WO1994002611A3 - Recombinant human erythropoietin with altered biological activity - Google Patents

Recombinant human erythropoietin with altered biological activity Download PDF

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Publication number
WO1994002611A3
WO1994002611A3 PCT/US1993/007116 US9307116W WO9402611A3 WO 1994002611 A3 WO1994002611 A3 WO 1994002611A3 US 9307116 W US9307116 W US 9307116W WO 9402611 A3 WO9402611 A3 WO 9402611A3
Authority
WO
WIPO (PCT)
Prior art keywords
biological activity
recombinant human
human erythropoietin
erythropoietin
altered biological
Prior art date
Application number
PCT/US1993/007116
Other languages
French (fr)
Other versions
WO1994002611A2 (en
Inventor
Arthur J Sytkowski
Jennifer Grodberg
Original Assignee
New England Deaconess Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New England Deaconess Hospital filed Critical New England Deaconess Hospital
Priority to EP93922677A priority Critical patent/EP0667903A1/en
Publication of WO1994002611A2 publication Critical patent/WO1994002611A2/en
Publication of WO1994002611A3 publication Critical patent/WO1994002611A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

DNA encoding modified, secretable erythropoietin proteins whose ability to regulate the growth and differentiation of red blood cell progenitors are different from the wildtype recombinant erythropoietin and to methods of modifying or altering the regulating activity of a secretable erythropoietin and using modified secretable erythropoietin proteins.
PCT/US1993/007116 1992-07-28 1993-07-28 Recombinant human erythropoietin with altered biological activity WO1994002611A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP93922677A EP0667903A1 (en) 1992-07-28 1993-07-28 Recombinant human erythropoietin with altered biological activity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92081092A 1992-07-28 1992-07-28
US07/920,810 1992-07-28

Publications (2)

Publication Number Publication Date
WO1994002611A2 WO1994002611A2 (en) 1994-02-03
WO1994002611A3 true WO1994002611A3 (en) 1994-03-31

Family

ID=25444454

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1993/007116 WO1994002611A2 (en) 1992-07-28 1993-07-28 Recombinant human erythropoietin with altered biological activity

Country Status (2)

Country Link
EP (1) EP0667903A1 (en)
WO (1) WO1994002611A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6153407A (en) * 1992-07-28 2000-11-28 Beth Israel Deaconess Medical Center Erythropoietin DNA having modified 5' and 3' sequences and its use to prepare EPO therapeutics
US5614184A (en) * 1992-07-28 1997-03-25 New England Deaconess Hospital Recombinant human erythropoietin mutants and therapeutic methods employing them
US5830851A (en) * 1993-11-19 1998-11-03 Affymax Technologies N.V. Methods of administering peptides that bind to the erythropoietin receptor
US5773569A (en) * 1993-11-19 1998-06-30 Affymax Technologies N.V. Compounds and peptides that bind to the erythropoietin receptor
US6187564B1 (en) 1997-07-10 2001-02-13 Beth Israel Deaconess Medical Center DNA encoding erythropoietin multimers having modified 5′ and 3′ sequences and its use to prepare EPO therapeutics
US6165476A (en) * 1997-07-10 2000-12-26 Beth Israel Deaconess Medical Center Fusion proteins with an immunoglobulin hinge region linker
US6242570B1 (en) 1997-07-10 2001-06-05 Beth Israel Deaconess Medical Center Production and use of recombinant protein multimers with increased biological activity
AU8182298A (en) * 1997-07-10 1999-02-08 Beth Israel Deaconess Medical Center Recombinant erythropoietin / immunoglobulin fusion proteins
JP2002512039A (en) 1998-04-22 2002-04-23 コーネル リサーチ ファンデーション インク． Canine erythropoietin gene and recombinant protein
US6696411B1 (en) 1998-04-22 2004-02-24 Cornell Research Foundation, Inc. Canine erythropoietin gene and recombinant protein
US6703480B1 (en) 1999-11-24 2004-03-09 Palani Balu Peptide dimers as agonists of the erythropoientin (EPO) receptor, and associated methods of synthesis and use
JP5406710B2 (en) 2006-05-19 2014-02-05 グライコフィ， インコーポレイテッド Erythropoietin composition
WO2022054748A1 (en) * 2020-09-10 2022-03-17 扶桑薬品工業株式会社 Erythropoietin signaling inhibitor protein

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0409113A1 (en) * 1989-07-20 1991-01-23 BEHRINGWERKE Aktiengesellschaft Human erythropoietin muteins, their production and their use
WO1992021029A1 (en) * 1991-05-10 1992-11-26 Genentech, Inc. Selecting ligand agonists and antagonists

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0409113A1 (en) * 1989-07-20 1991-01-23 BEHRINGWERKE Aktiengesellschaft Human erythropoietin muteins, their production and their use
WO1992021029A1 (en) * 1991-05-10 1992-11-26 Genentech, Inc. Selecting ligand agonists and antagonists

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHERN, Y. ET AL.: "Structural role of amino acids 99-110 in recombinant human erythropoietin", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 202, no. 2, December 1991 (1991-12-01), BERLIN, DE, pages 225 - 229 *
DUBÉ, S. ET AL.: "Glycosylation at specific sites of erythropoietin is essential for biosynthesis, secretion, and biological function", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 263, no. 33, 25 November 1988 (1988-11-25), BALTIMORE, MD US, pages 17516 - 17521 *
POWELL, J. ET AL.: "Human erythropoietin gene: high level expression in stably transfected mammalian cells and chromosome localization", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 83, no. 17, September 1986 (1986-09-01), WASHINGTON US, pages 6465 - 6469 *

Also Published As

Publication number Publication date
EP0667903A1 (en) 1995-08-23
WO1994002611A2 (en) 1994-02-03

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