WO1993001723A1 - Propylaxie et traitement d'affections bucco-dentaires a l'aide de peptides biologiquement actifs - Google Patents
Propylaxie et traitement d'affections bucco-dentaires a l'aide de peptides biologiquement actifs Download PDFInfo
- Publication number
- WO1993001723A1 WO1993001723A1 PCT/US1992/005757 US9205757W WO9301723A1 WO 1993001723 A1 WO1993001723 A1 WO 1993001723A1 US 9205757 W US9205757 W US 9205757W WO 9301723 A1 WO9301723 A1 WO 9301723A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- peptide
- lys
- amino acid
- ala
- seq
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A61K38/1751—Bactericidal/permeability-increasing protein [BPI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
Definitions
- n is at least 4.
- An XPF peptide may also have the following structure:
- CPF peptides as well as analogues and derivatives thereof are herein sometimes referred to collectively as CPF peptides.
- the peptide when the peptide includes the structure X 32 , the peptide may include the following structure:
- the peptide when the peptide includes the structure X 34 , the peptide may include the following structure:
- the peptide when the peptide includes the structure X 34 , the peptide may include the following structure:
- the peptide when the peptide includes the structure X 35 , the peptide may include the following structure:
- the peptide may have the structure (Y 58 ) a -X 58 -(Z 58 ) b , wherein X 58 , Y 58 , and Z 58 are as hereinabove described, a is 0 or 1, and b is 0 or 1.
- An ion having pharmacological properties is an ion which when introduced into a target cell inhibits and/or prevents and/or destroys the growth of a target cell.
- NAME/KEY Magainin II peptide.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Marine Sciences & Fisheries (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
Abstract
Procédé de prévention ou de traitement d'affection(s) bucco-dentaire(s), qui consiste à administrer à un hôte au moins une protéine ou un peptide biologiquement actif. Le peptide ou la protéine est du type ionophore. Ces peptides ou protéines agissent efficacement contre les bactéries, les champignons ou les virus associés à la plaque, la gingivite, les caries dentaires, la parodontolyse, les infections d'implants dentaires et d'autres affections dentaires ou bucco-dentaires.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU23237/92A AU667479B2 (en) | 1991-06-12 | 1992-07-09 | Treating the oral cavity with ion-channel forming peptides |
JP5502858A JPH07502979A (ja) | 1991-07-25 | 1992-07-09 | 生物活性ペプチドを利用する口腔内の有害な状態の予防と治療 |
EP92915677A EP0671930A4 (fr) | 1991-07-25 | 1992-07-09 | Propylaxie et traitement d'affections bucco-dentaires a l'aide de peptides biologiquement actifs. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73507091A | 1991-07-25 | 1991-07-25 | |
US735,070 | 1991-07-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1993001723A1 true WO1993001723A1 (fr) | 1993-02-04 |
Family
ID=24954237
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1992/005757 WO1993001723A1 (fr) | 1991-06-12 | 1992-07-09 | Propylaxie et traitement d'affections bucco-dentaires a l'aide de peptides biologiquement actifs |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0671930A4 (fr) |
JP (1) | JPH07502979A (fr) |
AU (1) | AU667479B2 (fr) |
CA (1) | CA2074626A1 (fr) |
WO (1) | WO1993001723A1 (fr) |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0671938A1 (fr) * | 1992-10-26 | 1995-09-20 | Magainin Pharmaceuticals Inc. | Nouveaux peptides a activite biologique et leurs applications |
US5593866A (en) * | 1992-08-21 | 1997-01-14 | The University Of British Columbia | Cationic peptides and method for production |
WO1998006419A1 (fr) * | 1996-08-15 | 1998-02-19 | Southern Illinois University | Facilitation de l'activite de peptides antimicrobiens au moyen d'ions metalliques |
US5789542A (en) * | 1994-04-22 | 1998-08-04 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Amphipathic peptides |
WO1999059536A1 (fr) * | 1998-05-15 | 1999-11-25 | Unilever Plc | Utilisation d'un agent de prevention des gingivites |
US5994306A (en) * | 1995-11-22 | 1999-11-30 | Intrabiotics Pharmaceuticals, Inc. | Fine-tuned protegrins |
US6025326A (en) * | 1995-07-07 | 2000-02-15 | Intrabiotics Pharmaceuticals, Inc. | Compositions and methods for the prevention and treatment of oral mucositis |
US6191254B1 (en) | 1995-08-23 | 2001-02-20 | University Of British Columbia | Antimicrobial cationic peptides |
US6297215B1 (en) | 1995-06-02 | 2001-10-02 | The University Of British Columbia | Antimicrobial cationic peptides |
US6566334B1 (en) | 1997-02-06 | 2003-05-20 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Short amphipathic peptides with activity against bacteria and intracellular pathogens |
US6653442B1 (en) | 1993-07-20 | 2003-11-25 | Intrabiotics Pharmaceuticals, Inc. | Protegrins |
EP1655018A1 (fr) * | 2004-09-08 | 2006-05-10 | Henkel Kommanditgesellschaft auf Aktien | Composition dentaires et buccales pour le soin et le nettoyage avec un effet anti-inflammatoire |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4810777A (en) * | 1987-03-04 | 1989-03-07 | The United States Of America As Represented By The Department Of Health And Human Services | Antimicrobial compounds |
US4962277A (en) * | 1988-12-09 | 1990-10-09 | Scripps Clinic And Research Foundation | Deletion analogues of magainin peptides |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ199891A (en) * | 1981-03-04 | 1985-07-31 | Univ Melbourne | Caries-inhibiting compositions containing casein or x-s-casein or phosuitin |
JPH04502904A (ja) * | 1988-10-21 | 1992-05-28 | マゲイニン サイエンセス インコーポレーテッド | 両親媒性ペプチドの投与方法およびその組成物 |
US5045531A (en) * | 1989-12-18 | 1991-09-03 | Magainin Sciences Inc. | Wound treatment employing biologically active ion channel forming peptides and proteins |
EP0514464A4 (en) * | 1990-02-08 | 1993-04-28 | Magainin Sciences, Inc. | Biologically active amphiphilic peptides and method of inhibiting growth of target cells, virus or virally-infected cell |
-
1992
- 1992-07-09 WO PCT/US1992/005757 patent/WO1993001723A1/fr not_active Application Discontinuation
- 1992-07-09 JP JP5502858A patent/JPH07502979A/ja active Pending
- 1992-07-09 AU AU23237/92A patent/AU667479B2/en not_active Expired - Fee Related
- 1992-07-09 EP EP92915677A patent/EP0671930A4/fr not_active Withdrawn
- 1992-07-24 CA CA002074626A patent/CA2074626A1/fr not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4810777A (en) * | 1987-03-04 | 1989-03-07 | The United States Of America As Represented By The Department Of Health And Human Services | Antimicrobial compounds |
US4962277A (en) * | 1988-12-09 | 1990-10-09 | Scripps Clinic And Research Foundation | Deletion analogues of magainin peptides |
Non-Patent Citations (1)
Title |
---|
See also references of EP0671930A4 * |
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5593866A (en) * | 1992-08-21 | 1997-01-14 | The University Of British Columbia | Cationic peptides and method for production |
EP0671938A1 (fr) * | 1992-10-26 | 1995-09-20 | Magainin Pharmaceuticals Inc. | Nouveaux peptides a activite biologique et leurs applications |
EP0671938A4 (fr) * | 1992-10-26 | 1997-01-15 | Magainin Pharma | Nouveaux peptides a activite biologique et leurs applications. |
US6653442B1 (en) | 1993-07-20 | 2003-11-25 | Intrabiotics Pharmaceuticals, Inc. | Protegrins |
US5789542A (en) * | 1994-04-22 | 1998-08-04 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Amphipathic peptides |
US6906035B2 (en) | 1995-06-02 | 2005-06-14 | The University Of British Columbia | Antimicrobial cationic peptides |
US6465429B1 (en) | 1995-06-02 | 2002-10-15 | The University Of British Columbia | Antimicrobial cationic peptides |
US6297215B1 (en) | 1995-06-02 | 2001-10-02 | The University Of British Columbia | Antimicrobial cationic peptides |
US6025326A (en) * | 1995-07-07 | 2000-02-15 | Intrabiotics Pharmaceuticals, Inc. | Compositions and methods for the prevention and treatment of oral mucositis |
US6191254B1 (en) | 1995-08-23 | 2001-02-20 | University Of British Columbia | Antimicrobial cationic peptides |
US7390873B2 (en) | 1995-08-23 | 2008-06-24 | University Of British Columbia | Antimicrobial cationic peptides |
US5994306A (en) * | 1995-11-22 | 1999-11-30 | Intrabiotics Pharmaceuticals, Inc. | Fine-tuned protegrins |
AU725954B2 (en) * | 1996-08-15 | 2000-10-26 | Board Of Trustees Of Southern Illinois University, The | Enhancement of antimicrobial peptide activity by metal ions |
US6042848A (en) * | 1996-08-15 | 2000-03-28 | The Board Of Trustees Of Southern Illinois University | Enhancement of antimicrobial peptide activity by metal ions |
WO1998006419A1 (fr) * | 1996-08-15 | 1998-02-19 | Southern Illinois University | Facilitation de l'activite de peptides antimicrobiens au moyen d'ions metalliques |
US6566334B1 (en) | 1997-02-06 | 2003-05-20 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Short amphipathic peptides with activity against bacteria and intracellular pathogens |
US7262163B2 (en) | 1997-02-06 | 2007-08-28 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Short amphipathic peptides with activity against bacteria and intracellular pathogens |
US6290975B1 (en) | 1998-05-15 | 2001-09-18 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Method for the prevention of gum disease |
WO1999059536A1 (fr) * | 1998-05-15 | 1999-11-25 | Unilever Plc | Utilisation d'un agent de prevention des gingivites |
EP1655018A1 (fr) * | 2004-09-08 | 2006-05-10 | Henkel Kommanditgesellschaft auf Aktien | Composition dentaires et buccales pour le soin et le nettoyage avec un effet anti-inflammatoire |
Also Published As
Publication number | Publication date |
---|---|
CA2074626A1 (fr) | 1993-01-26 |
EP0671930A1 (fr) | 1995-09-20 |
AU667479B2 (en) | 1996-03-28 |
AU2323792A (en) | 1993-02-23 |
JPH07502979A (ja) | 1995-03-30 |
EP0671930A4 (fr) | 1996-02-07 |
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