WO1993015183A1 - Device for biochemical characterization and/or bacterial culture and/or antibiogrammes and/or concurrent chemical tests in different environments - Google Patents
Device for biochemical characterization and/or bacterial culture and/or antibiogrammes and/or concurrent chemical tests in different environments Download PDFInfo
- Publication number
- WO1993015183A1 WO1993015183A1 PCT/FR1993/000062 FR9300062W WO9315183A1 WO 1993015183 A1 WO1993015183 A1 WO 1993015183A1 FR 9300062 W FR9300062 W FR 9300062W WO 9315183 A1 WO9315183 A1 WO 9315183A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cover
- base
- well
- atmosphere
- ribs
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/04—Flat or tray type, drawers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/12—Well or multiwell plates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/22—Transparent or translucent parts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
Definitions
- the present invention for "object biochemical characterization device, and / or culturing of bacteria, and / or susceptibility, and / or simultaneous chemical tests under various atmospheres.
- the initial sample to be studied is placed on one or, more often, several different culture media adapted to the type of research carried out and, if the germs analyzed require it, under different atmospheres, namely aerobic, anaerobic, enriched in C02, micro-aerophilic, etc., and sometimes without humidity.
- the immediate interest of this test is the screening with identification of the " germ, but for the counting the technician will have to inoculate agar (type A7 for mycoplasmas) under an anaerobic atmosphere. In the same way, for the study of chemicals it is often necessary to carry out tests with several reagents in 'different atmospheres.
- compartments which may include different culture media (Nos FR 2 157 050, EP 045 041, GB 1 026 253, US 4 072 577, etc.), others still propose supports " provided with several test tubes, or zones, with reagents for chemical or biochemical tests (Nos FR 2 384 023, WO 89/02 927 .).
- Patent No. FR88 05 191 filed by the applicant, describes a culture dish with several compartments making it possible to perform analyzes at the same time under aerobic and anaerobic atmospheres or controlled atmosphere.
- there is no unique material allowing simultaneous biological cultures, biochemical or chemical tests and / or antibiograms, and this under several different atmospheres.
- the invention consists of a single device, simple and inexpensive, making it possible either to carry out biochemical tests under one or more atmospheres and, simultaneously, one or more biological cultures, also under one or more atmospheres, the atmospheres being both tests biochemical ' that growth / isolation / identification media may be different, or to simultaneously perform several chemical tests under different atmospheres.
- the base consists of the combination of a base and a cover preferably made of injection-molded or thermoformed plastic, the base comprising, on the one hand, hollow imprints capable of forming wells for chemical or biochemical tests, Flats for atmosphere control products and optionally Worldwide Locations for 'cultivation "biological, and secondly, grooves or ribs and blocks or spacers delimiting isolated areas therebetween, the cover cooperating with the base, thanks to complementary grooves or ribs to make some of these zones sealed from one another and / or from the outside atmosphere.
- FIG. 1 represents the device without cover, seen from above, and FIGS. 2 and 3 are vertical cross sections, respectively according to arrows AA and BB of Figure 1, showing the base and the cover not assembled.
- the device, Figures 1 to 3 consists of a flat rectangular housing composed of a base 1 and a cover 2 each formed in one piece and can be made of various materials such as glass or metal. However, being mainly intended for "single use", the device will preferably be made of injection-molded or thermoformed plastic.
- the base 1 comprises hollow shapes with concavity directed upwards constituting wells 3, 4 for chemical or biochemical tests, locations or receptacles 5, 6 for biological culture or antibiograms as well as, where appropriate, housings 10 intended for receive desiccant products 8 or atmosphere controllers 9.
- the wells 3, 4 or spots for reading chemical or biochemical tests and / or the locations 5,6 for organic culture can be provided with bottoms comprising a finish, optically transparent, necessary for reading by nephelometry, spectrometry or other optical systems, the corresponding part of the cover will in this case receive the same finish.
- the locations for organic culture can be either the equivalent of a culture dish, or receptacles 6 that can receive culture dishes of the Petri dish type.
- housing 10 will be present to receive the atmosphere controllers 9 such as oxygen generators, or desiccants 8 or moisture absorber.
- Ribs 12 and studs 13 or ventilation wedges respectively delimit aerobic 15 and anaerobic 14 (or controlled atmosphere) zones.
- Some wells 4 may include a specific and unitary seal located at the single well by a male profile 11 formed in the cover 2 and coming to fit on the periphery of the upper edge of the well. This arrangement creates an anaerobiosis, if the male profile is flush with the volume of the reagent (including inoculum) contained in the well, which eliminates the use of paraffin oil or other similar product, usually deposited on the reagent to obtain anaerobiosis, this in particular in the case where said well is located in a compartment where the reaction carried out produces a gaseous evolution harmful to other reactions or cultures.
- the cover 2 has grooves 16 which fit tightly on the ribs 12 of the base 1 surrounding the anaerobic zones 14 or with controlled atmosphere, as well as pads 17 serving as support for the studs 13 or ventilation wedges allowing the air circulating freely in the aerobic zones 15. It is obvious that the grooves can be carried by the cover and the ribs by the base without modifying the operation of the system. Likewise, the ventilation studs 13 can either be located on the cover or on the base.
- the assembly is preferably made of injection molded plastic, for example polystyrene, or of thermoformed plastic, preferably of polyethylene or co-polyester, the only material known to date sterilizable by ionizing gamma rays without altering the transparency quality of these films, or PVC or other material sterilizable by chemical decontamination, in the case where an optically transparent box turns out to be necessary (example: counting of mycoplasmas on agar type A7, this is done using a microscope, the box overturned, that is to say that one reads the agar by transparency through the bottom of the box plated with the objective of the microscope), because the thermoformed materials are not always optically transparent; the same can be said for the spots for reading chemical or biochemical characters, so that these can be read on an optical, nephelemic, spectrometric or other system.
- the base 1 and / or the cover 2 can advantageously be fitted with lugs 18 in relief enabling the housing to be held on the plate holder of a microscope using the system provided for fixing said blades.
- the device described can be produced in a multitude of different versions, specifically adapted to a well-defined type of analysis or, on the contrary, allowing different searches to be carried out with a single model, so as to facilitate storage and reduce the cost price. It can be applied to biochemical analyzes as well as chemical analyzes of all kinds.
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP93904107A EP0625189A1 (en) | 1992-01-23 | 1993-01-22 | Device for biochemical characterization and/or bacterial culture and/or antibiogrammes and/or concurrent chemical tests in different environments |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9200967A FR2686618B1 (en) | 1992-01-23 | 1992-01-23 | DEVICE FOR BIOCHEMICAL CHARACTERIZATION, AND / OR CULTURE OF BACTERIA, AND / OR ANTIBIOGRAMS, AND / OR SIMULTANEOUS CHEMICAL TESTS UNDER DIFFERENT ATMOSPHERES. |
FR9200967 | 1992-01-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1993015183A1 true WO1993015183A1 (en) | 1993-08-05 |
Family
ID=9426115
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR1993/000062 WO1993015183A1 (en) | 1992-01-23 | 1993-01-22 | Device for biochemical characterization and/or bacterial culture and/or antibiogrammes and/or concurrent chemical tests in different environments |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0625189A1 (en) |
AU (1) | AU3503393A (en) |
FR (1) | FR2686618B1 (en) |
WO (1) | WO1993015183A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5580786A (en) * | 1995-06-07 | 1996-12-03 | Accumed, Inc. | Dual chamber blood culture bottle with syringe capture and piston assembly |
US5652143A (en) * | 1995-06-07 | 1997-07-29 | Accumed, Inc. | Dual chamber blood culture bottle with break seal |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU5857398A (en) * | 1996-12-18 | 1998-07-15 | Boehringer Mannheim Gmbh | Receptacle for cell cultures and use of multiple dishes for culturing antitumour cells |
FR3026745B1 (en) * | 2014-10-06 | 2018-03-02 | Fondation Mediterranee Infection | METHOD OF ANALYSIS AND AUTOMATED INTERPRETATION OF ANTIBIOGRAM |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3234107A (en) * | 1964-02-21 | 1966-02-08 | Pfizer & Co C | Diagnostic device |
DE1220083B (en) * | 1965-02-16 | 1966-06-30 | Rudolf Siegert Dr | Device for testing biochemical reactions in bacteria |
DE1933333A1 (en) * | 1968-07-01 | 1970-01-08 | Becton Dickinson Co | Container for biological substances |
US3582285A (en) * | 1970-03-19 | 1971-06-01 | Xerox Corp | Chemical package |
EP0337907A1 (en) * | 1988-04-15 | 1989-10-18 | Thierry Nicoloff | Containers for the simultaneous culture of aerobic and anaerobic micro-organisms |
-
1992
- 1992-01-23 FR FR9200967A patent/FR2686618B1/en not_active Expired - Fee Related
-
1993
- 1993-01-22 AU AU35033/93A patent/AU3503393A/en not_active Abandoned
- 1993-01-22 WO PCT/FR1993/000062 patent/WO1993015183A1/en not_active Application Discontinuation
- 1993-01-22 EP EP93904107A patent/EP0625189A1/en not_active Withdrawn
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3234107A (en) * | 1964-02-21 | 1966-02-08 | Pfizer & Co C | Diagnostic device |
DE1220083B (en) * | 1965-02-16 | 1966-06-30 | Rudolf Siegert Dr | Device for testing biochemical reactions in bacteria |
DE1933333A1 (en) * | 1968-07-01 | 1970-01-08 | Becton Dickinson Co | Container for biological substances |
US3582285A (en) * | 1970-03-19 | 1971-06-01 | Xerox Corp | Chemical package |
EP0337907A1 (en) * | 1988-04-15 | 1989-10-18 | Thierry Nicoloff | Containers for the simultaneous culture of aerobic and anaerobic micro-organisms |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5580786A (en) * | 1995-06-07 | 1996-12-03 | Accumed, Inc. | Dual chamber blood culture bottle with syringe capture and piston assembly |
US5652143A (en) * | 1995-06-07 | 1997-07-29 | Accumed, Inc. | Dual chamber blood culture bottle with break seal |
Also Published As
Publication number | Publication date |
---|---|
FR2686618A1 (en) | 1993-07-30 |
AU3503393A (en) | 1993-09-01 |
FR2686618B1 (en) | 1995-09-22 |
EP0625189A1 (en) | 1994-11-23 |
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