WO1992008740A3 - Receptor recognition factor and methods of use thereof - Google Patents

Receptor recognition factor and methods of use thereof Download PDF

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Publication number
WO1992008740A3
WO1992008740A3 PCT/US1991/008529 US9108529W WO9208740A3 WO 1992008740 A3 WO1992008740 A3 WO 1992008740A3 US 9108529 W US9108529 W US 9108529W WO 9208740 A3 WO9208740 A3 WO 9208740A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor recognition
factor
recognition factor
transcription factor
receptor
Prior art date
Application number
PCT/US1991/008529
Other languages
French (fr)
Other versions
WO1992008740A2 (en
Inventor
James E Darnell Jr
David E Levy
Original Assignee
Univ Rockefeller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rockefeller filed Critical Univ Rockefeller
Publication of WO1992008740A2 publication Critical patent/WO1992008740A2/en
Publication of WO1992008740A3 publication Critical patent/WO1992008740A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

A receptor recognition factor exists that recognizes the specific cell receptor to which a specific ligand has been bound, and that may thereby signal and/or initiate the binding of the transcription factor to the DNA site. The receptor recognition factor may itself be a part of a transcription factor or may interact with a transcription factor to cause it to activate and travel to the nucleus for DNA binding. The receptor recognition factor appears to be second-messenger-independent in its activity, as overt perturbations in second messenger concentrations are of no effect. The concept of the invention is illustrated by the results of studies conducted with interferon (IFN)-stimulated gene transcription, and particularly, the activation caused by IFNα. Additional observations derived from studies with IFNτ are also supportive.
PCT/US1991/008529 1990-11-14 1991-11-14 Receptor recognition factor and methods of use thereof WO1992008740A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61332690A 1990-11-14 1990-11-14
US613,326 1990-11-14

Publications (2)

Publication Number Publication Date
WO1992008740A2 WO1992008740A2 (en) 1992-05-29
WO1992008740A3 true WO1992008740A3 (en) 1992-08-06

Family

ID=24456859

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1991/008529 WO1992008740A2 (en) 1990-11-14 1991-11-14 Receptor recognition factor and methods of use thereof

Country Status (2)

Country Link
AU (1) AU9092091A (en)
WO (1) WO1992008740A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07505524A (en) * 1992-03-19 1995-06-22 ザ ロックフェラー ユニヴァーシティ IFN receptor recognition factor, its protein sequence and method of use
WO1994017180A1 (en) * 1993-01-19 1994-08-04 University Of Massachusetts Medical Center Nuclear localized transcription factor kinases
US20030054402A1 (en) 1993-03-31 2003-03-20 Cadus Pharmaceutical Corporation Methods and compositions for identifying receptor effectors
US6864060B1 (en) 1993-03-31 2005-03-08 Cadus Technologies, Inc. Yeast cells expressing modified G proteins and methods of use therefor
US7235648B1 (en) 1993-03-31 2007-06-26 Cadus Technologies, Inc. Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor
US6100042A (en) 1993-03-31 2000-08-08 Cadus Pharmaceutical Corporation Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor
US6255059B1 (en) 1993-03-31 2001-07-03 Cadus Pharmaceutical Corporation Methods for identifying G protein coupled receptor effectors
CA2172490A1 (en) * 1993-09-24 1995-03-30 James E. Darnell, Jr. Receptor recognition factors, protein sequences and methods of use thereof
US5723300A (en) * 1995-07-10 1998-03-03 University Of Massachusetts Medical Center Nuclear localized transcription factor kinase and diagnostic assays related thereto
US6716435B1 (en) 1997-04-18 2004-04-06 Ganeden Biotech, Inc. Absorbent product containing absorbent structure and Bacillus coagulans
US6355473B1 (en) 1998-05-06 2002-03-12 Cadus Pharmaceutical Corp. Yeast cells having mutations in stp22 and uses therefor
US7081360B2 (en) 1998-07-28 2006-07-25 Cadus Technologies, Inc. Expression of G protein-coupled receptors with altered ligand binding and/or coupling properties
US7273747B2 (en) 1998-08-27 2007-09-25 Cadus Technologies, Inc. Cell having amplified signal transduction pathway responses and uses therefor
US6251605B1 (en) 1998-10-27 2001-06-26 Cadus Pharmaceutical Corporation Yeast cells having mutations in Cav1 and uses therefor
AU2030000A (en) 1998-11-25 2000-06-13 Cadus Pharmaceutical Corporation Methods and compositions for identifying receptor effectors
US6504008B1 (en) 1999-02-01 2003-01-07 Cadus Technologies, Inc. Cell based signal generation
US6555325B1 (en) 1999-06-14 2003-04-29 Cadus Technologies, Inc. System for detection of a functional interaction between a compound and a cellular signal transduction component
US7223533B2 (en) 1999-09-10 2007-05-29 Cadus Technologies, Inc. Cell surface proteins and use thereof as indicators of activation of cellular signal transduction pathways

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Genes and Development, vol. 3, no. 9, September 1989, (Cold Spring Harbor, NY, US), D.E. LEVY et al.: "Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro", pages 1362-1371, see the abstract; figure 6; page 1368, right-hand column, lines 33-41 *
Genes and Development, vol. 4, no. 10, October 1990, (Cold Spring Harbor, NY, US), D.S. KESSLER et al.: "Interferon-alpha regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator", pages 1753-1765, see the abstract; figure 9 (cited in the application) *
Proceedings of the National Academy of Sciences of USA, vol. 87, no. 21, November 1990, (Washington, DC, US), X.-Y. FU et al.: "ISGF3, the transcriptional activator induced by interferon alpha, consists of multiple interacting polypeptide chains", pages 8555-8559, see the abstract (cited in the application) *
The EMBO Journal, vol. 9, no. 4, April 1990, (Oxford, GB), D.E. LEVY et al.: "Synergistic interaction between interferon-alpha and interferon-gamma through induced synthesis of one subunit of the transcription factor ISGF3", pages pages 1105-1111, see the abstract *
The New Biologist, vol. 2, no. 10, October 1990, (Philadelphia, US), D. LEVY et al.: "Interferon-dependent transcriptional activation: Signal transduction without second messenger involvement?", pages 923-928, see the abstract; figure 1; page 925, left-hand column, lines 22-27 *

Also Published As

Publication number Publication date
WO1992008740A2 (en) 1992-05-29
AU9092091A (en) 1992-06-11

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