WO1992008450A3 - UTILISATION ANTIVIRALE DE COMPOSE 2,6-DI-t-BUTYLPHENOL SUBSTITUE EN POSITION 4, NOTAMMENT VIS-A-VIS DES VIRUS DE L'HERPES ET DES PAPILLOMAVIRUS - Google Patents
UTILISATION ANTIVIRALE DE COMPOSE 2,6-DI-t-BUTYLPHENOL SUBSTITUE EN POSITION 4, NOTAMMENT VIS-A-VIS DES VIRUS DE L'HERPES ET DES PAPILLOMAVIRUS Download PDFInfo
- Publication number
- WO1992008450A3 WO1992008450A3 PCT/FR1991/000882 FR9100882W WO9208450A3 WO 1992008450 A3 WO1992008450 A3 WO 1992008450A3 FR 9100882 W FR9100882 W FR 9100882W WO 9208450 A3 WO9208450 A3 WO 9208450A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- group
- cooh
- papillomaviruses
- herpesviruses
- relation
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/11—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms
- C07C37/18—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions increasing the number of carbon atoms by condensation involving halogen atoms of halogenated compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/11—Aldehydes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/02—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with no unsaturation outside the aromatic ring
- C07C39/11—Alkylated hydroxy benzenes containing also acyclically bound hydroxy groups, e.g. saligenol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/56—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups
- C07C47/565—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups all hydroxy groups bound to the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
- C07C49/825—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups all hydroxy groups bound to the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
- C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
- C07C69/88—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with esterified carboxyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE69119605T DE69119605D1 (de) | 1990-11-12 | 1991-11-12 | Antivirale verwendung einer in position-4 substituierten 2,6-di-t-butylphenolverbindung, besonders gegen herpes- und papillomaviren |
EP91920899A EP0557404B1 (fr) | 1990-11-12 | 1991-11-12 | UTILISATION ANTIVIRALE DE COMPOSE 2,6-DI-t-BUTYLPHENOL SUBSTITUE EN POSITION 4, NOTAMMENT VIS-A-VIS DES VIRUS DE L'HERPES ET DES PAPILLOMAVIRUS |
US08/050,279 US5487893A (en) | 1990-11-12 | 1991-11-12 | Antiviral use of a 2,6-di-t-butylphenol compound substituted in 4 position against herpes viruses and papillomaviruses |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR90/13984 | 1990-11-12 | ||
FR9013984A FR2668931B1 (fr) | 1990-11-12 | 1990-11-12 | Utilisation antivirale de compose 2,6-di-t-butylphenol substitue en position 4, notamment vis-a-vis de l'herpes. |
FR9102028A FR2672799B1 (fr) | 1991-02-20 | 1991-02-20 | Composes 4-substitues de 2,6-di-t-butylphenol en tant que substances antipapillomavirus et leur utilisation vis-a-vis des condylomes. |
FR91/02028 | 1991-02-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1992008450A2 WO1992008450A2 (fr) | 1992-05-29 |
WO1992008450A3 true WO1992008450A3 (fr) | 1993-01-21 |
Family
ID=26228322
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR1991/000882 WO1992008450A2 (fr) | 1990-11-12 | 1991-11-12 | UTILISATION ANTIVIRALE DE COMPOSE 2,6-DI-t-BUTYLPHENOL SUBSTITUE EN POSITION 4, NOTAMMENT VIS-A-VIS DES VIRUS DE L'HERPES ET DES PAPILLOMAVIRUS |
Country Status (5)
Country | Link |
---|---|
US (1) | US5487893A (fr) |
EP (1) | EP0557404B1 (fr) |
AU (1) | AU9020991A (fr) |
DE (1) | DE69119605D1 (fr) |
WO (1) | WO1992008450A2 (fr) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0750604B1 (fr) * | 1994-03-14 | 1997-12-29 | Morten Sloth Weidner | Procede permettant de rendre des composes organiques solubles dans les systemes gras, nouveaux complexes chimiques de tels composes et leurs diverses applications |
US5476876A (en) * | 1994-05-24 | 1995-12-19 | The Procter & Gamble Company | Di-tert-butylphenol compounds useful as anti-inflammatory agents |
FR2721924B1 (fr) * | 1994-06-30 | 1996-10-31 | Fileco Sa | Nouveaux composes 2,6-di-tert-butylphenols substitues en position 4, les compositions pharmaceutiques les contenant et leur procede de preparation |
FR2721826B1 (fr) * | 1994-06-30 | 1996-09-20 | Fileco Sa | Utilisation de composes 2, 6-di-t-butylphenols substitues en position 4 dans le traitement et la prevention du sida |
US5912274A (en) * | 1995-09-22 | 1999-06-15 | Colgate-Palmolive Company | Antiplaque oral composition and method |
US5723500A (en) * | 1995-09-22 | 1998-03-03 | Colgate-Palmolive Company | Antiplaque oral composition and method |
US6475526B1 (en) * | 2001-06-05 | 2002-11-05 | Jeffrey B. Smith | Zinc containing compositions for anti-viral use |
KR100418260B1 (ko) * | 2001-08-10 | 2004-02-11 | 미원상사주식회사 | 3,5-디-tert-부틸-4-히드록시 벤질알코올의 제조방법 |
FR2835522B1 (fr) * | 2002-02-06 | 2006-04-07 | Robert Vachy | Preparation pour composes sensibles a l'oxydation et son procede de fabrication |
DE10246657A1 (de) * | 2002-10-07 | 2004-04-15 | Merck Patent Gmbh | Chirales Phenolderivat, dieses enthaltendes Flüssigkristallmedium, Verfahren zur Herstellung eines Flüssigkristallmediums und elektrooptische Flüssigkristallanzeige |
US20080274209A1 (en) * | 2002-11-04 | 2008-11-06 | Integritas Pharma, Inc. | Methods of treating inflammation |
US6855341B2 (en) * | 2002-11-04 | 2005-02-15 | Jeffrey B. Smith | Anti-viral compositions and methods of making and using the anti-viral compositions |
US7479507B2 (en) * | 2003-01-14 | 2009-01-20 | Adam Heller | Anti-inflammatory substituted phenols and elastomeric compositions for oral delivery of drugs |
FR2887249B1 (fr) * | 2005-06-21 | 2007-09-28 | Rdw Pharma Soc Par Actions Sim | Compose d-glucopyranose 1-[3,5-bis(1,1-dimenthylethyl)-4- hydroxybenzoate] et ses derives, leur preparation et leurs utilisations |
WO2008000920A1 (fr) * | 2006-06-23 | 2008-01-03 | Rdw Pharma | Compose d-glucopyranose 1-[3,5-bis(1 ,1-dimethylethyl)-4- hydroxybenzoate] et ses derives, leur preparation et leurs utilisations |
FR2933616B1 (fr) * | 2008-07-10 | 2011-08-19 | Robert Vachy | "compositions renfermant une association de propolis et d'un derive phenolique et leurs applications biologiques" |
FR2963736B1 (fr) * | 2010-08-10 | 2012-08-31 | Robert Vachy | Composition therapeutique comprenant un derive de galvinoxyl et de la propolis, et son utilisation contre les virus a capside lipidique, notamment les virus de l'herpes |
FR3058640B1 (fr) * | 2016-11-14 | 2020-06-19 | Robert Vachy | Composes pour leur utilisation dans le traitement de la grippe |
WO2021205083A2 (fr) | 2020-04-11 | 2021-10-14 | Finindsutria Srl | Composition pour la prévention ou le traitement du covid-19 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0061508A1 (fr) * | 1981-03-27 | 1982-10-06 | Rudolf Schanze | Procédé de séparation de produits contenant du propolis et produits contenant du propolis |
FR2507891A1 (fr) * | 1981-06-18 | 1982-12-24 | Gresval Laboratoires | Medicament, notamment pour le traitement des maladies a virus du type herpes |
US4708966A (en) * | 1986-06-27 | 1987-11-24 | The Procter & Gamble Company | Novel anti-inflammatory agents, pharmaceutical compositions and methods for reducing inflammation |
GB2200113A (en) * | 1987-01-21 | 1988-07-27 | Bromine Compounds Ltd | Process for preparing 2-tert-butyl-4-methoxyphenol |
EP0382077A2 (fr) * | 1989-02-10 | 1990-08-16 | BASF Aktiengesellschaft | Composé hétérocyclique diaryle-substitué, sa préparation et médicaments et produits cosmétiques à partir de celui-ci |
WO1991013626A1 (fr) * | 1990-03-12 | 1991-09-19 | Fileco | Composition therapeutique contenant un compose phenol et de la propolis utile contre le virus a capside lipidique, notamment les virus de l'herpes |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3974223A (en) * | 1975-05-07 | 1976-08-10 | Gulf Oil Corporation | Process for manufacture of 3,5-ditert.butyl-4-hydroxybenzaldehyde from 3,5-ditert.butyl-4-hydroxybenzyl alcohol |
RO81340B1 (ro) * | 1980-11-08 | 1983-02-28 | Ion Marinescu | Metoda de tratament a unor boli infectioase, de origine virala |
HU194052B (en) * | 1985-03-12 | 1988-01-28 | Caola Kozmetikai | Cosmetic composition against verrucae |
JP3047239B2 (ja) * | 1989-04-14 | 2000-05-29 | 日立金属株式会社 | 温間加工磁石及びその製造方法 |
-
1991
- 1991-11-12 DE DE69119605T patent/DE69119605D1/de not_active Expired - Lifetime
- 1991-11-12 EP EP91920899A patent/EP0557404B1/fr not_active Expired - Lifetime
- 1991-11-12 US US08/050,279 patent/US5487893A/en not_active Expired - Lifetime
- 1991-11-12 AU AU90209/91A patent/AU9020991A/en not_active Abandoned
- 1991-11-12 WO PCT/FR1991/000882 patent/WO1992008450A2/fr active IP Right Grant
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0061508A1 (fr) * | 1981-03-27 | 1982-10-06 | Rudolf Schanze | Procédé de séparation de produits contenant du propolis et produits contenant du propolis |
FR2507891A1 (fr) * | 1981-06-18 | 1982-12-24 | Gresval Laboratoires | Medicament, notamment pour le traitement des maladies a virus du type herpes |
US4708966A (en) * | 1986-06-27 | 1987-11-24 | The Procter & Gamble Company | Novel anti-inflammatory agents, pharmaceutical compositions and methods for reducing inflammation |
US4708966B1 (fr) * | 1986-06-27 | 1991-03-12 | Procter & Gamble | |
GB2200113A (en) * | 1987-01-21 | 1988-07-27 | Bromine Compounds Ltd | Process for preparing 2-tert-butyl-4-methoxyphenol |
EP0382077A2 (fr) * | 1989-02-10 | 1990-08-16 | BASF Aktiengesellschaft | Composé hétérocyclique diaryle-substitué, sa préparation et médicaments et produits cosmétiques à partir de celui-ci |
WO1991013626A1 (fr) * | 1990-03-12 | 1991-09-19 | Fileco | Composition therapeutique contenant un compose phenol et de la propolis utile contre le virus a capside lipidique, notamment les virus de l'herpes |
Non-Patent Citations (13)
Title |
---|
Antiviral Research, volume 5, no. 5, octobre 1985, Elsevier Science Publishers B.V. (Biomedical Division) J.T. Richards et al.: "Topical butylated hydroxytoluene treatment of genital herpes simplex virus infections of guinea pigs" pages 281-290, voir l'article en entier * |
Biochem J., volume 78, no. 4, 1961, J.C. Dacre: "The metabolism of 3:5-di-tert.-butyl-4-hydroxytoluene and 3:5-di-tert.-butyl-4-hydroxybenzoic acid in the rabbit", pages 758-766, voir page 759 (cité dans la demande) * |
Chemical Abstracts, volume 65, 1966, (Columbus, Ohio, US) N.P. Konovalova et al.: "Structure and antileukemic action of a series of substituted phenols", voir column 9522a, & Dokl. Akad. Nauk SSSR 168(6), 1419-21 (1966), voir le résumé * |
Database WPI/L, accession no. 83-762896, Derwent Publications Ltd, (Londres, GB) & RO, A, 81340 (COLENTINA SPITALUL) voir le résumé * |
Database WPI/L, accession no. 86-313850, Derwent Publications Ltd, (Londres, GB), & HU, A, 39606 (CAOLA KOZMETIKAI ES) voir le résumé * |
Farm. Zh. (Kiev), volume 30, no. 3, 1975, A.I. Tikhonov et al.: "Physico-chemical, microbiological and quantitative determination of watersoluble polyphenol propolis preparations", pages 42-48, voir le résumé * |
Journal of Medicinal and Pharmaceutical Chemistry, volume 2, no. 2, 1960, R.B. Moffett et al.: "Central nervous system depressants - III. 2- and 4-allyloxy-3,5-disubstituted benzoic acids and derivatives", pages 213-227, voir pages 214-215, tableau I * |
Journal of Organic Chemistry, volume 21, 1956, G.R. Yohe et al.: "The oxidation of 2,6-di-tert-butyl-4-methylphenol", pages 1289-1292, voir l'article en entier (cité dans la demande) * |
Science, volume 188, no. 4183, 4 avril 1975, W. Snipes et al.: "Butylated hydroxytoluene inactivates lipid-containing viruses", pages 64-65, voir l'article en entier (cité dans la demande) * |
Symposium on the Pharmacological Effects of Lipids, (The American Oil Chemist's Society, Champaign, Illinois, (US) 1978, W. Snipes et al.: "Hydrophobic alcohols and di-tert-butyl phenols as antiviral agents", pages 63-73, voir l'article en entier (cité dans la demande) * |
The New England Journal of Medicine, volume 314, no. 10, 6 mars 1986, D.M. Shlian: "Toxicity of butylated hydroxytoluene", pages 648-649, voir l'article en entier * |
West. J. Med., volume 139, no. 2, août 1983, J.G. Llaurodo: "Beware of phenolic antioxidants (BHT and BHA)", pages 229-230, voir l'article en entier * |
West. J. Med., volume 145, no. 2, août 1986, M.W. Grogan: "Toxicity from BHT ingestion", pages 245-246, voir l'article en entier * |
Also Published As
Publication number | Publication date |
---|---|
EP0557404A1 (fr) | 1993-09-01 |
AU9020991A (en) | 1992-06-11 |
US5487893A (en) | 1996-01-30 |
EP0557404B1 (fr) | 1996-05-15 |
WO1992008450A2 (fr) | 1992-05-29 |
DE69119605D1 (de) | 1996-06-20 |
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