WO1994004485A1 - LIGANDS UTILISES DANS LA TOMOGRAPHIE CARDIAQUE A POSITONS REALISEE AVEC DU Ga-68 - Google Patents

LIGANDS UTILISES DANS LA TOMOGRAPHIE CARDIAQUE A POSITONS REALISEE AVEC DU Ga-68 Download PDF

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Publication number
WO1994004485A1
WO1994004485A1 PCT/US1993/007769 US9307769W WO9404485A1 WO 1994004485 A1 WO1994004485 A1 WO 1994004485A1 US 9307769 W US9307769 W US 9307769W WO 9404485 A1 WO9404485 A1 WO 9404485A1
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WO
WIPO (PCT)
Prior art keywords
ligand
metal binding
binding group
general formula
formula
Prior art date
Application number
PCT/US1993/007769
Other languages
English (en)
Inventor
Dennis A. Moore
Original Assignee
Mallinckrodt Medical, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Medical, Inc. filed Critical Mallinckrodt Medical, Inc.
Priority to AU50191/93A priority Critical patent/AU5019193A/en
Publication of WO1994004485A1 publication Critical patent/WO1994004485A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/50—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/76—Metal complexes of amino carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
    • C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Abstract

Des ligands et des compositions utilisés dans la tomographie cardiaque à positions réalisée avec du gallium-68 sont décrits. Lesdits ligands forment des complexes stables avec le Ga-68. Des variations de substituants libres permettent de viser des organes particuliers tout en ayant des caractéristiques de perfusion semblables à celles d'un imitateur du potassium. L'invention concerne des ligands de type macrobicyclique, macrocyclique et acyclique.
PCT/US1993/007769 1992-08-19 1993-08-18 LIGANDS UTILISES DANS LA TOMOGRAPHIE CARDIAQUE A POSITONS REALISEE AVEC DU Ga-68 WO1994004485A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU50191/93A AU5019193A (en) 1992-08-19 1993-08-18 Ligands for ga-68 pet heart applications

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93215792A 1992-08-19 1992-08-19
US07/932,157 1992-08-19

Publications (1)

Publication Number Publication Date
WO1994004485A1 true WO1994004485A1 (fr) 1994-03-03

Family

ID=25461868

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1993/007769 WO1994004485A1 (fr) 1992-08-19 1993-08-18 LIGANDS UTILISES DANS LA TOMOGRAPHIE CARDIAQUE A POSITONS REALISEE AVEC DU Ga-68

Country Status (3)

Country Link
AU (1) AU5019193A (fr)
MX (1) MX9305039A (fr)
WO (1) WO1994004485A1 (fr)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998046276A1 (fr) * 1997-04-11 1998-10-22 Nycomed Imaging As Agents chelateurs
WO2001016272A2 (fr) * 1999-09-01 2001-03-08 Unilever Plc Ligand et complexe servant a blanchir un substrat selon un procede catalytique
WO2001064698A2 (fr) * 2000-03-01 2001-09-07 University College Cardiff Consultants Limited Ligands macrocycliques et complexes de ces derniers
WO2002006287A2 (fr) * 2000-07-17 2002-01-24 California Institute Of Technology Agents de contraste macrocycliques pour irm
US6432900B1 (en) 1999-09-01 2002-08-13 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Ligand and complex for catalytically bleaching a substrate
US6610641B2 (en) 2000-02-29 2003-08-26 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Composition and method for bleaching a substrate
WO2003059397A3 (fr) * 2001-12-26 2003-08-28 Immunomedics Inc Marquage d'agents de ciblage au gallium-68 et au gallium-67
US6627176B2 (en) * 2000-09-25 2003-09-30 Procter & Gamble Company Metal complexes for use in medical and therapeutic applications
US6673333B1 (en) 2000-05-04 2004-01-06 Research Corporation Technologies, Inc. Functional MRI agents for cancer imaging
US6713045B1 (en) 1995-06-02 2004-03-30 Research Corporation Technologies, Inc. Targeted magnetic resonance imaging agents for the detection of physiological processes
WO2007042504A2 (fr) * 2005-10-07 2007-04-19 Guerbet Composes comprenant une partie de reconnaissance d'une cible biologique, couplee a une partie de signal capable de complexer le gallium
US7354568B1 (en) 1997-10-27 2008-04-08 California Institute Of Technology Magnetic resonance imaging agents for the detection of physiological agents
EP1988925A2 (fr) * 2006-02-24 2008-11-12 Mallinckrodt, Inc. Conjugués chélatants métallifères bifonctionnels de dérivés de résorcinol, de thiorésorcinol et de dithiorésorcinol
US8986650B2 (en) 2005-10-07 2015-03-24 Guerbet Complex folate-NOTA-Ga68

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0287465A1 (fr) * 1987-04-14 1988-10-19 Guerbet S.A. Ligands cycliques azotés, complexes métalliques formés par ces ligands, compositions de diagnostic contenant ces complexes et procédé de préparation des ligands
US4957939A (en) * 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4957939A (en) * 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
EP0287465A1 (fr) * 1987-04-14 1988-10-19 Guerbet S.A. Ligands cycliques azotés, complexes métalliques formés par ces ligands, compositions de diagnostic contenant ces complexes et procédé de préparation des ligands

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
INORG. CHEM., Vol. 29, issued 1990, ULF AUERBACH et al., "Synthesis and Coordination Chemistry of the Hexadentate Ligands 1,4,7-Tris(2-Hydroxybenzyl)-1,4,6-Triazacyclononane (H3L1) and 1,4,7-Tris(3-Tert-Butyl-2-Hydroxybenzyl)-1,4,7-Triazacyclononane (H3L2). Crystal Structures of ÄHL1CuIIÜ and ÄL2FeIIIÜAcacH", pages 938-944. *

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6713045B1 (en) 1995-06-02 2004-03-30 Research Corporation Technologies, Inc. Targeted magnetic resonance imaging agents for the detection of physiological processes
WO1998046276A1 (fr) * 1997-04-11 1998-10-22 Nycomed Imaging As Agents chelateurs
US6004529A (en) * 1997-04-11 1999-12-21 Nycomed Imaging As Chelating agents
US6280706B1 (en) 1997-04-11 2001-08-28 Nycomed Imaging As Chelating agents
US7354568B1 (en) 1997-10-27 2008-04-08 California Institute Of Technology Magnetic resonance imaging agents for the detection of physiological agents
WO2001016272A2 (fr) * 1999-09-01 2001-03-08 Unilever Plc Ligand et complexe servant a blanchir un substrat selon un procede catalytique
WO2001016272A3 (fr) * 1999-09-01 2001-08-30 Unilever Plc Ligand et complexe servant a blanchir un substrat selon un procede catalytique
US6432900B1 (en) 1999-09-01 2002-08-13 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Ligand and complex for catalytically bleaching a substrate
US6610641B2 (en) 2000-02-29 2003-08-26 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Composition and method for bleaching a substrate
WO2001064698A2 (fr) * 2000-03-01 2001-09-07 University College Cardiff Consultants Limited Ligands macrocycliques et complexes de ces derniers
WO2001064698A3 (fr) * 2000-03-01 2002-01-31 Univ Cardiff Ligands macrocycliques et complexes de ces derniers
US6673333B1 (en) 2000-05-04 2004-01-06 Research Corporation Technologies, Inc. Functional MRI agents for cancer imaging
WO2002006287A2 (fr) * 2000-07-17 2002-01-24 California Institute Of Technology Agents de contraste macrocycliques pour irm
US6656450B2 (en) 2000-07-17 2003-12-02 California Institute Of Technology, Inc. Macrocyclic magnetic resonance imaging contrast agents
WO2002006287A3 (fr) * 2000-07-17 2002-10-17 California Inst Of Techn Agents de contraste macrocycliques pour irm
US6627176B2 (en) * 2000-09-25 2003-09-30 Procter & Gamble Company Metal complexes for use in medical and therapeutic applications
US7011816B2 (en) 2001-12-26 2006-03-14 Immunomedics, Inc. Labeling targeting agents with gallium-68 and gallium-67
WO2003059397A3 (fr) * 2001-12-26 2003-08-28 Immunomedics Inc Marquage d'agents de ciblage au gallium-68 et au gallium-67
EP2311500A1 (fr) * 2001-12-26 2011-04-20 Immunomedics, Inc. Marquage d'agents de ciblage avec gallium-68 et gallium-97
WO2007042504A2 (fr) * 2005-10-07 2007-04-19 Guerbet Composes comprenant une partie de reconnaissance d'une cible biologique, couplee a une partie de signal capable de complexer le gallium
WO2007042504A3 (fr) * 2005-10-07 2008-02-28 Guerbet Sa Composes comprenant une partie de reconnaissance d'une cible biologique, couplee a une partie de signal capable de complexer le gallium
US8926945B2 (en) 2005-10-07 2015-01-06 Guerbet Compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium
US8986650B2 (en) 2005-10-07 2015-03-24 Guerbet Complex folate-NOTA-Ga68
EP1988925A2 (fr) * 2006-02-24 2008-11-12 Mallinckrodt, Inc. Conjugués chélatants métallifères bifonctionnels de dérivés de résorcinol, de thiorésorcinol et de dithiorésorcinol

Also Published As

Publication number Publication date
MX9305039A (es) 1994-05-31
AU5019193A (en) 1994-03-15

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