim 17 wherein said NaCl is present in said capsule in a range of about 5-100 milligrams per capsule.
19. The process of claim 17 wherein said NaCl is present in less than about 70 milligrams per capsule.
20. The process of claim 17 wherein said NaCl is about 10 milligrams per capsule and said catalase release is substantially delayed for about 2-3 hours.
38
STATEMENT UNDER ARTICLE19
This Statement accompanies the amendments under PCT Article 19 submitted herewith, wherein original claims 1-28 are replaced by amended claims 1-20.
Original claims 1-5, 7 and 17-28 have been canceled. Original claim 6, now claim 1, has been amended to indicate that the capsule is a gelatin capsule and that the decomposing agent within the gelatin capsule is a proteolytic enzyme or a water soluble inorganic or organic salt. Support for the term "gelatin" is found on page 7 of the Specification, line 7 and 8 thereof. Support for the amendment relating to the decomposing agent is found on page 7 of the Specification, lines 10-15 thereof. New claims 2-10 correspond to original claims 8-16, respectively, with the dependencies corrected to reflect the renumbering of the new claims. New claims 7 and 10 have also been amended by deleting terms "catalase" and "catalase enzyme" and replacing them with the term "neutralizer." There is no antecedent basis in independent claim 1 for the term "catalase," while there is support for the term "neutralizer."
Applicant has presented new claims 11-18. These claims are all process claims and they track new composition claims 1-10.
The claims, as amended, of related case PCT/US93/12553 (filed 21/12/93) are directed to a preserved saline solution for disinfecting and cleaning contact lenses comprising a solid PVP- H202 hydrogen peroxide complex and a solid neutralizing component for neutralizing H202 wherein the neutralizer component comprises a gelatin capsule containing a neutralizing component and a capsule decomposing agent. The claims for that case also include a method for disinfecting and cleaning contact lenses using the foregoing preserved saline solution containing solid PVP-H202 complex and a gelatin capsule containing a neutralizing component and a decomposing agent. The claims of the present PCT application are directed to a method and composition for delaying release of a neutralizing composition into a solution of hydrogen peroxide for disinfecting contact lenses. In other words, the related case is directed to a solid PVP-H202 composition whereas the present application is directed to a solution of hydrogen peroxide.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU60494/94A AU676268B2 (en) | 1992-12-28 | 1993-12-21 | Controlled release composition for active substances into anaqueous medium |
| BR9307797A BR9307797A (en) | 1992-12-28 | 1993-12-21 | Composition and process for delaying the release of a neutralizing composition to a hydrogen peroxide solution to disinfect contact lenses |
| EP94907099A EP0675739A1 (en) | 1992-12-28 | 1993-12-21 | Controlled release composition for active substances into an aqueous medium |
| JP6515418A JPH08507700A (en) | 1992-12-28 | 1993-12-21 | Composition for controlled release of active substance in aqueous medium |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99742392A | 1992-12-28 | 1992-12-28 | |
| US07/997,423 | 1992-12-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1994014479A1 WO1994014479A1 (en) | 1994-07-07 |
| WO1994014479B1 true WO1994014479B1 (en) | 1994-08-04 |
Family
ID=25544005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1993/012494 WO1994014479A1 (en) | 1992-12-28 | 1993-12-21 | Controlled release composition for active substances into an aqueous medium |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5645848A (en) |
| EP (1) | EP0675739A1 (en) |
| JP (1) | JPH08507700A (en) |
| CN (1) | CN1091235A (en) |
| AU (1) | AU676268B2 (en) |
| BR (1) | BR9307797A (en) |
| CA (1) | CA2152961A1 (en) |
| SG (1) | SG47841A1 (en) |
| WO (1) | WO1994014479A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8137658B2 (en) | 2005-06-28 | 2012-03-20 | Isp Investments Inc. | Tooth whitening compositions |
| US7964551B2 (en) * | 2006-03-31 | 2011-06-21 | Isp Investments Inc. | Cleaning tablet |
| CA2684631C (en) | 2007-05-10 | 2015-10-06 | University Of Georgia Research Foundation, Inc. | Sulfur-based bulk reductants and methods of using same |
| CN101407358B (en) * | 2008-11-06 | 2013-01-30 | 天津大学 | Metal peroxide-based oxygen slow release composite material |
| US20110114517A1 (en) * | 2009-11-17 | 2011-05-19 | Kasey Jon Minick | Hydrogen peroxide solution and kit for disinfecting contact lenses |
| JP5564710B2 (en) | 2009-11-19 | 2014-08-06 | 日本曹達株式会社 | Reduction method of ballast water |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3912451A (en) * | 1973-06-04 | 1975-10-14 | Warner Lambert Co | Method for removing hydrogen peroxide from soft contact lenses |
| DE3277567D1 (en) * | 1981-12-21 | 1987-12-10 | Titmus Eurocon Kontaktlinsen | Method for disinfecting and cleaning contact lenses |
| US4748992A (en) * | 1981-12-21 | 1988-06-07 | Ciba Vision Care Corporation | Contact lens disinfection |
| FR2544880B1 (en) * | 1983-04-20 | 1986-08-29 | Pos Lab | PROCESS FOR THE CLEANING AND DECONTAMINATION OF CONTACT LENSES AND COMPOSITION FOR ITS IMPLEMENTATION |
| US4568517A (en) * | 1983-08-25 | 1986-02-04 | Barnes-Hind, Inc. | Disinfection of contact lenses |
| DE3666914D1 (en) * | 1985-07-10 | 1989-12-21 | Ciba Geigy Ag | Cleaning set for contact lenses |
| DE3701129A1 (en) * | 1987-01-16 | 1988-07-28 | Henkel Kgaa | METHOD FOR PRODUCING DISINFECTING CONTACT LENS CLEANING AGENT TABLETS |
| DE3721574A1 (en) * | 1987-06-30 | 1989-01-12 | Kettelhack Riker Pharma Gmbh | MEDICINAL PRODUCTS IN THE FORM OF PELLETS WITH ENZYMATICALLY CONTROLLED DRUG RELEASE |
| JPH0729883B2 (en) * | 1987-12-18 | 1995-04-05 | ホーヤ株式会社 | Composition for sterilizing contact lenses |
| US4882150A (en) * | 1988-06-03 | 1989-11-21 | Kaufman Herbert E | Drug delivery system |
| US5049395A (en) * | 1989-03-09 | 1991-09-17 | Micro Vesicular Systems, Inc. | Controlled release vehicle |
| SE8901279D0 (en) * | 1989-04-10 | 1989-04-10 | Pharmacia Ab | COMPOSITION |
| US5338480A (en) * | 1989-10-02 | 1994-08-16 | Allegan, Inc. | Compositions and methods to clean contact lenses |
| US5008106A (en) * | 1989-12-14 | 1991-04-16 | Gaf Chemicals Corporation | Method for reducing the microbial content of surfaces with a microbiocidal, anhydrous complex of PVP-H2 O2 |
| ES2022020A6 (en) * | 1990-05-03 | 1991-11-16 | Dirygesa Sl | Method and device for disinfecting contact lenses |
| US5145644A (en) * | 1990-12-20 | 1992-09-08 | Allergan, Inc. | Hydrogen peroxide destroying compositions and methods of making and using same |
| US5556480A (en) * | 1991-05-07 | 1996-09-17 | Dirygesa, S.L. | Procedure for disinfecting and cleaning contact lenses |
| US5223265A (en) * | 1992-01-10 | 1993-06-29 | Alza Corporation | Osmotic device with delayed activation of drug delivery |
| US5364601A (en) * | 1992-12-30 | 1994-11-15 | Bausch & Lomb Incorporated | Treating of contact lenses with compositions comprising PVP-H202 |
| US5362647A (en) * | 1993-02-12 | 1994-11-08 | Allergan, Inc. | Compositions and methods for destroying hydrogen peroxide |
| US5447650A (en) * | 1993-10-06 | 1995-09-05 | Allergan, Inc. | Composition for preventing the accumulation of inorganic deposits on contact lenses |
| US5549891A (en) * | 1994-04-05 | 1996-08-27 | Allergan | Method for disinfecting contact lens with catalase compositions |
-
1993
- 1993-12-21 AU AU60494/94A patent/AU676268B2/en not_active Ceased
- 1993-12-21 SG SG1996004664A patent/SG47841A1/en unknown
- 1993-12-21 BR BR9307797A patent/BR9307797A/en not_active Application Discontinuation
- 1993-12-21 CA CA002152961A patent/CA2152961A1/en not_active Abandoned
- 1993-12-21 EP EP94907099A patent/EP0675739A1/en not_active Withdrawn
- 1993-12-21 JP JP6515418A patent/JPH08507700A/en active Pending
- 1993-12-21 WO PCT/US1993/012494 patent/WO1994014479A1/en not_active Application Discontinuation
- 1993-12-28 CN CN93121778A patent/CN1091235A/en active Pending
-
1995
- 1995-06-06 US US08/471,669 patent/US5645848A/en not_active Expired - Fee Related
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