WO1993025682A3 - Chimeric receptor polypeptides, human h13 proteins and uses thereof - Google Patents

Chimeric receptor polypeptides, human h13 proteins and uses thereof Download PDF

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Publication number
WO1993025682A3
WO1993025682A3 PCT/US1993/005569 US9305569W WO9325682A3 WO 1993025682 A3 WO1993025682 A3 WO 1993025682A3 US 9305569 W US9305569 W US 9305569W WO 9325682 A3 WO9325682 A3 WO 9325682A3
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WO
WIPO (PCT)
Prior art keywords
chimeric receptor
binding
cells
tissues
infection
Prior art date
Application number
PCT/US1993/005569
Other languages
French (fr)
Other versions
WO1993025682A2 (en
WO1993025682A9 (en
Inventor
Daniel Meruelo
Takayuki Yoshimoto
Original Assignee
Univ New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ New York filed Critical Univ New York
Priority to JP50172794A priority Critical patent/JP3623230B2/en
Priority to AU45322/93A priority patent/AU4532293A/en
Priority to EP93915287A priority patent/EP0644936A1/en
Priority to US08/132,990 priority patent/US5834589A/en
Publication of WO1993025682A2 publication Critical patent/WO1993025682A2/en
Publication of WO1993025682A9 publication Critical patent/WO1993025682A9/en
Publication of WO1993025682A3 publication Critical patent/WO1993025682A3/en
Priority to US08/912,332 priority patent/US7071301B1/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Humanized animals, e.g. knockin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/30—Animal model comprising expression system for selective cell killing, e.g. toxins, enzyme dependent prodrug therapy using ganciclovir
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0337—Animal models for infectious diseases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/23—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a GST-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Abstract

Chimeric receptor polypeptides are disclosed which contain chimeric viral receptors of a first species which bind non-first species specific viruses and/or their envelope protein env binding domains, nucleic acid encoding therefore, cells or tissues expressing the chimeric receptor polypeptide, as well as methods of preparing and using thereof. Also disclosed are methods for rendering eukaryotic cells or tissues selectively susceptible to binding and/or infection by recombinant viral vectors or delivery vectors that bind a chimeric receptor of a chimeric receptor polypeptide expressed in target cells or tissues. Also disclosed are gene therapy methods which may be used on selected cells or tissues of a mammal, bird, insect or yeast through the use of transient or constitutive expression or vector association of a chimeric receptor polypeptide having a chimeric receptor binding site. The resulting chimeric receptor cells or tissues are thus rendered susceptible to infection or binding by viral vectors or env binding domains thereof which specifically bind the chimeric receptor. The chimeric receptor cells are then susceptible to infection and/or binding by therapeutic and/or diagnostic agents which comprise an env binding domain of a non-first species specific virus capable of binding a chimeric receptor polypeptide of the present invention.
PCT/US1993/005569 1990-12-14 1993-06-11 Chimeric receptor polypeptides, human h13 proteins and uses thereof WO1993025682A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP50172794A JP3623230B2 (en) 1992-06-11 1993-06-11 Chimeric receptor polypeptide, human H13 protein, and uses thereof
AU45322/93A AU4532293A (en) 1992-06-11 1993-06-11 Chimeric receptor polypeptides, human h13 proteins and uses thereof
EP93915287A EP0644936A1 (en) 1992-06-11 1993-06-11 Chimeric receptor polypeptides, human h13 proteins and uses thereof
US08/132,990 US5834589A (en) 1990-12-14 1993-10-07 Chimeric viral receptor polypeptides
US08/912,332 US7071301B1 (en) 1990-12-14 1997-08-18 Chimeric viral receptor polypeptides, human viral receptor polypeptides and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89907592A 1992-06-11 1992-06-11
US899,075 1992-06-11

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US89907592A Continuation-In-Part 1990-12-14 1992-06-11

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US8472993A Continuation-In-Part 1990-12-14 1993-06-29

Publications (3)

Publication Number Publication Date
WO1993025682A2 WO1993025682A2 (en) 1993-12-23
WO1993025682A9 WO1993025682A9 (en) 1994-02-03
WO1993025682A3 true WO1993025682A3 (en) 1994-03-17

Family

ID=25410455

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1993/005569 WO1993025682A2 (en) 1990-12-14 1993-06-11 Chimeric receptor polypeptides, human h13 proteins and uses thereof

Country Status (6)

Country Link
EP (1) EP0644936A1 (en)
JP (1) JP3623230B2 (en)
AU (1) AU4532293A (en)
CA (1) CA2137547A1 (en)
SG (1) SG52708A1 (en)
WO (1) WO1993025682A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5753499A (en) * 1994-12-23 1998-05-19 New York University Viral vector complexes having adapters of predefined valence
US6096548A (en) 1996-03-25 2000-08-01 Maxygen, Inc. Method for directing evolution of a virus
AU7127798A (en) * 1997-04-18 1998-11-13 President And Fellows Of Harvard College Bifunctional polypeptides for cell-specific viral targeting
US6060316A (en) * 1998-06-09 2000-05-09 President And Fellows Of Harvard College Methods of targeting of viral entry
JP2011501958A (en) * 2007-10-29 2011-01-20 バージニア テック インテレクチュアル プロパティーズ インコーポレーテッド Porcine DC-SIGN, ICAM-3 and LSECtin and their use
US9902962B2 (en) * 2012-09-04 2018-02-27 The Scripps Research Institute Chimeric polypeptides having targeted binding specificity
KR101859223B1 (en) * 2016-11-29 2018-06-01 단디바이오사이언스 주식회사 Marker for detecting of high pathogenic influenza virus and use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992010506A1 (en) * 1990-12-14 1992-06-25 New York University Human retrovirus receptor and dna coding therefor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992010506A1 (en) * 1990-12-14 1992-06-25 New York University Human retrovirus receptor and dna coding therefor

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
J.L. BATTINI ET AL.: "Receptor choice determinants in the envelope glycoproteins of amphotropic, xenotropic, and polytropic murine leukemia viruses", J. VIROL., vol. 66, no. 3, March 1992 (1992-03-01), AM. SOC. MICROBIOL. , BALTIMORE, US;, pages 1468 - 1475 *
T. YOSHIMOTO ET AL.: "Identification of amino acid residues critical for infection with ecotropic murine leukemia retrovirus", J. VIROL., vol. 67, no. 3, March 1993 (1993-03-01), AM. SOC. MICROBIOL. , BALTIMORE, US;, pages 1310 - 1314 *
T. YOSHIMOTO ET AL.: "Molecular cloning and characterization of a novel human gene homologous to the murine ecotropic retroviral receptor", VIROLOGY, vol. 185, no. 1, November 1991 (1991-11-01), ACADEMIC PRESS, INC. NEW YORK, US;, pages 10 - 17 *

Also Published As

Publication number Publication date
EP0644936A1 (en) 1995-03-29
AU4532293A (en) 1994-01-04
WO1993025682A2 (en) 1993-12-23
SG52708A1 (en) 1998-09-28
CA2137547A1 (en) 1993-12-23
JPH07509599A (en) 1995-10-26
JP3623230B2 (en) 2005-02-23

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