WO1993006790A2 - Dispositif d'allongement des tissus et procede - Google Patents

Dispositif d'allongement des tissus et procede Download PDF

Info

Publication number
WO1993006790A2
WO1993006790A2 PCT/US1992/006971 US9206971W WO9306790A2 WO 1993006790 A2 WO1993006790 A2 WO 1993006790A2 US 9206971 W US9206971 W US 9206971W WO 9306790 A2 WO9306790 A2 WO 9306790A2
Authority
WO
WIPO (PCT)
Prior art keywords
yarns
yarn
connective tissue
fibers
twisting
Prior art date
Application number
PCT/US1992/006971
Other languages
English (en)
Other versions
WO1993006790A3 (fr
Inventor
Craig L. Van Kampen
Original Assignee
Minnesota Mining And Manufacturing Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Minnesota Mining And Manufacturing Company filed Critical Minnesota Mining And Manufacturing Company
Publication of WO1993006790A2 publication Critical patent/WO1993006790A2/fr
Publication of WO1993006790A3 publication Critical patent/WO1993006790A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/08—Muscles; Tendons; Ligaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds

Definitions

  • the invention relates generally to tissue augmentation devices, and more particularly to a tissue augmentation device that is formed of generally biodegradable material.
  • tissue augmentation has been developed in order to protect transferred tissues used in ligament reconstruction by a load-sharing mechanism. Load-sharing is achieved by suturing an implant in parallel with the transferred tissue.
  • An example of a tissue augmentation device is sold under the trade designation "3M KENNEDY LAD Ligament Augmentation Device" by the Minnesota Mining and Manufacturing Company, St.
  • LAD ligament augmentation device
  • TAD tissue augmentation device
  • the "3M KENNEDY LAD” brand device comprises a generally flat diamond braided structure formed of untwisted polypropylene yarns that are braided at approximately ten picks per inch (394 picks/meter) .
  • Each yarn in that LAD is formed of a plurality of untwisted filaments of approximately 13 denier per filament, and standard industrial techniques are used to control static.
  • the polypropylene yarn of the "3M KENNEDY LAD” brand device has high tenacity (7.5 grams per denier), and the strength after braiding is maintained well (6.7 grams per denier) .
  • Polypropylene is considered to be biocompatible, but not biodegradable or bioabsorbable.
  • tissue augmentation device for the repair or reconstruction of tendons and ligaments.
  • That device includes one or more flat braided strap-like elements of stable biocompatible material connected in series with biodegradable elements.
  • the stable strap-like element may be formed of polypropylene
  • the biodegradable element may be formed of polylactic acid.
  • the biodegradable element of that device is designed to gradually lose its load-bearing capability after implantation in order to gradually transfer increased loads to the repaired or reconstructed tissue.
  • the strap-like elements of that construction may be formed by braiding nine or thirteen tows or bundles each containing 180 extruded polypropylene filaments.
  • the braided strap-like elements described in that patent are similar to the braided structure of the "3M
  • European Patent Publication No. 0 241 252 (Benicewicz et al.) describes an artificial, absorbable ligament prosthesis formed of a polymer of L(-)lactide which may contain up to 10% glycolide as a co-monomer.
  • the preferred structure of that prosthesis is described in the European publication as being an open structure which allows tissue ingrowth formed from "lightly-twisted" tows of "filaments having a 1 to 15 and preferably 2 to 8 twists per inch" (39-590 twists/meter and preferably 79-315 twists/meter) .
  • the idea advanced in the Benicewicz et al. publication is that the prosthesis "will provide a scaffold to induce natural tissue to form along the filaments of the prosthesis. After the natural tissue has grown along the filaments and formed a new ligament or tendon, the filaments will be absorbed, and within some time period will no longer be present at the implant site or anywhere in the body.”
  • U.S. Patent No. 4,792,336 (Hlavacek et al.) describes a flat braided ligament or tendon implant device having texturized yarns, and including an absorbable component comprising a glycolic or lactic acid ester linkage.
  • the structure of that device includes a flat braid having primarily axial (quoit) yarns of an absorbable polymer, sleeve or carrier yarns consisting completely of absorbable material that are turned at about 1.4 turns per inch (55 turns/meter) , and possibly a non-absorbable component blended into the axial yarns.
  • U.S. Patent No. 4,795,466 (Stuhmer et al.) describes an artificial crucial ligament for a knee joint.
  • That artificial ligament comprises a plurality of tubes, which may be of braided construction, disposed in concentric relation to define a stem, with alternating tubes extending from the stem to form to branches.
  • the tubes of that arrangement are formed by a plurality of polyester threads, which in turn are formed either by twisting a large number (e.g., 60) of monofilaments to form multifilament threads in the case of the outermost layers, or by a single monofilament in ' the case of the innermost tubes.
  • U.S. Patent No. 4,932,972 discusses a prosthetic ligament comprising a plurality of ultra high molecular weight polyethylene yarns. Each yarn is formed by parallel winding of at least fifty fibers (e.g., 120 fibers). The yarns of that device are formed into an 8-strand, 6-parallel wound plain braid ranging from 5-7 picks/inch (197-276 picks/meter) to provide an average gage section diameter of about 4-6mm.
  • U.S. Patent No. 4,773,910 (Chen et al.) describes a permanent ligament prosthesis intended to be used as a replacement of either the anterior or posterior cruciate ligament in a human knee. That prosthesis comprises two separately adjustable strands each comprising two tows twisted together to form the strand. The tows are formed by combining a number of individual yarns, which in turn are formed by a number (e.g., 118) of small individual filaments. The total number of filaments in each strand of that prosthesis is between 8,000 and 14,000, and the filaments are formed of polyolefins such as high molecular weight polyethylene and ultra high molecular weight polypropylene.
  • the Chen et al. patent describes the yarns making up the strand as having "very little twist, i.e., a twist of less than 3 twist per inch and preferably is 0 twist per inch" (less than 118 twists/meter and preferably zero twists/meter) .
  • the invention provides a biodegradable tissue augmentation device designed to be used in parallel with biological connective tissue, such as a ligament or tendon, in the repair or reconstruction of biological connective tissue. More specifically, the tissue augmentation device is designed for fixation to biological connective tissue and/or anatomical structures to augment the strength of the repaired or reconstructed connective tissue connecting the anatomical structures. The device is designed to gradually lose its load-bearing capability after implantation thereby gradually transferring increased loads to the biological connective tissue.
  • the tissue augmentation device is preferably designed to be bioabsorbable so that the material of the device is substantially absorbed by a patient's body over a period of time.
  • the tissue augmentation device of the invention comprises a strap-like element formed of a biocompatible material initially having sufficient mechanical properties at the time of implantation to support at least the working loads normally supported by the biological connective tissue being repaired or reconstructed.
  • the strap-like element comprises a braided structure formed by braiding a plurality of yarns. Each yarn is formed by twisting a plurality of fibers together to form the yarn with a twist rate of between about 20 and 150 turns per meter.
  • the fibers are formed of crystalline polylactic acid.
  • the strap-like element is adapted for fixation at the ends thereof to the biological connective tissue and/or the anatomical structures connected by the biological connective tissue, and the strap-like element is adapted to gradually lose its load-bearing capability after implantation thereby gradually transferring increased loads to the biological connective tissue.
  • the method of making the tissue augmentation device generally comprises forming a plurality of fibers of crystalline polylactic acid. A plurality of the fibers are twisted together at a twist rate of between about 20 and 150 turns per meter to form each single yarn. The yarns are then braided to form a braided structure, and the braided structure is bonded and cut into discrete braided strap-like elements that are adapted for fixation at the ends thereof to the biological connective tissue and/or the anatomical structures connected by the biological connective tissue.
  • Other features will be in part apparent and in part pointed out hereinafter.
  • Figure 1 is a partial view of a knee joint illustrating a tissue augmentation device of the invention as implanted in a patient;
  • Figure 2 is a frontal view of a tissue augmentation device of the invention
  • Figure 3 is an enlarged fragmentary frontal view of a portion 3-3 of the tissue augmentation view of figure
  • Figure 4 is an enlarged view of a plied yarn of the type that would be braided together with other plied yarns to form the tissue augmentation device of figures 1 and 2;
  • Figure 5 is an enlarged view of a single yarn of the type that would be twisted together with other single yarns to form the plied yarn of figure 4;
  • FIGS 6 and 7 are schematic illustrations of the "S" and "Z" directions, respectively, of twist.
  • Figure 8 is a flow chart illustrating a method of making the tissue augmentation device of figures 1-3.
  • a biodegradable tissue augmentation device 10 of the invention is designed to be used in parallel with biological connective tissue (not shown) , such as a ligament, tendon or a graft of a ligament or tendon, in the repair or reconstruction of biological connective tissue.
  • biological connective tissue such as a ligament, tendon or a graft of a ligament or tendon
  • biological connective tissue is intended to cover connective load-carrying tissue, and in particular includes ligaments and tendons.
  • a “ligament” is connective tissue that connects two bones together to stabilize a joint
  • a "tendon” is connective tissue that connects a muscle to a bone.
  • tissue augmentation device 10 of this invention is similar in some respects to the device described in co-assigned U.S. Patent Nos. 4,759,765 and 4,834,752 (Van Kampen) .
  • the augmentation device 10 and the tissue are adjacent one another along their lengths, and there may be inter-twining between the two.
  • the tissue augmentation device 10 is sutured or otherwise secured to the biological connective tissue along its length.
  • the biological connective tissue used in conjunction with the augmentation device may be autogenic tissue from the patient or allogenic tissue from a donor or cadaver.
  • tissue used in the reconstruction is typically a portion of the patellar tendon.
  • Other tissues such as the semitendinosus tendon, the rectus femoris tendon and fascia lata may also be used.
  • the biological tissue used in conjunction with the device 10 of the invention is the damaged ligament or tendon itself which has been reapproximated by standard surgical techniques.
  • reconstruction refers to the reconstruction of the function of the damaged tissue by replacing it with other tissue, e.g., as discussed above with respect to the anterior cruciate ligament.
  • repair refers to the repair of the actual damaged tissue.
  • the device 10 comprises a strap-like element (also 10) formed of a biocompatible material including polylactic acid, preferably consisting of essentially pure poly-L-lactic acid substantially without co-monomers such as glycolic acid and substantially without the D enantiomer.
  • a strap-like element is used broadly to connote flexibility, and although a preferred embodiment is flat in cross section, any cross-sectional geometry may be used.
  • the strap-like element 10 initially has sufficient mechanical properties at the time of implantation to support at least the working loads normally supported by the biological connective tissue being repaired or reconstructed.
  • the strap-like element 10 comprises a plurality of yarns 12 braided together to form a flat diamond braid structure.
  • each yarn 12 constitutes a "plied" yarn 12 (figure 4) comprising a plurality of single yarns 14 (figure 5) that are twisted together in one of the S and Z directions to form the plied yarn 12.
  • Each single yarn 14 may be formed by twisting together a plurality of fibers 16 at a twist rate of between 20 and 150 turns per meter in the other of the S and Z directions.
  • each single yarn 14 is formed by twisting fibers 16 together in one direction (e.g., the S direction in figure 5)
  • each plied yarn 12 is formed by twisting single yarns 14 together in the direction opposite to the twist of the fibers 16 (e.g., the Z direction in figure 4).
  • the fibers 16 may be formed by extruding one or more filaments (not shown) of poly-L-lactic acid (“PLA”) .
  • PLA poly-L-lactic acid
  • a yarn has S-twist if, when held in a vertical orientation, the spirals conform to the direction of the slope of the central portion of the letter "S".
  • a yarn has a Z-twist if, when held in a vertical orientation, the spirals conform to the direction of the slope of the central portion of the letter "Z”. See, e.g., N. Hollen and J. Stadler, Textiles, particularly at page 99 (The Macmillian Company, New York, 3d ed. , 1968).
  • diamond braid refers to a braid in which the directions of the yarns 12 being braided forms a generally diamond shaped pattern where the yarns 12 pass over other yarns 12. See, e.g., the diamond-shaped pattern designated by the reference numeral 18 in figure 3.
  • the twist rate of each single yarn 14 is between about 40 and 125 turns per meter in one direction, and the twist rate of each plied yarn 12 is between about 20 and 100 turns per meter in the other direction.
  • the single yarns 14 are twisted together at a twist rate between about 40 and 75 turns per meter to form each plied yarn 12.
  • the braided structure has a pick rate between about 6 and 10 picks per inch (240-400 picks/meter) , most preferably between about 7 and 9 picks per inch (280-350 picks/meter) .
  • pick refers to crossing of one yarn over another in a braided structure. Picks are counted along the longitudinal direction of the braid. A braided structure is considered to be "tighter" the greater the number of picks per unit length.
  • the filaments are preferably extruded of material consisting essentially of poly-L- lactic acid, without co-monomers such as glycolic acid or the D enantiomer.
  • poly-L-lactic acid such as poly-L-lactic acid is preferred for a number of reasons including the generally crystalline nature of the L enantiomer with the resulting strength of the fibers 16 under tension, and the greater resistance of the crystalline poly-L-lactic acid to hydrolytic degradation compared to the less crystalline DL form.
  • "crystalline” is intended to be a relative term indicating a material having much greater crystallinity than the polypropylene employed in the "3M KENNEDY LAD" brand device or the less crystalline poly-DL-lactic acid.
  • the relative purity of the L enantiomer of poly-L-lactic acid is indicated by itsOptical rotation, which is preferably approximately -156 degrees (at 25 degrees Celsius in chloroform, with the wavelength of the light being used in the measurement being 589 nanometers) .
  • High purity of the L enantiomer is important in obtaining a sufficiently crystalline poly-L-lactic acid filament.
  • the intrinsic viscosity of the preferred material is approxi ately 2.5 deciliters per gram at 25 degrees Celsius at a concentration of 0.5 milligrams per milliliter poly-L-lactic acid in chloroform. See also, e.g., F.
  • Suitable polylactic acid filaments have been produced by Gunze Limited, Kyoto, Japan.
  • European Patent Publication No. 0 431 188 (Suzuki et al.) is also incorporated herein by reference.
  • the strength retention of PLA fibers 16 to be employed in the invention may be tested by placing the fibers in a buffered saline solution at 37 degrees
  • Fibers 16 that can retain at least fifty percent of their original strength after six months in the saline solution are considered preferred for the ligament augmentation device 10.
  • the strap-like element 10 is adapted for fixation at the ends 20 and 22 thereof to the biological connective tissue and/or the anatomical structures connected by the biological connective tissue.
  • end 20 of the device is mounted along the anteromedial tibia 24, and the other end 22 of the device is mounted on the lateral femur 26, with the device 10 passing through a tunnel 28 drilled through the tibia 24.
  • U.S. Patent Nos. 4,759,765 and 4,834,752 which are incorporated herein by reference, describe various methods for attachment of a ligament augmentation device that may be used in implanting the device 10 of this invention.
  • a plurality of filaments are extruded preferably of material consisting essentially of substantially pure poly-L-lactic acid.
  • a plurality (e.g., 12) of the extruded filaments are then brought together in step 102 to form each fiber 16.
  • the filaments are preferably not twisted in forming the fibers 16. It is contemplated that a very long fiber (multiple thousands of meters) could be formed, and then cut to form a plurality (e.g., 24) of shorter but still long fibers.
  • a number (e.g., 24) of the fibers 16 formed in step 102 are then twisted together in either the S or Z directions at a twist rate of between about 20 and 150 turns per meter to form a single yarn 14 in step 104.
  • the single yarn 14 would conveniently be long enough to provide sufficient material such that when cut a plurality (e.g., 4) of single yarns 14 are formed.
  • the length of each single yarn 14 formed in step 104 could be, for example, 1000 meters:
  • a plurality (e.g., 4) of single yarns 14 are then twisted together in the other of the S and Z directions (the opposite direction of twist to that used in forming the single yarns 14) to form each plied yarn 12 as indicated in step 106. If the length of the single yarns 14 is 1000 meters, the length of the plied yarn 12 formed in step 106 would also be approximately 1000 meters before the plied yarn 12 is cut to form a suitable plurality (e.g., 13) of plied yarns 12.
  • Step 108 indicates that the plurality of the plied yarns 12 are braided according to standard braiding techniques to form a braided structure.
  • Steps 110 and 112 indicate bonding and cutting, respectively, of the braided structure into discrete braided strap-like elements 10 that are adapted for fixation at the ends 22 and 24 thereof to biological connective tissue and/or anatomical structures connected by biological connective tissue.
  • Example l PLA fiber was produced of extruded poly-L-lactic acid to form 12 filaments of 4.4 denier per filament.
  • Single yarns were prepared from 24 fibers with a twist of 100 turns per meter in the S direction. Four single yarns were then plied together to form a plied yarn with a twist of 40 turns per meter in the Z direction. The yarn helix angle of the single yarns was calculated to be approximately 8.8 degrees, and the helix angle of the plied yarn was approximately 5.9 degrees. Yarn balance was achieved with a 2.9 degree offset in the S direction. The tenacity of the plied yarn was 4.2 grams/denier.
  • Example 2 Thirteen plied yarns prepared according to Example 1 were loosely braided in a flat diamond construction with 8.5 picks per inch (335 picks/meter) . The tenacity of the braided construction was 2.9 grams/denier. The strength loss due to braiding was measured to be 30%.
  • Dynamic tensile testing was performed to l million cycles by alternately loading and unloading the braid between load levels of 50 Newtons and 500 Newtons at a rate of one cycle per second. This testing showed virtually no loss of strength due to fatigue, and only a limited amount of creep of 0.04% per decade. Bending strength was tested to 1 million cycles by flexing the braid between an angle of 15 degrees and 45 degrees across a blunt edge while under spring tension. As a consequence of this motion and action, the tension on the braid cycled between 150 and 300 Newtons while flexing at a rate of 4 cycles per second. The bending strength was lowered by fatigue in the amount of 8% after 1 million cycles.
  • Example 3 PLA fiber was produced with 12 filaments of 4.6 denier per filament.
  • Single yarns were prepared from 24 fibers with a twist of 100 turns per meter in the S direction.
  • Four single yarns were then plied together to form a plied yarn with twist of 75 turns per meter in the z direction.
  • the yarn helix angle of the single yarns was calculated to be approximately 8.8 degrees, and the helix angle of the plied yarn was approximately 11.1 degrees.
  • Yarn balance was achieved with a 2.3 degree offset in the S direction.
  • Tenacity of the plied yarn was 4.4 grams/denier.
  • Example 5 PLA fiber was produced with 12 filaments of 4.7 denier per filament.
  • Single yarns were prepared from 30 fibers with a twist of 125 turns per meter in the S direction. Three single yarns were then plied together to form a plied yarn with a twist of 75 turns per meter in the Z direction.
  • the single yarn helix angle was calculated to be approximately 11.9 degrees, and the helix angle of the plied yarn was approximately 9.9 degrees.
  • Yarn balance was achieved with a 2.0 degree offset in the S direction.
  • Tenacity of the plied yarn was 4.0 grams/denier.

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Rehabilitation Therapy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Un dispositif bioabsorbable d'allongement des tissus (10) est conçu pour être utilisé en parallèle avec un tissu conjonctif biologique, tel qu'un ligament ou un tendon, dans le but d'une réparation ou d'une reconstruction du tissu conjonctif biologique. Le dispositif (10) comprend un élément analogue à une bande (10) formé d'un matériau biocompatible présentant initialement des propriétés mécaniques suffisantes au moment de l'implantation afin de supporter au moins les charges de travail normalement supportés par le tissu conjonctif biologique en réparation ou reconstruction. L'élément analogue à une bande (10) comprend une structure tressée (10) obtenue en tressant une pluralité de fils (12, 14), chacun d'eux ayant été produit en entrelaçant une pluralité de fibres (16) formant ainsi le fil (12, 14) à une vitesse de torsion comprise entre environ 20 et 150 tours par mètre. Les fibres sont en acide polylactique, de préférence un acide poly-L-lactique énantiomériquement pur. L'élément analogue à une bande (10) est conçu pour se fixer au niveau de ses extrémités au tissu conjonctif biologique et/ou aux structures anatomiques reliées au tissu conjonctif biologique; cet élément (10) est également conçu pour perdre graduellement après l'implantation sa capacité de support de charges, transférant ainsi graduellement des charges accrues au tissu conjonctif biologique.
PCT/US1992/006971 1991-10-04 1992-08-24 Dispositif d'allongement des tissus et procede WO1993006790A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US77173391A 1991-10-04 1991-10-04
US771,733 1991-10-04
US84155992A 1992-02-26 1992-02-26
US841,559 1992-02-26

Publications (2)

Publication Number Publication Date
WO1993006790A2 true WO1993006790A2 (fr) 1993-04-15
WO1993006790A3 WO1993006790A3 (fr) 1993-07-22

Family

ID=27118510

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1992/006971 WO1993006790A2 (fr) 1991-10-04 1992-08-24 Dispositif d'allongement des tissus et procede

Country Status (2)

Country Link
AU (1) AU2510192A (fr)
WO (1) WO1993006790A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009139871A2 (fr) * 2008-05-16 2009-11-19 Mimedx, Inc. Constructions médicales de longueurs torsadées de fibres de collagène et leurs procédés de fabrication
CN103445884A (zh) * 2013-07-17 2013-12-18 绍兴县易比纺织科技有限公司 一种具有双向形状记忆功能的智能肌腱修复器件及其制备方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4411027A (en) * 1979-04-27 1983-10-25 University Of Medicine And Dentistry Of New Jersey Bio-absorbable composite tissue scaffold
EP0238223A2 (fr) * 1986-03-17 1987-09-23 Minnesota Mining And Manufacturing Company Dispositif pour renforcer un tissu
EP0239775A2 (fr) * 1986-03-03 1987-10-07 American Cyanamid Company Dispositif chirurgical de réparation
EP0241252A2 (fr) * 1986-04-07 1987-10-14 JOHNSON & JOHNSON ORTHOPAEDICS INC. Prothèse ligamenteuse absorbable
US4773910A (en) * 1987-08-17 1988-09-27 Johnson & Johnson Consumer Products, Inc. Permanent ligament prosthesis
US4946377A (en) * 1989-11-06 1990-08-07 W. L. Gore & Associates, Inc. Tissue repair device
US5024669A (en) * 1988-09-09 1991-06-18 Baxter International Inc. Artificial ligament of differential weave structure

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4411027A (en) * 1979-04-27 1983-10-25 University Of Medicine And Dentistry Of New Jersey Bio-absorbable composite tissue scaffold
EP0239775A2 (fr) * 1986-03-03 1987-10-07 American Cyanamid Company Dispositif chirurgical de réparation
EP0238223A2 (fr) * 1986-03-17 1987-09-23 Minnesota Mining And Manufacturing Company Dispositif pour renforcer un tissu
EP0241252A2 (fr) * 1986-04-07 1987-10-14 JOHNSON & JOHNSON ORTHOPAEDICS INC. Prothèse ligamenteuse absorbable
US4773910A (en) * 1987-08-17 1988-09-27 Johnson & Johnson Consumer Products, Inc. Permanent ligament prosthesis
US5024669A (en) * 1988-09-09 1991-06-18 Baxter International Inc. Artificial ligament of differential weave structure
US4946377A (en) * 1989-11-06 1990-08-07 W. L. Gore & Associates, Inc. Tissue repair device

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009139871A2 (fr) * 2008-05-16 2009-11-19 Mimedx, Inc. Constructions médicales de longueurs torsadées de fibres de collagène et leurs procédés de fabrication
WO2009139871A3 (fr) * 2008-05-16 2010-04-01 Mimedx, Inc. Constructions médicales de longueurs torsadées de fibres de collagène et leurs procédés de fabrication
US9216077B2 (en) 2008-05-16 2015-12-22 Mimedx Group, Inc. Medical constructs of twisted lengths of collagen fibers and methods of making same
EP2291143A4 (fr) * 2008-05-16 2017-06-21 Mimedx, Inc. Constructions médicales de longueurs torsadées de fibres de collagène et leurs procédés de fabrication
US10149918B2 (en) 2008-05-16 2018-12-11 Mimedx Group, Inc. Medical constructs of twisted lengths of collagen fibers and methods of making same
CN103445884A (zh) * 2013-07-17 2013-12-18 绍兴县易比纺织科技有限公司 一种具有双向形状记忆功能的智能肌腱修复器件及其制备方法
CN103445884B (zh) * 2013-07-17 2018-07-31 绍兴易比纺织科技有限公司 一种具有双向形状记忆功能的智能肌腱修复器件

Also Published As

Publication number Publication date
WO1993006790A3 (fr) 1993-07-22
AU2510192A (en) 1993-05-03

Similar Documents

Publication Publication Date Title
US7905918B2 (en) Elastic metallic replacement ligament
AU594435B2 (en) Ligament or tendon implant device
JP5615891B2 (ja) 腱の人工装具およびその製造方法
EP0238263B1 (fr) Ligament prothétique
EP0238223B1 (fr) Dispositif pour renforcer un tissu
US5217495A (en) Synthetic semiabsorbable composite yarn
US5147400A (en) Connective tissue prosthesis
US5024669A (en) Artificial ligament of differential weave structure
US6773459B2 (en) Medical, bioresorbable implant, process for its production and the use thereof
US5458636A (en) Prosthetic device for repair and replacement of fibrous connective tissue
EP0169045B1 (fr) Prothèse pour tissu conjonctif
US20010044659A1 (en) Pre-adjusted prosthetic ligament and method of manufacture
JPH0194853A (ja) 永久靭帯プロテーゼ
JPH03505823A (ja) 柔軟な組織プロテーゼ
JPS6140420B2 (fr)
JP2002532156A (ja) 可撓性糸状要素を含む人または動物に移植するための移植片
WO1993006790A2 (fr) Dispositif d'allongement des tissus et procede
CN115315277A (zh) 编织外科植入物
Moutos et al. Anterior cruciate ligament reconstruction using engineered textile structures

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU CA JP KR

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL SE

AK Designated states

Kind code of ref document: A3

Designated state(s): AU CA JP KR

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
NENP Non-entry into the national phase in:

Ref country code: CA

122 Ep: pct application non-entry in european phase