JP2602614B2 - Chemical container - Google Patents

Abstract

Of the type that permit the mixing of two products located in two containers (1 and 5, 5'.) In the inside of the top container (5, 5'), there is a tubular sleeve (13) with a wing terminated by a truncated-cone shaped portion (15) like a medicine dropper, and with a bevel-edged bottom edge (17) to cut the bottom of the vessel (5), upon screwing down the cap (18) after removing a safety seal (19.) The container (5, 5') extends into a neck (8.) It is characterized in that the mouth of the neck (8) has an annular recess (22) and a discoidal wing (14) provided with a bevel (26) that is retained in the annular recess (22) upon the bottom of the container (5) breaking, preventing the removal of the tubular sleeve (13), the latter containing a pointed longitudinal appendix (24) to break the tearable bottom (6) without making any additional effort. Diametrically opposite the appendix (24) there is a longitudinal recess (27) that prevents the complete cutting of the perimeter of the bottom (6) which remains connected to the top container (5) by a small piece, preventing the falling of the bottom (7) to the bottom container (1.> It has diverse seals and sealing rings. Its assembly is adaptable to the packaging process and conditioning chosen, permitting the selective and independent filling of the top part and bottom part as if there were two separate containers. <IMAGE>

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a medicine container for storing, mixing and administering two kinds of medicines which are stored separately and mixed and administered.

[0002]

BACKGROUND OF THE INVENTION The pharmaceutical industry in general, and especially skin, eyes,
In the field of otic, oral and nasal diseases, there are various products, such as certain eye drops, where once all the ingredients are mixed, the shelf life is often less than 4 weeks. .

[0003] Under such circumstances, it is often the case now that the components of a product are divided into two parts and each is separately packaged.

[0004] Generally, one of these components is a freeze-dried powder and the other is a liquid. Each of the components must be stored separately when not in use, and the user must mix both components before administering the product.

[0005] EP 344,849 and EP 217,425 provide solutions to this problem. EP 217,425 protects a device of the type in which the container has a thread at the mouth and a cap with a seal mounted thereon. Similarly, there is a cup pressed onto the mouth, into which a tubular sleeve is inserted, which has a disc-shaped wing at its upper end and extends along a truncated cone-shaped part. It also performs the function of a drug infusion device.

In the present invention, after removing the seal from the cap, the cap can be screwed down. This movement of the cap pushes on the tubular sleeve, which pushes on and breaks the bottom of the cup, and mixing of both chemicals takes place.

[0007] This patent is an inconvenient configuration in that after removing the seal, some effort is required to break the bottom. At the same time, it is necessary to push the container in order to administer the mixture. Cup and / or
Or, releasing the tubular sleeve releases all the drug, which is very inconvenient if it differs from the required dose. In addition, there are no seals to prevent the two liquids from mixing, no protection from anticipated damage to the container, and no equipment for repeated dose control (eg, infusion). There is also no mobility and eventual adjustment in filling the contents of the container.

[0008] With respect to EP 344,849,
The flap is located coaxially on the outside and includes an annular rib inside, which is retained at the end of the container opening and prevents the cup from being removed when dispensing takes place. Can be On the other hand, this model is not used as a dropper for drugs because the administration of the drug mixture tends to be performed all during the preparation of the drug mixture.
As such, such features are not required for this model. In this patent, breaking the bottom by pressing the cup and not screwing it in like in the previous case means breaking the bottom of the cup because more force must be applied to break the bottom of the cup There is greater difficulty for.

By the way, in the cited patent, the cylindrical sleeve is separated by administration, which is also inconvenient and problematic.

[0010]

SUMMARY OF THE INVENTION The present invention provides a bevel edge of a tubular container having a bottom container and a disc-shaped flange at the top and extending from there to a truncated cone-shaped portion for use as a drug dropper. Or having a top container with a weak perimeter that can be cut by a protrusion on the bottom of the tubular sleeve, and after removing the seal, screwing down the cap will cause the cap to bend the lower end of the bevel edge or longitudinal protrusion of the tubular sleeve. , Press to cut a part of the weak part of the bottom of the top container,
The medicine container which is opened after mixing the medicines filled in the bottom container and the top container respectively while preventing the fragile bottom from falling while simultaneously opening the space between both containers completely by partial cutting. The purpose is to provide.

Another object of the present invention is to provide a holding mechanism for the tubular sleeve in the top container. This causes the bottom of the top container to be cut once, causing the mixing of the two chemicals so that if the mixture is dispensed by pressing on the bottom container or by improper handling of the container, the tubular sleeve cannot dislodge. I have to. If the medicine stored in the bottom container is spilled, accurate dosing of the mixture will not be possible.

The invention is further characterized in that the container remains sealed before and after the seal is removed and is protected from damage. Prior to the removal of the seal, these two properties are maintained in each part and the seal is broken and
Even after the mixing of the component drugs has taken place, the final sealing and wound protection inside the container is retained as well, and it is only possible to release the mixture from the drug dose dropper.

[0013] This container allows the final filling and dispensing of a wide variety of drugs, and by defining the order in which the top and bottom are filled, a cross-contamination problem which is a typical problem in the pharmaceutical industry. Problem can be avoided.

In particular, the present invention includes a bottom container, which is a bottle with a top container mounted thereon, and more particularly, the tubular sleeve is retained within the top container after cutting the bottom of the top container. The top container is held at the edge of the mouth of the bottom container. This prevents the top container and / or the tubular sleeve from separating during the administration of the mixture, while at the same time allowing for the administration of a precise dose of the mixture. The present invention has various projection rings, labyrinth type seals and projections to ensure a good seal of the entire device before and after breaking the seal. In the same way, the container seal is assured by its ability to protect against accidental handling of the container. Another advantage provided by the present invention is that
The ability to charge the drug separately in two separate containers and in any desired order.

To establish these advantages, the top container of the present invention has a retaining rib coaxially located with the top container for retaining and including the edge of the mouth of the bottom container. Particularly preferably, the top container further has a spiral groove for the cap to seal between the cap and the annular recess of its mouth.

Inside the top container, as before,
The upper end is a disc-shaped flange from which a tubular sleeve is extended that extends further into a truncated cone-shaped part that acts as a drug dropper. In one embodiment of the invention, the disc-shaped flange is preferably provided with some conicity to define a bevel that is complementary to an annular recess provided in the mouth of the top container, so that the tubular sleeve is attached to the top container. Establish retention inside the mouth.

In one embodiment of the invention, the lower end of the tubular sleeve is conventionally a beveled edge. In another embodiment, this is improved, in which, at the horizontal lower end, there is provided a projection with a continuously decreasing cross-section, which partially breaks the bottom of the top container without additional effort. The bottom is only partially broken, but this is due to the fact that there is a vertical recess on the diagonally opposite side of the projection, which prevents the top container from being completely broken, and a small portion breaks the bottom. This is to keep it connected to the top container. Because the bottom is connected flexibly, two chemicals can be mixed,
On the other hand, the bottom of the top container is prevented from falling into the bottom container.

In the present invention, the center of the bottom of the top container is preferably thicker to prevent chemicals from moving through the bottom of the top container. The bottom of the top container may have a weak portion around the inside as before to prevent particles from being generated due to inadequate cutting, and furthermore, the weak portion may be outside or inside and outside. May be provided.

After removing the seal from the cap of the drug container of the present invention, the cap is unscrewed to move the tubular sleeve, which breaks a portion of the bottom of the top container without additional additional effort. A bevel of a disk-shaped wing is held in an annular recess provided in the mouth of the top container, and the cup and the annular sleeve are held coaxially.
Thus, separation of the top container and / or the tubular sleeve cannot occur even when the desired dose is dispensed by pressing the bottom container.

Hereinafter, embodiments of the present invention will be described with reference to the drawings.

EXAMPLE 1 In Example 1, the device of the invention has a bottom container (1) filled with one of the chemicals (4) to be mixed (see FIGS. 1 and 2).

This bottom container (1) has a neck (2) with an edge (3) at the mouth.

Above the mouth of the bottom container (1) there is a top container (5) with a small skirt attached. An annular rib (12) is provided inside the skirt, for which the top container (5) is held on the edge (3) of the bottom container (1).

The top container (5) has a fragile bottom (6)
, So that a second chemical (7) to be mixed with the first chemical filled in the bottom container (1) can be introduced, the latter separating the latter from the former. .

The top container (5) extends further up through a neck (8) having a helical groove (9) allowing the cap (18) to be screwed inside. The end of this tubular sleeve (13) passes through a disc-shaped flange (14) and its upper end leads to a truncated cone-shaped part (15) which serves as a drug dropper.

There is a projection (10) around the neck (8), which holds the seal (19) of the cap (18).

Inside the top container (5) is introduced a tubular sleeve (13) having a lower end (17) which is a beveled edge of reduced cross section.

The end of the tubular sleeve (13) passes through a disc-shaped wing (14), the upper end of which leads to a truncated cone-shaped part (15) which serves as a chemical dropper.

The surrounding projections (10) have a number of serrated projections which seal (1) on the cap (18).
Complementary to many serrations given in 9).

The cap (18) with the seal (19) can be screwed on until the seal contacts the small skirt that supports the annular rib (12) of the top container (5). In this situation, the lock between the projection (10) and the seal (19) is provided by the saw tooth. Remove the cap (18) and remove the seal (1
If 9) is broken, the seal can be removed. When the seal is removed and the cap (18) is twisted, the cap contacts the projection (10) and its movement causes the tubular sleeve (1) to move.
3) is pushed axially, so that a part of the bottom (6) can be cut off with the aid of the bevel edge (17) at the lower end, simply and without additional effort.

The drugs (4 and 7) can then be mixed and these drugs are administered in a defined dose when the bottom container (1) is pressed.

[0031]

Embodiment 2 Embodiment 2 is an improvement of the properties of Embodiment 1. In this example, complete retention and total sealing between the different elements was achieved as described below.

In order to achieve these objects, in Example 2, the top container (5) is provided with a tubular sleeve (1).
Several transverse sealing rings (21) are provided, complementary to the sealing ring (25) provided near the lower end of 3), when the tubular sleeve (13) is inserted inside the top container (5 '). To allow a complete seal between both containers.

On the other hand, the bottom (6) of the top container (5 ')
At the lower end of the tubular sleeve (13) there is a sharp longitudinal projection (24) with a reduced cross section to facilitate tearing. On the opposite side on the diagonal, a long-axis recess (2
7) is provided so that the entire periphery of the bottom (6) of the top container (5 ') is not cut.

An edge around the circumference of the disc-shaped flange (14) of the tubular sleeve (13) is given a certain conicity and defines a bevel (26). This bevel (26) is complementary to the annular recess (22) inside the mouth of the neck of the top container (5 '). Thus, if the cap is unscrewed after removing the seal and the bottom (6) is torn in exactly the same way as in the first embodiment, the bevel (26) will have a tubular shape inside the mouth of the neck of the top container (5 '). It is held axially by the recess (22) and effectively secures between both parts.

On the upper part of the neck (2) of the bottom container (1), once the annular rib (1) is operated when this apparatus is operated.
A sealing ring (23) is provided for sealing between the top container and the bottom container after 2) has caught on the edge (3) of the mouth of the bottom container (1).

The truncated tip (15) at the tip of the tubular sleeve is fitted with an internal coaxial cylinder (29).
Thanks to it can be operated as a drug dropper with a controlled dose.

The tubular sleeve (13) has a recess (2
8), which is complementary to the inner projection of the cap (18), the cap (18 ') and the tubular sleeve (13).
Guarantees the sealing performance.

As a result, the device of the present invention has a triple sealing level and a mechanism to avoid tampering. Sealing by the above components, the first stage is between the bottom container (1) and the top container (5), the second stage is between the tubular sleeve (13) and the top container (5), and the third stage is the cap (18) and tubular sleeve (1
3) is established.

The fragile bottom (6) of the top container (5)
Has a very thick central area to reduce the movement through the bottom (6), a weak part of the inner perimeter and (3)
0) and a weak portion (31) of the outer periphery are provided to prevent improper splitting and particle formation due to the bottom.

The operating mechanism according to the second embodiment of the present invention is very similar to that of the first embodiment, but has the above-mentioned improvements.

In addition, in the second embodiment, the neck (2) of the bottom container (1) extends through the bottom container (1) after the assembly of other parts is completed.
It should be pointed out that an external skirt (20) is included which half encloses.

In both embodiments, the bottom container (1) is first filled with the drug (7) and sealed, after which the top container (5) or (5 ') is filled with the drug (4) and the tubular sleeve is filled. The latter is closed in (13), and finally the cap (18, 18 ') is screwed to fill with the chemical.

On the other hand, in the present invention, as another method, the top container (5, 5 ') is first filled with the product (7), which is closed with the tubular sleeve (13), and the cap (18, 18'). , And finally the bottom container (1) is filled with the chemical (4) and the whole device is sealed and used.

Other ways of assembling the different elements are to fill the top container (5, 5 ') and close it with a tubular sleeve (13) or fill the tubular sleeve (13) first and fill the cap (18). , 18 ') is to seal the top container. Since the filling can be reversed in this way, fluids having different viscosities,
It can be packaged as a powder, a lipophilic compound or a pill.

From now on, the present specification will be better understood,
A series of figures are shown to further illustrate the whole image. These drawings are not intended to limit the invention, but to illustrate the invention.

[Brief description of the drawings]

FIG. 1 is a partial cross-sectional view before assembling components of a medicine container according to a first embodiment of the present invention.

FIG. 2 is a partial cross-sectional view of the medicine container according to the first embodiment of the present invention, showing a state where components are assembled and a seal is removed.

FIG. 3 is an exploded view in which the medicine container according to the second embodiment of the present invention is disassembled into components.

FIG. 4 is a sectional view of parts other than the cap of the same medicine container as in FIG. 3;

FIG. 5 is a cross-sectional view of the medicine container according to the second embodiment, showing a state before assembling parts and breaking the bottom of the top container.

6 is a view of the same medicine container as in FIG. 5 as viewed from the outside.

FIG. 7 shows a state in which the cap of the top container is torn down by screwing down the cap and the cap is removed after removing the seal of the same chemical container as in FIG. 5;

8 is a view of the medicine container in the same state as in FIG. 7 as viewed from the outside.

FIG. 9 is a sectional view of a top container.

[Explanation of symbols]

1: bottom container, 2: neck, 3: edge, 4,
7: medicine, 8: neck, 9: groove, 10: tooth-like projection, 1
2: annular rib, 13: tubular sleeve, 14: flange,
15: cone-shaped part whose tip is cut, 16: hollow, 1
7: bevel edge, 18, 18 ': cap, 19: seal, 20: skirt, 21, 23: sealing ring, 22: annular recess, 26: bevel, 27: longitudinal recess, 28: recess, 29: cylinder, 30: weak part around the inside, 31: weak part around the outside

 ──────────────────────────────────────────────────続 き Continuation of the front page (72) Inventor Francesque Javier Jimenez Guash Spain 08330 Premier de Mar (Barcelona), Haume Balmes No. 9 (56) References JP-A-53-146886 (JP) , A)

Claims (12)

(57) [Claims] 1. A bottom container (1) for storing a first substance of two kinds of substances, for storing a second substance,
A top container (5, 5 ') having a brittle bottom (6); and
In the top container (5, 5 ') there is a tubular sleeve (13) mounted for movement in the top container, and the bottom part of the tubular sleeve (13) has a cap (18,1).
The bottom (6) of the top container (6) is removed when the cap (18, 18 ') is screwed onto the top container by removing the safety seal (19) connected to the cap by a brittle line at the annular end of 8'). Means for partial cutting are provided, the upper end of the tubular sleeve (13) is a flange (14), on which a truncated cone-shaped part (15) serving as a drug dropping member is provided. A chemical container provided with an edge (3) at the opening of the bottom container (1);
A skirt is provided outside the top container (5, 5 '), and an annular rib (12) for holding an annular edge (3) of the bottom container (1) is provided inside the skirt. (5, 5 ') The upper part is a cap (18, 1').
8 ') is a neck (8) with a helical groove (9). Around the neck (8) there is further provided a tooth (10), (10) engages with the teeth formed on the seal (19) to keep the cap (18, 18 ') locked so that the cap (18, 18') is not screwed in. If the brittle line of the seal is broken, the seal (19) is removed. Storing two separate chemicals, characterized in that the seal (19) can be removed and the cap (18, 18 ') can be screwed off to cut the fragile bottom (6) if the seal (19) is removed;
A medicine container for mixing and administering at the time of administration. 2. The means for partially cutting the top container at the bottom of the tubular sleeve (13) comprises a bevel edge (17).
The drug container according to claim 1, wherein 3. A means for partially cutting the top container at the bottom of the tubular sleeve (13) comprises a downwardly tapering pointed longitudinal projection (24) on the horizontal bottom. ), Which can break the fragile bottom (6) without the need for applying any additional force; longitudinal projections
On the opposite side of the diagonal of (24), a longitudinal recess (27)
Are not completely cut around the bottom (6); since the cut is not completely cut, the bottom (6) after cutting is rotatably connected to the top container by a weak connection part, whereby the complete chemicals are removed. 2. The chemical container according to claim 1, characterized in that mixing is achieved and the bottom (6) is prevented from falling into the bottom container (1). 4. A coaxial cylinder (29) is provided inside a truncated cone-shaped part (15) of a tubular sleeve (13), and the truncated cone is formed by the action of the cylinder (29). A drug container according to claim 3, wherein the mold part (15) serves as a drug dropping device. 5. A disk-shaped flange of a tubular sleeve (13).
An annular recess (2) provided in the mouth of the top container (5 ') by providing an edge with a specific consistency around (14).
2) defines a bevel (26) to be fitted, whereby the bevel (26) is retained in the tubular recess (22) and therefore in the top container (5 ') even when the fragile bottom (6) is cut. A drug container according to any of the preceding claims, characterized in that the tubular sleeve (13) is held in the container. 6. The bottom container (1) is a sealing ring.
(23), said sealing ring (23) sealing between the outer walls of the bottom container (1) and the top container (5); this sealing is achieved by the annular rib (12) and the edge (3) of the bottom container opening. ), Reinforced by mating between; tubular sleeve
Near the lower end of (13), a sealing ring (25) is provided which is complementary to a plurality of other sealing rings (21) provided inside the top container (5 '), by means of which the tubular sleeve ( 13) and top container
The seal between the outer walls of (5 ') can be made; after the chemical has been mixed, the tightness of the device is achieved by the engagement of the annular recess (22) in the top container (5') with the bevel (26) of the tubular sleeve. Is enhanced; an internal recess at the upper end of the tubular sleeve (13)
A drug container according to claim 5, characterized in that it has a (28) which is complementary to the inner projection of the cap (18 ') and seals between them. 7. A medicine container according to claim 3, wherein the skirt (20) covers half of the circumference of the neck of the bottom container (1). 8. A fragile bottom (6) of the top container (5, 5 ') having a thickened center to reduce the migration of chemicals through the bottom of the top container, resulting in improper tears and particles. 8. A chemical container according to any of claims 1, 3 to 7, wherein the bottom (6) has a weakened portion (30) around the inside and / or a weakened portion (31) around the outside. 9. The toothed projection on the outer periphery is saw-toothed, and the toothed projection attached to the seal is saw-toothed. Chemical container. 10. The chemical (4) to the bottom container (1) first
, Then seal the bottom container with the top container (5,5 ') before or after filling with the drug, then seal the top container (5,5') with the tubular sleeve (13), 10. Filling of two kinds of chemicals and assembling of a device by screwing a cap (18, 18 ') onto a neck (8) of a top container (5, 5'). A method for filling and assembling the described drug container. 11. The top container (5, 5 ′) is first filled with the chemical (7), and then the top container (5, 5 ′) is sealed with a tubular sleeve (13), and the top container (5, 5 ′) is sealed.
Screw the cap (18, 18 ') onto the neck (8) of the 5') and finally fill the bottom container (1) with the chemical (4),
The method for filling and assembling a medicine container according to any one of claims 1 to 9, wherein the filling of the two kinds of medicines and the assembling of the apparatus are performed by sealing the entire apparatus. 12. A cap (18, 1) containing a chemical (7) in advance.
Filling the top container (5,5 ') with the drug by filling into the tubular sleeve (13) fitted with 8') and then tubular onto the neck (8) of the top container (5,5 ') Bottom container with cap (18, 18 ') screwed on with sleeve (13) and finally filled with chemical (4)
The method for filling and assembling a medicine container according to any one of claims 1 to 9, wherein the filling of the two kinds of medicine and the assembling of the device are performed by sealing (1) with a top container (5, 5 ').