WO1994003605A3 - Compositions and methods for detecting human herpesvirus 6 strain z29 - Google Patents

Compositions and methods for detecting human herpesvirus 6 strain z29 Download PDF

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Publication number
WO1994003605A3
WO1994003605A3 PCT/US1993/007213 US9307213W WO9403605A3 WO 1994003605 A3 WO1994003605 A3 WO 1994003605A3 US 9307213 W US9307213 W US 9307213W WO 9403605 A3 WO9403605 A3 WO 9403605A3
Authority
WO
WIPO (PCT)
Prior art keywords
strain
human herpesvirus
hhv
compositions
methods
Prior art date
Application number
PCT/US1993/007213
Other languages
French (fr)
Other versions
WO1994003605A2 (en
Inventor
Demetrio Sanchez-Martinez
Philip E Pellett
Timothy R Dambaugh
Original Assignee
Us Army
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Army filed Critical Us Army
Priority to AU47959/93A priority Critical patent/AU4795993A/en
Publication of WO1994003605A2 publication Critical patent/WO1994003605A2/en
Publication of WO1994003605A3 publication Critical patent/WO1994003605A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/085—Herpetoviridae, e.g. pseudorabies virus, Epstein-Barr virus
    • C07K16/087—Herpes simplex virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16511—Roseolovirus, e.g. human herpesvirus 6, 7
    • C12N2710/16522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention provides a nucleic acid encoding a highly immunoreactive 101 kilodalton apparent molecular mass protein (101K) of human herpesvirus 6 strain Z29 (HHV-6(Z29)). Amino acid sequences encoded by the nucleic acids of the present invention are also contemplated. The present invention also provides a method of diagnosing HHV-6(Z29) infection in a subject comprising detecting the presence of HHV-6(Z29) 101K or a specific immunoreactive epitope thereof.
PCT/US1993/007213 1992-07-31 1993-07-30 Compositions and methods for detecting human herpesvirus 6 strain z29 WO1994003605A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU47959/93A AU4795993A (en) 1992-07-31 1993-07-30 Compositions and methods for detecting human herpesvirus 6 strain z29

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92374392A 1992-07-31 1992-07-31
US07/923,743 1992-07-31

Publications (2)

Publication Number Publication Date
WO1994003605A2 WO1994003605A2 (en) 1994-02-17
WO1994003605A3 true WO1994003605A3 (en) 1994-03-31

Family

ID=25449198

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1993/007213 WO1994003605A2 (en) 1992-07-31 1993-07-30 Compositions and methods for detecting human herpesvirus 6 strain z29

Country Status (2)

Country Link
AU (1) AU4795993A (en)
WO (1) WO1994003605A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4013536A1 (en) * 1989-05-04 1990-11-08 Univ Kansas Monoclonal antibodies reactive with herpes virus-6 infected cells - useful in diagnosis and affinity purification
EP0524421A1 (en) * 1991-07-08 1993-01-27 BEHRINGWERKE Aktiengesellschaft Human herpesvirus type 6 protein p100, the corresponding DNA sequences, their preparation and use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4013536A1 (en) * 1989-05-04 1990-11-08 Univ Kansas Monoclonal antibodies reactive with herpes virus-6 infected cells - useful in diagnosis and affinity purification
EP0524421A1 (en) * 1991-07-08 1993-01-27 BEHRINGWERKE Aktiengesellschaft Human herpesvirus type 6 protein p100, the corresponding DNA sequences, their preparation and use

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
NEIPEL, F. ET AL.: "Gene for major antigenic structural protein (p100) of Human Herpesvirus 6", JOURNAL OF VIROLOGY, vol. 66, no. 6, June 1992 (1992-06-01), pages 3918 - 3924 *
PELLETT, P.E. ET AL.: "A strongly immunoreactive virion protein of human herpesvirus 6 variant B strain Z29 : identification and characterization of the gene and mapping of a variant specific monoclonal antibody reactive epitope", VIROLOGY, vol. 195, no. 2, August 1993 (1993-08-01), pages 521 - 531 *
YAMAMOTO, M. ET AL.: "Identification of a nucleocapsid protein as a specific serological marker of human herpesvirus 6 infection", JOURNAL OF CLINICAL MICROBIOLOGY, vol. 28, no. 9, September 1990 (1990-09-01), pages 1957 - 62 *

Also Published As

Publication number Publication date
AU4795993A (en) 1994-03-03
WO1994003605A2 (en) 1994-02-17

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