WO1993013658A1

WO1993013658A1 - Tablet formulation with internal desiccant

Info

Publication number: WO1993013658A1
Application number: PCT/US1992/011305
Authority: WO
Inventors: David Allan Jackisch
Original assignee: E.I. Du Pont De Nemours And Company
Priority date: 1992-01-06
Filing date: 1992-12-30
Publication date: 1993-07-22
Also published as: BR9207062A; FI943206A0; TR28073A; EP0620706A1; CA2127093A1; AU668706B2; JPH07502745A; HUT68006A; AU3426193A; HU9402031D0; FI943206A; CN1074083A

Abstract

A tablet formulation comprising a pesticide and a delivery system, the delivery system comprising a range of acid/base combinations, a dispersant, a wetting agent, polyvinylpolypyrrolidone, and a characterizing internal desiccant to ensure tablet stability, the tablet being selected to complement the particular class of base selected for the formulation.

Description

TITLE

TABLET FORMULAΗON WITH INTERNAL DESICCANT

An effervescent tablet produces gas bubbles by the reaction between an acid and a base. Should the water level in the tablet exceed about 0.1%, the tablet will begin to lose its effervescence even though it is stored in its container. Normally, an amount of water exceeding 0.1% is required to formulate a tablet having acceptable integrity and strength.

One way to keep the water employed during formulation from ruining the tablet during long-term storage is to package the tablet with a desiccant. The water in the tablet diffuses out and is taken up by the desiccant. This water is held by the desiccant and so cannot cause the acid/base reaction to occur.

However, the need for an external desiccant complicates design of the tablet package.

One such tablet formulation that does not have an internal desiccant is disclosed in WO 90/00007. Two formulations that contain an internal desiccant are disclosed in CA-A-2,013,918 and WO 88/09161. CA-A-2,013,918 discloses a tablet comprising potassium carbonate and/or potassium bicarbonate as bases and a desiccant which physically adsorbs water. WO 88/09161 discloses an effervescent tablet for cleaning dentures comprising pancreatin, an acid component, a base component, and a drying agent.

SUMMARY OF THE INNENTION

This invention comprises a tablet formulation consisting essentially of by total weight of the formulated composition:

(i) about 0.1% to 75% of a pesticide;

(ii) about 25% to 99.9% of a delivery system characterized by a panel of components complementary to the pesticide of (i) having the following

components:

(a) about 5% to 75% of a dibasic or tribasic organic carboxylic acid or a mixture thereof;

(b) about 5% to 75% of an ammonium, lithium, sodium or potassium carbonate or bicarbonate or a mixture thereof;

(c) about 0.5% to 20% of a dispersant;

(d) about 0.1% to 5% of water-insoluble cross-linked polyvinyl- polypyrrolidone; (e) about 0.1% to 5% of an anionic or nonionic wetting agent; and

(f) about 1% to 20% of an internal desiccant being selected from the group:

(A) one or a mixture of desiccants that chemically bind water, and (B) one or a mixture of desiccants that physically adsorb water;

the desiccant being (A) when (b) is potassium carbonate or potassium bicarbonate.

This delivery system is characterized by the inter-relationship of components (a) to (f) in the recited ranges to effect rapid disintegration of finely dispersed pesticide particles (i). Preferred ranges of the composition are 5% to

70%, more preferably 10% to 60% of the pesticide; and 30% to 95%, more preferably 40% to 90% of the delivery system.

By "tablet formulation" is meant the tablet made from the composition described herein, as well as the composition formulated in accordance with this disclosure but not in tablet form. The preferred tablet formulation of the present invention is in the form of a tablet.

Contemplated pesticides include those selected from the following classes, including mixtures thereof: herbicides, fungicides, bactericides, insecticides, nematocides, acaricides, and growth regulants.

Preferred dibasic and tribasic organic carboxylic acids include citric, fumaric, phthalic, maleic, malic, oxalic, adipic, glutaric, 2-methyl glutaric, succinic, and tartaric, or mixtures of any of them.

The term "dispersants" includes sodium, potassium, ammonium and calcium salts of naphthalene sulfonic acid-formaldehyde condensates; lithium, sodium, potassium, calcium, and ammonium salts of lignosulfonates; sodium; potassium and ammonium salts of polyacrylates and carboxylates; sodium salts of maleic a-nhydride-isobutylene copolymers; and water soluble nonionic polymers such as polyvinyl-pyrrolidone, polyethylene oxides and cellulose derivatives. Preferred dispersants include the sodium, potassium, ammonium and calcium salts of naphthalene sulfonic acid-formaldehyde condensates, with the ammonium salts more preferred.

Water-insoluble, cross-linked polyvinylpolypyrrolidone disintegrant refers to any of the generic, but is not limited to. crospovidone disintegrating agents.

The term "anionic wetting agent" includes, but is not limited to, salts of alkylbenzene sulfonates, alkyl and dialkylnaphthalene sulfonates, alkyl and alcohol sulfates, sulfoalkylamides, carboxylates, alpha-olefin sulfonates and dialkyl sulfosuccinates. The term "nonionic wetting agent" includes acetylenic diols, ethylene oxide-propylene oxide copolymers, alkylphenol ethoxylates, fatty acid ethoxylates, alcohol ethoxylates, sorbitan fatty acid ester ethoxylates and castor oil ethoxylates. The preferred wetting agents are sodium dialkyl sulfosuccinates of which sodium diisobutyl sulfosuccinate, sodium diamyl sulfosuccinate and sodium dicyclohexyl sulfosuccinate are more preferred.

The internal desiccants that "chemically bind" water are those that actually undergo chemical reactions with water to form a new compound. An example of this type of material is CaO which reacts with water to form Ca(OH)₂. Other materials representative of those which react in this manner are magnesium oxide and boric anhydride.

The internal desiccants that "physically adsorb" water are. those selected from the group consisting of highly-dispersed silicilic acids such as silica gel; aluminum oxide; clays such as montmorillonite; and amorphous and crystalline aluminosilicates such as molecular sieves and zeolites. Combinations of these desiccants with those that form hydroxides and hydrates can be used. Kirk- Othmer's Encyclopedia of Chemical Technology (3rd ed., Nol. 8, p 115) describes desiccants suitable for use in the tablet formulation of this invention as Type 1 and Type 4 desiccants. Either type can be employed, singly or in combination, as long as the desiccant does not expand when it picks-up water. Such expansion causes the tablet to crack or crumble on long term storage.

Internal desiccants useful in the tablet formulation of this invention also include materials that chemically bind water, not in the sense of a Chemical reaction that forms a hydroxide, but in the sense of a chemical reaction that produces a hydrate. Representative of useful desiccants that form hydrates are CaSO₄, ΝaOAc, MgSO₄, Νa₂SO₄, CaCl₂, and ZnSO₄. Representative of the hydrate-forming reaction is that undergone by CaCl₂ to form CaCl₂.H₂O. One or more desiccants from each group, the hydroxide-forming and the hydrate- forming, can be employed, alone or in combination, depending on the particular properties sought by the formulator. In any event, the desiccants employed in the tablets of this invention are not those of the water-adsorbing type employed in prior art tablet formulations. Kirk-Othmer's Encyclopedia of Chemical

Technology (Third Edition, Vol. 8, page 115) further describes desiccants of the type contemplated for this invention as so-called Type 1 materials. A preferred tablet formulation is one wherein component (b) is an ammonium, sodium or lithium carbonate or bicarbonate or mixture thereof, and the internal desiccant is selected from (A), (B) and a mixture of (A) and (B).

Also preferred is a tablet formulation wherein (b) is potassium carbonate or bicarbonate or mixture thereof, and the internal desiccant is (A).

Preferred pesticides are those having a melting point of at least about 100°C and solubility in pH 7 water at 20°C of no more than about 5% by weight.

Representatives of such pesticides are herbicides such as: acifluorfen, asulam, atrazine, bensulfuron, bentazon, bromacil, bromoxynil, chloramben, chlorimuron ethyl, chloroxuron, chlorsulfuron, chlortoluron, clomazone, cyanazine, dazomet, desmediphan, dicamba, dichlobenil, dichlorprop, diphenamid, dipropetryn, diuron, thiameturon, 2-[[[[N-(4-methoxy-6-methyl-1,3,5-triazine-2-yl)-N- methylamino]carbonyl]amino]sulfonyl]benzoic acid, methyl ester, fenac, fenuron, fluometuron, fluridone, fomesafen, glyphosate, hexazinone,imazamethabenz, imazaquin, imazethapyr, ioxynil, isoproturon, isouron, isoxaben, karbutilate, lenacil, MCPA, MCPB, mefluidide, methabenzthiazuron, methazole, metribuzin, metsulfuron methyl, monuron, naptalam, neburon, nitralin, norflurazon, oryzalin, perfluidone, phenmedipham, picloram, prometryn, pronamide, propazine, pyrazon, siduron, simazine, sulfometuron methyl, tebuthiuron, terbacil, terbuthylazine, terbutryn, triclopyr, 2,4-D, 2,4-DB, triasulfuron, primisulfuron, 2-/3-(4,6-bis(difluoromethoxy)pyrimidin-2-yl)ureidosulfonyl)benzoic acid methyl ester, 5-pyrazolesulfonamide, N-[(4-methoxy-6-methyl-pyrimidine-2-yl)-amino- carbonyl]-4-methoxy-carbonyl-1-methyl-], N-[[(4,6-dimethoxy-2-pyrimidinyl)- amino]carbonyl]-3-(ethylsulfonyl)-2-pyridinesulfonamide, 2-[[[[(4,6-dimethoxy- 2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]-N,N -dimethyl-3 -pyridine- carboxamide, methyl 2-[[[[[4-ethoxy-6-(methylamino)-1,3,5-triazin-2-yl]- amino]carbonyl]amino]sulfonyI]benzoate, methyl 2-[[[[(4,6-dimethoxy-2- pyrimidinyl)amino]carbonyl]amino]sulfonyl]-6-(trifluoromethyl)-3-pyridine- carboxylate, 2-(2-chloroethoxy)-N-[[(4-methoxy-6-methyl-1,3,5-triazin-2- yl)amino]carbonyl]benzenesulfonamide, methyl 2-[[[[[4-(dimethyl-amino)-6- (2.2.2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino]carbonyl]sulfonyl]-3-methyl- benzoate, sodium 2-chloro-6-[(4,6-dimethoxy-2-pyrimidinyl)thio]benzoate;

fungicides such as: carbendazim, thiuram, dodine, chloroneb, cymoxanil, captan, folpet, thiophanatemethyl, thiabendazole, chlorothalonil, dichloran, captafol, iprodione, vinclozolin, kasugamycin, triadimenol, flutriafol, flusilazol, hexaconazole or fenarimol; bactericides such as oxytetracycline dihydrate;

acaricides such as: hexathiazox, oxythioquinox, dienochlor or cyhexatin;

insecticides such as: carbofuran, carbaryl, thiodicarb or deltamethrin.

More preferred pesticides are hexazinone, 2,4-D, chlorsulfuron,

sulfometuron methyl, chlorimuron ethyl, metsulfuron methyl, ethametsulfuron methyl, thifensulfuron methyl, tribenuron ethyl, bensulfuron methyl,

primisulfuron, methyl 2-[[[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]- amino]sulfonyl]-6-(trifluoro-methyl)-3-pyridinecarboxylate, 2-(2-chloroethoxy)- N-[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl]benzenesulfonamide, ethyl 5-[[[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]-1- methyl-1H-pyrazole-4-carboxylate, N-[[(4,6-dimethoxy-2-pyrimidinylamino]- carbonyl]-3-(ethylsulfonyl)-2-pyridinesulfonamide, 2-[[[[(4,6-dimethoxy-2- pyrimidinyl)amino]carbonyl]amino]sulfonyl]-NN-dimethyl-3-pyridine- carboxamide, methyl 2-[[[[[4-(dimethylamino)-6-(2,2,2-trifluoroethoxy)-1,3,5- triazin-2-yl]amiαo]carbonyl]sulfonyl]-3-methylbenzoate, and sodium 2-chloro-6- [(4,6-dimethoxy-2-pyrimidinyl)thio]benzoate.

The most preferred pesticides are sulfonylurea herbicides such as

chlorsulfuron, sulfometuron methyl, chlorimuron ethyl, metsulfuron methyl, ethametsulfuron methyl, thifensulfuron methyl, tribenuron ethyl, bensulfuron methyl, primisulfuron, methyl 2-[[[[(4,6-dimethoxy-2-pyrimidinyl)amino]- carbonyl]amino]sulfonyl]-6-(trifluoromethyl)-3-pyridinecarboxylate, 2-(2- chloroethoxy)-N-[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)ammo]carbonyl]- benzenesulfonamide, ethyl 5-[[[[(4,6-dimethoxy-2-pyrimidinyl)amino]- carbonyl]amino]sulfonyl]-1-methyl-1H-pyrazole-4-carboxylate, N-[[(4,6- dimethoxy-2-pyrimidinylamino]carbonyl]-3-(ethylsulfonyl)-2-pyridine- sulfonamide, 2-[[[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]amino]- sulfonyl]-N,N-dimethyl-3-pyridinecarboxamide, and methyl 2-[[[[[4- (dimethylamino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino]carbonyl]- sulfonyl]-3-methylbenzoate.

DETAILS OF THE INVENTION

The most common method for applying water insoluble pesticides is as fine aqueous dispersions which are sprayed onto the field or crop using ground or aerial spray rigs. The tablets of this invention combine a high level of physical integrity with rapid break-up in water using minimal or no agitation while providing fine dispersions of active ingredient. Since the spray nozzles are typically protected against clogging by 50 mesh screens (U.S. mesh size), the dispersions must be fine enough to pass through this size screen without plugging it. This ability is characteristic of pesticide dispersions delivered by the delivery system of tfiis invention.

High physical integrity of the tablets is desirable so that the tablets themselves can withstand the tabletting operation and survive handling, packaging and shipping without breaking. An axial breaking strength of greater than about 9x10³ newtons is generally necessary for a tablet to survive such treatment.

Rapid break-up in water is desirable for the convenience of the growers who require quick turnaround times for the preparation of the dispersions. Generally, the tablets of the invention disperse completely in less than 10 minutes, most in less than 5 minutes using even the cold water drawn from wells in the early spring.

It is substantially impossible to obtain rapid break-up of a tablet of substantially water-insoluble active ingredient in aqueous media without the use of effervescence. The reaction of the organic acid and carbonate or bicarbonate base affords carbon dioxide gas which aids in this respect.

A dispersant is required so that the particles of the active ingredient formed during the disintegration of the tablet remain separated in the cold, hard water.

The disintegrant allows the penetration of the water into the interior of the tablet through a wicking or swelling action. Common starch or cellulose-based disintegrants are unsuitable in agricultural applications as they typically form gels on the 50 mesh spray nozzle screens. Hence, a water insoluble cross-linked polyvinylpolypyrrolidone is used.

A wetting agent is required to control the size of the carbon dioxide bubbles formed during the reaction of the acid base. The wetting agent reduces the surface tension between the bubbles and the solid tablet resulting in the formation of smaller bubbles which readily detach from the tablet surface. As a

consequence, the tablet remains submerged in the water for a longer period of time, thus improving contact of the entire tablet surface with water.

If a tablet floats immediately after being dropped in the water its top rapidly dries out and the reaction slows down there. This increases the time required for complete dispersion of active ingredient. When a tablet sinks, water wets the entire exterior of the tablet. Then, when the tablet floats to the surface (as a result of the buoyancy of the attached carbon dioxide bubbles when the tablet has partially dispersed and become lighter) the top remains wet so that effervescent reaction continues. Dispersion times for active ingredients formulated as described herein are very much more rapid than in formulations that produce tablets designed for flotation. To ensure that the tablet will sink initially, inert ingredients are employed that produce a tablet with a density greater than that of water (specific gravity greater than 1.00).

Inert ingredients up to 99.9% of the total weight of the composition can be employed. Inert fillers such as sugar or clay can be added as long as they do not affect the chemical stability of the active ingredient(s). Materials such as glidants, anti-adherents, and lubricants can also be employed to facilitate production in the tablet press. The amounts and types of such ingredients will be readily determinable by one skilled in the tabletting art given the disclosure herein.

The formulation ingredients are typically ground and mixed in a mill, e.g., an air or hammermill. The ground premix is passed through a 50 or 100 mesh (U.S.A. Standard Sieve Series) screen. The average particle size of the ground premix should be in the range of 5 to 15 microns. If it is much smaller, the tablet will be strong, but will not break up very fast. If the premix is much larger, the dispersion will not be fine enough to pass a wet screen test used to indicate whether the dispersion will clog the spray nozzle and protective screen discussed previously.

The tablets can be prepared using conventional tablet-making equipment. Their diameter can vary from about 1 cm or less, to 7.5 cm, depending on the tablet weight desired. Flat-faced, beveled-edge punches, with or without a breakline, product attractive tablets.

To keep the tablet from sticking to the die or punch faces, a lubricant such as magnesium stearate or boric acid can be used. Such lubricants and anti- adherents can be brushed onto the die surface or incorporated into the

formulation.

Tablets have been formed in a hydraulic press with a capacity of 18,000 kg of force. Pressures between about 3.43x10⁷ to 6.86x10⁷ pascals will produce strong tablets that break up rapidly. Break-up times are determined by dropping a tablet, typically 5 to 15 g into 1000 mL of water. The "end point" of final dispersion is easy to determine because the tablet floats to the surface as it loses weight shortly before it finally disperses. The resultant dispersion is then poured through a nest of 50/100/200 mesh screens (300 mm, 150 mm, 75 mm holes, respectively). A qualitative judgment is then made about the amount of material that is retained on each screen. A good tablet will leave just a "trace" on the 200 mesh screen, and the larger screens will be free of residue.

The strength of the tablet can be measured by a tester such as the Erweka^®

Model TBH 28. The tablet is- stood on end and die machine tip moves to the tablet along an axial path. The force to break the tablet in two is normally recorded in newtons (N). Good tablets normally have strengths in the range of 8.896x10³ to 4.448X10⁴ N.

EXAMPLE 1

The following ingredients were weighed out and milled for 1 min in a

Tekmar^® A-10 analytical laboratory mill. The premix was passed through a 50 mesh screen and blended well. A 15 g tablet, 4.34 cm in diameter, was made with a hand-operated hydraulic press at a pressure of 525 kg/cm².

Concentration, Ingredient Weight %

Thifensulfuron methyl 55.3

Citric Acid 10.0 Sodium Bicarbonate 25.4

LomarPWA^® (ammonium salt of naphthalene

sulfonic acid-formaldehyde condensate) 5.7

Polyplasdone XL- 100^® (polyvinylpolypyrrolidone) 1.22

Monawet MB-100^® (sodium diisobutyl

sulfosuccinate) 1.05

Magnesium Oxide 1.33

The fresh tablet took 2 min and 23 sec to dissolve in 25°C water with only a trace of solids on die screens. A second 15 g tablet was allowed to sit at room temperature for 3 days to allow the water in it to diffuse into the internal desiccant (MgO). The tablet was sealed in a tight jar and aged at 45°C for 3 weeks. This accelerated aging simulates about two years of storage at ambient conditions.

After aging, the tablet took 3 min and 10 sec to dissolve in 25°C water. The wet screens had only a trace of solids on them. EXAMPLE 2

The following ingredients were milled and tableted as in Example 1.

Concentration, Ingredient Weight %

Thifensulfuron methyl 52.7

Citric Acid 9.5

Sodium Bicarbonate 24.2

Lomar PWA^® (ammonium salt of naphthalene

sulfonic acid-formaldehyde condensate) 5.45 Polyplasdone XL-100^® (polyvinylpolypyrrolidone) 1.15

Monawet MB-100^® (sodium diisobutyl

sulfosuccinate) 1.00

Molecular Sieves 6.00

The fresh tablet took 2 min and 50 s to break-up in 25°C water. There was only a trace of solids on the screens. The second tablet was aged as in Example 1. After aging, the tablet took 2 min and 51 s to break-up. There was only a trace of solids on the wet screens.

EXAMPLES 3 TO 19

In the same manner employed for Example 1, tablets can be prepared using the active ingredients in the first column of Table 2 with one or more of the desiccants listed in the second and third columns, except that when the base employed is potassium carbonate or bicarbonate, the desiccant(s) employed therewith are to be selected solely from Column A.

EXAMPLES 20 TO 37

By the general procedure of Example 1, tablet formulations can be made whereby the active ingredient pesticide is as described hereafter and the delivery system with its characteristic internal desiccant is as defined herein.

EXAMPLE 20

The pesticide, described in more detail in U.S. 4,127,405, is a compound of the formula:

wherein

R₁ is

R₃ and R₆ are independendy hydrogen, fluorine, chlorine, bromine, iodine, alkyl of 1-4 carbon atoms, alkoxy of 1-4 carbon atoms, nitro, trifluoromethyl, cyano, CH₃S(O)_n- or CH₃CH₂S(O)_n-;

R₄ is hydrogen, fluorine, chlorine, bromine or methyl;

R₅ is hydrogen, fluorine, chlorine, bromine, methyl or methoxy;

R₇ is hydrogen, fluorine, chlorine, bromine, alkyl of 1-2 carbon atoms or alkoxy of 1-2 carbon atoms;

R₈ is hydrogen, methyl, chlorine or bromine;

R₉ and R₁₀ are independently hydrogen, methyl, chlorine or bromine; W and Q are independently oxygen or sulfur;

n is 0, 1 or 2;

X is hydrogen, chlorine, bromine, methyl, ethyl, alkoxy of 1-3 carbon atoms, trifluoromethyl, CH₃S- or CH₃OCH₂-; and

Z is methyl or methoxy, or their agriculturally suitable salts.

EXAMPLE 21

The pesticide, described in more detail in U.S. 4,394,506, is a compound of the formula:

N-(heterocyclicaminocarbonyl)arylsulfonamides in which the aryl radical is substituted in the 2-position by a carboxy radical, ester, thioester, or amide thereof; e.g., N-[(4,6-dimethylpyrimidin-2yl)aminocarbonyl]- methoxycarbonyl]benzenesulfonamide or N-[(4,6-dimethoxy-1,3,5- triazin-2-yl)amino-carbonyl]-2-methoxycarbonylbenzenesulfonamide.

EXAMPLE 22

The pesticide, described in more detail in U.S. 4,481,029, is a compound of the formula:

wherein

W' is O or S;

A' is H, Cl, Br, C₁-C₄ alkyl, OCH₃, ΝO₂ or CF₃;

O T

A is -C-Q-R^I or -C-R^II where

Q is O, S or -N-;

R₄

OR^III

/

T is O or =N

where R^III is H, C₁-C₄ alkyl or C₃-C₄ alkenyl; when Q is O or S then

R^I is C₁-C₆ alkyl C₃-C₆ alkenyl; C₃-C₆ alkynyl; C₂-C₆ alkyl substituted with 1-3 Cl, F or Br, or one of CN or OCH₃; C₃-C₆ alkenyl substituted with 1-3 Cl; C₃-C₆ alkynyl substituted with Cl; C₅-C₆ cycloalkyl; cyclohexenyl; cyclohexyl substituted with 1-3 CH₃;

C₄-C₇ cycloalkylalkyl or

where

R₇ and R₈ are independently H, Cl, CH₃ or OCH₃;

n is 0 or 1 ; and

R₉ is H or CH₃;

where

Z is N, CH or C-F;

X=H, Cl, -CH₃, -OCH₃ or -OCH₂CH₃;

Y=H, Cl, C₁-C₄ substituted alkyl;

with the proviso that when X and Y are both H, then

R^I and R^II are less than 5 carbons;

X₁=H, Cl, OCH₃, OCH₂CH₃ or CH₃;

Y₁=H, OCH₃ or CH₃; and X_III=O or CH₂ and further provided that when A contains greater than 5 carbon atoms, then Y contains≤4 carbon atoms,and their agriculturally suitable salts;

all other substituents being as defined in U.S.4,481,029.

EXAMPLE 23

The pesticide, described in more detail in U.S.4,435,205, is a compound of the formula:

where

W is O or S;

Q is O or NR₅;

R₁ is C₁-C₄ alkyl, C₁-C₄ alkyl substimted with 1-3 atoms of F, Cl or Br, CH₂CH₂OCH₃, CH₂CH₂CH₂OCH₃ or

R₂ is H, F, Cl, Br, OCH₃, NO₂, CF₃ or C₁-C₂ alkyl;

R₃ is H, F, Cl, Br orCH₃;

R₄ is H, CH₃ or OCH₃;

R₅ is C₁-C₄ alkyl;

R₆ and R₇ are independently H, F, Cl, Br, CH₃, CF₃, NO₂ or OCH₃;

A is

X is NH₂, N(CH₃)₂, NHCH₃, C₁-C₄ alkyl, C₁-C₄ alkyl substimted with 1-3 atoms of F, Cl or Br, CH₂OCH₃, CH₂OCH₂CH₃, C₁-C₄ alkoxy, C₁-C₂ alkylthio, C₃-C₄ alkenyloxy, C₃-C₄ alkynyloxy, OCH₂CH₂OCH₃ or C₂-C₄ alkoxy substimted with 1-3 atoms of F, Cl or Br;

n is 1 or 2;

Y is H, CH₃, OCH₃ or Cl;

X₁ is O or CH₂;

Y₁ is H, CH₃, OCH₃ or Cl;

X₂ and Y₂ are independently CH₃ or OCH₃; and

Z is CH, N, CCH₃, CBr, CCl, CF, Cl, CC₂H₅, CCH₂CH₂Cl or

CCH₂CH=CH₂.

EXAMPLE 24

The pesticide, described in more detail in U.S. 4,420,325, is a compound of the formula:

wherein R₁ is F, Cl, Br, CF₃, C₁-C₃ alkoxy, C₁-C₃ alkyl, NO₂, CO₂R₄, SO₂R₅,

SO₂NR₆R₇, SO₂N(OCH₃)CH₃, SO₂OCH₂CF₃, OSO₂R₅ or CH₂L; L is SO₂NR₆R₇, OCH₃, OC₂H₅, CO₂H₅, CO₂CH₃ or CO₂C₂H₅;

R₂ is H, Cl, Br, F, CF₃ or OCH₃;

R₄ is C₁-C₃ alkyl, CH₂CH=CH₂, CH₂CH₂Cl or CH₂CH₂OCH₃;

R₅ is C₁-C₃ alkyl or CF₃;

R₆ and R₇ are independendy C₁-C₃ alkyl;

R₈ is H or CH₃;

R₉ is H or C₁-C₃ alkyl;

R₃ is

W is O or S;

X is CH₃, OCH₃ or Cl;

Y is CH₃, C₂H₅, OCH₃, OC₂H₅, CH₂OCH₃, NH₂, NHCH₃ or N(CH₃)₂;

Z is CH or N;

X₁ is H, Cl, CH₃, OCH₃ or OC₂H₅;

X₂ is CH₃, C₂H₅, OCH₃ or OC₂H₅;

X₃ is CH₃ or OCH₃; and

Y₁ is CH₃ or OCH₃; and dieir agriculturally suitable salts.

EXAMPLE 25

The pesticide, described in more detail in U.S. 4,514,211, is a compound of the formula:

wherein

Q is O, S, SO or SO₂;

Q₁ is O, S or SO₂;

W

L is SO₂NHCNA;

R₁₂

R₁ is H or C₂-C₄ alkyl; R₂ is H or C₁-C₄ alkyl;

R₃ is H or CH₃;

R₄ is H, Cl, CH₃, CF₃, OCH₃, Br, F, SCH₃ or OCF₂H;

R₅ is H, CH₃, OCH₃, Cl, Br, NO₂, CO₂R₇, SO₂R₈, OSO₂R₉,

SO₂NR₁₀R₁₁, F, CF₃, SCH₃, OCF₂H or SO₂N(OCH₃)CH₃; R₆ is H, Cl, Br or C₁ -C₄ alkyl;

R₆ is H, CH₃, Cl or Br;

R₇ is C₁-C₃ alkyl, CH₂CH=CH₂, CH₂CH₂OCH₃ or CH₂CH₂Cl;

R₈ is C₁-C₃ alkyl;

R₉ is C₁-C₃ alkyl or CF₃;

R₁₀ and R₁₁ are independentiy C₁-C₂ alkyl;

R₁₂ is H or CH₃;

W is O or S;

A is

X is H, CH₃, OCH₃, Cl. F. OCF₂H or SCF₂H;

Y is CH₃, OCH₃, OC₂H₅, CH₂OCH₃, ΝH₂, NHCH₃, N(CH₃)₂,

CH(OCH₃)₂, CH(OCH₂CH₃)₂, C₂H₅, CF₃, CH₂=CHCH₂O, CH≡CCH₂O, CF₃CH₂O, OCH₂CH₂Cl, OCH₂CH₂Br, OCH₂CH₂F, CN, CH₂OCH₂CH₃, OCH₂CH₂OCH₃ or GCF₂T wherein G is O or S and T is H, CHClF, CHBrF, CF₂H or CHFCF₃;

Z is CH, N, CCH₃, CC₂H₅, CCl or CBr;

Y₁ is O or CH₂;

X₁ is CH₃, OCH₃, OC₂H₅ or OCF₂H;

X₂ is CH₃, C₂H₅ or CH₂CF₃;

Y₂ is C₂H₅, CH₃, OCH₃, OC₂H₅, SCH₃ or SC₂H₅; and

X₃ is CH₃ or OCH₃.

EXAMPLE 26

The pesticide, described in more detail in U.S. 4,547,215, is a compound of the formula:

wherein

R is C₂H₅ or CH(CH₃)₂;

and their agriculturally suitable salts.

EXAMPLE 27

The pesticide, described in more detail in U.S. 4,548,638, is a compound of the formula:

wherein

R is CO₂CH₃, CO₂CH₂CH₃, CO₂CH₂CH₂CH₃, CO₂CH₂CH=CH₂,

CO₂CH(CH₃), CO₂CH₂CH₂Cl, SO₂N(CH₃)₂ or OSO₂CH₃. EXAMPLE 28

The pesticide, described in more detail in U.S. 4,479,821, is a compound of the formula:

wherein

A is a C₁-C₆ alkyl radical which is substituted by C₁-C₄ alkoxy, C₁-C₄ alkylthio, C₁-C₄ alkylsulfinyl or C₁-C₄ alkylsulfonyl;

X is oxygen, sulfur, a sulfinyl or sulfonyl bridge;

Z is oxygen or sulfur;

m is 1 or 2;

R₂ is hydrogen, halogen, C₁-C₅ alkyl, C₂-C₅ alkenyl, C₁-C₄haloalkyl, or a radical -Y-R₅, -COOR₆, -NO₂ or -CO-NR₇R₈;

R₃ and R₄, each independendy of die oth er, are hydrogen, C₁ -C₄ alkyl,

C₁-C₄ alkoxy, C₁-C₄ alkylthio, C₁-C₄ haloalkyl, halogen or alkoxy- alkyl of at most 4 carbon atoms;

R₅ and R₆, each independendy of the other, are C₁-C₅ alkyl, C₂-C₅ alkenyl or C₂-C₆ alkynyl;

R₇ and R₈, each independendy of the other, are hydrogen, C₁-C₅ alkyl,

C₂-C₅ alkenyl or C₂-C₆ alkynyl; and

Y is oxygen, sulfur, a sulfinyl or sulfonyl bridge, and salts of these

compounds.

EXAMPLE 29

The pesticide, described in more detail in U.S. 4,566,898, is a compound of the formula:

EXAMPLE 30

The pesticide, described in more detail in U.S. 4,435,206, is a compound of the formula:

wherein

R is

R₁ is H, Cl, Br, F, C₁-C₄ alkyl, C₁-C₄ alkoxy, C₁-C₄ alkylthio, NO₂, CF₃, COOR₅ or SO₂NR₆R₇;

R₂ is H, Cl, Br or CH₃;

R₃ and R₄ are independendy H or CH₃;

R₅ is C₁-C₆ alkyl, C₃-C₆ alkenyl, CH₂CH₂OCH₃, CH₂CH₂OCH₂CH₃,

CH₂CH₂CH₂OCH₃ or CH₂CH₂Cl;

R₆ and R₇ are independently CH₃ or CH₃CH₂;

W is oxygen or sulfur;

X is CH₃ -OCH₃ or -OCH₂CH₃;

Y is H, Cl, CH₃, CF₃, -NHCH₃, -N(CH₃)₂-, -CH₂OR₈, -CH₂CH₂OR₈,

-OCH₂CF₃ or NR₆;

Z is CH or Ν;

N is oxygen or sulfur;

R₈ is CH₃, CH₃CH₂-, CH₂CO₂R₈, -CH₂CH₂OR⁶, C(CH₃)HCO₂R₈ or

CH₂CH₂CO₂R₈;

Y₁ is H, CH₃ or OCH₃; and X₁ is H, Cl, -OCH₃, -OCH₂CH₃ or CH₃;

and agricultural salts thereof.

EXAMPLE 31

The pesticide, described in more detail in U.S.4,514,212, is a compound of the formula:

and die salts thereof with amines, alkali metal or alkaline earth metal bases or with quaternary ammonium bases wherein:

Q is fluorine, fluoromethyl, chloromethyl, trichloromethyl, 1,2-dichloro- ethyl, 1,2-dibromoemyI, 1,2-dichloropropyl, 1,2-dibromopropyl, 1,2-dibromoisobutyl, 1,2-dichloro-1-methyl-ethyl or 1,2-dibromo- 1-methylethyl;

X is oxygen, sulfur, a sulfinyl or sulfonyl bridge;

Z is oxygen or sulfur;

R₂ is hydrogen, halogen, C₁-C₅ alkyl, C₂-C₅ alkenyl, C₁-C₄haloalkyl, or a radical -Y-R₅, -COOR₆, -NO₂ or -CO-NR₇-R₈;

R₃ and R₄, each independendy of die other, are hydrogen, C₁-C₄ alkyl, C₁-C₄ alkoxy, C₁-C₄ alkylthio, C₁-C₄ haloalkyl, halogen or alkoxyalkyl of at most 4 carbon atoms;

R₅ and R₆, each independently of die other, are C₁-C₅ alkyl, C₂-C₅ alkenyl or C₂-C₆ alkynyl;

R₇ and R₈, each independendy of die other, are hydrogen, C₁-C₅ alkyl, C₂-C₅ alkenyl or C₂-C₆ alkynyl; and

Y is oxygen, sulfur, a sulfinyl or sulfonyl bridge.

EXAMPLE 32

The pesticide, described in more detail in U.S.4,478,635, is a compound ofie formula:

wherein

X is a radical of the formula:

Y is C₁-C₃ alkyl, C₁-C₃ haloalkyl, C₁-C₃ alkoxy, C₁-C₃ haloalkoxy, C₂-C₃ alkoxyalkyl, C₁-C₃ alkylthio, halogen or -NR₁₆R₁₇;

Z is oxygen or sulfur;

R₁ is hydrogen, halogen, cyano, nitro, C₁-C₄ haloalkyl, C₁-C₄ alkyl, C₁-C₄ alkoxy, -CO-R₆, -NR₇R₈, -S(O)_m-C₁-C₄ alkyl or -SO₂R₉; R₂ is hydrogen, fluorine, chlorine, bromine, nitro, trifluoromethyl,

-NR₂₀R₂₁, methyl, ethyl, methoxy, ethoxy or -S(O)_m-C₁-C₄ alkyl; R₃ is hydrogen, fluorine, chlorine, bromine, amino, nitro or methoxy;

R₆ is hydrogen, C₁-C₄ alkyl, C₁-C₃ alkenyloxy, C₃-C₅ alkynyloxy, C₁-C₄ haloalkyl, C₁-C₅ alkylthio, phenoxy, benzyloxy, -NR₁₀R₁₁ or C₁-C₅ alkoxy which is unsubstituted or substimted by 1 to 3 halogen atoms or C₁-C₃ alkoxy;

R₇ is hydrogen, methoxy, ethoxy, C₁-C₄ alkyl or -CO-R₁₂;

R₈ is hydrogen or -CO-R₁₂;

R₉ is an -O-R₁₃ or -NR₁₄R₁₅ group;

R₁₁ is C₁-C₄ alkyl which is unsubstituted or substimted by 1 to 3 halogen atoms, or is phenyl or benzyl;

R₁₂ is hydrogen, C₁-C₄ alkyl or C₁-C₄ alkoxy; and

m is 0, 1 or 2; and R₄ has the same meaning as R₂; R₅ has die same meaning as R₁; R₁₀, R₁₁, R₁₄ and R₂₀ each have the same meaning as R₇; and R₁₂ ,R₁₅, R₁₆, R₁₇ and R₂₁ each have die same meaning as R₈.

EXAMPLE 33

The pesticide, described in more detail in U.S. 4,634,465, is a compound of the formula:

wherein

Z is oxygen or sulfur;

E is nitrogen or =C-;

R₁ is hydrogen, halogen, nitro, C₁-C₄ alkyl, C₁-C₄ haloalkyl, C₁-C₄

alkoxy, C₁-C₄ haloalkoxy, C₁-C₄ alkoxycarbonyl, C₁-C₄ alkylthio, C₁-C₄ alkylsulfinyl, C₁-C₄ alkylsulfonyl or C₂-C₅ alkoxyalkoxy;

R₂ is hydrogen, C₁-C₄ alkyl or C₁-C₃ alkoxy;

R₃ and R₄, each independendy of die other, are hydrogen, C₁-C₄ alkyl, C₁-C₄ alkoxy, C₁-C₄ haloalkoxy, C₁ -C₄ haloalkylthio, C₁-C₄ alkylthio, halogen, C₂-C₅ alkoxyalkyl, C₂-C₅ alkoxyalkoxy or -NR₅R₆, wherein R₅ and R₄ are hydrogen or C₁ -C₄ alkyl; and

A is an unsubstimted or substimted bridge of 3 or 4 atoms which contains 1 or 2 oxygen, sulfur or nitrogen atoms and, together with die linking carbon atom, forms a non-aromatic 5- or 6-membered heterocyclic ring system, with die proviso that two oxygen atoms are separated by at least one carbon atom and that oxygen and sulfur atoms are only linked to each other if the sulfur atom takes the form of the -SO- or -SO₂- group.

EXAMPLE 34

The pesticide, described in more detail in EPA-202,830, is:

2-[[N-(4-medιoxy-6-medιyl-1,3,5-triazin-2-yl)-N-methylamino- carbonyl]aminosulfonyl]benzoic acid, metiiyl ester. EXAMPLE 35

The pesticide, described in more detail in EPA-237,292, is a compound of the formula:

wherein

J is

R is H or CH₃;

R₁ is H or C₁-C₃ alkyl;

R₂ is C₁-C₃ alkyl or C₁-C₂ alkoxy; or

R₁ and R₂ may be taken together to form -(CH₂)_n-, wherein n is 2, 3 or 4;

R₃ is H, Cl, F, Br, CH₃, CF₃, OCH₃ or COF₂H; and

X is CH₃, CH₂F, CH₂CH₃, OCH₃, OCH₂CH₃, Cl, OCF₂H or CH₂OCH₃.

EXAMPLE 36

The pesticide, described in more detail in EPA-87,780, is a compound of the formula:

wherein

A represents a hydrogen atom, a C₁-C₈ alkyl group or a phenyl group which may be substituted with C₁-C₈ alkyl groups, halogen atoms or nitro groups; B and C represent independendy hydrogen atoms, halogen atoms, mtro groups, C₁-C₈ alkyl groups, arylalkyl groups, C₁-C₈ alkoxy groups; haloalkyl groups, -CO₂R [where R is a hydrogen atom, a C₁-C₈ alkyl group, an allyl group or a propargyl group), -CONR₁R₂ (where R₁ is a hydrogen atom, a C₁-C₈ alkyl group or a phenyl group, R₂ is a hydrogen atom or a C₁-C₈ alkyl group, or R₁ and R₂ taken togedier may represent -(CH₂)_m- (m is 4, 5 or 6), -CH₂CH₂OCH₂CH₂-, or -CH₂CH₂N(CH₃)CH₂CH₂-], -S(O)_nR₃ (where R₃ is a C₁-C₈ alkyl group, a phenyl group or an arylalkyl group and n is 0, 1 or 2), -SO₂NR₄R₅ [where R₄ is a C₁-C₈ alkyl group, R₅ is a hydrogen atom or a C₁-C₈ alkyl group, or R₄ and R₅ taken togedier may represent -(CH₂)_p- ( p is 4, 5 or 6), -CH₂CH₂OCH₂CH₂- or -CH₂CH₂N(CH₃)CH₂CH₂-] or a phenyl group which may be substimted with C₁-C₈ alkyl groups, halogen atoms or nitro groups, D represents a hydrogen atom or a C₁-C₈ alkyl group; X and Y represent independendy hydrogen atoms, halogen atoms, C₁-C₈ alkyl groups, C₁-C₈ alkoxy groups, C₁-C₈ alkoxyalkyl groups, -CF₃ groups, C₁-C₈ haloalkoxy groups, alkylamino

R

/

groups, dialkylamino groups, -OCHCO₂R₇ (where R₆

and R₇ each represent hydrogen atoms or C₁-C₈ alkyl groups) or either X or Y may form a five-membered ring containing an oxygen atom together with X; and X represents a nitrogen atom or C-R₈

(where R₈ represents a hydrogen atom, a haloalkyl group or may form a five -membered ring containing an oxygen atom together with X or Y).

EXAMPLE 37

The pesticide, described in more detail in U.S. 4,710,221, is a compound of the formula:

wherein

R is H or CH₃;

R₁ is C₁-C₃ alkyl, C₃-C₄ alkoxyalkyl, C₂-C₄ haloalkyl, C₃-C₄ alkenyl or

C₃-C₄ alkynyl;

R₂ is C₂-C₆ alkoxy, C₃-C₆ cycloalkoxy, C₄-C₆ cycloalkylalkoxy, C₁-C₆ haloalkoxy, C₂-C₆ alkenyloxy, C₂-C₆ haloalkenyloxy, C₃-C₆ alkynyloxy, C₃-C₆ haloalkynyloxy, C₂-C₄ alkoxyalkoxy, C₂-C₄ haloalkoxy alkoxy, C₂-C₄ alkylthioalkoxy, C₂-C₄ haloalkylthio- alkoxy, C₂-C₄ alkylsulfinylalkoxy, C₂-C₄ haloalkylsulfinylalkoxy, C₂-C₄ alkylsulfonylalkoxy, C₂-C₄ haloalkylsulfonylalkoxy, C₂-C₄ cyanoalkoxy, OCH₂C(O)CH₃, OCH₂CH₂C(O)CH₃, C₂-C₄ aminoalkoxy, C₁-C₈ alkylthio, C₃-C₆ cycloalkylthio, C₄-C₆ cycloalkylalkylthio, C₁-C₈ haloalkylthio, C₂-C₆ alkenylthio, C₂-C₆ haloalkenyldiio, C₃-C₆ alkynylth io, C₃-C₆ haloalkynyldiio, C₂-C₄ alkoxy alkylthio, C₂-C₄ haloalkoxyalkylthio, C₂-C₄ alkylthio- alkyldiio, C₂-C₄ haloalkylthioalkylthio, C₂-C₄ cyanoalkylthio, SCH₂C(O)CH₃, SCH₂CH₂C(O)CH₃, C₂-C₄ aminoalkylthio, SC₆H₅,

SCH₂C₆H₅, C₁-C₈ alkylsulfinyl, C₃-C₆ cycloalkylsulfmyl, C₄-C₆ cycloalkylalkylsulfinyl, C₁-C₈ haloalkylsulfinyl, C₂-C₆ alkenyl- sulfinyl, C₂-C₆ haloalkenylsulfinyl, C₃-C₆ alkynylsulfinyl, C₃-C₆ haloalkynylsulfinyl, C₂-C₄ alkoxyalkylsulfϊnyl, C₂-C₄ haloalkoxy- alkylsulfinyl, C₂-C₄ cyanoalkylsulfinyl, S(O)CH₂C(O)CH₃,

S(O)CH₂CH₂C(O)CH₃, C₂-C₄ aminoalkylsulfinyl, C₂-C₈ alkylsulfonyl, C₃-C₆ cycloalkylsulfonyl, C₄-C₆ cycloalkylalkyl- sulfonyl, C₁-C₈ haloalkylsulfonyl, C₂-C₆ alkenylsulfonyl, C₂-C₆ haloalkenylsulfonyl, C₃-C₆ alkynylsulfonyl, C₃-C₆ haloalkynyl- sulfonyl, C₂-C₄ alkoxyalkylsulfonyl, C₂-C₄ haloalkoxyalkylsulfonyl, C₂-C₄ cyanoalkylsulfonyl, SO₂CH₂C(O)CH₃,

SO₂CH₂CH₂C(O)CH₃, C₂-C₄ aminoalkylsulfonyl, CH₂F, CH₂Cl,

CHCl₂, CH₂Br, CHBr₂, C₂-C₆ alkyl substimted with 1-3 atoms of F, Cl or Br, C₂-C₆ alkenyl, C₂-C₆ haloalkenyl, C≡CH, C₂-C₆ haloalkynyl, OC(O) C₁-C₄ alkyl, CH₂C(O)NR_aR_b, NHCH₃, NR_bR_c or C₁-C₄ alkyl substimted with C₁-C₄ alkoxy, C₃-C₄ cycloalkoxy, cyclopropylmethoxy, C₁-C₄ haloalkoxy, C₂-C₄ alkenyloxy, C₂-C₄ haloalkenyloxy, C₃-C₄ alkynyloxy, C₃-C₄ haloalkynyloxy, C₂-C₄ alkoxyalkoxy, C₂-C₄ aminoalkoxy, C₁-C₄ alkylcarbonyloxy, C₁-C₄ haloalkylcarbonyloxy, C₁-C₄ carbamoyloxy, C₁-C₄ alkoxy- carbonyloxy, OH, OP(O)(OC₁-C₂ alkyl)₂, C₁-C₄ alkylsulfonyloxy, C₁-C₂ haloalkylsulfonyloxy. OSi(CH₃)₃, OSi(CH₃)₂C(CH₃)₃, C₁-C₄ alkylthio, C₃-C₄ cycloalkylthio, cyclopropylmethyldiio, C₁-C₄ haloalkyldiio, C₂-C₄ alkenylthio, C₂-C₄ haloalkenylthio, C₃-C₄ alkynyltiiio, C₃-C₄ haloalkynylthio, C₂-C₄ alkoxy alkylthio, C₂-C₄ aminoalkyltiiio, SH, SP(O)(OC₁-C₂ alkyl)₂, C₁-C₄ alkylsulfinyl, C₃-C₄ cycloalkylsulfonyl, cyclopropylmediylsulfinyl, C₁-C₄ haloalkylsulfinyl, C₂-C₄ alkenylsulfinyl, C₂-C₄ haloalkenylsulfinyl, C₃-C₄ alkynylsulfinyl, C₃-C₄ haloalkynylsulfinyl, C₂-C₄

alkoxyalkylsulfinyl, C₂-C₄ aminoalkylsulfinyl, C₁-C₄ alkylsulfonyl, C₃-C₄ cycloalkylsulfonyl, cyclopropylmediylsulfonyl, C₁-C₄ haloalkylsulfonyl, C₂-C₄ alkenylsulfonyl, C₂-C₄ haloalkenylsulfonyl,

C₃-C₄ alkynylsulfonyl, C₃-C₄ haloalkynylsulfonyl, C₂-C₄

alkoxyalkylsulfonyl or C₂-C₄ aminoalkylsulfonyl;

R_a and R_b are independendy H or C₁-C₃ alkyl;

R_c is C₂-C₄ alkyl, cyclopropylmethyl, C₂-C₄ cyanoalkyl, CH₂C(O)CH₃, CH₂CH₂C(O)CH₃, C₁₀-C₄ haloalkyl, C₃-C₄ alkenyl, C₃-C₄ haloalkenyl, C₃-C₄ alkynyl, C₃-C₄ haloalkynyl, C₁-C₄ alkyl substimted widi C₁-C₄ alkoxy, C₁-C₄ alkylthio, C₁-C₄ alkylsulfinyl, C₁-C₄ alkylsulfonyl, OH, NH₂, NHCH₃ or N(CH₃)₂;

X is CH₃, OCH₃, OC₂H₅, Cl or Br; Y is C₁-C₂ alkyl, C₁-C₂ alkoxy, OCH₂CH₂F, OCH₂CHF₂, OCH₂CF₃,

NHCH₃ or N(CH₃)₂; and

Z is CH or N; and

tiieir agriculturally suitable salts.

Claims

CLAIMS What is claimed is:

1. A tablet formulation consisting essentially of by total weight of the formulated composition:

(i) about 0.1% to 75% of a pesticide;

(ii) about 25% to 99.9% of a delivery system characterized by a panel of components complementary to the pesticide of (i) having the following components:

(c) about 0.5% to 20% of a dispersant;

(d) about 0.1% to 5% of water-insoluble cross-linked polyvinylpolypyrrolidone;

(e) about 0.1% to 5% of an anionic or nonionic wetting agent; and

(f) about 1% to 20% of an internal desiccant being selected from the group:

(A) one or a mixture of desiccants that chemically bind water, and OB) one or a mixture of desiccants diat physically adsorb water;

2. A tablet formulation according to Claim 1 wherein (b) is an ammonium, sodium or lithium carbonate or bicarbonate or mixture thereof, and die internal desiccant is selected from (A), (B) and a mixture of (A) and (B).

3. A tablet formulation according to Claim 1 wherein (b) is potassium carbonate or bicarbonate or mixture thereof, and the internal desiccant is (A).

4. A tablet formulation according to Claim1 in die form of a tablet.

5. A tablet formulation according to Claim2 in die form of a tablet.

6. A tablet formulation according to Claim3 in the form of a tablet.

7. A tablet formulation according to any one of Claims 1 to 6 wherein the pesticide is a sulfonylurea herbicide selected from the group consisting of chlorsulfuron, sulfometuron metiiyl, chlorimuron etiiyl, metsulfuron methyl, ediametsulfuron methyl, diifensulfuron methyl, tribenuron etiiyl. bensulfuron metiiyl, primisulfuron, methyl 2-[[[[(4,6-dimedιoxy-2-pyrimidinyl)amino]- carbonyl]ammo]sulfonyl]-6-(trifluoro-methyl)-3-pyridinecarboxylate, 2-(2- chloroethoxy)-N-[[(4-methoxy-6-memyl-1,3,5-triazin-2-yl)amino]carbonyl]- benzenesulfonamide, ethyl 5-[[[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]- amino]sulfonyl]-1-methyl-1H-pyrazole-4-carboxylate, N-[[(4,6-dimethoxy-2- pyrimidmylamino]carbonyl]-3-(ethylsulfonyl)-2-pyridinesulfonamide, 2-[[[[(4,6- dimethoxy-2-pyriiidmyl)ammo]carbonyl]ammo]sulfonyl]-NN-dimethyl-3- pyridinecarboxamide, and meth yl 2-[[[[[4-(dimethylamino)-6-(2,2,2-trifluoro- ethoxy)-1,3,5-triazin-2-yl]amino]carbonyl]sulfonyl]-3-methylbenzoate.

8. A tablet formulation according to Claim 7 wherein the pesticide is a sulfonylurea herbicide selected from the group consisting of thifensulfuron methyl, tribenurrn ethyl, and bensulfuron meth yl.