WO1993012128A1 - DERIVATIVES OF 9-(β-D-XYLOFURANNOSYL)ADENINE AND OF 1-(β-D-XYLOFURANNOSYL)CYTOSINE, PREPARATION THEREOF AND APPLICATION IN THERAPEUTICS - Google Patents
DERIVATIVES OF 9-(β-D-XYLOFURANNOSYL)ADENINE AND OF 1-(β-D-XYLOFURANNOSYL)CYTOSINE, PREPARATION THEREOF AND APPLICATION IN THERAPEUTICS Download PDFInfo
- Publication number
- WO1993012128A1 WO1993012128A1 PCT/FR1992/001182 FR9201182W WO9312128A1 WO 1993012128 A1 WO1993012128 A1 WO 1993012128A1 FR 9201182 W FR9201182 W FR 9201182W WO 9312128 A1 WO9312128 A1 WO 9312128A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- adenine
- group
- xylofurannosyl
- acetyl
- cytosine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP5510676A JPH06505510A (en) | 1991-12-12 | 1992-12-14 | Derivatives of 9-(β-D-xylofuranosyl)adenine and 1-(β-D-xylofuranosyl)cytosine, their preparation and application as therapeutic agents |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9115420A FR2684997A1 (en) | 1991-12-12 | 1991-12-12 | DERIVATIVES OF 9- (BETA-D-XYLOFURANNOSYL) ADENINE AND 1- (BETA-D-XYLOFURANNOSYL) CYTOSINE, THEIR PREPARATION AND THEIR THERAPEUTIC USE. |
FR91/15420 | 1991-12-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1993012128A1 true WO1993012128A1 (en) | 1993-06-24 |
Family
ID=9419960
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR1992/001182 WO1993012128A1 (en) | 1991-12-12 | 1992-12-14 | DERIVATIVES OF 9-(β-D-XYLOFURANNOSYL)ADENINE AND OF 1-(β-D-XYLOFURANNOSYL)CYTOSINE, PREPARATION THEREOF AND APPLICATION IN THERAPEUTICS |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0572644A1 (en) |
JP (1) | JPH06505510A (en) |
CA (1) | CA2103884A1 (en) |
FR (1) | FR2684997A1 (en) |
WO (1) | WO1993012128A1 (en) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0624372A2 (en) * | 1993-03-18 | 1994-11-17 | Nippon Chemiphar Co., Ltd. | Medicament for treating human immunodeficiency virus |
US5808047A (en) * | 1995-03-24 | 1998-09-15 | Eli Lilly And Company | Process for the preparation of 2,2'-anhydro- and 2'-keto-1-(3',5'-di-O-protected-β-D-arabinofuranosyl) nucleosides |
US5990093A (en) * | 1993-09-10 | 1999-11-23 | Emory University | Treating HBV with phospholipid prodrugs of β-L-2',3'-dideoxyadenosine 5'-monophosphate |
US6245749B1 (en) | 1994-10-07 | 2001-06-12 | Emory University | Nucleosides with anti-hepatitis B virus activity |
WO2002069943A2 (en) * | 2001-03-03 | 2002-09-12 | Ulrich Walker | Use of pyrimidine nucleosides and/or the prodrugs thereof for combating the side-effects of haart (highly active anti-retroviral therapy) and other anti-viral therapies |
US7439351B2 (en) | 1993-09-10 | 2008-10-21 | The Uab Research Foundation | 2′ or 3′ -deoxy and 2′, 3′-dideoxy-β-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti-viral agents |
US9073960B2 (en) | 2011-12-22 | 2015-07-07 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR6164M (en) * | 1966-10-13 | 1968-07-08 | ||
DE2105560A1 (en) * | 1971-02-06 | 1972-09-07 | Boehringer Mannheim Gmbh, 6800 Mannheim | Purine ribonucleoside derivatives and processes for making the same |
EP0098186A1 (en) * | 1982-06-14 | 1984-01-11 | Synthelabo | Pharmaceutical compositions containing purine or pyrimidine xylosides and lyxosides |
EP0317728A2 (en) * | 1987-09-22 | 1989-05-31 | Warner-Lambert Company | Use of 9-(beta-D-arabinofuranosyl) adenine derivatives for the preparation of pharmaceutical compositions for the treatment of aids |
EP0322384A1 (en) * | 1987-11-03 | 1989-06-28 | Medivir Aktiebolag | Nucleosides for use in therapy |
-
1991
- 1991-12-12 FR FR9115420A patent/FR2684997A1/en not_active Withdrawn
-
1992
- 1992-12-14 CA CA002103884A patent/CA2103884A1/en not_active Abandoned
- 1992-12-14 WO PCT/FR1992/001182 patent/WO1993012128A1/en not_active Application Discontinuation
- 1992-12-14 EP EP93902329A patent/EP0572644A1/en not_active Withdrawn
- 1992-12-14 JP JP5510676A patent/JPH06505510A/en active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR6164M (en) * | 1966-10-13 | 1968-07-08 | ||
DE2105560A1 (en) * | 1971-02-06 | 1972-09-07 | Boehringer Mannheim Gmbh, 6800 Mannheim | Purine ribonucleoside derivatives and processes for making the same |
EP0098186A1 (en) * | 1982-06-14 | 1984-01-11 | Synthelabo | Pharmaceutical compositions containing purine or pyrimidine xylosides and lyxosides |
EP0317728A2 (en) * | 1987-09-22 | 1989-05-31 | Warner-Lambert Company | Use of 9-(beta-D-arabinofuranosyl) adenine derivatives for the preparation of pharmaceutical compositions for the treatment of aids |
EP0322384A1 (en) * | 1987-11-03 | 1989-06-28 | Medivir Aktiebolag | Nucleosides for use in therapy |
Non-Patent Citations (10)
Title |
---|
CANADIAN JOURNAL OF CHEMISTRY. vol. 66, no. 5, 1988, OTTAWA CA pages 1258 - 1262 M.J.ROBBINS ET AL. 'Nucleic Acid Related Compounds. 53. Synthesis and Biological Evaluation of 2'-deoxy-beta-threo-pentofuranosyl Nucleosides. ' * |
CHEMICAL ABSTRACTS, vol. 101, no. 23, 1984, Columbus, Ohio, US; abstract no. 207519, B.B.GOSWAMI ET AL. 'Mechanism of Inhibition of Herpesvirus Growth by 2'-5'-Linked Trimer of 9-B-D-Xylofuranosyladenine' page 345 ;colonne 2 ; * |
CHEMICAL ABSTRACTS, vol. 103, no. 25, 1985, Columbus, Ohio, US; abstract no. 215691g, G.GOSSELIN ET AL. 'Synthesis of Arabinofuranonucleosides from Certain Xylofuranonucleosides' page 934 ;colonne 2 ; * |
CHEMICAL ABSTRACTS, vol. 112, 1990, Columbus, Ohio, US; abstract no. 151297j, V.M.SHOBUKHOV ET AL. 'A Comparative Study of Antiherpetic Effects of 9-B-D-Xylofuranosyladenine and 9-B-D-arabinofuranosyladenine and their Inhibitory Effect for HSV-1 with Abnormal Genome in Cell Culture' page 21 ;colonne 2 ; * |
CHEMICAL ABSTRACTS, vol. 112, no. 11, 1990, Columbus, Ohio, US; abstract no. 99118k, A.NEUMANN ET AL. 'Facile Synthesis of Anomerical Pure 9-(beta-D-xylofuranosyl) adenine.' page 809 ;colonne 2 ; * |
CHEMICAL ABSTRACTS, vol. 66, 1967, Columbus, Ohio, US; abstract no. 83226q, J.DE RUDDER ET AL. 'Inhibitory Activity of 9-B-D-Xylofuranosyladenine on Herpes virus Multiplication in Cell Cultures' page 7782 ;colonne 2 ; * |
CHEMICAL ABSTRACTS, vol. 75, no. 3, 1971, Columbus, Ohio, US; abstract no. 20873p, M.IKEHARA ET AL. 'Nucleosides and Nucleotides. L. Purine Cyclonucleosides. 14. Synthesis and Properties of Cyclonucleosides Derived from 9-D-Xylofuranosyladenine' page 503 ;colonne 1 ; * |
CHEMICAL ABSTRACTS, vol. 93, no. 1, 1980, Columbus, Ohio, US; abstract no. 10y, R.I.GLAZER 'Potentiation by 2'-Deoxycoformycin of the Inhibitory Effects of Cordycepin and Xylosyladenine on Nuclear RNA Synthesis in L1210 Cells' page 1 ;colonne 2 ; * |
JOURNAL OF MEDICINAL CHEMISTRY. vol. 29, no. 2, 1986, WASHINGTON US pages 203 - 213 G.GOSSELIN ET AL. 'Systematic Synthesis and Biological Evaluation of alpha- and beta-D-Xylofuranosyl Nucleosides of the Five Naturally Occurring Bases in Nucleic Acids and Related Analogues' * |
JOURNAL OF ORGANIC CHEMISTRY. vol. 33, no. 4, 1968, EASTON US pages 1600 - 1603 E.J.REIST ET AL. 'The Synthesi and Reactions of some 8-Substituted Purine Nucleosides' * |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0624372A2 (en) * | 1993-03-18 | 1994-11-17 | Nippon Chemiphar Co., Ltd. | Medicament for treating human immunodeficiency virus |
EP0624372A3 (en) * | 1993-03-18 | 1995-02-01 | Nippon Chemiphar Co | Medicament for treating human immunodeficiency virus. |
US5990093A (en) * | 1993-09-10 | 1999-11-23 | Emory University | Treating HBV with phospholipid prodrugs of β-L-2',3'-dideoxyadenosine 5'-monophosphate |
US6525033B1 (en) | 1993-09-10 | 2003-02-25 | Emory University | Nucleosides with anti-hepatitis B virus activity |
US7439351B2 (en) | 1993-09-10 | 2008-10-21 | The Uab Research Foundation | 2′ or 3′ -deoxy and 2′, 3′-dideoxy-β-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti-viral agents |
US6245749B1 (en) | 1994-10-07 | 2001-06-12 | Emory University | Nucleosides with anti-hepatitis B virus activity |
US7468357B2 (en) | 1994-10-07 | 2008-12-23 | Emory University | Nucleosides with anti-hepatitis B virus activity |
US5808047A (en) * | 1995-03-24 | 1998-09-15 | Eli Lilly And Company | Process for the preparation of 2,2'-anhydro- and 2'-keto-1-(3',5'-di-O-protected-β-D-arabinofuranosyl) nucleosides |
US6992072B2 (en) | 2001-03-03 | 2006-01-31 | Pharma Nord Aps | Combating side-effects |
WO2002069943A3 (en) * | 2001-03-03 | 2003-04-17 | Ulrich Walker | Use of pyrimidine nucleosides and/or the prodrugs thereof for combating the side-effects of haart (highly active anti-retroviral therapy) and other anti-viral therapies |
WO2002069943A2 (en) * | 2001-03-03 | 2002-09-12 | Ulrich Walker | Use of pyrimidine nucleosides and/or the prodrugs thereof for combating the side-effects of haart (highly active anti-retroviral therapy) and other anti-viral therapies |
US9073960B2 (en) | 2011-12-22 | 2015-07-07 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
US10464965B2 (en) | 2011-12-22 | 2019-11-05 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
US11021509B2 (en) | 2011-12-22 | 2021-06-01 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
US10485815B2 (en) | 2012-03-21 | 2019-11-26 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
Also Published As
Publication number | Publication date |
---|---|
FR2684997A1 (en) | 1993-06-18 |
EP0572644A1 (en) | 1993-12-08 |
CA2103884A1 (en) | 1993-06-13 |
JPH06505510A (en) | 1994-06-23 |
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