WO1992013491A1 - Materiel chirurgical ameliore avec enrobage en argent bacteriostatique et procede d'utilisation de ce materiel - Google Patents

Materiel chirurgical ameliore avec enrobage en argent bacteriostatique et procede d'utilisation de ce materiel Download PDF

Info

Publication number
WO1992013491A1
WO1992013491A1 PCT/US1992/000209 US9200209W WO9213491A1 WO 1992013491 A1 WO1992013491 A1 WO 1992013491A1 US 9200209 W US9200209 W US 9200209W WO 9213491 A1 WO9213491 A1 WO 9213491A1
Authority
WO
WIPO (PCT)
Prior art keywords
hardware
silver
surgical
silver coating
wound
Prior art date
Application number
PCT/US1992/000209
Other languages
English (en)
Inventor
Claude Vidal
Russell J. Redmond
Original Assignee
Minnesota Mining And Manufacturing Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Minnesota Mining And Manufacturing Company filed Critical Minnesota Mining And Manufacturing Company
Publication of WO1992013491A1 publication Critical patent/WO1992013491A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/064—Surgical staples, i.e. penetrating the tissue

Definitions

  • This invention relates to surgical hardware of the type used to close wounds, and to an improved method of closing wounds using such hardware.
  • Various items of metal hardware have been developed to assist in closing wounds. At one time such hardware was made from solid silver. However, because of silver's high ductility and relatively low strength, silver hardware had to be made very coarse to have adequate mechanical properties. For many applications solid silver hardware was objectionably coarse. High strength metals such as stainless steel and titanium, permit more slender, clinically desirable hardware designs, and have for decades been the state of the art materials for surgical hardware.
  • Wound infection is always a serious concern because of its system-wide effect and retardation of normal wound healing, but when surgical hardware is required and used there are additional potential complications from wound infection including dehiscence or splitting of the wound, leakage from the wound, and formation of adhesions. While conventional steel and titanium hardware can be sterilized, it does not appear to have significant bacteriostatic effect, and may actually promote infection compared with other materials. Nevertheless, because these high strength metals permit the manufacture of such small, high strength hardware, these metals are still widely used.
  • the present invention provides an improved item of surgical hardware that provides the strength and compact size of a high strength metal such as stainless steel or titanium, and bacteriostatic properties to reduce the risk of wound infection.
  • This hardware allows wounds to be neatly and effectively closed, and provides some bacteriostatic action that reduces the risk of many of the complications encountered in the use of surgical hardware.
  • the invention relates to a staple, wire suture, clip, or other item of surgical hardware used in closing wounds.
  • the surgical hardware constructed according to the principles of the present invention comprises an item of surgical hardware that is made from a high strength metal, for example stainless steel or titanium, and which has a silver coating.
  • the silver coating may be either silver plating, or a coating of silver salt.
  • the method of closing wounds comprises closing the wounds with surgical hardware made from a high strength metal and which has a silver coating.
  • the hardware of the present invention provides all of the advantages of being constructed from a high strength metal, including high strength and compact size, and the additional benefit of bacteriostatic action which helps to reduce the risk of complications resulting from the use of the hardware.
  • the compact design permitted by the present invention ensures that the hardware has sufficient strength to hold the wound closed, and a sufficiently compact size that it does not unduly disturb the wound site or interfere with healing.
  • the cost of manufacturing hardware according to the principles of the present invention is only marginally higher than the cost of manufacturing conventional hardware.
  • the method of this invention provides a way to close wounds with reduced risk of infection and complications.
  • FIGURE 1 is a perspective view of an internal (soft tissue) staple constructed according to the principles of this invention
  • FIGURE 2 is a perspective view of a skin staple constructed according to the principles of this invention
  • FIGURE 3 is a perspective view of a fascia staple constructed according to the principles of this invention
  • FIGURE 4 is a. perspective view of a vascular staple constructed according to the principles of this invention
  • FIGURE 5 is a perspective view of a vascular clip constructed according to the principles of this invention
  • FIGURE 6 is a perspective view of a wire suture constructed according to the principles of this invention.
  • FIGURE 7 is a cross-sectional view of the wire suture, taken along the plane of line 7-7 in Figure 6.
  • Surgical staples constructed according to the principles of the present invention are indicated generally as 20, 22, 24, and 26 in Figures 1 - 4.
  • a surgical clip constructed according to the principles of the present invention is indicated generally as 28 in Figure 5.
  • a wire suture constructed according to the principles of the present invention is indicated generally as 30 in Figure 6.
  • the staples 20 - 26, the clip 28, and the suture 30 are made from a high strength surgical metal such as a stainless steel or titanium.
  • the staples 20 - 26, the clip 28, and the wire suture 30 have a silver coating. This is best shown in Figure 7 where the suture is shown as comprising high strength surgical metal 32 with a silver coating 34.
  • the silver coating provides a bacteriostatic action that inhibits infection. Thus infection is less likely to propagate when the surgical hardware of the present invention is used, and thus there is a reduced risk from infection-related complications from the use of such hardware.
  • the silver coating may be silver plating applied by a hot dip or electro-deposition process, or some other method.
  • the coating may be a silver salt applied to the exterior of the item of hardware, for example silver nitrate, or silver-zinc allantoinate.
  • the method of the present invention relates to an improved method of closing surgical wounds with reduced risk of infection.
  • the method comprises the step of closing the wound with a staple, wire suture, clip or other item of surgical hardware made from a high strength metal that has a silver coating.
  • the bacteriostatic effect of the hardware of this invention was tested by introducing a silver coated staple according to the principles of this invention, a stainless steel staple, and titanium staple into two difference agar media: Trypticase Soy Sheep Agar and Mueller Hinton Agar.
  • Each of the staples was screened against staph aureus, Escherichia coli, Pseudomonas aeriginosa, and strep faecales.
  • the plates were inoculated with a standard turbidity of a 0.5 McFarland standard.
  • the staples were placed on top of the agar and the plates were incubated at 35°C for 24 hours.
  • only the silver coated staple of the present invention showed any bacteriostatic action showing a zone of inhibition around the staple.

Abstract

L'invention se rapporte à une agrafe, un fil de suture, une attache ou autre article de matériel chirurgical, qui peut être utilisé pour fermer une plaie et qui est fabriqué à partir d'un métal très résistant de façon à présenter un profil extra-plat pour réduire au minimum les gênes occasionnées à la plaie, et qui possède un enrobage en argent bactériostatique destiné à réduire les risques d'infection de la plaie par le matériel. L'invention décrit également un procédé qui permet de fermer des plaies chirurgicales en réduisant les risques d'infection et qui consiste à fermer la plaie au moyen d'une agrafe, d'un fil de suture, d'une attache ou d'un autre article de matériel chirurgical fabriqué à partir d'un métal très résistant recouvert d'un enrobage d'argent.
PCT/US1992/000209 1991-02-06 1992-01-08 Materiel chirurgical ameliore avec enrobage en argent bacteriostatique et procede d'utilisation de ce materiel WO1992013491A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65335391A 1991-02-06 1991-02-06
US653,353 1991-02-06

Publications (1)

Publication Number Publication Date
WO1992013491A1 true WO1992013491A1 (fr) 1992-08-20

Family

ID=24620504

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1992/000209 WO1992013491A1 (fr) 1991-02-06 1992-01-08 Materiel chirurgical ameliore avec enrobage en argent bacteriostatique et procede d'utilisation de ce materiel

Country Status (2)

Country Link
EP (1) EP0570452A1 (fr)
WO (1) WO1992013491A1 (fr)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001080920A2 (fr) 2000-04-17 2001-11-01 Nucryst Pharmaceuticals Corp. Matieres antimicrobiennes bioabsorbables
KR20020057446A (ko) * 2001-01-04 2002-07-11 안정오 금이나 은 함유 수술실
EP1449816A1 (fr) 2003-02-20 2004-08-25 Gemtron Corporation Verre antimicrobien et produits vitreux et procédé de leur préparation
US6861570B1 (en) 1997-09-22 2005-03-01 A. Bart Flick Multilayer conductive appliance having wound healing and analgesic properties
US6989156B2 (en) 2001-04-23 2006-01-24 Nucryst Pharmaceuticals Corp. Therapeutic treatments using the direct application of antimicrobial metal compositions
WO2006021155A1 (fr) * 2004-08-25 2006-03-02 Xiaoyan Ren Fil recouvert de nanoparticules d’argent
US7385101B2 (en) 2001-12-20 2008-06-10 Noble Fiber Technologies, Llc Antibiotic textile materials suitable for wound dressings and wound dressings incorporating the same
US8097017B2 (en) 2004-10-18 2012-01-17 Tyco Healthcare Group Lp Surgical fasteners coated with wound treatment materials
US20130302427A1 (en) * 2012-05-11 2013-11-14 Dentsply International Inc. Medical device having a surface comprising nanoparticles
US8636191B2 (en) 2003-05-09 2014-01-28 Covidien Lp Anastomotic staple with capillary which expels a bonding agent upon deformation
RU2517121C2 (ru) * 2012-08-21 2014-05-27 Государственное научное учреждение Институт экспериментальной ветеринарии Сибири и Дальнего Востока Российской академии сельскохозяйственных наук (ГНУ ИЭВСиДВ Россельхозакадемии) Способ повышения качества хирургической нити
RU2770277C1 (ru) * 2021-08-23 2022-04-15 Федеральное государственное бюджетное учреждение науки Южный научный центр Российской академии наук (ЮНЦ РАН) Способ повышения количества и антибактериальной активности наночастиц серебра на шовном материале из шелка
WO2023009082A1 (fr) * 2021-07-30 2023-02-02 Dogan Oezcan Agrafes cutanées chirurgicales avec revêtement d'ions argent

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1981002668A1 (fr) * 1980-03-27 1981-10-01 Nat Res Dev Implants orthopediques
EP0046715A2 (fr) * 1980-08-25 1982-03-03 United States Surgical Corporation Agrafes chirurgicales
CH654738A5 (en) * 1985-02-26 1986-03-14 Ines Blaettler Surgical implants and repair plates
EP0206024A2 (fr) * 1985-06-07 1986-12-30 Becton, Dickinson and Company Surfaces antimicrobiennes et inhibition de la croissance des micro-organismes sur ces surfaces
EP0255248A2 (fr) * 1986-07-24 1988-02-03 Minnesota Mining And Manufacturing Company Pansement microbicide pour blessure
EP0328421A2 (fr) * 1988-02-11 1989-08-16 The Trustees Of Columbia University In The City Of New York Compositions résistant aux infections, dispositifs et surfaces médicaux et méthode pour leur préparation et leur utilisation
EP0406014A1 (fr) * 1989-06-30 1991-01-02 Ethicon, Inc. Agrafe chirurgicale pour améliorer la qualité de son image

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1981002668A1 (fr) * 1980-03-27 1981-10-01 Nat Res Dev Implants orthopediques
EP0046715A2 (fr) * 1980-08-25 1982-03-03 United States Surgical Corporation Agrafes chirurgicales
CH654738A5 (en) * 1985-02-26 1986-03-14 Ines Blaettler Surgical implants and repair plates
EP0206024A2 (fr) * 1985-06-07 1986-12-30 Becton, Dickinson and Company Surfaces antimicrobiennes et inhibition de la croissance des micro-organismes sur ces surfaces
EP0255248A2 (fr) * 1986-07-24 1988-02-03 Minnesota Mining And Manufacturing Company Pansement microbicide pour blessure
EP0328421A2 (fr) * 1988-02-11 1989-08-16 The Trustees Of Columbia University In The City Of New York Compositions résistant aux infections, dispositifs et surfaces médicaux et méthode pour leur préparation et leur utilisation
EP0406014A1 (fr) * 1989-06-30 1991-01-02 Ethicon, Inc. Agrafe chirurgicale pour améliorer la qualité de son image

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6861570B1 (en) 1997-09-22 2005-03-01 A. Bart Flick Multilayer conductive appliance having wound healing and analgesic properties
WO2001080920A2 (fr) 2000-04-17 2001-11-01 Nucryst Pharmaceuticals Corp. Matieres antimicrobiennes bioabsorbables
KR20020057446A (ko) * 2001-01-04 2002-07-11 안정오 금이나 은 함유 수술실
US6989156B2 (en) 2001-04-23 2006-01-24 Nucryst Pharmaceuticals Corp. Therapeutic treatments using the direct application of antimicrobial metal compositions
US7385101B2 (en) 2001-12-20 2008-06-10 Noble Fiber Technologies, Llc Antibiotic textile materials suitable for wound dressings and wound dressings incorporating the same
EP1449816A1 (fr) 2003-02-20 2004-08-25 Gemtron Corporation Verre antimicrobien et produits vitreux et procédé de leur préparation
US6921546B2 (en) 2003-02-20 2005-07-26 Gemtron Corporation Antimicrobial glass and glass-like products and method of preparing same
US8636191B2 (en) 2003-05-09 2014-01-28 Covidien Lp Anastomotic staple with capillary which expels a bonding agent upon deformation
US10092289B2 (en) 2003-05-09 2018-10-09 Covidien Lp Anastomotic staple with capillary which expels a bonding agent upon deformation
US9301762B2 (en) 2003-05-09 2016-04-05 Covidien Lp Anastomotic staple with capillary which expels a bonding agent upon deformation
US10736627B2 (en) 2003-05-09 2020-08-11 Covidien Lp Anastomotic staple with capillary which expels a bonding agent upon deformation
WO2006021155A1 (fr) * 2004-08-25 2006-03-02 Xiaoyan Ren Fil recouvert de nanoparticules d’argent
US8435263B2 (en) 2004-10-18 2013-05-07 Covidien Lp Surgical fasteners coated with wound treatment materials
US8758404B2 (en) 2004-10-18 2014-06-24 Covidien Lp Surgical fasteners coated with wound treatment materials
US8097017B2 (en) 2004-10-18 2012-01-17 Tyco Healthcare Group Lp Surgical fasteners coated with wound treatment materials
US20130302427A1 (en) * 2012-05-11 2013-11-14 Dentsply International Inc. Medical device having a surface comprising nanoparticles
US9889237B2 (en) * 2012-05-11 2018-02-13 Dentsply Sirona Inc. Medical device having a surface comprising nanoparticles
RU2517121C2 (ru) * 2012-08-21 2014-05-27 Государственное научное учреждение Институт экспериментальной ветеринарии Сибири и Дальнего Востока Российской академии сельскохозяйственных наук (ГНУ ИЭВСиДВ Россельхозакадемии) Способ повышения качества хирургической нити
WO2023009082A1 (fr) * 2021-07-30 2023-02-02 Dogan Oezcan Agrafes cutanées chirurgicales avec revêtement d'ions argent
RU2770277C1 (ru) * 2021-08-23 2022-04-15 Федеральное государственное бюджетное учреждение науки Южный научный центр Российской академии наук (ЮНЦ РАН) Способ повышения количества и антибактериальной активности наночастиц серебра на шовном материале из шелка

Also Published As

Publication number Publication date
EP0570452A1 (fr) 1993-11-24

Similar Documents

Publication Publication Date Title
WO1992013491A1 (fr) Materiel chirurgical ameliore avec enrobage en argent bacteriostatique et procede d'utilisation de ce materiel
US4886505A (en) Antimicrobial surfaces and inhibition of microorganism growth thereby
JP5118346B2 (ja) バイオフィルム形成を阻害するガリウム
US4602632A (en) Bio absorbable metal hemostatic clip
US7687076B2 (en) Deposition products, composite materials and processes for the production thereof
Swanson et al. Suture materials, 1980s: properties, uses, and abuses
GB9903842D0 (en) Substrates and substrate treatment process
CA2170913A1 (fr) Catheter enroule en serpentin et exempt de plis
CA2170941A1 (fr) Polyoxaesters absorbables
CA2024188A1 (fr) Methode de traitement de l'ejaculation prematuree a l'aide de la sertraline
WO2000031051B1 (fr) Composes de quinoleine et quinoxaline utilises comme inhibiteurs du recepteur pdgf et/ou de la tyrosine kinase lck
EP0686706A4 (fr) Piece decorative blanche et procede pour sa fabrication
WO2007097790A1 (fr) Surfaces antimicrobiennes activées par ultraviolets
EP1513563B1 (fr) Implant a action longue duree antibiotique
EP1384451B1 (fr) Prothèse d'étrier
US3088846A (en) Processes of treating nickel-phosphorus alloy coatings and the resulting modified coatings
NZ335997A (en) Substituted pyrimidine compounds for treating TNF and interleukin diseases
Morris et al. Binding of organic antimicrobial agents to cotton fabric as zirconium complexes
GB2271500A (en) Improvements in ear piercing studs
Bambauer et al. Surface-treated versus untreated large-bore catheters as vascular access in hemodialysis and apheresis treatments
AU2002366331A1 (en) Treating vascular disease by inhibiting myeloid differentiation factor 88
CA2120680C (fr) Article metallique possedant une surface de couleur brillante et de faible reflectivite, et procede pour obtenir une telle surface
DK176442B1 (da) Fremgangsmåde til bekæmpelse af Venturia spp.
JP3014073U (ja) 殺菌性縫合糸
ES2111139T3 (es) Concentrado para baño de activacion y de afinado y baño obtenido a partir de este concentrado.

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): CA JP

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IT LU MC NL SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 1992904466

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1992904466

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: CA

WWW Wipo information: withdrawn in national office

Ref document number: 1992904466

Country of ref document: EP