WO1993016601A1 - Produit alimentaire pour bebes - Google Patents

Produit alimentaire pour bebes Download PDF

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Publication number
WO1993016601A1
WO1993016601A1 PCT/EP1993/000394 EP9300394W WO9316601A1 WO 1993016601 A1 WO1993016601 A1 WO 1993016601A1 EP 9300394 W EP9300394 W EP 9300394W WO 9316601 A1 WO9316601 A1 WO 9316601A1
Authority
WO
WIPO (PCT)
Prior art keywords
infant
feed
infants
protein
formula
Prior art date
Application number
PCT/EP1993/000394
Other languages
English (en)
Inventor
Robert Brockbank
Peter John Dudek
Alan Lucas
Original Assignee
The Boots Company Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Boots Company Plc filed Critical The Boots Company Plc
Publication of WO1993016601A1 publication Critical patent/WO1993016601A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/20—Dietetic milk products not covered by groups A23C9/12 - A23C9/18
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/19—Dairy proteins

Definitions

  • the present invention relates to an infant feed and, in particular, to a feed with a high whey- predominant protein content which is suitable for feeding low birthweight infants, particularly premature infants, which have reached a weight of at least about 1800 g.
  • the invention also provides a method and a use of such a feed for the nourishment of such infants..
  • 'low-birthweight' denotes an infant born at a weight of less than about 2500 g. Such infants are normally (but not necessarily) premature infants, that is infants born before the end of the normal nine months gestation period.
  • the expression 'term' denotes an infant aged at least nine months post-conception, whilst the expression 'pre-term' denotes a premature infant below this age, i.e. normally less than about 36 weeks post-conception.
  • Such humanised milk formulations typically contain about 1.5 g protein per 100 ml.
  • Dedicova and Drbohlov in Veda-a-Vyzkum-v-Potravinarskem-
  • Prungslu, 30, 127-142 describe 'humanised' infant feeds comprising variously 1.57 and 1.55 g protein per 100 ml.
  • EP-A-129418 (Farley Health Products) discloses an infant feed comprising inter alia 2 g protein and 70 mg calcium per 100 ml of feed.
  • the formulation is stated to be intended primarily for use in the nourishment of infants have a body weight of 1850 g or less, more particularly 1200 g or less.
  • US-A-421623 (Mueller et al) discloses a feed comprising inter alia 2.16 g whey-predominant protein and 52.5 mg calcium (per 100 ml) for use in the nourishment of new-born babies which are delicate, dysmature or premature.
  • Cow and Gate have marketed a low birthweight formula infant feed comprising inter alia 2.2 g protein and 108 mg calcium per 100 ml.
  • SMA have marketed a low birthweight formula infant feed comprising inter alia 2 g protein and 77 mg calcium per 100 ml.
  • Milupa have marketed a low birthweight formula infant feed comprising inter alia 2 g protein and 70 mg calcium per 100 ml.
  • EPGAN European Society of Paediatric Gastroenterology and Nutrition
  • infants may down-regulate feed intake in relation to the energy or nutrient density, and that adding higher levels of protein may not therefore result in increased nutrient uptake (see, for example, Brookes and Kinsey, Arch. Dis. Child. (1985) 60, 42-46 and Foman et al, Acta Paediatr. Scand. (1975) 64, 172-181) .
  • an infant feed comprising between about 1.6 and
  • the feed comprises between about 1.7 and 1.9 g suitably about 1.85 g protein per 100 ml, and preferably between about 60 and 90 mg, suitably about 70 mg calcium per 100 ml.
  • the protein has a whey to casein ratio of between about 55:45 and 65:35, suitably about 60:40.
  • the feed comprises at least 100 ⁇ g, preferably about 650 ⁇ g of iron per 100 ml.
  • the feed comprises between about 20 and 50 mg, suitably about 35 mg phosphorus per 100 ml.
  • the feed comprises .between about 400 ⁇ g and 1 mg, suitably about 600 ⁇ g of zinc per 100 ml.
  • the feed further comprises at least 3.5 ⁇ g, preferably about 5 ⁇ g of manganese per 100 ml and preferably at least 70 mg, preferably about 78 mg of potassium per 100 ml.
  • the feed comprises between about 45 and about 110 ⁇ g, suitably about 60 ⁇ g copper.per 100 ml.
  • the feed is vitamin enhanced, with between about 40 and 100 ⁇ g, suitably about 95 ⁇ g of vitamin Bl; between about 60 and 180 ⁇ g, suitably about 100 ⁇ g of vitamin B2; between about 40 and 100 ⁇ g, preferably about 80 ⁇ g of vitamin B6; between about 0.15 and 0.25 ⁇ g, preferably about 0.2 ⁇ g vitamin B12; between about 0.5 and 2 ⁇ g, preferably about 1.1 ⁇ g biotin; between about 3.4 and 50 ⁇ g, preferably about 25 ⁇ g folate; between about 690 and 1200 ⁇ g, suitably about 1000 ⁇ g niacin between about 300 and 500 ⁇ g, preferably about 400 ⁇ g pantothenic acid; between about 7 and 28 mg, preferably about 15 mg vitamin C; between 5 about 0.5 and 8 ⁇ g, preferably about 1.3 ⁇ g vitamin D, between about 0.5 and 10 mg, preferably about 1.5 mg vitamin E; and between about 3 and 7 ⁇ g, preferably about 6 ⁇ g vitamin
  • the infant feed will normally comprise fats and 10 carbohydrates.
  • the fat content provides a proportion of the energy requirement, supplies essential fatty acids (EFAs) and aids the absorption of fat-soluble vitamins. Fat utilisation is less efficient in low birthweight infants
  • the carbohydrate content makes an important contribution to the energy requirement, the preferred carbohydrate for use being lactose.
  • the infant feeds according to the invention also preferably contain a small amount (relative to lactose) of a glucose donor
  • maltodextrin improves the tolerance of the infant food by helping to make the osmolarity similar to body fluids and by increasing the margin of tolerance for lactose.
  • the ratio of lactose:maltodextrin is with advantage from 5:1 to 9:1 by weight, advantageously about 6:1 by weight.
  • the invention also provides a method of feeding a low-birthweight infant by use of an infant feed as defined above.
  • the feed is supplied only after the infant has reached a weight of about 1800 g, preferably about 2000 g, suitably about 2500 g.
  • the feed will normally be supplied to an infant only after it is considered fit for discharge from hospital.
  • the feed is then supplied for a period of at least three months, preferably six to nine . months, and in a preferred method the feed is supplied as the main source of nutrition until the infant is weaned and then as a dietary supplement throughout infancy.
  • an infant feed as defined above to feed a low birthweight infant, and especially a premature infant, which has reached a weight of at least about 1800 g, preferably about 2000 g.
  • the infant feeds according to the invention may conveniently be in ready-to-use, sterilised liquid form, in the form of a reconstitutable liquid concentrate or in solid (e.g. powder) form.
  • Suitable forms and methods for their production are described in European Patent Publication No. 0129418 in the name of the Boots Company PLC, which is herein incorporated by reference.
  • the invention is illustrated by the following example.
  • a research nurse examined each infant fortnightly to record anthropometry. Weight was measured to the nearest 10 g using a Sartorius MP (Trade Mark) electronic balance; length was measured using a horizontal stadiometer to the next succeeding 1 mm; occipitofrontal circumference was measured to the next succeeding 1 mm using a paper tape measure; skinfold thicknesses - triceps and subscapular - were measured to the nearest 0.1 mm using Harpenden calipers.
  • Sartorius MP Trade Mark
  • the infants received the assigned diet, either as a sole source of nutrition or in conjunction with other foods until 9 months corrected postnatal age.
  • Figures 1 to 3 show longitudinal data (means + SE [standard error] for (a) body weight, (b) body length, (c) head circumference respectively, in babies fed a standard formula [formula 2] (solid line) versus those fed the follow-on formula [formula 1] (dotted line) from recruitment (mean 3 weeks pre-term) to 40 weeks post- term.
  • Data are for both sexes combined; centiles derived from Gardner-Pearson Charts (published by Castlemead, UK) . Differences between the diet groups are apparent on visual inspection of the chart.
  • Table 2 shows milk volume intake in litres at corrected postnatal ages-
  • Measurement of bone width and mineral content was undertaken using single photon absorptiometry using equipment available under the trade designation "Lunar SP2" from Lunar Radiation Corporation.
  • a collimated beam of photons from an 125j source was passed across the arm to a photomultiplier detector. Source and detector were moved in tandem across the arm, and the bone width and mineral content were calculated in known manner from the attenuation of the photon beam.
  • Each infant was placed supine with the left arm extended.
  • the forearm was enfolded in a tissue-equivalent bag made from dialysis tubing filled with warm water. With the arm held perpendicular to the beam .path, two scans across the forearm were undertaken along the same track. Where the difference between scans exceeded 5% the scan was repeated.
  • Measurements were undertaken at. the one third distal site, that is the position corresponding to one third of the distance from the tip of the olecranon to the ulnar styloid process, measured distally from the styloid process.
  • the radius at this point approximates a cylinder over a two or three centimetre distance and thus provides a geometrically stable measuring area.
  • Bone mineral content estimated by SPA correlates well with total body calcium measured by in-vivo neutron activation analysis and. dual energy X-ray absorptiometry in adults. The results therefore suggest an overall increase in the total amount of bone mineral in the skeleton for those infants who received Formula 1.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Dairy Products (AREA)

Abstract

Produit alimentaire pour bébés comportant de 1,6 à 2 g environ de protéines par 100 ml, ainsi qu'au moins 55 mg environ de calcium par 100 ml. La protéine présente un rapport lactosérum:caséine supérieur à 1:1. Ce produit est destiné à l'alimentation des bébés présentant un faible poids de naissance d'au moins 1800 g environ.
PCT/EP1993/000394 1992-02-26 1993-02-19 Produit alimentaire pour bebes WO1993016601A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9204050.0 1992-02-26
GB929204050A GB9204050D0 (en) 1992-02-26 1992-02-26 Infant feed

Publications (1)

Publication Number Publication Date
WO1993016601A1 true WO1993016601A1 (fr) 1993-09-02

Family

ID=10711046

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1993/000394 WO1993016601A1 (fr) 1992-02-26 1993-02-19 Produit alimentaire pour bebes

Country Status (3)

Country Link
AU (1) AU3498093A (fr)
GB (1) GB9204050D0 (fr)
WO (1) WO1993016601A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003005837A1 (fr) * 2001-07-13 2003-01-23 Abbott Laboratories Preparations enterales
EP2224826A1 (fr) * 2007-11-26 2010-09-08 Nestec S.A. Système de nutrition adapté à l'âge pour bébé

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1446431A (en) * 1972-04-20 1976-08-18 Williams J Nutritional supplement
FR2388503A1 (fr) * 1977-04-27 1978-11-24 Nestle Sa Aliment lacte pour nourrissons et son procede de fabrication
US4337278A (en) * 1980-09-09 1982-06-29 Brog Roy A Imitation milk
EP0129418A2 (fr) * 1983-06-16 1984-12-27 Farley Health Products Limited Produit alimentaire infantile
WO1991008675A1 (fr) * 1989-12-20 1991-06-27 Slattery Charles W Formules pour enfants contenant de l'alpha-lactalbumine et de la beta-caseine humaines recombinees

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1446431A (en) * 1972-04-20 1976-08-18 Williams J Nutritional supplement
FR2388503A1 (fr) * 1977-04-27 1978-11-24 Nestle Sa Aliment lacte pour nourrissons et son procede de fabrication
US4337278A (en) * 1980-09-09 1982-06-29 Brog Roy A Imitation milk
EP0129418A2 (fr) * 1983-06-16 1984-12-27 Farley Health Products Limited Produit alimentaire infantile
WO1991008675A1 (fr) * 1989-12-20 1991-06-27 Slattery Charles W Formules pour enfants contenant de l'alpha-lactalbumine et de la beta-caseine humaines recombinees

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003005837A1 (fr) * 2001-07-13 2003-01-23 Abbott Laboratories Preparations enterales
EP2224826A1 (fr) * 2007-11-26 2010-09-08 Nestec S.A. Système de nutrition adapté à l'âge pour bébé
EP2272381A3 (fr) * 2007-11-26 2011-06-29 Nestec S.A. Système de nutrition personnalisée en fonction de l'âge pour nourrissons
CN103054029A (zh) * 2007-11-26 2013-04-24 雀巢产品技术援助有限公司 按年龄配制的婴儿营养系统
CN103054029B (zh) * 2007-11-26 2015-06-24 雀巢产品技术援助有限公司 按年龄配制的婴儿营养系统
EP2224826B1 (fr) * 2007-11-26 2018-12-26 Nestec S.A. Système de nutrition personnalisée en fonction de l'âge pour nourrissons

Also Published As

Publication number Publication date
GB9204050D0 (en) 1992-04-08
AU3498093A (en) 1993-09-13

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