WO1993004059A1 - Derive de 4-acylaminoimidazole - Google Patents

Derive de 4-acylaminoimidazole Download PDF

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Publication number
WO1993004059A1
WO1993004059A1 PCT/JP1992/001044 JP9201044W WO9304059A1 WO 1993004059 A1 WO1993004059 A1 WO 1993004059A1 JP 9201044 W JP9201044 W JP 9201044W WO 9304059 A1 WO9304059 A1 WO 9304059A1
Authority
WO
WIPO (PCT)
Prior art keywords
lower alkyl
substituted
represents hydrogen
aii
alkoxycarbonyl
Prior art date
Application number
PCT/JP1992/001044
Other languages
English (en)
Japanese (ja)
Inventor
Toshihiro Watanabe
Toshio Okazaki
Kazumi Kikuchi
Akira Suga
Osamu Inagaki
Isao Yanagisawa
Original Assignee
Yamanouchi Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharmaceutical Co., Ltd. filed Critical Yamanouchi Pharmaceutical Co., Ltd.
Publication of WO1993004059A1 publication Critical patent/WO1993004059A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Nouveaux dérivés de 4-acylaminoimidazole répondant à la formule générale (I), sel pharmaceutiquement acceptable de celui-ci, et procédé de production dudit dérivé. Dans ladite formule, R1 représente alkyle inférieur; R2 représente (a) ou bien (b) où R5 représente alcényle inférieur qui peut être substitué par carboxy, amino, alkylamino inférieur, alcoxycarbonyle inférieur ou aryle, alkyle inférieur substitué par alcoxy inférieur ou aryloxy, alcoxycarbonyle inférieur, ou (c), R6 représente hydrogène ou alkyle inférieur, A1 représente alkylène C¿2? à C6 qui peut être substitué par alkyle inférieur; R?3¿ représente cyano ou -C(=O)-O-R7 où R7 représente hydrogène ou un reste ester; et R4 représente hydrogène ou aralkyle. Etant donné que le composé décrit ci-dessus (I) est un antagoniste de l'angiotensine II (AII), il est utile dans le traitement de diverses maladies dues aux effets physiologiques de l'AII.
PCT/JP1992/001044 1991-08-21 1992-08-19 Derive de 4-acylaminoimidazole WO1993004059A1 (fr)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP23417391 1991-08-21
JP3/234173 1991-08-21
JP3/273421 1991-09-25
JP27342191 1991-09-25
JP3/325224 1991-11-13
JP32522491 1991-11-13
JP4/88080 1992-03-12
JP8808092 1992-03-12

Publications (1)

Publication Number Publication Date
WO1993004059A1 true WO1993004059A1 (fr) 1993-03-04

Family

ID=27467473

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1992/001044 WO1993004059A1 (fr) 1991-08-21 1992-08-19 Derive de 4-acylaminoimidazole

Country Status (3)

Country Link
AU (1) AU2449592A (fr)
TW (1) TW209213B (fr)
WO (1) WO1993004059A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0648763A1 (fr) * 1993-10-19 1995-04-19 Roussel Uclaf Nouveau procédé de préparation de dérivés soufrés de l'imidazole et les nouveaux intermédiaires obtenus
EP0668272A2 (fr) * 1994-01-28 1995-08-23 Takeda Chemical Industries, Ltd. Un procédé de production de composés de tétrazole
US5459148A (en) * 1992-12-17 1995-10-17 Sankyo Company, Limited Biphenyl derivatives and their use for the treatment of hypertension and cardiac disease
US5616599A (en) * 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
US7692023B2 (en) 2004-02-11 2010-04-06 Teva Pharmaceutical Industries Ltd. Candesartan cilexetil polymorphs
CN107922348A (zh) * 2015-06-22 2018-04-17 大日本住友制药株式会社 双环杂环酰胺衍生物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0374369A (ja) * 1989-06-01 1991-03-28 Merck & Co Inc アンギトテンシン２拮抗剤

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0374369A (ja) * 1989-06-01 1991-03-28 Merck & Co Inc アンギトテンシン２拮抗剤

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616599A (en) * 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
US5646171A (en) * 1991-02-21 1997-07-08 Sankyo Company, Limited Angiotensin II antagonist 1-biphenylmethylimidazole compounds and their therapeutic use
US5459148A (en) * 1992-12-17 1995-10-17 Sankyo Company, Limited Biphenyl derivatives and their use for the treatment of hypertension and cardiac disease
EP0648763A1 (fr) * 1993-10-19 1995-04-19 Roussel Uclaf Nouveau procédé de préparation de dérivés soufrés de l'imidazole et les nouveaux intermédiaires obtenus
FR2711367A1 (fr) * 1993-10-19 1995-04-28 Roussel Uclaf Nouveau procédé de préparation de dérivés soufrés de l'imidazole et les nouveaux intermédiaires obtenus.
EP0668272A2 (fr) * 1994-01-28 1995-08-23 Takeda Chemical Industries, Ltd. Un procédé de production de composés de tétrazole
EP0668272A3 (fr) * 1994-01-28 1995-08-30 Takeda Chemical Industries, Ltd. Un procédé de production de composés de tétrazole
US5578733A (en) * 1994-01-28 1996-11-26 Takeda Chemical Industries, Ltd. Process for the production of tetrazolyl compounds
US5763619A (en) * 1994-01-28 1998-06-09 Takeda Chemical Industries, Ltd. Process for the production of tetrazolyl compounds
US7692023B2 (en) 2004-02-11 2010-04-06 Teva Pharmaceutical Industries Ltd. Candesartan cilexetil polymorphs
CN107922348A (zh) * 2015-06-22 2018-04-17 大日本住友制药株式会社 双环杂环酰胺衍生物

Also Published As

Publication number Publication date
AU2449592A (en) 1993-03-16
TW209213B (fr) 1993-07-11

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