WO1993015972A1 - Multiple package for pharmaceutical products - Google Patents

Multiple package for pharmaceutical products Download PDF

Info

Publication number
WO1993015972A1
WO1993015972A1 PCT/IT1993/000010 IT9300010W WO9315972A1 WO 1993015972 A1 WO1993015972 A1 WO 1993015972A1 IT 9300010 W IT9300010 W IT 9300010W WO 9315972 A1 WO9315972 A1 WO 9315972A1
Authority
WO
WIPO (PCT)
Prior art keywords
alveolus
support
plug
alveoli
seal closing
Prior art date
Application number
PCT/IT1993/000010
Other languages
French (fr)
Inventor
Stefano Di Stefano
Original Assignee
Tecnilens S.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT000306A external-priority patent/ITMI920306A1/en
Priority claimed from ITMI922037A external-priority patent/IT1256358B/en
Application filed by Tecnilens S.R.L. filed Critical Tecnilens S.R.L.
Publication of WO1993015972A1 publication Critical patent/WO1993015972A1/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/002—Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1691—Packages or dispensers for intraocular lenses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/325—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
    • B65D75/327—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming several compartments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2575/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes or webs of flexible sheet material, e.g. in folded wrappers
    • B65D2575/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by association or interconnecting two or more sheets or blanks
    • B65D2575/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D2575/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D2575/3209—Details
    • B65D2575/3218—Details with special means for gaining access to the contents
    • B65D2575/3227—Cuts or weakening lines
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2585/00—Containers, packaging elements or packages specially adapted for particular articles or materials
    • B65D2585/54—Containers, packaging elements or packages specially adapted for particular articles or materials for articles of special shape not otherwise provided for
    • B65D2585/545—Contact lenses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2585/00—Containers, packaging elements or packages specially adapted for particular articles or materials
    • B65D2585/56—Containers, packaging elements or packages specially adapted for particular articles or materials for medicinal tablets or pills

Definitions

  • the present invention concerns a disposable
  • said confections having a first sheet of plastic material in which alveoli are formed wherein medicines in solid preparation are inserted, and a second sheet, usually of composite type, which is fixed on the first sheet in order to protect the solid
  • This patent application provides a plastic material support having a plurality of alveoli arranged in lines. A predetermined amount of liquid physiological solution for the treatment of contact lenses is contained within each alveolus. A film is fixed to said support, sealing the alveoli and retaining the liquid therein exclusively by means of the film.
  • This solution has major drawbacks in that it may happen that the film that is fixed to the support to seal the alveoli breaks up dispersing in the surrounding environment the liquid contained in the single alveoli, what may have even more serious consequences whenever it is the case of liquid or pulverulent medicinal preparations.
  • the danger of breaking may take place especially when metallic films are used, in particular of aluminium, which may also have a certain degree of porosity which may cause, eventually, the evaporation of the product contained in the alveoli, or the penetration of polluting agents which may compromise its sterility and alter its chemical composition.
  • Another object of the present invention is to obtain a device which eliminates the risk of contamination of the product contained therein, due to the porosity or the breaking of the sealing film.
  • a further object of the present invention is to obtain a container which eliminates any risk of evaporation of the liquid contained therein.
  • Yet another object of the present invention is to obtain a packaging device of high reliability, of easy production and use, with competitive costs and which provides the use, with the minimum waste, of an alveolus at a time for each treatment operation.
  • a disposable packaging device characterized in that it consists of a support comprising one or more alveoli provided with removable and reinsertable seal closing means suitable to separate said alveoli from the sealing means which contain the support or are fixed thereon.
  • said device has the advantages of a double protection of the product against contamination and evaporation, and of an effective seal closing of the used alveoli, which prevents the dispersion of the product residues, if any, remained after the use.
  • Fig.1 is a top plan view of a packaging device according to the invention
  • Fig.2 is a sectional view according to line II-II of fig.1;
  • Fig.3 is a view similar to that of fig.2 of a device with two alveoli, exemplifying how the seal closing and sealing means are used;
  • Fig.4 is a plan view similar to that of fig.1, with a plurality of a second type of alveoli;
  • Fig.5 is a sectional side view of a device with two alveoli of the second type illustrated in fig.4, and with different sealing means;
  • Fig.6 is a plan view of a first seal closing means or plug;
  • Fig.7 is a plan view of an alveolus, in the embodiment of figs.4 and 5; and Figs.8, 9 and 10 show sectional side views of some embodiments of alveolus with the respective seal closing and sealing means.
  • the packaging device consists of a support 1 which comprises at least one alveolus 2 of pre-established size sealed in its upper part, for example by a film 3, and containing a predetermined dose of product 4, for example a treatment liquid for the disinfection and/or maintenance of prostheses such as contact lenses.
  • seal closing means are provided, separating the product 4 contained in each alveolus 2 from the sealing means preferably consisting of a film which may be stuck or fixed on the support 1 and removed therefrom to use the product 4.
  • Said seal closing means preferably consist, for each alveolus, of a plug 5 suitable to enter partially the mouth of the corresponding alveolus, extractable and reinsertable in the alveolus (see fig.3), preferably made of an alimentary/pharmaceutical type of material, having a certain elasticity.
  • Means for the irreversible dispensing of the liquid treatment product may also be provided, including a second pull-off plug (not shown) which seals an opening or small beak (not shown as well) formed in a peripheral wall of the alveolus. Said second plug, once it has been pulled off, allows the exit of the predetermined dose of liquid treatment product from said opening.
  • the alveoli 2 are preferably gathered in arranged groups, as shown in fig.1, according to the well known blister technology, in order to make their production easier and to reduce the costs thereof.
  • the number and shape of the alveoli depend on the particular application for which the device is intended (for example according to the type of disinfection or maintenance treatment of prostheses). In particular, for the use in the field of the maintenance of contact lenses and/or the packaging of contact lenses reference will be made to the device illustrated in figs.4-7.
  • the sealing means of the device consist of a sealed sachet 6 which externally includes a pair of alveoli 7 of a second type, each of them being provided with a respective sealing plug 8 but, differently from the alveoli 2 of figs.1-3, the alveoli 7 have an inclined portion 9 on their bottom which favours the extraction of a contact lens immersed in the physiological solution 10.
  • sealing plug 8 come in touch with the mouth of the alveolus, small cavities 11 are provided to make easier the extraction of the plug.
  • the latter may also be slightly sunken in its upper part in order to make possible the insertion between each plug and the sealing means of pills and/or powders of substances for particular treatments of each contact lens.
  • both the above-described embodiments are particularly useful for the packaging not only of solutions for the treatment of contact lenses and the like, but also of fluid or semi-fluid preparations in general, such as single-dose syrups etc. which require the complete utilization of the alveolus contents.
  • the support 1 has a plurality of weakness lines 12, or prearranged split lines, for the mutual separation of the alveoli.
  • medicinal products which are different but necessary to the achievement of the preparation to be administered, such as the mentioned two-components antibiotics and other similar products, also non medicinal, but requiring an absolute isolation from the external environment due to contamination problems and the like.
  • annular groove 13 constitutes the seat wherein the peripheral edge of the respective seal plug 14 is housed, said plug in turn being sealed, for example, by an overlying film 15, said groove 13 being formed near the mouth of the alveolus 16.
  • annular rims 17 and 18 are illustrated, defining an annular housing seat 19 wherein a respective seal plug 20 can be inserted, said plug being sealed, for example, by a film 21, said housing 19 being near the mouth of the alveolus 22, similarly to the preceding case.
  • a further embodiment, shown in fig.10, provides seal closing means of an alveolus 23 including also a plug 24 suitable to be housed in an annular groove 25 formed in a middle portion of the inner wall of the alveolus 23, in addition to a plug 26 insertable into the mouth of the alveolus in any of the above shown ways (for example, here reference has been made to the embodiment of fig.9).
  • the plug 26, completely similar to the preceding seal closing plugs 14 and 20 separates the alveolus 23 from an external film 27, the inner plug 24 divides the volume of the alveolus 23 in two different areas, an upper one and a lower one, capable of containing different products.
  • a pharmaceutical product in powder form may be inserted in an area, and the respective solvent in the other one.
  • seal closing plugs are perforable, in particular those difficult to remove and indicated for medicinal products, that is those relative to the figs.8, 9 and 10.
  • the contents may be extracted from the respective alveoli, in case of liquid medicinal preparations, or it will be possible to inject solvent for medicines packaged in powder form and extract the medicinal mixture thus obtained in solution, in this latter case with particular reference to the embodiment of fig.10.
  • the present invention is capable of achieving the appointed objects, being an efficacious alternative to the confections of known type, strongly reducing the use of expensive material, such as glass and the like, replaced by cheaper and easily recyclable materials, such as the plastic materials.
  • the packaging device according to the invention is obviously susceptible of several changes and versions compared to the above-described and illustrated embodiments, always remaining within the purview of the invention.
  • the sealing plugs may be fixed within the respective alveoli by fixing rings or other similar devices, and all the elements may be replaced by other mechanically equivalent elements, while the materials used as well as the shape, number and size of the alveoli may be any, according to the requirements.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Mechanical Engineering (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Composite Materials (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Packages (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

A disposable packaging device, particularly for pharmaceutical products and the like and for the treatment of prostheses in general, includes at least one alveolus (2) suitable to contain a predetermined dose of pharmaceutical or treatment product (4) and seal closing means (5) of said alveolus suitable to separate said product from sealing means (3) of the alveolus. The latter are fixable on said support or externally contain it. In a preferred embodiment the packaging device includes a support (1) having a plurality of alveoli of pre-established size and a film (3) fixable on said support in a removable way, seal closing means (5) of each alveolus being provided, which separate said alveolus from said film.

Description

Multiple package for pharmaceutical products.
The present invention concerns a disposable
5 packaging device particularly suitable for pharmaceutical products and the like and for the treatment of prostheses in general.
It is known that confections called "blister" are often used for the packaging of medicines and the like
10 of solid kind, said confections having a first sheet of plastic material in which alveoli are formed wherein medicines in solid preparation are inserted, and a second sheet, usually of composite type, which is fixed on the first sheet in order to protect the solid
15 medicine preparations from polluting agents.
This technology, which has reached very high levels of specialization and competitive costs on the market, yet reveals itself nearly inadequate for preparations of medicinal type and the like, liquid or pulverulent.
20 In particular, for the treatment, for example of maintenance or disinfection, of prosthesis members in general, such as removable dental members, contact lenses and the like, more or less complicated operations are presently necessary, requiring, as in
25 the most frequent case of contact lenses, various containers for the lenses and the treatment solutions, as well as complicated pouring operations from a container to another.
The French patent application N.2.452.463 intends
4 j j 30 to solve the problem of the conservation and marketing of liquid physiological solutions for the treatment of contact lenses in blister-type containers as above mentioned. This patent application provides a plastic material support having a plurality of alveoli arranged in lines. A predetermined amount of liquid physiological solution for the treatment of contact lenses is contained within each alveolus. A film is fixed to said support, sealing the alveoli and retaining the liquid therein exclusively by means of the film.
This solution has major drawbacks in that it may happen that the film that is fixed to the support to seal the alveoli breaks up dispersing in the surrounding environment the liquid contained in the single alveoli, what may have even more serious consequences whenever it is the case of liquid or pulverulent medicinal preparations. The danger of breaking may take place especially when metallic films are used, in particular of aluminium, which may also have a certain degree of porosity which may cause, eventually, the evaporation of the product contained in the alveoli, or the penetration of polluting agents which may compromise its sterility and alter its chemical composition.
In order to avoid this, a multi-layer film has to be used, which is more expensive than a simple aluminium film. Anyway, once the sealing film has been removed, a dispersion of the preparation residues, if any, in the environment after the use is probable, which would be extremely serious especially in the case of vaccines or antibiotics ready to use inserted in such a confection. Furthermore, two-components antibiotics are well known in pharmaceutical technology, that is medicines which, in one confection, have a phial containing a solvent and a small bottle containing an antibiotic in powder form, to be dissolved in the solvent prior to its administration. These confections result particularly bulky and expensive due to the need to use two containers different in shape and size, involving packaging problems which the above-mentioned French patent application can not solve.
Finally, for liquid medicinal preparations particularly sensitive to the polluting agents, the conventional type packagings presently used, though they perform excellently the tasks entrusted thereto, result particularly expensive. On the other hand, the solution suggested by the above-mentioned French patent application puts the preparation in contact with films which, though they are of the pharmaceutical and/or alimentary type, may always have on their surface polluting agents capable of altering the preparation inserted in each alveolus.
It is therefore an object of the present invention to eliminate or substantially reduce the above- mentioned drawbacks by providing a disposable packaging device, particularly for pharmaceutical products and the like and for the treatment of prostheses in general, which eliminates the risk of dispersion into the environment of the product contained in the alveoli, both in case of breaking of the covering film, and after the use, as far as the remained residues, if any, are concerned.
Another object of the present invention is to obtain a device which eliminates the risk of contamination of the product contained therein, due to the porosity or the breaking of the sealing film.
A further object of the present invention is to obtain a container which eliminates any risk of evaporation of the liquid contained therein. Yet another object of the present invention is to obtain a packaging device of high reliability, of easy production and use, with competitive costs and which provides the use, with the minimum waste, of an alveolus at a time for each treatment operation.
These and other objects are achieved by means of a disposable packaging device characterized in that it consists of a support comprising one or more alveoli provided with removable and reinsertable seal closing means suitable to separate said alveoli from the sealing means which contain the support or are fixed thereon.
Therefore, said device has the advantages of a double protection of the product against contamination and evaporation, and of an effective seal closing of the used alveoli, which prevents the dispersion of the product residues, if any, remained after the use.
Further characteristics and advantages of the disposable packaging device according to the present invention will be apparent from the description of some embodiments thereof, illustrated as non-limiting examples in the annexed drawings wherein:
Fig.1 is a top plan view of a packaging device according to the invention; Fig.2 is a sectional view according to line II-II of fig.1;
Fig.3 is a view similar to that of fig.2 of a device with two alveoli, exemplifying how the seal closing and sealing means are used; Fig.4 is a plan view similar to that of fig.1, with a plurality of a second type of alveoli;
Fig.5 is a sectional side view of a device with two alveoli of the second type illustrated in fig.4, and with different sealing means; Fig.6 is a plan view of a first seal closing means or plug;
Fig.7 is a plan view of an alveolus, in the embodiment of figs.4 and 5; and Figs.8, 9 and 10 show sectional side views of some embodiments of alveolus with the respective seal closing and sealing means.
Referring to the drawings, in particular to figs.l- 3, the packaging device according to the invention consists of a support 1 which comprises at least one alveolus 2 of pre-established size sealed in its upper part, for example by a film 3, and containing a predetermined dose of product 4, for example a treatment liquid for the disinfection and/or maintenance of prostheses such as contact lenses.
As a peculiar feature of the present invention, also seal closing means are provided, separating the product 4 contained in each alveolus 2 from the sealing means preferably consisting of a film which may be stuck or fixed on the support 1 and removed therefrom to use the product 4. Said seal closing means preferably consist, for each alveolus, of a plug 5 suitable to enter partially the mouth of the corresponding alveolus, extractable and reinsertable in the alveolus (see fig.3), preferably made of an alimentary/pharmaceutical type of material, having a certain elasticity.
Means for the irreversible dispensing of the liquid treatment product may also be provided, including a second pull-off plug (not shown) which seals an opening or small beak (not shown as well) formed in a peripheral wall of the alveolus. Said second plug, once it has been pulled off, allows the exit of the predetermined dose of liquid treatment product from said opening.
The alveoli 2 are preferably gathered in arranged groups, as shown in fig.1, according to the well known blister technology, in order to make their production easier and to reduce the costs thereof. The number and shape of the alveoli depend on the particular application for which the device is intended (for example according to the type of disinfection or maintenance treatment of prostheses). In particular, for the use in the field of the maintenance of contact lenses and/or the packaging of contact lenses reference will be made to the device illustrated in figs.4-7.
In a typical embodiment, shown in fig.5, the sealing means of the device consist of a sealed sachet 6 which externally includes a pair of alveoli 7 of a second type, each of them being provided with a respective sealing plug 8 but, differently from the alveoli 2 of figs.1-3, the alveoli 7 have an inclined portion 9 on their bottom which favours the extraction of a contact lens immersed in the physiological solution 10.
Moreover, where the edges of the sealing plug 8 come in touch with the mouth of the alveolus, small cavities 11 are provided to make easier the extraction of the plug. The latter may also be slightly sunken in its upper part in order to make possible the insertion between each plug and the sealing means of pills and/or powders of substances for particular treatments of each contact lens.
As far as the above considered application is concerned, relative to the contact lenses, such as the cleaning of the lens and other treatment baths, the advantages given by the packaging device according to the invention are apparent, said device:
-allowing the treatment of each single lens in a bath having an optimum dose of treatment liquid; -permitting the treatment of a single lens too;
-allowing the use of the treatment liquid also in other types of container, thanks to the second pull-off plug which permits to pour the dose of liquid in other containers; -assuring the sterility of the liquid, thanks to the seal and the plug 8, which prevent any contamination of the liquid prior to the opening of the alveolus;
-resulting easily disposable, in particular without dispersing the liquid product 10 in the environment, thanks to the seal exerted by the plug 8 within the alveolus 7;
-eliminating all the risks, well known by contact lenses users, of residual dirt remained in the container, typical in the case of reusable containers.
Obviously, these advantages are found also in the other possible applications of the device, in fact both the above-described embodiments are particularly useful for the packaging not only of solutions for the treatment of contact lenses and the like, but also of fluid or semi-fluid preparations in general, such as single-dose syrups etc. which require the complete utilization of the alveolus contents.
In both the above-described cases, the support 1 has a plurality of weakness lines 12, or prearranged split lines, for the mutual separation of the alveoli. In this way it is possible to package in single alveoli also medicinal products which are different but necessary to the achievement of the preparation to be administered, such as the mentioned two-components antibiotics and other similar products, also non medicinal, but requiring an absolute isolation from the external environment due to contamination problems and the like.
On the other hand, whenever the packaging concerns medicinal preparations, such as antibiotics, vaccines and the like, in powder form and with the respective solvents, it is preferable to use other embodiments of the alveoli, described hereafter.
As shown in fig.8, an annular groove 13 constitutes the seat wherein the peripheral edge of the respective seal plug 14 is housed, said plug in turn being sealed, for example, by an overlying film 15, said groove 13 being formed near the mouth of the alveolus 16.
In fig.9, instead, two annular rims 17 and 18 are illustrated, defining an annular housing seat 19 wherein a respective seal plug 20 can be inserted, said plug being sealed, for example, by a film 21, said housing 19 being near the mouth of the alveolus 22, similarly to the preceding case.
A further embodiment, shown in fig.10, provides seal closing means of an alveolus 23 including also a plug 24 suitable to be housed in an annular groove 25 formed in a middle portion of the inner wall of the alveolus 23, in addition to a plug 26 insertable into the mouth of the alveolus in any of the above shown ways (for example, here reference has been made to the embodiment of fig.9). While the plug 26, completely similar to the preceding seal closing plugs 14 and 20, separates the alveolus 23 from an external film 27, the inner plug 24 divides the volume of the alveolus 23 in two different areas, an upper one and a lower one, capable of containing different products. For example, a pharmaceutical product in powder form may be inserted in an area, and the respective solvent in the other one. It should be noted that all the seal closing plugs are perforable, in particular those difficult to remove and indicated for medicinal products, that is those relative to the figs.8, 9 and 10. By means of injection needles and the like, the contents may be extracted from the respective alveoli, in case of liquid medicinal preparations, or it will be possible to inject solvent for medicines packaged in powder form and extract the medicinal mixture thus obtained in solution, in this latter case with particular reference to the embodiment of fig.10.
From the practical tests carried out it has been verified that the present invention is capable of achieving the appointed objects, being an efficacious alternative to the confections of known type, strongly reducing the use of expensive material, such as glass and the like, replaced by cheaper and easily recyclable materials, such as the plastic materials.
The packaging device according to the invention is obviously susceptible of several changes and versions compared to the above-described and illustrated embodiments, always remaining within the purview of the invention. For example, the sealing plugs may be fixed within the respective alveoli by fixing rings or other similar devices, and all the elements may be replaced by other mechanically equivalent elements, while the materials used as well as the shape, number and size of the alveoli may be any, according to the requirements.

Claims

1. A disposable packaging device, particularly for pharmaceutical products and the like and for the treatment of prostheses in general, characterized in that it consists of a support (1) including at least one alveolus (2, 7, 16, 22, 23) and of removable and reinsertable seal closing means of said alveolus, suitable to separate said alveolus from sealing means of said alveolus external to said support (1) or fixable thereon.
2. A device according to claim 1, characterized in that said support (1) includes a plurality of alveoli (2, 7, 16, 22, 23) arranged in lines.
3. A device according to claim 1, characterized in that the seal closing means are perforable by means of an injection needle or the like.
4. A device according to claim 3, characterized in that the seal closing means include a plug (5, 8, 14, 20, 26) of a material of the alimentary/pharmaceutical type having characteristics of elasticity.
5. A device according to claim 3, characterized in that the sealing means include a film (3, 15, 21, 27) suitable to stick to said support (1) and to be removed therefrom or to be perforated to use the product, upon removal or perforation of the underlying seal closing means.
6. A device according to claim 4, characterized in that each alveolus (16, 22) has an annular seat (13, 19), in the peripheral wall near the mouth, suitable to house the peripheral edge of the seal closing plug (14, 20, 26).
7. A device according to claim 6, characterized in that the annular seat (19) is formed by two annular rims (17, 18).
8. A device according to claim 6 or 7, characterized in that, in addition to the annular seat (13, 19), each alveolus (23) has a second annular seat (25) in the middle area in height of the peripheral wall, suitable to house a second sealing plug (24) suitable to separate the inner volume of the alveolus (23) into two different areas one on top of the other.
9. A device according to claim 1, characterized in that the alveolus (7) has an inclined bottom area (9).
10. A device according to claim 4, characterized in that the support (1) is provided with cavities (11) positioned by the edge of the plug (5, 8) and suitable to favour the removal of said plug (5, 8).
11. A device according to claim 2, characterized in that the support (1) has a plurality of prearranged split lines (12) suitable to allow the separation of the single alveoli (2, 7, 16, 22, 23).
12. A device according to claim 2, characterized in that said device includes also a predetermined dose of pharmaceutical product or of product for the treatment of prostheses in general (4, 10) contained in each alveolus (2, 7, 16, 22, 23).
13. A device according to claim 12, characterized in that the support (1) includes a pair of alveoli (2, 7, 16, 22, 23) and is externally contained by a sealed sachet (6) .
14. A device according to one or more of the preceding claims, characterized in that the alveolus (2, 7, 16, 22, 23) is provided also with a non- reclosable plug which closes an opening or a small beak located in the lower part of said alveolus and suitable to allow the exit of the whole contents of said alveolus.
PCT/IT1993/000010 1992-02-13 1993-02-11 Multiple package for pharmaceutical products WO1993015972A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
ITMI92A000306 1992-02-13
IT000306A ITMI920306A1 (en) 1992-02-13 1992-02-13 DISPOSABLE CONTAINER FOR CONTACT LENSES
ITMI922037A IT1256358B (en) 1992-08-31 1992-08-31 Disposable packaging device especially for pharmaceutical and similar products
ITMI92A002037 1992-08-31

Publications (1)

Publication Number Publication Date
WO1993015972A1 true WO1993015972A1 (en) 1993-08-19

Family

ID=26330833

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IT1993/000010 WO1993015972A1 (en) 1992-02-13 1993-02-11 Multiple package for pharmaceutical products

Country Status (2)

Country Link
AU (1) AU3659693A (en)
WO (1) WO1993015972A1 (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0650676A1 (en) * 1993-11-02 1995-05-03 JOHNSON & JOHNSON VISION PRODUCTS, INC. Packaging arrangement for contact lenses
WO1996006581A1 (en) * 1994-08-30 1996-03-07 R.P. Scherer Limited Ocular treatment device
US6425888B1 (en) 1994-08-30 2002-07-30 R. P. Scherer Corporation Ocular treatment device
EP1362788A3 (en) * 2002-05-09 2005-07-20 Lifescan, Inc. Devices, systems and methods for the containing and use of liquid solutions
WO2006054021A2 (en) * 2004-11-16 2006-05-26 Valois Sas Fluid product dispensing device
US7722808B2 (en) 2003-09-12 2010-05-25 Novartis Ag Method and kits for sterilizing and storing soft contact lenses
WO2016138230A1 (en) * 2015-02-27 2016-09-01 Monosol, Llc Web of cleaning products and method of manufacture

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR982538A (en) * 1943-07-12 1951-06-12 Multiple plastic packaging with individual lids
US3331495A (en) * 1965-01-28 1967-07-18 Schering Ag Moisture-proof push-through package
US3343897A (en) * 1964-03-26 1967-09-26 Participations Et Procedes Ind Dehydrating device
US3650390A (en) * 1970-08-14 1972-03-21 Int Automated Machines Composite package and method of forming same
DE2303684A1 (en) * 1973-01-26 1974-09-05 Tabak Engineering Gmbh Tech En PORTION PACKAGING FOR LIQUIDS, IN PARTICULAR LIQUIDS, AND PROCESS FOR THEIR PRODUCTION
EP0084119A1 (en) * 1982-01-16 1983-07-27 pfm Plastik für die Medizin GmbH Medicine dispenser
US4499148A (en) * 1983-01-10 1985-02-12 Canton Bio-Medical Products, Inc. Composite materials of silicone elastomers and polyolefin films, and method of making

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR982538A (en) * 1943-07-12 1951-06-12 Multiple plastic packaging with individual lids
US3343897A (en) * 1964-03-26 1967-09-26 Participations Et Procedes Ind Dehydrating device
US3331495A (en) * 1965-01-28 1967-07-18 Schering Ag Moisture-proof push-through package
US3650390A (en) * 1970-08-14 1972-03-21 Int Automated Machines Composite package and method of forming same
DE2303684A1 (en) * 1973-01-26 1974-09-05 Tabak Engineering Gmbh Tech En PORTION PACKAGING FOR LIQUIDS, IN PARTICULAR LIQUIDS, AND PROCESS FOR THEIR PRODUCTION
EP0084119A1 (en) * 1982-01-16 1983-07-27 pfm Plastik für die Medizin GmbH Medicine dispenser
US4499148A (en) * 1983-01-10 1985-02-12 Canton Bio-Medical Products, Inc. Composite materials of silicone elastomers and polyolefin films, and method of making

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0650676A1 (en) * 1993-11-02 1995-05-03 JOHNSON & JOHNSON VISION PRODUCTS, INC. Packaging arrangement for contact lenses
US6726665B1 (en) 1994-08-30 2004-04-27 Pharmacia Aktiebolag Ocular treatment device
EP0845253A2 (en) * 1994-08-30 1998-06-03 Pharmacia & Upjohn AB Ocular Treatment device
EP0845253A3 (en) * 1994-08-30 1999-08-11 Pharmacia & Upjohn Aktiebolag Ocular Treatment device
US6425888B1 (en) 1994-08-30 2002-07-30 R. P. Scherer Corporation Ocular treatment device
WO1996006581A1 (en) * 1994-08-30 1996-03-07 R.P. Scherer Limited Ocular treatment device
GB2306902A (en) * 1994-08-30 1997-05-14 Scherer Ltd R P Ocular treatment device
EP1362788A3 (en) * 2002-05-09 2005-07-20 Lifescan, Inc. Devices, systems and methods for the containing and use of liquid solutions
US7722808B2 (en) 2003-09-12 2010-05-25 Novartis Ag Method and kits for sterilizing and storing soft contact lenses
WO2006054021A2 (en) * 2004-11-16 2006-05-26 Valois Sas Fluid product dispensing device
WO2006054021A3 (en) * 2004-11-16 2006-09-21 Valois Sas Fluid product dispensing device
US8739783B2 (en) 2004-11-16 2014-06-03 Aptar France Sas Fluid product dispensing device
EP2949599A1 (en) * 2004-11-16 2015-12-02 APTAR France SAS Reservoir assembly for a fluid product dispensing device
WO2016138230A1 (en) * 2015-02-27 2016-09-01 Monosol, Llc Web of cleaning products and method of manufacture
US9828154B2 (en) 2015-02-27 2017-11-28 Monosol, Llc Web of cleaning products and method of manufacture

Also Published As

Publication number Publication date
AU3659693A (en) 1993-09-03

Similar Documents

Publication Publication Date Title
US4444310A (en) Segmented multi-product package assembly
JP2602614B2 (en) Chemical container
AU726273B2 (en) Improved mixing and delivery system
US4998623A (en) Medication dispensing package
US20140183070A1 (en) Device for Disposing Medicament Products
US4227615A (en) Medicine container
EP2598403B1 (en) Re-closable container for fluid products, particularly for medical, pharmaceutical and cosmetic products
US8298174B2 (en) Apparatus to assist with pill ingestion
EP0634340B1 (en) Bottle for preserving in a separated condition substance to be mixed together before dispensing
ES2313057T3 (en) BOTTLE FOR FLUID PRODUCTS, IN PARTICULAR PHARMACEUTICAL, MEDICINAL AND COSMETIC PRODUCTS.
JPH0226506B2 (en)
US20140360966A1 (en) Dual compartment container for holding solid and liquid
US3841513A (en) Container having safety closure
WO1993015972A1 (en) Multiple package for pharmaceutical products
BR102022008634A2 (en) TAMPER-PROOF PLASTIC CLOSURE FOR BOTTLES FOR THE STORAGE OF SUBSTANCES FOR MEDICAL OR PHARMACEUTICAL APPLICATIONS AND USE THEREOF
KR20100031674A (en) Upgraded single-dose container particularly for fluid products
US5478311A (en) Hand held combination pill crushing and dispensing device
US5119560A (en) Medicine dosage device
US3245589A (en) Medication dispenser
GB2499567A (en) Collapsible container for mixing pharmaceutical composition
US3662463A (en) Spoon
KR100308466B1 (en) Solid Pharmaceutical Dispenser
RU2567227C2 (en) Device of packaging, storage and preparation before use of several active components
JP4754070B2 (en) package
US8007883B2 (en) Container comprising a transparent cylindrical container wall

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AT AU BB BG BR CA CH CZ DE DK ES FI GB HU JP KP KR LK LU MG MN MW NL NO NZ PL PT RO RU SD SE SK UA US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR SN TD TG

122 Ep: pct application non-entry in european phase
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

NENP Non-entry into the national phase

Ref country code: CA